Bacterial Pathogens and their Virulence Factors contains a detailed description of 32 major bacterial pathogens that affect human health and their associated virulence determinants. Chapter 1 gives an overview of the different types and classes of general virulence factors involved in host cell adherence and invasion, dissemination within the host, host cell damage, and evasion of host defense systems, as well as mechanisms by which these virulence factors are regulated. Chapters 2 through 33 give concise descriptions of the disease states associated with the 32 bacterial genera and their major pathogenic species, along with an in-depth description of the individual virulence factors that have been found to be functionally involved in pathogenicity. A detailed bibliography derived from primary literature and review articles accompanies each of these chapters, allowing the reader to delve more deeply into individual pathogens and their virulence determinants. Chapter 34 discusses the exciting possibilities and initial successes of using detailed information on a pathogen’s virulence toolkit to design new therapeutics aimed at specific virulence traits.
This book is concerned with evaluating the antiquity of the domestication changes in northern Africa, considering the nature of the environments in which they arose, their social implications and the influence of climatic change on their later progress.
A comprehensive overview of symbiotic relationships between insects and microbes Insects and Their Beneficial Microbes is an authoritative and accessible synthesis of insect associations with beneficial microorganisms. Angela Douglas distills the vast literature in entomology and microbiology, as well as the burgeoning microbiome literature, to explore the full scope of insect-microbial interactions and their applications to real-world problems in agriculture and medicine. Douglas investigates how insects acquire and support their microbial partners, and examines how microorganisms contribute to insect nutrition, the defense against natural enemies, and the detoxification of natural allelochemicals and chemical insecticides. She analyzes how beneficial microbes can be harnessed to solve real-world problems in insect pest management, including strategies to suppress the transmission of viruses and microbial disease agents by mosquitoes and other insects. She also addresses the use of insects as biomedical models for effective microbial therapies treating a range of chronic human diseases, and considers how knowledge of insect-microbial interactions can promote the health of beneficial insects, especially in the context of environmental pollutants and climate change. Insects and Their Beneficial Microbes provides a much-needed conceptual framework for the growing discipline of insect-microbial interactions, and offers a wealth of insights into insect symbioses from molecular, physiological, ecological, and evolutionary perspectives.
Tens of thousands of readers have relied on this leading text and practitioner reference--now revised and updated--to understand the issues the legal system most commonly asks mental health professionals to address. Highly readable, the volume demystifies the forensic psychological assessment process and provides guidelines for participating effectively and ethically in legal proceedings. Presented are clinical and legal concepts and evidence-based assessment procedures pertaining to criminal and civil competencies, the insanity defense and related doctrines, sentencing, civil commitment, personal injury claims, antidiscrimination laws, child custody, juvenile justice, and other justice-related areas. Case examples, exercises, and a glossary facilitate learning; 19 sample reports illustrate how to conduct and write up thorough, legally admissible evaluations. New to This Edition *Extensively revised to reflect important legal, empirical, and clinical developments. *Increased attention to medical and neuroscientific research. *New protocols relevant to competence, risk assessment, child custody, and mental injury evaluations. *Updates on insanity, sentencing, civil commitment, the Americans with Disabilities Act, Social Security, juvenile and family law, and the admissibility of expert testimony. *Material on immigration law (including a sample report) and international law. *New and revised sample reports.
Comprehensive text highlighting current clinical research in the area of multiple sclerosis. Includes expanded coverage of genetics, neurobiology, pathophysiology, and historical background.
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