The fourth industrial revolution, according to the World Economic Forum, is about to begin. This will blend the physical and digital worlds in ways we couldn’t imagine a few years ago. Advances in machine learning and AI will help usher in these existing changes. Machine learning is transformative which opens up new scenarios that were simply impossible a few years ago. Profound gaining addresses a significant change in perspective from customary programming improvement models. Instead of having to write explicit top-down instructions for how software should behave, deep learning allows your software to generalize rules of operations. Deep learning models empower the engineers to configure, characterized by the information without the guidelines to compose. Deep learning models are conveyed at scale and creation applications—for example, car, gaming, medical services, and independent vehicles. Deep learning models employ artificial neural networks, which are computer architectures comprising multiple layers of interconnected components. By avoiding data transmission through these connected units, a neural network can learn how to approximate the computations required to transform inputs to outputs. Deep learning models require top-notch information to prepare a brain organization to carry out a particular errand. Contingent upon your expected applications, you might have to get thousands to millions of tests. This chapter takes you on a journey of AI from where it got originated. It does not just involve the evolution of computer science, but it involves several fields say biology, statistics, and probability. Let us start its span from biological neurons; way back in 1871, Joseph von Gerlach proposed the reticulum theory, which asserted that “the nervous system is a single continuous network rather than a network of numerous separate cells.” According to him, our human nervous system is a single system and not a network of discrete cells. Camillo Golgi was able to examine neural tissues in greater detail than ever before, thanks to a chemical reaction he discovered. He concluded that the human nervous system was composed of a single cell and reaffirmed his support for the reticular theory. In 1888, Santiago Ramon y Cajal used Golgi’s method to examine the nervous system and concluded that it is a collection of distinct cells rather than a single cell.