Nobody can know everything. For the successful application of techniques based on nuclear magnetic resonance to clinical problems, it is a vital necessity that individuals with widely different skills should learn a little of each others' trades by co-operation and communication. Ernest Cady has long proved himself a master of these arts to his colleagues at University College London, and by writing this excellent book he extends his experience to a wide circle of readers. Although the nuclear magnetic resonance (NMR) phenomenon had been predicted theoretically (and to some degree demonstrated experimentally) appreciably earlier, it required the advances in electronics that took place during World War II to turn NMR into a practical technique, as demonstrated independently in 1946 by Bloch and Purcell. Since then, NMR has been used extensively and increasingly by chemists and physicists. In the 1970s the first applications of NMR to animal organs yielded important advances in our knowledge of the biochemical and physiological processes as they occur in genuinely intact tissues. They showed incidentally that some conventional techniques introduce significant artifacts.
The Rawson family a revised memoir or Edward Rawson, secretary of the colony of Massachusetts Bay, from 1650-1686, with genealogical notices of his descendants, including nine generations.
“In all the vast collection of books on the American Civil War there is no book like this one,” says Bruce Catton. Never before has such a stunning body of facts dealing with the war been gathered together in one place and presented in a coherent, useful, day-by-day narrative. And never before have statistics revealed human suffering of such heroic and tragic magnitude. The text begins in November, 1860, and ends with the conclusion of hostilities in May, 1865, and the start of reconstruction. It is designed to furnish the reader not only with information, but to tell a story. Here, in addition to the momentous events that are a familiar part of our history, the daily entries recount innumerable lesser military actions as well as some of the other activities and thoughts of men great and unknown engaged in America’s most costly war: · May 5, 1864—a private in the Army of Northern Virginia writes at the beginning of the Battle of the Wilderness, “It is a beautiful spring day on which all this bloody work is being done.” · May 6, 1864—Gen. Lee rides among his men and is shouted to the rear by his protective troops. · April 30, 1864—Joe David, five-year-old son of the Confederate President, dies after a fall from the high veranda of the White House in Richmond. · April 14, 1865—President Lincoln’s busy day includes a Cabinet meeting where he tells of his recurring dream of a ship moving with great rapidity toward a dark and indefinite shore; that night Mr. Lincoln attends a performance of a trifling comedy at Ford’s Theatre, “Our American Cousin”.
RF Probeheads 1. J. Link, Faellanden, Switzerland The Design of Resonator Probes with Homogeneous Radiofrequency Fields 2. M. Schnall, Philadelphia, PA/USA Probes Tuned to Multiple Frequencies for In-Vivo NMR RF Pulses 3. P.C.M. van Zijl, Rockville, MD/USA; C.T.W. Moonen, Bethesda, MD/USA Solvent Suppression Strategies for In Vivo Magnetic Resonance Spectroscopy 4. M. Garwood, K. Ugurbil, Minneapolis, MN/USA B1 Insensitive Adiabatic RF Pulses 5. P.G. Morris, Nottingham, UK Frequency Selective Excitation Using Phase-Compensated RF Pulses in One andTwo Dimensions 6. S. Mueller, Basel, Switzerland RF Pulses for MultipleFrequency Excitation: Theory and Application Spectrum Analysis 7. R. de Beer, D. van Ormondt, Delft, The Nethelands Analysis of NMR Data Using Time Domain Fitting Procedures 8. E.B. Cady, London, UK Determination of Absolute Concentrations of Metabolites from NMR Spectra.
There has been increasing interest in neonatal neurology, especially since imaging techniques were introduced in the neonatal ward. Looking at the natural history of imaging techniques, we can identify three main axes of its development. Logically, it was first essential to image the brain morphologically. For this purpose, computed tomography was initially used, followed by ultra sound. However, to improve the quality of the images, magnetic resonance imaging was introduced. Major features of ultrasound and magnetic reso nance imaging are their safety and lack of ionization. Morphological imaging techniques have proved to be insufficient to ex plain the mechanisms underlying CNS injuries. Thus, it was essential to develop functional techniques to assess cerebral hemodynamics and oxy genation. The use of Doppler ultrasound, PET scanning, SPECT scanning and, more recently, NIRS have widened our knowledge of general neurolog ical problems. Finally, to achieve our goal of attaining a better understanding of CNS injuries, it is important to assess cerebral cellular metabolism. Magnetic resonance spectroscopy was introduced to achieve this goal. We hope that this book links these different techniques in order to widen our horizon. The future is promising and bound to provide further develop ments, which however can only be understood if we grasp the present level of development.
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