Eckhard Wolf's Books

Animal Models for the Study of Human Disease

Chapter 32. Genetically Tailored Pig Models for Translational Biomedical Research

By: Bernhard Aigner,Barbara Kessler,Nikolai Klymiuk,Mayuko Kurome,Simone Renner,Annegret Wünsch,Eckhard Wolf

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Animal Models for the Study of Human Disease

Chapter 32. Genetically Tailored Pig Models for Translational Biomedical Research

By: Bernhard Aigner,Barbara Kessler,Nikolai Klymiuk,Mayuko Kurome,Simone Renner,Annegret Wünsch,Eckhard Wolf

Basic research of the pathobiology of diseases as well as of therapeutic strategies usually is carried out in rodents as animal models. Translational research that transfers novel results from basic research to clinical application often requires analyses in additional nonrodent models and/or large animal models that share specific pathophysiological characteristics with the human diseases in question. As prerequisites for the generation of appropriate disease models by genetic engineering, pigs exhibit suitable reproductive performance traits, pig genome analyses resulted in the availability of several resources of genomic data, and efficient and precise techniques for the genetic modification of pigs have been established. In the recent years, genetically engineered pigs were increasingly generated as biomedical research tools for specific human genetic diseases. Here, we review the current state of the techniques used for the production of genetically engineered pigs as well as the establishment of genetically engineered pigs as models for human diseases.

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Elsevier Inc. Chapters

Published Date

ISBN 10

0128072229

ISBN 13

9780128072226

Paul the Missionary

Realities, Strategies and Methods

By: Eckhard J. Schnabel

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Paul the Missionary

Realities, Strategies and Methods

By: Eckhard J. Schnabel

Drawing on his monumental scholarly study Early Christian Mission (Volume 2), Eckhard J. Schnabel's gives us an overview of Paul's missionary practices, strategies and methods, and then weighs contemporary evangelical missiology and practice in light of Paul.

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519

Publisher

InterVarsity Press

Published Date

ISBN 10

0830879005

ISBN 13

9780830879007

A Benchmark Approach to Quantitative Finance

By: Eckhard Platen,David Heath

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A Benchmark Approach to Quantitative Finance

By: Eckhard Platen,David Heath

A framework for financial market modeling, the benchmark approach extends beyond standard risk neutral pricing theory. It permits a unified treatment of portfolio optimization, derivative pricing, integrated risk management and insurance risk modeling. This book presents the necessary mathematical tools, followed by a thorough introduction to financial modeling under the benchmark approach, explaining various quantitative methods for the fair pricing and hedging of derivatives.

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704

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Springer Science & Business Media

Published Date

ISBN 10

3540478566

ISBN 13

9783540478560

A-Way with It!

Contemporary Innovative Fiction

By: Eckhard Gerdes

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A-Way with It!

Contemporary Innovative Fiction

By: Eckhard Gerdes

A-way with it! Simply put, that's what this is all about. The authors in this volume of The Journal of Experimental Fiction have demonstrated time and again that they have a way with words. Literature is ultimately driven by language, and these folks understand how to use language better than most. They prod it, ply it, tweak it, fry it, sling it, smash it, caress it, destroy it, uphold it, defend it, laugh at it, play with it, split it, spit on it, cajole it, stir it, freeze it, melt it, stomp on it, and hold it up for all to see as if it were the most precious thing in the entire world. Maybe it is.

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509

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iUniverse

Published Date

ISBN 10

0595260748

ISBN 13

9780595260744

Chronotopes of the Uncanny

Time and Space in Postmodern New York Novels. Paul Auster's »City of Glass« and Toni Morrison's »Jazz«

By: Petra Eckhard

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Chronotopes of the Uncanny

Time and Space in Postmodern New York Novels. Paul Auster's »City of Glass« and Toni Morrison's »Jazz«

By: Petra Eckhard

Using the theoretical frameworks of Freud, Todorov, and Bahktin, this book explores how American writers of the late 20th century have translated the psychoanalytical concept of »the uncanny« into their novelistic discourses. The two texts under scrutiny - Paul Auster's »City of Glass« and Toni Morrison's »Jazz« - show that the uncanny has developed into a crucial trope to delineate personal and collective fears that are often grounded on the postmodern disruption of spatio-temporal continuities and coherences.

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207

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transcript Verlag

Published Date

ISBN 10

3839418410

ISBN 13

9783839418413

The Notochord

Development, Evolution and contributions to the vertebral column

By: P. Eckhard Witten,Brian K. Hall

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The Notochord

Development, Evolution and contributions to the vertebral column

By: P. Eckhard Witten,Brian K. Hall

Although it is the defining organ of the Chordata, the notochord and its cells are one of the least understood vertebrate organs. This may be because large parts of the notochord are often replaced with cartilaginous or bony vertebral bodies. The presence of cartilage in the notochord raises questions about the evolutionary relationships between notochord cells and cartilage cells. This book integrates classical analytical studies with recent palaeontological, experimental, and molecular studies in both developmental and evolutionary contexts. For example, although the early signaling function of the notochord is conserved across the vertebrates, many will be surprised to find that the role of the notochord in vertebral body development in tetrapods is not the blueprint for all vertebrates. Recent studies on zebrafish and medaka embryos have uncovered the molecular mechanisms of a somite-independent notochord-driven segmentation process that establishes vertebral centra and intervertebral spaces. As this process is not restricted to teleosts, the authors have written a general discussion about the role of the notochord in vertebral formation. Modularity and segmentation of the vertebral column are related topics. Further overarching themes are the structure, function and fate of the notochord in adult vertebrates and notochord–cartilage relationships. Key Features The first book devoted to notochord development, function and evolution Includes and integrates information on the notochord from studies going back 169 years Integrates developmental, molecular, functional, experimental and palaeontological studies Documents the fate of the notochord across the vertebrates Extensively illustrated with classical and new images Related Titles Bard, J. Evolution: The Origins and Mechanisms of Diversity (ISNB 978-0-3673-5701-6) Leys, S. and Hejnol. A. Origin and Evolution of Metazoan Cell Types (ISBN 978-1-1380-3269-9)

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301

Publisher

CRC Press

Published Date

ISBN 10

1351652036

ISBN 13

9781351652032

John Barth, Bearded Bards & Splitting Hairs

By: Eckhard A Gerdes

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John Barth, Bearded Bards & Splitting Hairs

By: Eckhard A Gerdes

The premier international source for literature at the forefront, The Journal of Experimental Fiction has done it again! It has collected writing by some of the bravest, most innovative and thought-provoking, most emotive authors working today. A special section features a previously unpublished essay by John Barth presented as a lecture at Macon State College and 17 narrative responses written by students. Other selections include fiction by Steven Kedrowski, Amina Memory Cain, Daniel Borzutzky, Antoinette Nora Claypoole, Lee Groban, Persis Gerdes, Todd Smith , and Kari Edwards. Famous works of experimental fiction are parodied by Thomas McCain, Dawn Hamilton and Eckhard Gerdes. Also featured are a critical essay by Tim Miller and a review of John Barth's new novel, "Coming Soon!!!" This anthology is a welcome and vital addition to the great literature of our age!

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206

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iUniverse

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ISBN 10

059520466X

ISBN 13

9780595204663

The Trial and Crucifixion of Jesus

Texts and Commentary

By: David W. Chapman,Eckhard J. Schnabel

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The Trial and Crucifixion of Jesus

Texts and Commentary

By: David W. Chapman,Eckhard J. Schnabel

The authors of this volume set themselves one task, to trace the extra-biblical primary texts that are relevant for understanding Jesus' trial and crucifixion. With that goal in mind, the book is built on three major themes: (1) Jesus' trial / interrogation before the Sanhedrin, (2) Jesus' trial before Pontius Pilatus, and (3) crucifixion as a method of execution in antiquity. In chronologically sequential order (where possible), the authors select and arrange an overwhelming amount of extra-biblical primary texts -- 462 to be exact -- underneath these three categories (75, 46, and 341 texts respectively)."--Brian J. Wright in Religious Studies Review

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912

Publisher

Mohr Siebeck

Published Date

ISBN 10

3161537866

ISBN 13

9783161537868

Successfully Managing S/4HANA Projects

The Definitive Guide to the Next Digital Transformation

By: Denise Banks-Grasedyck,Eckhard Lippke,Hans Oelfin,Reinhold Schwaiger,Volker Seemann

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Successfully Managing S/4HANA Projects

The Definitive Guide to the Next Digital Transformation

By: Denise Banks-Grasedyck,Eckhard Lippke,Hans Oelfin,Reinhold Schwaiger,Volker Seemann

The book describes the complete project process in individual steps for SAP S/4HANA project management based on the SAP ACTIVATE implementation methodology. By imparting knowledge based on experience with real SAP projects, the book supports project managers in developing skills and qualifications that will lead them to the successful management of SAP projects. In this context it emphasizes the crucial role of human interaction from the start to the successful completion of projects and provides useful tips on how to recognize and avoid pitfalls. Enriched with a wide range of material such as templates, checklists and practical examples, the book provides concrete guidance for project managers and participants on how to successfully manage ongoing projects. The book is valuable for both beginners and experienced project managers and also gives decision makers and stakeholders an excellent insight into the planning and management of large projects.

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365

Publisher

Springer Nature

Published Date

ISBN 10

3030860841

ISBN 13

9783030860844

Songs for a Revolution

The 1848 Protest Song Tradition in Germany

By: Eckhard John,David Robb

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Songs for a Revolution

The 1848 Protest Song Tradition in Germany

By: Eckhard John,David Robb

Makes available twenty-two protest songs of the period up to and including the 1848 Revolution in Germany along with a reception history of the songs through their revival after 1945.

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385

Publisher

Boydell & Brewer

Published Date

ISBN 10

1640140484

ISBN 13

9781640140486

40 Questions about the End Times

By: Eckhard J. Schnabel

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40 Questions about the End Times

By: Eckhard J. Schnabel

Benjamin L. Merkle is professor of New Testament at Malaysia Baptist Theological Seminary and is the author of numerous articles, which have appeared in journals such as JETS and Trinity Journal. He earned his Ph.D. from Southern Baptist Theological Seminary, where he wrote his dissertation on deacons and elders.

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354

Publisher

Kregel Academic

Published Date

ISBN 10

0825438969

ISBN 13

9780825438967

Microscopic Approaches to Quantum Liquids in Confined Geometries

By: Eckhard Krotscheck,Jes£s Navarro

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Microscopic Approaches to Quantum Liquids in Confined Geometries

By: Eckhard Krotscheck,Jes£s Navarro

This volume assembles review articles that present the status of frontline research in this field in a manner that makes the material accessible to the educated, but non-specialist, reader. The articles focus on the many-body aspects of the theory of quantum liquids in confined geometry. Research is in the very satisfactory situation where several accurate approaches are available that allow one to describe these systems in a quantitative manner without modelling uncertainty and uncontrolled assumptions. For example, dynamic situations of direct experimental relevance can be modelled with high accuracy.

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446

Publisher

World Scientific

Published Date

ISBN 10

9810246404

ISBN 13

9789810246402

Quaternion and Clifford Fourier Transforms

By: Eckhard Hitzer

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Quaternion and Clifford Fourier Transforms

By: Eckhard Hitzer

Quaternion and Clifford Fourier Transforms describes the development of quaternion and Clifford Fourier transforms in Clifford (geometric) algebra over the last 30 years. It is the first comprehensive, self-contained book covering this vibrant new area of pure and applied mathematics in depth. The book begins with a historic overview, followed by chapters on Clifford and quaternion algebra and geometric (vector) differential calculus (part of Clifford analysis). The core of the book consists of one chapter on quaternion Fourier transforms and one on Clifford Fourier transforms. These core chapters and their sections on more special topics are reasonably self-contained, so that readers already somewhat familiar with quaternions and Clifford algebra will hopefully be able to begin reading directly in the chapter and section of their particular interest, without frequently needing to skip back and forth. The topics covered are of fundamental interest to pure and applied mathematicians, physicists, and engineers (signal and color image processing, electrical engineering, computer science, computer graphics, artificial intelligence, geographic information science, aero-space engineering, navigation, etc.). Features Intuitive real geometric approach to higher-dimensional Fourier transformations A comprehensive reference, suitable for graduate students and researchers Includes detailed definitions, properties, and many full step-by-step proofs Many figures and tables, a comprehensive biography, and a detailed index make it easy to locate information

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475

Publisher

CRC Press

Published Date

ISBN 10

1000429342

ISBN 13

9781000429343

Disaster or Culture?

The Aesthetics Principle and Social Progress

By: Eckhard Schindler

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Disaster or Culture?

The Aesthetics Principle and Social Progress

By: Eckhard Schindler

This book deals with two areas, for which there is rarely a search for a common denominator: the human nervous system and the problems of civilisation. What are the performance features of the nervous system? How do these act together? How do modes of behaviour, emotions, cognitive achievements, artistic inclinations, the psyche and the self-conscious mind evolve from this? This subject is a controversial area and there are many attempts at interpreting the named phenomena from different fields. Eckhard Schindler adds another one. He directs attention to significant findings from neurosciences and applies the method of abstraction to this. The result is a hypothetical but consistent description of the system which could be concealed behind the nervous system. In the other section of the book, the human failings of our time are subject to a critical analysis. In large parts of the world crime, violence and corruption prevail. A substantial part of technological achievements is aimed at being able to commit brutal acts of war. The natural environment and biodiversity are our livelihoods, but we are knowingly destroying this abundance. We are following the principles of accelerated consumption, economic growth and the increase in shareholder value towards disaster. We have efficient technologies and industries and allow people to starve. It can also hardly be denied that the human being is equipped with a pronounced propensity towards destructive modes of behaviour. Great cultural achievements are at any moment undermined by disaster. Analysis of this dark side of civilisation is followed by the search for solutions. The idea of a largely peaceful, fair and systematic (sustainable) management of global cultural society appears to be a utopia considering the geopolitical realities. Eckhard Schindler contrasts this resigned perception with practical problem-solving approaches. The principles of the system behind the nervous system here act as a starting point.

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289

Publisher

BoD – Books on Demand

Published Date

ISBN 10

3734795451

ISBN 13

9783734795459

Numerical Solution of Stochastic Differential Equations with Jumps in Finance

By: Eckhard Platen,Nicola Bruti-Liberati

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Numerical Solution of Stochastic Differential Equations with Jumps in Finance

By: Eckhard Platen,Nicola Bruti-Liberati

In financial and actuarial modeling and other areas of application, stochastic differential equations with jumps have been employed to describe the dynamics of various state variables. The numerical solution of such equations is more complex than that of those only driven by Wiener processes, described in Kloeden & Platen: Numerical Solution of Stochastic Differential Equations (1992). The present monograph builds on the above-mentioned work and provides an introduction to stochastic differential equations with jumps, in both theory and application, emphasizing the numerical methods needed to solve such equations. It presents many new results on higher-order methods for scenario and Monte Carlo simulation, including implicit, predictor corrector, extrapolation, Markov chain and variance reduction methods, stressing the importance of their numerical stability. Furthermore, it includes chapters on exact simulation, estimation and filtering. Besides serving as a basic text on quantitative methods, it offers ready access to a large number of potential research problems in an area that is widely applicable and rapidly expanding. Finance is chosen as the area of application because much of the recent research on stochastic numerical methods has been driven by challenges in quantitative finance. Moreover, the volume introduces readers to the modern benchmark approach that provides a general framework for modeling in finance and insurance beyond the standard risk-neutral approach. It requires undergraduate background in mathematical or quantitative methods, is accessible to a broad readership, including those who are only seeking numerical recipes, and includes exercises that help the reader develop a deeper understanding of the underlying mathematics.

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868

Publisher

Springer Science & Business Media

Published Date

ISBN 10

364213694X

ISBN 13

9783642136948

Contextual Schema Therapy

An Integrative Approach to Personality Disorders, Emotional Dysregulation, and Interpersonal Functioning

By: Eckhard Roediger,Bruce A. Stevens,Robert Brockman

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Contextual Schema Therapy

An Integrative Approach to Personality Disorders, Emotional Dysregulation, and Interpersonal Functioning

By: Eckhard Roediger,Bruce A. Stevens,Robert Brockman

In this groundbreaking book, three internationally recognized psychologists present a step-by-step guide outlining the most up-to-date innovations in schema therapy (ST). This important book offers a clear and practical road map for putting the schema mode model into practice, improving clients' interpersonal functioning, and integrates the latest advances in contextual behavioral psychology. ST is a powerful, integrative treatment model that combines aspects of cognitive, behavioral, and psychodynamic therapies. It has proven highly effective in treating a number of mental health issues, including difficult-to-treat personality disorders. ST’s main premise is that mental health issues arise as a result of unmet emotional needs in childhood, leading to the development of early maladaptive schemas (EMS). But, more and more, ST has shifted away from EMS to focus on schema content—that is, changing the way clients relate to their experiences and to others. This book incorporates the latest findings in contextual behavioral science with a focus on clients’ coping styles—or schema modes—and improving interpersonal functioning. The book includes exercises from compassion-focused therapies, acceptance and commitment therapy (ACT), and even functional analytic psychotherapy (FAP) to help your clients become more aware of their own unhealthy coping patterns and behaviors. You’ll also discover a range of emotion-focused and experiential techniques to use in therapy with your client.

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334

Publisher

New Harbinger Publications

Published Date

ISBN 10

1684030978

ISBN 13

9781684030972

New Testament Theology

By: Eckhard J. Schnabel

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New Testament Theology

By: Eckhard J. Schnabel

New Testament Theology is a major new contribution to New Testament scholarship by renowned scholar Eckhard Schnabel. While many New Testament theologies approach the material through a particular thematic construct (e.g., covenant), Schnabel takes a different approach. First, he focuses on Jesus Messiah and his significance for the early church. Second, he seeks to describe the theology of the New Testament as it was written and read in its historical context. This approach honors the fact that the authors and original readers of the New Testament were real people dealing with real issues in their specific ecclesiological, cultural, and missiological settings. Schnabel comprehensively combines a historical description of the New Testament's theology with a systematic reflection on the New Testament's message and the convictions of Jesus and his early followers. This valuable contribution to the field will be insightful reading for students, scholars, and pastors.

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1358

Publisher

Baker Books

Published Date

ISBN 10

1493443062

ISBN 13

9781493443062

Numerical Solution of Stochastic Differential Equations

By: Peter E. Kloeden,Eckhard Platen

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Numerical Solution of Stochastic Differential Equations

By: Peter E. Kloeden,Eckhard Platen

The numerical analysis of stochastic differential equations (SDEs) differs significantly from that of ordinary differential equations. This book provides an easily accessible introduction to SDEs, their applications and the numerical methods to solve such equations. From the reviews: "The authors draw upon their own research and experiences in obviously many disciplines... considerable time has obviously been spent writing this in the simplest language possible." --ZAMP

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680

Publisher

Springer Science & Business Media

Published Date

ISBN 10

3540540628

ISBN 13

9783540540625

Acts

By: Eckhard J. Schnabel

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Acts

By: Eckhard J. Schnabel

With attention to issues that continue to surface in today’s church, the Zondervan Exegetical Commentary on the New Testament series offers pastors, students, and teachers a focused resource for reading, teaching, and preaching the Book of Acts. Acts highlights (1) the work of God through the exalted Jesus who grants the presence of the Holy Spirit; (2) the significance of Jesus who is Israel’s Messiah and the Savior of the world and who directs the expansion of the church; (3) the work of the Holy Spirit as transforming power present in the lives of the followers of Jesus and their communities; (4) the identity of the church as the community of God, comprised of Jews and Gentiles who are followers of Jesus; (5) the mission of the church whose leaders take the gospel to cities and regions of the Roman Empire in which Jesus has not yet been proclaimed as Messiah and Savior; (6) the historical events and the persons who played a role in the expansion of earliest Christianity.

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1169

Publisher

Zondervan Academic

Published Date

ISBN 10

0310532132

ISBN 13

9780310532132

Cytolytic Lymphocytes and Complement Effectors of the Immune System

Volume 1

By: Eckhard R. Podack

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Cytolytic Lymphocytes and Complement Effectors of the Immune System

Volume 1

By: Eckhard R. Podack

These volumes, Cytolytic Lymphocytes and Complement: Effectors of the Immune System, originate from the realization that pathways of recognition and killings of foreign targets follow similar routes in the humoral and cellular part of the immune system. In particular, the homology of immunoglobins with the T-cell-MHC-antigen receptor at the beginning of the recognition sequence and the homology of complement component C9 with lymphocyte perforin 1 (P1) as pore formers at the end of the effector sequence are striking examples.

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Page Count

400

Publisher

CRC Press

Published Date

ISBN 10

1351088203

ISBN 13

9781351088206

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