This is a comprehensive self-contained text suitable for use by undergraduate mathematics, science and engineering students following courses in vector analysis. The earlier editions have been used extensively in the design and teaching of may undergraduate courses. Vectors are introduced in terms of Cartesian components, an approach which is found to appeal to many students because of the basic algebraic rules of composition of vectors and the definitions of gradient divergence and curl are thus made particularly simple. The theory is complete, and intended to be as rigorous as possible at the level at which it is aimed.
The Chronology and Calendar of Documents relating to the London Book Trade 1641-1700 provides, for the first time, easy access to information about the authors, printers, and distributors of books in the later seventeenth century. Chronological entries allow an insight into the day-to-day workings of the book trade. Substantial indexes allow quick reference to information on specific book titles, named authors, and book trade personnel, and specific topics such as booksellers' bills, coffee-houses, and imported books.
The how's and why's of successful drug repositioning Drug repositioning, also known as drug reprofiling or repurposing, has become an increasingly important part of the drug development process. This book examines the business, technical, scientific, and operational challenges and opportunities that drug repositioning offers. Readers will learn how to perform the latest experimental and computational methods that support drug repositioning, and detailed case studies throughout the book demonstrate how these methods fit within the context of a comprehensive drug repositioning strategy. Drug Repositioning is divided into three parts: Part 1, Drug Repositioning: Business Case, Strategies, and Operational Considerations, examines the medical and commercial drivers underpinning the quest to reposition existing drugs, guiding readers through the key strategic, technical, operational, and regulatory decisions needed for successful drug repositioning programs. Part 2, Application of Technology Platforms to Uncover New Indications and Repurpose Existing Drugs, sets forth computational-based strategies, tools, and databases that have been designed for repositioning studies, screening approaches, including combinations of existing drugs, and a look at the development of chemically modified analogs of approved agents. Part 3, Academic and Non-Profit Initiatives & the Role of Alliances in the Drug Repositioning Industry, explores current investigations for repositioning drugs to treat rare and neglected diseases, which are frequently overlooked by for-profit pharmaceutical companies due to their lack of commercial return. The book's appendix provides valuable resources for drug repositioning researchers, including information on drug repositioning and reformulation companies, databases, government resources and organizations, regulatory agencies, and drug repositioning initiatives from academia and non-profits. With this book as their guide, students and pharmaceutical researchers can learn how to use drug repositioning techniques to extend the lifespan and applications of existing drugs as well as maximize the return on investment in drug research and development.
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