Derek Leroith's Books

Year Book of Medicine 2012

By: Nancy M. Khardori,James Jim Barker,Bernard J. Gersh,Derek LeRoith,Richard S. Panush,Nicholas J Talley,J. Tate Thigpen,Renee Garrick

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Year Book of Medicine 2012

By: Nancy M. Khardori,James Jim Barker,Bernard J. Gersh,Derek LeRoith,Richard S. Panush,Nicholas J Talley,J. Tate Thigpen,Renee Garrick

The Year Book of Medicine brings you abstracts of the articles that reported the year's breakthrough developments in medicine, carefully selected from more than 500 journals worldwide. Expert commentaries evaluate the clinical importance of each article and discuss its application to your practice. There's no faster or easier way to stay informed! Sections are included on Rheumatology, Infectious Disease, Hematology and Oncology, Kidney, Water, and Electrolytes, Pulmonary Disease, Heart and Cardiovascular Disease, The Digestive System, and Endocrinology, Diabetes, and Metabolism.

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Page Count

517

Publisher

Elsevier Health Sciences

Published Date

ISBN 10

0323089666

ISBN 13

9780323089661

Molecular and Cellular Biology of Insulin-like Growth Factors and Their Receptors

By: Derek Leroith,Mohan K. Raizada

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Molecular and Cellular Biology of Insulin-like Growth Factors and Their Receptors

By: Derek Leroith,Mohan K. Raizada

An essential element in the development and functional integrity of all organisms is intercellular communication. This is achieved by the secretion of soluble messenger molecules which subsequently interact with receptor-effector pathways in the responsive cells. Hormones are traditionally defined as chemical messengers synthesized by endocrine glands. Unlike hormones produced by endocrine glands, growth factors are hormone-related substances produced by many tissues and play an important role in controlling growth and development. While the exact physiological roles of growth factors have yet to be elucidated, they play important roles in the regulation of cellular proliferation and/or differentiation during ontogenesis, growth and differentiation. During recent years there has been a substantial increase in research related to peptide growth factors, their receptors, and modes of action. With the discovery and characterization of numerous growth factors, it became clear that these growth factors had multiple features in common with classic hormones as well as with oncogenes. Furthermore, there are distinct families of growth factors based either on structural or functional similarities.

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Page Count

505

Publisher

Springer Science & Business Media

Published Date

ISBN 10

1468456857

ISBN 13

9781468456851

Insulin-like Growth Factors

Molecular and Cellular Aspects

By: Derek LeRoith

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Insulin-like Growth Factors

Molecular and Cellular Aspects

By: Derek LeRoith

During the past decade, the continued interest in insulin-related growth factors has been documented by a plethora of research programs and publications focused on these growth factors. Both molecular and cellular biological techniques have improved and enabled investigators to study the properties of the growth factors in depth. This volume covers the molecular (genetic) aspects of the growth factors, their binding proteins and receptors, as well as those factors affecting their gene transcription and translation. In addition, aspects of the cellular action of these growth factors through their receptors and how this impacts normal cellular function are discussed. The book will provide valuable information for researchers in physiology, biology, endocrinology, and metabolism.

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Page Count

328

Publisher

CRC Press

Published Date

ISBN 10

0849357128

ISBN 13

9780849357121

Prevention of Type 2 Diabetes

From Science to Therapy

By: Derek LeRoith

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Prevention of Type 2 Diabetes

From Science to Therapy

By: Derek LeRoith

There is a world-wide epidemic on obesity. This epidemic is driving the immense proportions of Type 2 diabetes across the globe. While there are numerous therapies for treating Type 2 diabetes, the most effective therapy is prevention. Prevention of Type 2 diabetes can be achieved properly by simultaneous prevention of obesity. Prediabetes, or metabolic syndrome, is the period between simple obesity and diabetes, and this critical period needs to be identified in a more consistent and systematic manner by clinicians worldwide. Clinical trials have indicated that diabetes prevention can be achieved by lifestyle changes and also by certain medications, though none are yet approved for use in prevention. On the other hand, there are funding agencies such as the NIH, CDC, and State Institutions that are interested in studying the prevention paradigms in different communities and ethnic minorities who are most prone to this epidemic. For these reasons, this title by renowned physician-scientist Derek LeRoith is both timely and vitally important for academic physicians, practitioners, allied health care providers, analysts, community activists, and all others interested in this increasing epidemic. This book provides a unique and comprehensive synthesis of the prevention and early diagnosis of Type 2 Diabetes, focusing on identifying risk factors and then moving into topics that address how to prevent their progression to full-blown diabetes. The difficult task of changing patients’ behavior is given special emphasis. The chapters in this practical volume are written by a wide range of international experts, reflecting the editor’s distinguished, internationally renowned career. The volume is organized in eight sections: an introduction to the overall issue of prevention, definitions of values based on ADA guidelines, pathophysiology, discussion of a range of interventional trials regarding prevention, and an overview of state-of-the-art clinical management approaches. Comprehensive and timely, Prevention of Type 2 Diabetes: From Science to Therapy is an essential reference for those treating and researching Type 2 Diabetes.

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