Donald R. Kirsch's Books

The Genetics of Candida

By: Donald R. Kirsch,Rosemarie Kelly,Myra B. Kurtz

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The Genetics of Candida

By: Donald R. Kirsch,Rosemarie Kelly,Myra B. Kurtz

The objective of this volume is to provide a preliminary data base for Candida albicans plus serve as a reference for the genetic methods now available for the manipulation of several species in the genus Candida. This comprehensive review focuses primarily on C. albicans and includes reference data on the types and complementation status of mutations isolated in C. albicans, preliminary recombination mapping, chromosome analysis, physical measurements of DNA content and complexity, mitochondrial genome mapping, and analyses of restriction fragment length polymorphisms. It discusses a variety of genetic techniques in relation to current research questions aimed at virulence factors, dimorphism, and the potential use of Candida strains in biotechnology processes. This up-to-date publication is an indispensable resource for everyone who is involved with microbiology, genetics, and molecular and cellular biology.

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Page Count

232

Publisher

CRC Press

Published Date

ISBN 10

0849355702

ISBN 13

9780849355707

The Drug Hunters

The Improbable Quest to Discover New Medicines

By: Donald R. Kirsch,Ogi Ogas

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The Drug Hunters

The Improbable Quest to Discover New Medicines

By: Donald R. Kirsch,Ogi Ogas

The surprising, behind-the-scenes story of how our medicines are discovered, told by a veteran drug hunter. The search to find medicines is as old as disease, which is to say as old as the human race. Through serendipity— by chewing, brewing, and snorting—some Neolithic souls discovered opium, alcohol, snakeroot, juniper, frankincense, and other helpful substances. Ötzi the Iceman, the five-thousand-year-old hunter frozen in the Italian Alps, was found to have whipworms in his intestines and Bronze-age medicine, a worm-killing birch fungus, knotted to his leggings. Nowadays, Big Pharma conglomerates spend billions of dollars on state-of the art laboratories staffed by PhDs to discover blockbuster drugs. Yet, despite our best efforts to engineer cures, luck, trial-and-error, risk, and ingenuity are still fundamental to medical discovery. The Drug Hunters is a colorful, fact-filled narrative history of the search for new medicines from our Neolithic forebears to the professionals of today, and from quinine and aspirin to Viagra, Prozac, and Lipitor. The chapters offer a lively tour of how new drugs are actually found, the discovery strategies, the mistakes, and the rare successes. Dr. Donald R. Kirsch infuses the book with his own expertise and experiences from thirty-five years of drug hunting, whether searching for life-saving molecules in mudflats by Chesapeake Bay or as a chief science officer and research group leader at major pharmaceutical companies.

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Page Count

298

Publisher

Simon and Schuster

Published Date

ISBN 10

1628727195

ISBN 13

9781628727197

The Drug Hunters

The Improbable Quest to Discover New Medicines

By: Donald R. Kirsch,Ogi Ogas

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The Drug Hunters

The Improbable Quest to Discover New Medicines

By: Donald R. Kirsch,Ogi Ogas

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Page Count

298

Publisher

Simon and Schuster

Published Date

ISBN 10

1628727195

ISBN 13

9781628727197

Innovators

16 Visionary Scientists and Their Struggle for Recognition—From Galileo to Barbara McClintock and Rachel Carson

By: Donald R. Kirsch

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Innovators

16 Visionary Scientists and Their Struggle for Recognition—From Galileo to Barbara McClintock and Rachel Carson

By: Donald R. Kirsch

Scientific breakthroughs that changed the way we understand the world—and the fascinating stories of the scientists behind them Some of the most significant breakthroughs in science don’t receive widespread recognition until decades later, sometimes after their author’s death. Nobel Prize–winner Max Planck, whose black-body radiation law established the discipline of quantum mechanics, stated this as what has become known as Planck’s principle, commonly summarized as “Science progresses one funeral at a time.” In other words, for some truly groundbreaking discoveries, a new consensus builds only when proponents of the old consensus die off. Breakthrough discoveries require a paradigm shift, and it takes time and new minds for the new paradigm to be adopted. In Innovators, Donald Kirsch tells the stories of sixteen visionary scientists who suffered this fate, some now famous like Max Planck himself, Galileo, and Gregor Mendel, and some less well known. Among them are Barbara McClintock who, working with Indian corn, discovered transposons, also known as jumping genes, which provide a major mechanism driving biological evolution; Rachel Carson, catalyst for the environmental movement; and Roger Revelle, the climatologist whose findings were the first to be described by the term “global warming.” The breakthroughs cover fields from biology to medicine to physics and earth sciences and include the discovery of prions, life-changing treatments such as drugs for high blood pressure, ulcers, and organ transplantation; the process of continental drift; and our understanding of how molecules form matter.

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Page Count

311

Publisher

Simon and Schuster

Published Date

ISBN 10

1956763821

ISBN 13

9781956763829

Tissue Engineering and Artificial Organs

By: Joseph D. Bronzino,Donald R. Peterson

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Tissue Engineering and Artificial Organs

By: Joseph D. Bronzino,Donald R. Peterson

Over the last century, medicine has come out of the "black bag" and emerged as one of the most dynamic and advanced fields of development in science and technology. Today, biomedical engineering plays a critical role in patient diagnosis, care, and rehabilitation. As such, the field encompasses a wide range of disciplines, from biology and physiolo

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Page Count

1322

Publisher

CRC Press

Published Date

ISBN 10

1420003879

ISBN 13

9781420003871

Innovators

16 Visionary Scientists and Their Struggle for Recognition—From Galileo to Barbara McClintock and Rachel Carson

By: Donald R. Kirsch

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Innovators

16 Visionary Scientists and Their Struggle for Recognition—From Galileo to Barbara McClintock and Rachel Carson

By: Donald R. Kirsch

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Solve jigsaw puzzle

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Page Count

311

Publisher

Simon and Schuster

Published Date

ISBN 10

1956763821

ISBN 13

9781956763829

Book's by Donald R. Kirsch

The Genetics of Candida

The Genetics of Candida

The Drug Hunters

The Drug Hunters

The Drug Hunters

The Drug Hunters

Innovators

Innovators

Tissue Engineering and Artificial Organs

Tissue Engineering and Artificial Organs

Innovators

Innovators

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