This issue of Hematology/Oncology Clinics will focus on Gene Therapy. Topics include, but are not limited to Historical Perspective and Current Renaissance, Integrating Vectors, Nonintegrating Vectors, Gene Editing, Conditioning Therapies for Autologous HSCT, Approaches to Immunodeficiency, Approaches to Hemoglobinopathy, Approaches to Hemophilia, Hematopoietic Gene Therapies for Neurologic and Metabolic Disease, Gene Therapy Approaches to HIV and other Infectious Diseases, HSC Approaches to Cancer, and Gene Modified T Cell Therapies for Cancer.
Pediatric Allergy supplies the comprehensive guidance you need to diagnose, manage, and treat virtually any type of allergy seen in children. Drs. Leung, Sampson, Geha, and Szefler present the new full-color second edition, with coverage of the diagnosis and management of anaphylaxis, the immune mechanisms underlying allergic disease, the latest diagnostic tests, and more. Treat the full range of pediatric allergic and immunologic diseases through clinically focused coverage relevant to both allergists and pediatricians. Understand the care and treatment of pediatric patients thanks to clinical pearls discussing the best approaches. Easily refer to appendices that list common food allergies and autoantibodies in autoimmune diseases. Apply the newest diagnostic tests available—for asthma, upper respiratory allergy, and more—and know their benefits and contraindications. Treat the allergy at its source rather than the resulting reactions through an understanding of the immune mechanisms underlying allergic diseases. Get coverage of new research that affects methods of patient treatment and discusses potential reasons for increased allergies in some individuals. Better manage potential anaphylaxis cases through analysis of contributing facts and progression of allergic disease. Effectively control asthma and monitor its progression using the new step-by-step approach. Eliminate difficulty in prescribing antibiotics thanks to coverage of drug allergies and cross-reactivity.
Integrating basic science, engineering, and medical applications, this handbook provides a treatment of materials used in or on the human body - ranging from biopolymers for controlled release drug delivery systems to metal plates used in bone repair and absorbable devices such as sutures.
Why are all U.S. Presidents white men? Why does technology enchant us? Why do some people commit suicide? Why are sports so important to Americans? How will the Internet change society? Why do people ′do good′? This very teachable and short new introductory text explores these and other ′riddles′ to stir students′ sociological curiosity and promote active learning as the sure path toward mastering the fundamentals of the discipline. "Once again, Pine Forge Press has done us Intro teachers a great service with The Riddles of Human Society. The authors have produced a remarkable text, designing it from the point of view of how students actually acquire sociological tools and imagination when reflecting on their social world. ... It is written as a conversation with readers, yet is organized with learning tools like chapter summaries, discussion questions, and an in-text glossary. It considers a broad range of topics from micro to macro levels, thus uniquely blending the best of a shorter textbook and a monograph. It will serve very well as a main text for introductory sociology courses. I recommend it highly." Stephen Sharkey, Department of Social Science, Alverno College
NEW chapter on MR spinal imaging provides the latest information on the diagnosis of spinal cord disease through the use of CT and MRI. NEW information on digital imaging covers the newest advances in digital imaging. Updated coverage of procedures such as the esophagram, upper GI examination, excretory urography, and cystography helps in determining when and how these procedures are performed in today’s practice. Revised chapters on basic interpretation make information easier to find, with in-depth discussions of the principles of image acquisition and interpretation, radiography, radiation safety, and basic coverage of normal variants.
This book provides an invaluable resource for school teachers, administrators, board members, policy makers, and citizens who would like to understand what's behind performance pay, what might work and what will not, and how to build a school improvement effort that includes teacher compensation as one of its strategies.
Including a new section on evaluation accountability, this Third Edition details 30 standards which give advice to those interested in planning, implementing and using program evaluations.
In the first full biography of Lieutenant General John McAllister Schofield (1831-1906), Donald Connelly examines the career of one of the leading commanders in the western theater during the Civil War and the role of politics in the formulation of milita
Biochemical kinetics refers to the rate at which a reaction takes place. Kinetic mechanisms have played a major role in defining the metabolic pathways, the mechanistic action of enzymes, and even the processing of genetic material. The Handbook of Biochemical Kinetics provides the "underlying scaffolding" of logic for kinetic approaches to distinguish rival models or mechanisms. The handbook also comments on techniques and their likely limitations and pitfalls, as well as derivations of fundamental rate equations that characterize biochemical processes.Key Features* Over 750 pages devoted to theory and techniques for studying enzymic and metabolic processes* Over 1,500 definitions of kinetic and mechanistic terminology, with key references* Practical advice on experimental design of kinetic experiments* Extended step-by-step methods for deriving rate equations* Over 1,000 enzymes, complete with EC numbers, reactions catalyzed, and references to reviews and/or assay methods* Over 5,000 selected references to kinetic methods appearing in the Methods in Enzymology series* 72-page Wordfinder that allows the reader to search by keywords* Summaries of mechanistic studies on key enzymes and protein systems* Over 250 diagrams, figures, tables, and structures
Get the most from your study time...and experience a realistic USMLE simulation! These new additions to the Rapid Review Series—highly rated in the First Aid rankings—make it easy for you to master all of the basic science material covered on the USMLE Step 1 Exam. Each title focuses on a particular basic science subject, providing an at-a-glance, outline-format review of all the information you need to know. A user-friendly 2-color layout, Hi-Yield Margin Notes, and Key Points make studying easy. 100 high-quality USMLE-style review questions inside each book allow you to practice for the USMLE, and include a full rationale that lets you know why every possible answer is right or wrong. Another 250 USMLE-style questions for each title are available at www.studentconsult.com—mirroring the look and feel of the actual exam, and providing detailed feedback on which areas you may need to study more.
Computational chemistry, including electronic structure modeling, is a fast and accurate tool for treating large chemically meaningful systems. Unique among current quantum chemistry texts, Electronic Structure Modeling: Connections Between Theory and Software enables nonspecialists to employ computational methods in their own investigations. The t
The essays included in this volume honor a truly gifted teacher and sociologist, John C. Pock. After a brief stint at the University of Illinois, Pock moved in 1955 to Reed College, a highly regarded but very small liberal arts institution (roughly 1,000 students) located in Portland, Oregon. Pock has spent the rest of his career (to date) there. During his forty-year tenure at Reed College, the sociology department usually had only two faculty members. Even so, during this period as many as 104 students graduated with majors in sociology and 69 established professional careers as sociologists. (A listing, which is assuredly incomplete, of Reed students during Pock's tenure who went on to professional careers in sociology is presented in an appendix to this volume.) Many of these sociologists have been extremely successful and influential within the discipline. Reed sociologists have taught or are teaching at the University of California at Berkeley, the University of Chicago, Columbia, Cornell, Duke, Michigan, Northwestern, Stanford, UCLA, Wisconsin, and other leading U.S. academic departments. Others have been employed as researchers in such prominent institutions within and outside the United States as RAND, the National Academy of Sciences, the National Opinion Research Center, the East-West Center, the U.S. Census Bureau and Bureau of Labor Statistics, the Sloan Foundation, and the Australian National University.
Früher wurde das Tourette-Syndrom (TS) als seltene Störung betrachtet; mittlerweile jedoch wurde erkannt, daß TS häufig in der Kindheit beginnt. Man weiß jetzt auch, daß die Anfälligkeit für TS über Generationen hinweg vererbt wird. Diagnose, Genetik, Phänomenologie, Geschichte und Behandlung von TS werden hier dargestellt, ausgehend von einem einmaligen Ansatz, der Beziehungen zwischen der Störung und dem normalen Entwicklungsweg herstellt. (8/98)
Incorporating new and updated information, this second edition of THE bestselling text in Bayesian data analysis continues to emphasize practice over theory, describing how to conceptualize, perform, and critique statistical analyses from a Bayesian perspective. Its world-class authors provide guidance on all aspects of Bayesian data analysis and include examples of real statistical analyses, based on their own research, that demonstrate how to solve complicated problems. Changes in the new edition include: Stronger focus on MCMC Revision of the computational advice in Part III New chapters on nonlinear models and decision analysis Several additional applied examples from the authors' recent research Additional chapters on current models for Bayesian data analysis such as nonlinear models, generalized linear mixed models, and more Reorganization of chapters 6 and 7 on model checking and data collection Bayesian computation is currently at a stage where there are many reasonable ways to compute any given posterior distribution. However, the best approach is not always clear ahead of time. Reflecting this, the new edition offers a more pluralistic presentation, giving advice on performing computations from many perspectives while making clear the importance of being aware that there are different ways to implement any given iterative simulation computation. The new approach, additional examples, and updated information make Bayesian Data Analysis an excellent introductory text and a reference that working scientists will use throughout their professional life.
This issue of Hematology/Oncology Clinics will focus on Gene Therapy. Topics include, but are not limited to Historical Perspective and Current Renaissance, Integrating Vectors, Nonintegrating Vectors, Gene Editing, Conditioning Therapies for Autologous HSCT, Approaches to Immunodeficiency, Approaches to Hemoglobinopathy, Approaches to Hemophilia, Hematopoietic Gene Therapies for Neurologic and Metabolic Disease, Gene Therapy Approaches to HIV and other Infectious Diseases, HSC Approaches to Cancer, and Gene Modified T Cell Therapies for Cancer.
In this volume Donald Munro, author of important studies on early and contemporary China, provides a critical analysis of the doctrines of the Sung Neo-Confucian philosopher Chu Hsi (1130-1200). For nearly six centuries Confucian orthodoxy was based on Chu Hsi's commentaries on Confucian classics. These commentaries were the core of the curriculum studied by candidates for the civil service in China until 1905 and provided guidelines both for personal behavior and for official policy. Munro finds the key to the complexities of Chu Hsi's thought in his mode of discourse: the structural images of family, stream of water, mirror, body, plant, and ruler. Furthermore, he discloses the basic framework of Chu Hsi's ethics and the theory of human nature that is provided by these illustrative images. As revealed by Munro, Chu Hsi's thought is polarized between family duty and a broader altruism and between obedience to external authority and self-discovery of moral truth. To understand these tensions moves us toward clarifying the meaning of each idea in the sets. The interplay of these ideas, selectively emphasized over time by later Confucians, is a background for explaining modern Chinese thought. In it, among other things, Confucianism and Marxism-Leninism co-exist. Originally published in 1988. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.
Now in its third edition, this classic book is widely considered the leading text on Bayesian methods, lauded for its accessible, practical approach to analyzing data and solving research problems. Bayesian Data Analysis, Third Edition continues to take an applied approach to analysis using up-to-date Bayesian methods. The authors—all leaders in the statistics community—introduce basic concepts from a data-analytic perspective before presenting advanced methods. Throughout the text, numerous worked examples drawn from real applications and research emphasize the use of Bayesian inference in practice. New to the Third Edition Four new chapters on nonparametric modeling Coverage of weakly informative priors and boundary-avoiding priors Updated discussion of cross-validation and predictive information criteria Improved convergence monitoring and effective sample size calculations for iterative simulation Presentations of Hamiltonian Monte Carlo, variational Bayes, and expectation propagation New and revised software code The book can be used in three different ways. For undergraduate students, it introduces Bayesian inference starting from first principles. For graduate students, the text presents effective current approaches to Bayesian modeling and computation in statistics and related fields. For researchers, it provides an assortment of Bayesian methods in applied statistics. Additional materials, including data sets used in the examples, solutions to selected exercises, and software instructions, are available on the book’s web page.
Global analysis describes diverse yet interrelated research areas in analysis and algebraic geometry, particularly those in which Kunihiko Kodaira made his most outstanding contributions to mathematics. The eminent contributors to this volume, from Japan, the United States, and Europe, have prepared original research papers that illustrate the progress and direction of current research in complex variables and algebraic and differential geometry. The authors investigate, among other topics, complex manifolds, vector bundles, curved 4-dimensional space, and holomorphic mappings. Bibliographies facilitate further reading in the development of the various studies. Originally published in 1970. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.
The Soldier Vote tells the story of how Americans in the armed forces gained the right to vote while away from home. The ability for deployed military personnel to cast a ballot was difficult and often vociferously resisted by politicians of both political parties. While progress has been made, significant challenges remain. Using newly obtained data about the military voter, The Soldier Vote challenges some widely held views about the nature of the military vote and how service personnel vote.
The Fifth Ir Gene Workshop was held at the Chase-Park Plaza Hotel, St. Louis, MO, August 28-31, 1982; 240 scientists participated in the Workshop. The man uscripts compiled in this book describe the state of the art concerning Ir genes. Although the notion of Ir Genes: Past, Present, and Future has not been ad dressed specifically by each author, the reader is certain to get this flavor from the contributions. In this Preface, we have tried to summarize some of the salient ob servations and discussions from the Workshop. The mUltiple genes of the I region have been defined traditionally by serolog ical analysis of intra-H-2 recombinant mice and the pattern of immune responses to certain antigens developed by these recombinant mice. The application of sev eral new techniques, such as gene cloning and DNA sequencing, production of T and B cell hybridomas, and development of cloned T cell lines has changed this tradition and introduced a new phase into the analysis of the I region, Ia antigens, and Ir genes.
They always win the halftime. Members of the Fightin' Texas Aggie Band, embodying the spirit, camaraderie, and excellence of the school they represent, have marched and played proudly for one hundred years. Here is the story of the music, the precision, the tradition of that exceptional band. Illustrated with 121 black and white photographs and eight pages of color pictures of bands and band members past and present, this lively history pays tribute to the bandmasters and musicians who have made the organization the pulse of the spirit of Aggieland. Organized around the tenure of its founder, Joseph Holick, and its directors--Richard J. Dunn, E. V. Adams, Joe T. Haney, and Ray E. Toler, the men who became "The Colonel" to generations of Aggie Band members--the book marches through a century of tradition and excellence. From the birth of the band, through the development of its marching style and its stirring, distinctive music, to its most recent triumphs of precision maneuvers and military music, the story is as bold and bright as the band itself. War years, fish bands, boots, band lyres, corps trips, parades, and other traditions known and loved by former band members and other former students of Texas A&M University fill the book's pages. An appendix lists all of the band's seven thousand-plus present and former members. This is a story of the determination, discipline, and enduring pride that rests deep in the heart of those young men and women who have been tough enough, proud enough, and good enough to be "The Noble Men of Kyle.
Focusing on a wide range of professional settings, this book provides a compendium of the latest research related to multicultural competency and the hands-on framework to develop specialized multicultural practices.
Volume 16 Reviews In Computational Chemistry Kenny B. Lipkowitz and Donald B. Boyd The focus of this book is on methods useful in molecular design. Tutorials and reviews span (1) methods for designing compound libraries for combinatorial chemistry and high throughput screening, (2) the workings of artificial neural networks and their use in chemistry, (3) force field methods for modeling materials and designing new substances, and (4) free energy perturbation methods of practical usefulness in ligand design. From Reviews of the Series "This series spans all the subdisciplines in the field, from techniques to practical applications, and includes reviews from many of the acknowledged leaders in the field. the reviews cross many subdisciplines yet are both general enough to be of wide interest while including detailed information of use to workers in particular subdisciplines." -Journal of the American Chemical Society
Drawing on an extensive range of resources, including government reports, scholarly publications, and analyses from a range of private organizations, Introduction to US Health Policy provides scholars, policymakers, and health care providers with a comprehensive platform of ideas that is key to understanding and influencing the changes in the US health care system.
Excitons: Their Properties and Uses presents the fundamental properties of excitons and emphasizes the extensive use of excitons as a tool in understanding the properties of materials. This book explores the basic and technological importance of the physical parameters of materials. Organized into eight chapters, this text starts with a discussion on the theoretical aspects of excitons, and then explores the high-density exciton systems in which the interaction between the constituents is important. Other chapters discuss the experimental observations of exciton phenomena with proper theoretical interpretation of the data. The reader is then introduced to the interactions of excitons with other systems. The final chapter examines the experimental techniques used in the study of excitons and the importance of excitons in materials technology. This book is a valuable resource for scientists and researchers working with semiconductors and other areas of materials technology. Second-year graduate students of solid-state physics will find this book extremely useful.
The American Teacher is a comprehensive education foundations text with an emphasis on the historical continuity of educational issues and their practical application in the classroom. Aspiring teachers enter the classrooms with an innate optimism, and the challenge of The American Teacher is to engage them and to provide meaningful direction to channel their idealism. By reconnecting individuals with their society, community, and workplace, this engaging text provides education students with a grounding in their profession and an understanding of how important social and political issues affect educational practice.
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