Ecosystem" is an intuitively appealing concept to most ecologists, but, in spite of its widespread use, the term remains diffuse and ambiguous. The authors of this book argue that previous attempts to define the concept have been derived from particular viewpoints to the exclusion of others equally possible. They offer instead a more general line of thought based on hierarchy theory. Their contribution should help to counteract the present separation of subdisciplines in ecology and to bring functional and population/community ecologists closer to a common approach. Developed as a way of understanding highly complex organized systems, hierarchy theory has at its center the idea that organization results from differences in process rates. To the authors the theory suggests an objective way of decomposing ecosystems into their component parts. The results thus obtained offer a rewarding method for integrating various schools of ecology.
In all fields of science today, data are collected and theories are developed and published faster than scientists can keep up with, let alone thoroughly digest. In ecology the fact that practitioners tend to be divided between such subdisciplines as aquatic and terrestrial ecology, as well as between popula tion, community, and ecosystem ecology, makes it even harder for them to keep up with all relevant research. Ecologists specializing in one sub discipline are not always aware of progress in another subdiscipline that relates to their own. Syntheses are frequently needed that pull together large bodies of information and organize them in ways that makes them more coherent, and thus more understandable. I have tried to perform this task of integration for the subject area that encompasses the interrelationships between the dynamics of ecological food webs and the cycling of nutrients. I believe this area cuts across many of the subdisciplines of ecology and is pivotal to our progress in understanding ecosystems and in dealing with human impacts on the environment. Many current ecological problems involve human disturbances of both food webs and the nutrients that cycle through them. Little progress can be made towards elucidating the complex feedback relations inherent in the study of nutrient cycles in ecological systems without the tools of mathematics and computer modelling. These tools are therefore liberally used throughout the book.
Cybernetics, a science concerned with understanding how systems are regulated, has reflected the preoccupations of the century in which it was born. Regulation is important in twentieth century society, where both machines and social organizations are complex. Cybernetics focused on and became primarily associated with the homeostasis or stability of system behavior and with the negative feedbacks that stabilize systems. It paid less attention to the processes opposite to negative feedback, the positive feedback processes that act to change systems. We attempt to redress the balance here by illustrating the enormous importance of positive feedbacks in natural systems. In an article in the American Scientist in 1963, Maruyama called for increased attention to this topic, noting that processes of change could occur when a "deviation in anyone component of the system caused deviations in other components that acted back on the first component to reinforce of amplify the initial deviation." The deviation amplification is the result of positive feedback among system components. Maruyama demonstrated by numerous examples that the neglect of such processes was unjustified and suggested that a new branch of cybernetics, "the second cybernetics," be devoted to their study.
Integrating basic science, engineering, and medical applications, this handbook provides a treatment of materials used in or on the human body - ranging from biopolymers for controlled release drug delivery systems to metal plates used in bone repair and absorbable devices such as sutures.
This work, a companion to the author's Broadway Sheet Music: A Comprehensive Listing of Published Music from Broadway and Other Stage Shows, 1918 through 1993 (McFarland 1996), provides information about all sheet music published (1843-1918) from all Broadway productions--plus music from local shows, minstrel shows, night club acts, vaudeville acts, touring companies, and shows on the road that never made it to Broadway--and all the major musicals from Chicago.
Annotation Medical science has always promised -- and often delivered -- a longer, better life. But as the pace of science accelerates, do our expectations become unreasonable, fueled by an industry bent on profits and a media desperate for big news?Hope or Hype is a taboo-shattering look at what drives the American obsession with medical "miracles," exposing the equipment manufacturers and pharmaceutical companies; doctors and hospitals too quick to order surgery; the politicians; the press; and our own "technoconsumption" mindset. The authors spread blame for the parade of so-called miracle cures that too often are marginally effective at best -- and sometimes downright dangerous. They examine consumers? eager embrace of medical advances, and present riveting stories of the conscientious doctors and researchers who blew the whistle on ineffective treatments. Finally, they provide sane, practical recommendations for the adoption of new developments. The consequences of questionable practices include costly recalls, billions in wasted money, and the pain and suffering of innumerable patients and their families. In short, they must stop.
Known as the bible of biomedical engineering, The Biomedical Engineering Handbook, Fourth Edition, sets the standard against which all other references of this nature are measured. As such, it has served as a major resource for both skilled professionals and novices to biomedical engineering. Molecular, Cellular, and Tissue Engineering, the fourth volume of the handbook, presents material from respected scientists with diverse backgrounds in molecular biology, transport phenomena, physiological modeling, tissue engineering, stem cells, drug delivery systems, artificial organs, and personalized medicine. More than three dozen specific topics are examined, including DNA vaccines, biomimetic systems, cardiovascular dynamics, biomaterial scaffolds, cell mechanobiology, synthetic biomaterials, pluripotent stem cells, hematopoietic stem cells, mesenchymal stem cells, nanobiomaterials for tissue engineering, biomedical imaging of engineered tissues, gene therapy, noninvasive targeted protein and peptide drug delivery, cardiac valve prostheses, blood substitutes, artificial skin, molecular diagnostics in personalized medicine, and bioethics.
The third volume in the author's Horror and Science Fiction Films series covers new titles released from 1981 to 1983, and updates entries in the original list.
The how's and why's of successful drug repositioning Drug repositioning, also known as drug reprofiling or repurposing, has become an increasingly important part of the drug development process. This book examines the business, technical, scientific, and operational challenges and opportunities that drug repositioning offers. Readers will learn how to perform the latest experimental and computational methods that support drug repositioning, and detailed case studies throughout the book demonstrate how these methods fit within the context of a comprehensive drug repositioning strategy. Drug Repositioning is divided into three parts: Part 1, Drug Repositioning: Business Case, Strategies, and Operational Considerations, examines the medical and commercial drivers underpinning the quest to reposition existing drugs, guiding readers through the key strategic, technical, operational, and regulatory decisions needed for successful drug repositioning programs. Part 2, Application of Technology Platforms to Uncover New Indications and Repurpose Existing Drugs, sets forth computational-based strategies, tools, and databases that have been designed for repositioning studies, screening approaches, including combinations of existing drugs, and a look at the development of chemically modified analogs of approved agents. Part 3, Academic and Non-Profit Initiatives & the Role of Alliances in the Drug Repositioning Industry, explores current investigations for repositioning drugs to treat rare and neglected diseases, which are frequently overlooked by for-profit pharmaceutical companies due to their lack of commercial return. The book's appendix provides valuable resources for drug repositioning researchers, including information on drug repositioning and reformulation companies, databases, government resources and organizations, regulatory agencies, and drug repositioning initiatives from academia and non-profits. With this book as their guide, students and pharmaceutical researchers can learn how to use drug repositioning techniques to extend the lifespan and applications of existing drugs as well as maximize the return on investment in drug research and development.
This practical reference examines the structure and properties of the atmosphere, including listings of compounds in clouds, fog, rain, snow, and ice; a listing of compounds detected in the stratosphere; and a compendium of compounds in indoor air. An introduction to carcinogenicity and bioassay of atmospheric compounds is also presented. Readers will find the extensive cross-referencing especially useful--compounds can be located by chemical type, name, CAS registry number, or source.
FOREST ECOLOGY Authoritative resource covering traditional plant ecology topics and contemporary components such as climate change, invasive species, ecosystem services, and more Forest Ecology provides comprehensive coverage of the field, focusing on traditional plant ecology topics of tree structure and growth, regeneration, effects of light and temperature on tree physiology, forest communities, succession, and diversity. The work also reviews abiotic factors of light, temperature, physiography (landforms and topography), soil, and disturbance (especially fire), and provides coverage of ecosystem-level topics including carbon storage and balance, nutrient cycling, and forest ecosystem productivity. The 5th edition of Forest Ecology retains the readability and accessibility of the previous editions and includes important additional topical material that has surfaced in the field. All topics are approached with a landscape ecosystem or geo-ecological view, which places biota (organisms and communities) in context as integral parts of whole ecosystems that also include air (atmosphere and climate), topography, soil, and water. As such, the book fills a niche utilized by no other forest ecology text on the market, helping students and researchers consider whole ecosystems at multiple scales. Sample topics covered in Forest Ecology include: Contemporary components of forest ecology, including climate change, invasive species, diversity, ecological forestry, landscape ecology, and ecosystem services. Characteristics of physiography important for forest ecosystems, including its effects on microclimate, disturbance, soil, and vegetation. Genetic diversity of woody plants and genecological differentiation of tree species, including the importance of hybridization, polyploidy, and epigenetics. Site quality estimation using tree height and ground flora, and multiple-factor approaches to forest site and ecosystem classification and mapping. Forest Ecology is a highly accessible text for students, but it also serves as an excellent reference for academics. In addition, practitioners of forest ecology can also harness the information within to gain better insight into the field for practical application of concepts.
Few units in the U.S. Army can boast as proud a unit history as the Third Infantry Division; it fought on all of the Europe and North African fronts that American soldiers were engaged against the Axis forces during World War II. The 3rd Infantry Division saw combat in North Africa, Sicily, Italy, France, Germany and Austria for 531 consecutive days. In this official division history written by the officers who served with the unit at the time serves as a fascinating memorial and a detailed history of the “Marne Division” during World War II. The 3rd Inf. Division made landfall in Fedala on the 8th November 1942 as part of Operation Torch during the Allied invasion of North Africa and was engaged in heavy fighting before the German and Italian troops were finally levered out of the continent. The division was back in the thick of the fighting in Sicily under the command of such famous leaders as Generals Lucien Truscott, Omar Bradley and George S. Patton. As part of General Mark Clark’s U.S. Fifth army it engaged in some of the bloodiest engagements of the Italian campaign at Salerno beaches, Volturno river, Monte Cassino and Anzio. Under their old division commander General Truscott they formed part of the force that landed in Southern France and battled into the heart of Germany before the eventual capitulation of the Nazi High command in 1945. Richly illustrated with maps and pictures throughout.
Features a comprehensive summary of the chemical, physiological, and nutritional relationships of all recognized vitamins! Maintaining the standards of excellence set forth in the previous editions, the Handbook of Vitamins, Third Edition presents a thorough examination of the fundamental characteristics, functions, and roles of vitamins in human health. Extensively updated and expanded to reflect the latest advances in analytical and separation methodologies! Offering a compendium of authoritative, current knowledge on the nature and function of each known nutrient, the Third Edition discusses.... improvements in the methodology, isolation, identification, and the synthesis of vitamins the chemistry, metabolism, and biochemical functions of vitamins vitamin interactions with environmental factors, drugs, alcohol, and smoking vitamins in disease prevention and health promotion the efficacy and hazards of high vitamin dosages and more! New sections cover... the roles vitamins play as catalysts, cellular regulators, and co-substrates biochemical markers for vitamin deficiency and groups at risk the relationship of B12 and folate metabolism to homocysteine regulation, and the possible connections of homocysteine to vascular diseases and developmental defects new roles for vitamins A, K, and D, and the role of vitamin E and flavonoids in oxidant defense Containing over 2800 literature references and 150 illustrations and tables, the Handbook of Vitamins, Third Edition serves as an indisputably valuable reference for human and animal nutritionists, dietitians, food scientists and technologists, biochemists, organic and analytical chemists, pharmacologists, toxicologists, physiologists, physicians in general practice, and makes an indispensable text for upper-level undergraduate and graduate students in these disciplines.
Perry’s The Chemotherapy Source Book, now in its fifth edition, provides information on the choice of chemotherapeutic agents, the use of combination chemotherapy, and the toxicity of individual drugs. Organized by site, this is the only book of its kind to focus strictly on the clinical practice of chemotherapy, and is meant to serve as a “one-stop shop” for information on choice of chemotherapeutic agents, treatment outlines, grading of side effects, and dose modification.
In all fields of science today, data are collected and theories are developed and published faster than scientists can keep up with, let alone thoroughly digest. In ecology the fact that practitioners tend to be divided between such subdisciplines as aquatic and terrestrial ecology, as well as between popula tion, community, and ecosystem ecology, makes it even harder for them to keep up with all relevant research. Ecologists specializing in one sub discipline are not always aware of progress in another subdiscipline that relates to their own. Syntheses are frequently needed that pull together large bodies of information and organize them in ways that makes them more coherent, and thus more understandable. I have tried to perform this task of integration for the subject area that encompasses the interrelationships between the dynamics of ecological food webs and the cycling of nutrients. I believe this area cuts across many of the subdisciplines of ecology and is pivotal to our progress in understanding ecosystems and in dealing with human impacts on the environment. Many current ecological problems involve human disturbances of both food webs and the nutrients that cycle through them. Little progress can be made towards elucidating the complex feedback relations inherent in the study of nutrient cycles in ecological systems without the tools of mathematics and computer modelling. These tools are therefore liberally used throughout the book.
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