Various subcortical structures in the brain are thought to be important in genesis or propagation of seizures. Deep Brain Stimulation (DBS) of these structures aims to influence these key “pacemaker” areas in the brain and is gaining increasing interest as a possible new surgical modality for treatment of patients with intractable epilepsy. Based on this background, this volume brings together the experience of the Zurich Epilepsy Surgery Center with stereotactic recordings and stimulations of various subcortical nuclei, with special reference to the Forel H fields, the thalamic nuclei and the periaqueductal gray matter. This volume also addresses the important issues of DC recording/polarisation and of biochemical measurement of excitatory and inhibitory transmitters released in the primary epileptogenic area during epileptic discharges. This book is destined to improve understanding of the involvement of subcortical structures in seizure genesis or propagation in a time when exhaustive invasive presurgical evaluation is diminishing because of the today’s availability of modern non-invasive imaging technique.
According to its descriptive nature, this booklet is an intermediate between an atlas and a series of well-illustrated case studies undertaken with a view towards possible epilepsy surgery at a time when modern diagnostic tools were not available. Since exhaustive invasive presurgical evaluation is diminishing because of the today's availability of modern non-invasive imaging techniques, the findings of these patients might help to better understand the role of the explored deep brain structures in various types of epilepsy.
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