The most comprehensive compendium of information available on calcium channels Calcium channels are a common component of the membranes of a wide range of excitable cells, and their presence is crucial to the functioning of these cells. This book presents a current review of the biophysics, physiology, pharmacology, and clinical role of calcium channels. Chapters discussing the biophysics of calcium channels include topics in ion permeation, channel activation, channel inactivation, and second messenger modulation. The chapters on physiology cover excitation-contraction coupling, excitation-secretion coupling, sensory transduction, regulation of electrical activity, and the regulation of cell growth and development. Issues discussed in the pharmacology chapters of the book include the effects of permeant and inhibitory inorganic ions, blocking and activating effects of organic ions, and the regulatory effects of naturally occurring compounds. The chapters exploring the clinical aspects of calcium channels examine topics such as the modulation of calcium channels in the treatment of ischemic heart disease, cardiomyopathies, hypertension, cardiac arrhythmias, peripheral vascular diseases, platelet-related disorders, neurological disorders, and psychiatric disorders. Physicians neuroscientists, and pharmacologists should consider this book essential to their reference collections.
It is impossible to understand the cultures and achievements of the Greeks, Romans, Byzantines, and Arabs, without knowing something of their technology. Rome, for example, made advances in many areas which were subsequently lost and not regained for more than a millenium. This is a knowledgeable yet lucid account of the wonderful triumphs and the limitations of ancient and medieval engineering. This book systematically describes what is known about the evolution of irrigation works, dams, bridges, roads, building construction, water and wind power, automata, and clocks, with references to the social, geographical, and intellectual context.
This volume profiles 60 American journalists from colonial times to the present and focuses on news reporters, editors, publishers, and broadcasters whose careers significantly advanced or were symbolic of major changes in their profession. Illustrations, fact boxes, and quotations from the subjects themselves, together with the depth and breadth of historical information, make this volume an illuminating and fascinating read.
Individual Retirement Account Answer Book is designed to provide quick, accurate, and timely information pertaining to traditional and Roth IRAs that concerns accountants, attorneys, financial planners, mutual fund brokers, and other pension professionals. The Nineteenth Edition provides you with: Accurate answers to virtually every IRA question Clear explanations of IRA reporting and disclosure requirements Strategies for tax, estate, and retirement planning Full guidelines for establishing traditional and Roth IRAs, SIMPLEs, SEPs, ESAs, and HSAs Tax-cutting tips, examples, calculations, and worksheets State rules on taxation of traditional IRA and Roth IRA distributions Financial and estate planning strategies involving IRAs
Highly illustrated and easy to use, Dermatology in Pediatrics, by Drs. Donald Shenenberger, Bernard Cohen, Jonathan Glass, and Joel Spitz, is a practical, everyday reference not only for dermatologists and dermatology residents, but also for pediatricians, family medicine physicians, and other clinicians who care for children. For each dermatologic condition, you’ll find a two-page spread: on the left is concise, templated information on diagnosis and management; on the right are full-color illustrations and clinical photographs that provide real-world visual guidance. From cover to cover, an easy-to-navigate, open, and visually appealing layout speeds you to the information you need.
Interest and information in the field of medical toxicology has grown rapidly, but there has never been a concise, authoritative reference focused on the subjects of natural substances, chemical and physical toxins, drugs of abuse, and pharmaceutical overdoses. Medical Toxicology of Natural Substances finally gives you an easily accessible resource for vital toxicological information on foods, plants, and animals in key areas in the natural environment.
Ecotoxicology Essentials: Environmental Contaminants and Their Biological Effects on Animals and Plants provides a fundamental understanding of this area for students and professionals in ecotoxicology, ecology, conservation, chemistry, public health, wildlife management, fisheries, and many other disciplines. Although new chemicals and potential problems are developed every year, a basic education is essential to address these new challenges, and this work gives such training. Written with the regulatory framework in mind, the material guides readers on modelling, how to conduct assessments, and human and wildlife risk, focusing on effects on animals rather than transport of chemicals. Simple discussions of chemistry are complemented by coverage on the behavior of the animal, dynamics of the ecosystem, real-life situations like drought, and predators in the system – i.e., the natural system versus the lab setting. The book's first section contains chapters on the principles of contaminant toxicology including a brief history of the science of ecotoxicology, basic principles of the science, testing methods, and ways of determining if animals have been exposed to either acute or chronic concentrations of contaminants. The second section deals with the primary classes of contaminants including their chemical characteristics, sources, uses, and effects on organisms. The third section focuses on more complex issues such as the regulation of pollution, population and community effects, risk assessment and modelling. - Uses examples from both aquatic and terrestrial environments and species - Includes a Terms to Know section and a list of study questions in each chapter, fostering a greater understanding of the issues - Focuses on the effects of contaminants on wildlife while providing enough chemistry to allow a detailed understanding of the various contaminant groups - Emphasizes natural examples and 'real' species, rather than laboratory studies on only a handful of organisms - Features case histories, detailing actual events that include aspects of how the contamination occurred and its effects on wildlife - Provides material from a wide variety of international sources
These studies represent the major contributions to the history of Islamic technology during the second half of the 20th century beside Donald Hill’s separate publications on the mechanical devices of Pseudo-Apollonios, the Banu Musa and al-Jazari. A gifted linguist who was trained as a historian of Islamic civilisation, and also a professional engineer, Hill achieved his goal of setting his subject on a solid basis. The papers reprinted here include his early studies of the trebuchet and the camel and horse, several overviews of different aspects of Islamic technology, articles on specific topics such as the Cairo Nilometer and al-Biruni’s geared luni-solar device, and the first notice of an extremely important Andalusian treatise on mechanical devices discovered in 1975.
The aim of this work is to provide a fuller spectrum of information in a single source on enzyme-catalyzed reactions than is currently available in any published reference work or as part of any Internet database. The Enzyme Reference: A Comprehensive Guidebook to Enzyme Nomenclature, Reactions, and Methods includes 20,000 review articles and seminal research papers. Additionally, it provides a novel treatment of so-called ATPase and GTPase reactions to account for the noncovalent substratelike and productlike states of molecular motors, elongation factors, transporters, DNA helicases, G-reulatory proteins, and other energases. - Includes a compendium of over 6,000 enzyme reactions (including enzyme commission numbers, alternative names, substrates, products, alternative substrates, and properties) - Covers over 900 chemical structures of key metabolites and cofactors - Index directs readers to the exact pages for over 9,500 enzyme names
Who Wrote That? examines nine authorship controversies, providing an introduction to particular disputes and teaching students how to assess historical documents, archival materials, and apocryphal stories, as well as internet sources and news. Donald Ostrowski does not argue in favor of one side over another but focuses on the principles of attribution used to make each case. While furthering the field of authorship studies, Who Wrote That? provides an essential resource for instructors at all levels in various subjects. It is ultimately about historical detective work. Using Moses, Analects, the Secret Gospel of Mark, Abelard and Heloise, the Compendium of Chronicles, Rashid al-Din, Shakespeare, Prince Andrei Kurbskii, James MacPherson, and Mikhail Sholokov, Ostrowski builds concrete examples that instructors can use to help students uncover the legitimacy of authorship and to spark the desire to turn over the hidden layers of history so necessary to the craft.
Proposed energy resource development in the arid western United States raises a number of potential problems for an environment that does not have a great deal of resiliency. Projected population increases associated with large-scale development activities may go beyond the capacity of small, isolated rural communities to absorb them; and constraints on western agricultural and industrial development—for example, demands for water already exceeding the supply available—also limit energy development. The authors of this wide-ranging book first evaluate western energy resources, then objectively discuss the consequences of development on the region’s physical and social environments. Among the questions they consider are: Who will reap the economic benefits of development, and who will bear the environmental costs? What will be the effects on the environment? The social structure? The quality of life? Are open spaces a national treasure in their present form, or should they be regarded as space available for development? What are the unique demands of reclamation in the arid west? And, given the recent trend of western states-rights militancy and shifts of population to the southwest, what impact will new federal and state policies have on resource management?
The Fifth Ir Gene Workshop was held at the Chase-Park Plaza Hotel, St. Louis, MO, August 28-31, 1982; 240 scientists participated in the Workshop. The man uscripts compiled in this book describe the state of the art concerning Ir genes. Although the notion of Ir Genes: Past, Present, and Future has not been ad dressed specifically by each author, the reader is certain to get this flavor from the contributions. In this Preface, we have tried to summarize some of the salient ob servations and discussions from the Workshop. The mUltiple genes of the I region have been defined traditionally by serolog ical analysis of intra-H-2 recombinant mice and the pattern of immune responses to certain antigens developed by these recombinant mice. The application of sev eral new techniques, such as gene cloning and DNA sequencing, production of T and B cell hybridomas, and development of cloned T cell lines has changed this tradition and introduced a new phase into the analysis of the I region, Ia antigens, and Ir genes.
Lifestyle Modification to Control Heart Disease: Evidence and Policy is a review and critical examination of the scientific literature on cardiovascular lifestyle modification. This book provides systematic critiques of prior published research in order to clarify some of the debate around addressing coronary heart disease through lifestyle modification. It fills gaps in current published systematic reviews, particularly with respect to the cost-effectiveness of lifestyle modification; gender, racial and ethnic disparities in treatment of coronary heart disease; and multifactorial programs. It also explores existing research on disparities in coronary artery disease treatment and utilization and suggests potential solutions to address barriers at the system, provider and patient level. By summarizing research findings in a reader-friendly format, it assists health care practitioners in working with patients more effectively, improves students’ background knowledge to enhance preparation for clinical work, and sets a context for future researchers who want to continue to address key questions this area.
Pediatric Gastroenterology and Clinical Nutrition provides in-depth coverage of major clinical nutrition problems in pediatrics, and highlights the importance of nutrition in the care of complex gastrointestinal complications. Includes detailed information on the diagnosis and management of major gastrointestinal and nutritional disorders. The comprehensive appendices provide the latest information on infant formulas and supplements, updated to July 2002, together with US and UK nutrition guidelines - providing an essential reference source for all those involved in pediatric nutrition. Unlike many clinical nutrition textbooks of this magnitude this book is written entirely by three authors, affording continuity of style and content. Their complementary expertise provide an authoritative volume that will be of immense practical value to those involved in this field of clinical practice.
This immensely practical volume describes the rationale, development, and utilization of cognitive-behavioral techniques in promoting health, preventing disease, and treating illness, with a particular focus on pain management. An ideal resource for a wide range of practitioners and researchers, the book's coverage of pain management includes theoretical, research, and clinical issues, and includes illustrative case material.
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