This book gives an overview of commonly-used disposables in the manufacture of biopharmaceuticals, their working principles, characteristics, engineering aspects, economics, and applications. With this information, readers will be able to come to an easier decision for or against disposable alternatives and to choose the appropriate system. The book is divided into two parts – the first is related to basic knowledge about disposable equipment; and the second discusses applications through case studies that illustrate manufacturing, quality assurance, and environmental influence.
The completion of the Human Genome Project and the rapid progress in cell bi- ogy and biochemical engineering, are major forces driving the steady increase of approved biotech products, especially biopharmaceuticals, in the market. Today mammalian cell products (“products from cells”), primarily monoclonals, cytokines, recombinant glycoproteins, and, increasingly, vaccines, dominate the biopharmaceutical industry. Moreover, a small number of products consisting of in vitro cultivated cells (“cells as product”) for regenerative medicine have also been introduced in the market. Their efficient production requires comprehensive knowledge of biological as well as biochemical mammalian cell culture fundamentals (e.g., cell characteristics and metabolism, cell line establishment, culture medium optimization) and related engineering principles (e.g., bioreactor design, process scale-up and optimization). In addition, new developments focusing on cell line development, animal-free c- ture media, disposables and the implications of changing processes (multi-purpo- facilities) have to be taken into account. While a number of excellent books treating the basic methods and applications of mammalian cell culture technology have been published, only little attention has been afforded to their engineering aspects. The aim of this book is to make a contribution to closing this gap; it particularly focuses on the interactions between biological and biochemical and engineering principles in processes derived from cell cultures. It is not intended to give a c- prehensive overview of the literature. This has been done extensively elsewhere.
Local approaches to fatigue assessment are used to predict the structural durability of welded joints, to optimise their design and to evaluate unforeseen joint failures. This standard work provides a systematic survey of the principles and practical applications of the various methods. It covers the hot spot structural stress approach to fatigue in general, the notch stress and notch strain approach to crack initiation and the fracture mechanics approach to crack propagation. Seam-welded and spot-welded joints in structural steels and aluminium alloys are also considered.This completely reworked second edition takes into account the tremendous progress in understanding and applying local approaches which has been achieved in the last decade. It is a standard reference for designers, structural analysts and testing engineers who are responsible for the fatigue-resistant in-service behaviour of welded structures. - Completely reworked second edition of a standard work providing a systematic survey of the principles and practical applications of the various methods - Covers the hot spot structural stress approach to fatigue in general, the notch stress and notch strain approach to crack initiation and the fracture mechanics approach to crack propagation. - Written by a distinguished team of authors
This volume, occasioned by the centenary of the Fritz Haber Institute, formerly the Institute for Physical Chemistry and Electrochemistry, covers the institute's scientific and institutional history from its founding until the present. The institute was among the earliest established by the Kaiser Wilhelm Society, and its inauguration was one of the first steps in the development of Berlin-Dahlem into a center for scientific research. Its establishment was made possible by an endowment from Leopold Koppel, granted on the condition that Fritz Haber, well-known for his discovery of a method to synthesize ammonia from its elements, be made its director. The history of the institute has largely paralleled that of 20th-century Germany. It undertook controversial weapons research during World War I, followed by a "Golden Era" during the 1920s, in spite of financial hardships. Under the National Socialists it experienced a purge of its scientific staff and a diversion of its research into the service of the new regime, accompanied by a breakdown in its international relations. In the immediate aftermath of World War II it suffered crippling material losses, from which it recovered slowly in the post-war era. In 1953, shortly after taking the name of its founding director, the institute joined the fledgling Max Planck Society. During the 1950s and 60s, the institute supported diverse researches into the structure of matter and electron microscopy in a territorially insular and politically precarious West-Berlin. In subsequent decades, as both Berlin and the Max Planck Society underwent significant changes, the institute reorganized around a board of coequal scientific directors and a renewed focus on the investigation of elementary processes on surfaces and interfaces, topics of research that had been central to the work of Fritz Haber and the first "Golden Era" of the institute.
Filled with a comprehensive collection of information from experts in the commodity investment industry, this detailed guide shows readers how to successfully incorporate commodities into their portfolios. Created with both the professional and individual investor in mind, The Handbook of Commodity Investments covers a wide range of issues, including the risk and return of commodities, diversification benefits, risk management, macroeconomic determinants of commodity investments, and commodity trading advisors. Starting with the basics of commodity investments and moving to more complex topics, such as performance measurement, asset pricing, and value at risk, The Handbook of Commodity Investments is a reliable resource for anyone who needs to understand this dynamic market.
In-operation vibration monitoring for complex mechanical structures and rotating machines is of key importance in many industrial areas such as aeronautics (wings and other structures subject to strength), automobile (gearbox mounting with a sports car body), rail transportation, power engineering (rotating machines, core and pipes of nuclear power plants), and civil engineering (large buildings subject to hurricanes or earthquakes, bridges, dams, offshore structures). Tools for the detection and the diagnosis of small changes in vibratory characteristics are particularly useful to set up a preventive maintenance policy based on the actual evolution of the state of the monitored machine or structure, as opposed to systematic a priori planning. Ambient Vibration Monitoring is the backbone of such structural assessment monitoring and control. It provides the possibility to gain useful data under ambient conditions for the assessment of structures and components. Written by a widely respected authority in this area, Ambient Vibration Monitoring describes the current practice of ambient vibration methodologies illustrated by a number of practical examples. Designed to aid the practical engineer with their understanding of the topic, it is the culmination of many years of practical research and includes numerous ‘real world’ examples. It also provides information on applicable solutions. This book will enable not only practitioners (in civil, mechanical and aerospace engineering), but also researchers and students, to learn more about the theory and practical applications of this subject.
A unique description of the phenomena that arise from the interaction between quantum systems and their environment. Because of the novel character of the approach discussed, the book addresses scientists from all fields of physics and related disciplines as well as students of physics.
In five chapters, this volume presents recent developments in fatigue assessment. In the first chapter, a generalized Neuber concept of fictitious notch rounding is presented where the microstructural support factors depend on the notch opening angle besides the loading mode. The second chapter specifies the notch stress factor including the strain energy density and J-integral concept while the SED approach is applied to common fillet welded joints and to thin-sheet lap welded joints in the third chapter. The forth chapter analyses elastic-plastic deformations in the near crack tip zone and discusses driving force parameters. The last chapter discusses thermomechanical fatigue, stress, and strain ranges.
Laser Processing and Chemistry gives an overview of the fundamentals and applications of laser-matter interactions, in particular with regard to laser material processing. Special attention is given to laser-induced physical and chemical processes at gas-solid, liquid-solid, and solid-solid interfaces. Starting with the background physics, the book proceeds to examine applications of laser techniques in micro-machining, and the patterning, coating, and modification of material surfaces. This third edition has been revised and enlarged to cover new topics such as the synthesis of nanoclusters and nanocrystalline films, ultrashort-pulse laser processing, laser polishing, cleaning, and lithography. Graduate students, physicists, chemists, engineers, and manufacturers alike will find this book an invaluable reference work on laser processing.
This book is based on Reinforced Concrete-Prestressed Concrete, Volume 2, Accounting for the Effects of Creep and Shrinkage on the Behavior of Structural Systems by Hubert Rusch and Dieter Jungwirth, which appeared in German in 1976. Even then, it was Hubert Rusch's fervent wish to have his thoughts on the deformations of concrete translated into English in order to reach a wider audience. His earlier efforts to contribute a study to the Series of Monographs of the Ameri can Institute had unfortunately not succeeded. Despite a serious illness, Hubert Rusch undertook, with his characteristic prudence and thoroughness, the preparatory work for the translation and related revision of his book. Unfortunately fate did not grant him the satisfaction of seeing his work completed. Hubert Rusch died on October 17, 1979. In writing this book, Hubert Rusch drew on his many years of devoted study of the creep problem. These investigations go back to 1934. His awareness of the plastic deformation of concrete under sustained load, which had been reported to him on the occasion of an American sojourn, led him to discover the causes of a major building collapse. At his urging, Professor A. Hummel published, in 1935, a critical survey of the test results then available on concrete creep.
For us humans the question of the temporal end of our existence is of great importance. The answer that faith seeks is not the task and goal of this book, but the rational answer. The author remains on the ground of science and soberly examines how far we can reveal the mystery of the temporal end and answer the question from the scientific facts and from the standpoint of logical thinking: Is there life after life? But what can science contribute to a subject that is otherwise occupied by philosophy and the various faiths? The answer is: very much! For in natural science there are the extremely strange phenomena of quantum physics, which, despite their oddity, have the potential to shed light on those areas that philosophy has not yet been able to illuminate. In the end, there is confidence and the light of knowledge about the liberation of consciousness from the shackles of time.
Hepatology -- a systematic overview The 1st edition was sold out within one year and a reprint became necessary. The 2nd edition has been updated, revised and extended to include some 900 pages. Unique - 477 top-quality coloured figures containing clinical and immunological findings, laparoscopic and and histologic features as well as imaging procedures - all figures directly integrated in the respective text; this results in a new form of learning from "seeing" to "understanding" Attractive - 306 tables in colour - coloured highlighting of important principles and statements for better reading - well-structured and systematic approaches support the content - derived from clinical hepatology for practical use by specialists and in hospital Instructive - detailed presentation of morphology and its integration in liver disease - precise recommendations for therapy and summarized descriptions of special forms of treatment (inlcuding a separate chapter on "Therapy" Manual - about 7,000 references are listed in full; quotations of significant historical publications - first authors of therapy procedures, methods, medical techniques and invasive measures are given as far as possible - comprehensive subject index and register of abbreviations
This book gives an overview of commonly-used disposables in the manufacture of biopharmaceuticals, their working principles, characteristics, engineering aspects, economics, and applications. With this information, readers will be able to come to an easier decision for or against disposable alternatives and to choose the appropriate system. The book is divided into two parts – the first is related to basic knowledge about disposable equipment; and the second discusses applications through case studies that illustrate manufacturing, quality assurance, and environmental influence.
The completion of the Human Genome Project and the rapid progress in cell bi- ogy and biochemical engineering, are major forces driving the steady increase of approved biotech products, especially biopharmaceuticals, in the market. Today mammalian cell products (“products from cells”), primarily monoclonals, cytokines, recombinant glycoproteins, and, increasingly, vaccines, dominate the biopharmaceutical industry. Moreover, a small number of products consisting of in vitro cultivated cells (“cells as product”) for regenerative medicine have also been introduced in the market. Their efficient production requires comprehensive knowledge of biological as well as biochemical mammalian cell culture fundamentals (e.g., cell characteristics and metabolism, cell line establishment, culture medium optimization) and related engineering principles (e.g., bioreactor design, process scale-up and optimization). In addition, new developments focusing on cell line development, animal-free c- ture media, disposables and the implications of changing processes (multi-purpo- facilities) have to be taken into account. While a number of excellent books treating the basic methods and applications of mammalian cell culture technology have been published, only little attention has been afforded to their engineering aspects. The aim of this book is to make a contribution to closing this gap; it particularly focuses on the interactions between biological and biochemical and engineering principles in processes derived from cell cultures. It is not intended to give a c- prehensive overview of the literature. This has been done extensively elsewhere.
This will help us customize your experience to showcase the most relevant content to your age group
Please select from below
Login
Not registered?
Sign up
Already registered?
Success – Your message will goes here
We'd love to hear from you!
Thank you for visiting our website. Would you like to provide feedback on how we could improve your experience?
This site does not use any third party cookies with one exception — it uses cookies from Google to deliver its services and to analyze traffic.Learn More.