Structure-based drug discovery is a collection of methods that exploits the ability to determine and analyse the three dimensional structure of biological molecules. These methods have been adopted and enhanced to improve the speed and quality of discovery of new drug candidates. After an introductory overview of the principles and application of structure-based methods in drug discovery, this book then describes the essential features of the various methods. Chapters on X-ray crystallography, NMR spectroscopy, and computational chemistry and molecular modelling describe how these particular techniques have been enhanced to support rational drug discovery, with discussions on developments such as high throughput structure determination, probing protein-ligand interactions by NMR spectroscopy, virtual screening and fragment-based drug discovery. The concluding chapters complement the overview of methods by presenting case histories to demonstrate the major impact that structure-based methods have had on discovering drug molecules. Written by international experts from industry and academia, this comprehensive introduction to the methods and practice of structure-based drug discovery not only illustrates leading-edge science but also provides the scientific background for the non-expert reader. The book provides a balanced appraisal of what structure-based methods can and cannot contribute to drug discovery. It will appeal to industrial and academic researchers in pharmaceutical sciences, medicinal chemistry and chemical biology, as well as providing an insight into the field for recent graduates in the biomolecular sciences.
Note: If you are purchasing an electronic version, MyManagementLab does not come automatically packaged with it. To purchase MyManagementLab, please visit www.MyManagementLab.com or you can purchase a package of the physical text and MyManagementLab by searching for ISBN 10: 0133357279 / ISBN 13: 9780133357271. Management is a dynamic subject, and a textbook on it should reflect those changes to help prepare students to manage under the current conditions. The eleventh Canadian edition of Management has been written to provide students with the best possible understanding of what it means to be a manager confronting change.
Lead Babies reveals important new information about in utero lead transfer from mother to unborn child - Lead poisoning is causing an epidemic of learning and behavior problems in our children. - Despite decades of concern about lead's toxicity, the lead industry flourishes, putting unborn children and people of all ages at risk from a multitude of seemingly harmless sources.
Note: If you are purchasing an electronic version, MyManagementLab does not come automatically packaged with it. To purchase MyManagementLab, please visitwww.MyManagementLab.com or you can purchase a package of the physical text and MyManagementLab by searching for ISBN 10: 0133357279 / ISBN 13: 9780133357271. Management is a dynamic subject, and a textbook on it should reflect those changes to help prepare students to manage under the current conditions. The eleventh Canadian edition of Management has been written to provide students with the best possible understanding of what it means to be a manager confronting change.
As inspector John Underwood and his team frantically try to piece together the last hours of Olympic athlete Lucy Harrington, events take an extraordinary turn. Harrington's murderer contacts English Literature lecturer Heather Stussman and challenges her to explain his actions to the police. But not until another woman is murdered does Stussman realise that the key to the killer's terrifying motive lies buried in the works of a port who has been dead for nearly four hundred years...
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