This book effectively summarizes our knowledge of recent advances in prostate cancer. It focuses on our state-of-the-art understanding of risk factors, prevention, detection, prognosis and treatment of prostate cancer and identifies basic science findings that are being translated into clinical practice. In addition, the book singles out key areas of research that have potential for clinical translation. Both basic scientists and clinicians will be invited to provide up-to-date reviews in each area of prostate cancer. During the last decade the pace of clinical discovery and the scientific advances in prostate cancer have been very rapid. For instance, currently there are more than 100 drugs in the pharmaceutical pipeline that have the potential for clinical management of prostate cancer. Therefore, it has been very difficult for clinicians and basic scientists to keep pace with the field as a whole. Recently, some of these discoveries are already having an impact on clinical practice. For example, the discovery of the androgen receptor gene amplification in prostate cancer has led to the development of a OC super-antiandrogenOCO, which is being tested in clinical trials. Also, recent knowledge of androgen synthesis in prostate cancer cells has led to clinical trials with steroid-metabolism inhibitors. Finally, robotic surgery has also dramatically changed clinical practice. Thus, this important book serves to provide readers with a one-stop overview of the field of prostate cancer research and its translation into the clinical arena.
Ciguatera poisoning is a worldwide problem whose impact has serious health and economic ramifications. Ciguatera Seafood Toxins provides an introduction and technical reference for this syndrome, covering topics such as medical approaches to treatment, legal avenues for those who become poisoned, and an overview of the areas where ciguatera is common. Other chapters in the text discuss research issues, such as assay systems for ciguatera, neurological effects of the disease, and light and electron microscopy studies of tissue exposed to ciguatera-type toxins. The book provides comprehensive coverage of the laboratory techniques used in the purification and molecular characterization of the toxins implicated in the disease, as well as a discussion of the genetic variability of one of the causative organisms (Gambierdiscus toxicus) in culture. This is a "must have" book for anyone concerned with ciguatera poisoning and its legal, scientific, and medical consequences.
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