Dieter Huzel was an electronic engineer with his whole career ahead of him when Germany lurched into the Second World War, he was conscripted and destined for the Russian Front when fate intervened. He and many other scientists were re-assigned from combat duty to the top secret installation at Peenemünde Island off the Baltic coast as part of the Nazi search for “Wonder Weapons”. Huzel describes how he became an integral part of the V weapon program which, despite the frequent Allied bombings, produced the feared V-1 and V-2 rockets that rained down on liberated parts of Europe during the later years of the war. As the tide turned against the Nazi regime, Huzel tells of the shifts in production of these weapons to central Germany and his team’s rising fear that the rocket technology would fall into the hands of the Russians. However, Huzel and his team were captured by the West and offered re-location to Britain or America. Huzel and his former director, Werner Von Braun, opted for America where they would become part of the ground-breaking Rocketdyne research team and spearhead of the NASA push for space exploration.
This book identifies and classifies the causes of component wear and failure. It then turns to the analytical and investigative methods to find the causes of excessive wear and failure at the mechanical, dynamic interfaces within tested components weak links." These methods are described in a cookbook fashion. They are supported by a thorough discussion of the experiences with the application of these processes to actual components, the weak links found, the corrective actions taken, and the significant improvements in service life achieved. The great effect that properties of nonmetallic materials have on component life are included. This includes an introduction to the family tree of polymeric materials and an extensive tabulation of 120 dynamic interface configurations and designs that were investigated and rated
The completion of the Human Genome Project and the rapid progress in cell bi- ogy and biochemical engineering, are major forces driving the steady increase of approved biotech products, especially biopharmaceuticals, in the market. Today mammalian cell products (“products from cells”), primarily monoclonals, cytokines, recombinant glycoproteins, and, increasingly, vaccines, dominate the biopharmaceutical industry. Moreover, a small number of products consisting of in vitro cultivated cells (“cells as product”) for regenerative medicine have also been introduced in the market. Their efficient production requires comprehensive knowledge of biological as well as biochemical mammalian cell culture fundamentals (e.g., cell characteristics and metabolism, cell line establishment, culture medium optimization) and related engineering principles (e.g., bioreactor design, process scale-up and optimization). In addition, new developments focusing on cell line development, animal-free c- ture media, disposables and the implications of changing processes (multi-purpo- facilities) have to be taken into account. While a number of excellent books treating the basic methods and applications of mammalian cell culture technology have been published, only little attention has been afforded to their engineering aspects. The aim of this book is to make a contribution to closing this gap; it particularly focuses on the interactions between biological and biochemical and engineering principles in processes derived from cell cultures. It is not intended to give a c- prehensive overview of the literature. This has been done extensively elsewhere.
Dieter Huzel was an electronic engineer with his whole career ahead of him when Germany lurched into the Second World War, he was conscripted and destined for the Russian Front when fate intervened. He and many other scientists were re-assigned from combat duty to the top secret installation at Peenemünde Island off the Baltic coast as part of the Nazi search for “Wonder Weapons”. Huzel describes how he became an integral part of the V weapon program which, despite the frequent Allied bombings, produced the feared V-1 and V-2 rockets that rained down on liberated parts of Europe during the later years of the war. As the tide turned against the Nazi regime, Huzel tells of the shifts in production of these weapons to central Germany and his team’s rising fear that the rocket technology would fall into the hands of the Russians. However, Huzel and his team were captured by the West and offered re-location to Britain or America. Huzel and his former director, Werner Von Braun, opted for America where they would become part of the ground-breaking Rocketdyne research team and spearhead of the NASA push for space exploration.
This book identifies and classifies the causes of component wear and failure. It then turns to the analytical and investigative methods to find the causes of excessive wear and failure at the mechanical, dynamic interfaces within tested components weak links." These methods are described in a cookbook fashion. They are supported by a thorough discussion of the experiences with the application of these processes to actual components, the weak links found, the corrective actions taken, and the significant improvements in service life achieved. The great effect that properties of nonmetallic materials have on component life are included. This includes an introduction to the family tree of polymeric materials and an extensive tabulation of 120 dynamic interface configurations and designs that were investigated and rated
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