Heterogeneity, or mixtures, are ubiquitous in genetics. Even for data as simple as mono-genic diseases, populations are a mixture of affected and unaffected individuals. Still, most statistical genetic association analyses, designed to map genes for diseases and other genetic traits, ignore this phenomenon. In this book, we document methods that incorporate heterogeneity into the design and analysis of genetic and genomic association data. Among the key qualities of our developed statistics is that they include mixture parameters as part of the statistic, a unique component for tests of association. A critical feature of this work is the inclusion of at least one heterogeneity parameter when performing statistical power and sample size calculations for tests of genetic association. We anticipate that this book will be useful to researchers who want to estimate heterogeneity in their data, develop or apply genetic association statistics where heterogeneity exists, and accurately evaluate statistical power and sample size for genetic association through the application of robust experimental design.
This six-volume anthology documents the history of women's drama throughout the 18th century, starting with the emergence in 1695-6 of the second generation of women dramatists to Aphra Benn. It includes the work of Catherine Trotter, Mary Pix, Eliza Haywood and Elizabeth Griffith.
Derek Walcott's eighth collection of poems, The Arkansas Testament, is divided into two parts--"Here," verse evoking the poet's native Caribbean, and "Elsewhere." It opens with six poems in quatrains whose memorable, compact lines further Walcott's continuous effort to crystallize images of the Caribbean landscape and people. For several years, Derek Walcott has lived mainly in the United States. "The Arkansas Testament," one of the book's long poems, is a powerful confrontation of changing allegiances. The poem's crisis is the taking on of an extra history, one that challenges unquestioning devotion.
The power of theatrical performance is universal, but the style and concerns of theatre are specific to individual cultures. This volume in the Global Theatre Perspectives series presents a reconstructed ancient performance text, four one-act indigenous African plays and five modern dramas from various regions of Africa and the Caribbean Diaspora. Because these plays span centuries and are the work of artists from diverse cultures, readers can see elements that occur across time and space. Physicalized ritual, direct interaction with spectators, improvisation, music, drumming, and metaphorical animal characters help create the theatrical forms in multiple plays. Recurring themes include the establishment or challenging of political authority, the oppression or corruption of government, societal expectations based on gender, the complex and transformational nature of identity, and the power of dreams. Though each play is its own unique entity, reading them together allows readers to explore what theatrical elements and cultural concerns are perhaps essentially African. The Caribbean plays add further perspective to the questions of what values, theatrical and societal, are part of African drama, how these have influenced the Caribbean aesthetic, and what the relationships are between the old and new world. Among the creators of the pieces are two Nobel Laureates, those who have been exiled or jailed for the political nature of their work, and the author of his country's first constitution. The volume can serve as the primary text for an intensive semester-long investigation of African drama and culture. But it is also possible to use this volume along with others in the series as texts for a single course on drama from around the world. The global perspectives approach, letting works from ancient, indigenous, and modern times resonate with each other, encourages thinking across boundaries and connective human understanding.
A message, a general, and an impossible journey... Four decades into the future, America is spotted with smoggy, military-ruled cities. Economic failure, riots, and war have poisoned the land. In northern Michigan, Richard Braxton lives with his friends. When a newcomer arrives, he assumes the boy is another spy for the transhumans. But when the outsider tells him of a coming war and an unstoppable army, Richard is plunged into a journey battling the horrors of a country left in ruins.
What if not only everything you knew about yourself was wrong, but everything everyone else knew about you was wrong too? // Pig is in hell. // He's been in hell for the twenty years since half a continent was atomised; since his own ignominious and contentious escape from a fate that never came; when a face from his past comes offering alleviation, he inadvertently drags behind him a young revolutionary, an extracted spy, and an admin assistant way out of her depth on an unexplained mission that will take them across the world, and which may well solve nothing at all... // ""I'm always pleased to see Derek Des Anges writing, with his acute understanding of the horror we do to each other and the tactics we take to survive it."" - Kieron Gillen (Wicked + Divine, Darth Vader)
Gerard Philippson is Professor of Bantu Languages at the Institut National des Langues et Civilisations Orientales and is a member of the Dyamique de Langage research team of the Centre National de la Recherche Scientifique, Lyon II University. He has mainly worked on comparative Bantu tonology. Other areas of interest include Afro-Asiatic, general phonology, linguistic classification and its correlation with population genetics.
Presents the final report on the excavations of a Kerma Ancien cemetery discovered by the Sudan Archaeological Research Society during its Northern Dongola Reach Survey (1993-1997). It is one of the very few cemeteries of this date to have been fully excavated and provides interesting data on funerary culture as practised in a rural environment.
In Moon-Child, the poet and playwright Derek Walcott returns to the island of St. Lucia for a lush and vivid tale of spirituality and the supernatural. In this lyrical new work, the crafty Planter (who may or may not be the Devil in disguise) schemes to take over the island for development. Between him and his goal lies the Bouton family, whose ailing matriarch strikes a bargain: if any of her three sons can get the Devil to feel anger and human weakness, the islanders will win the right to spend the rest of their days in wealth and peace. In a fable that reaches from St. Lucia's verdant forests to an explosive ending amid its plantation homes, Walcott has crafted a masterwork rich in flowing language and colorful Creole patois. With roots in Caribbean folklore and an eye toward the island's postcolonial legacy and complex racial identities, Moon-Child marks a remarkable new addition to the canon of one of the world's most prolific Caribbean playwrights.
This book is directed at all those who take to Bollywood as a modern-day El Dorado movie hopefuls, aspiring filmmakers, wannabe stars, serious investors in cinema and anybody remotely curious about the myth and magic of Hindi cinema. While deconstructing some of the myths, the book seeks to answer the most common and fundamental question: Is there a secret formula to a Bollywood hit? Through simple, easy to follow examples, the reader is introduced to ten basic principles, which eliminate all chances of failure and contribute to the making of a hit. These are listed as the Ten Mantras of Success . In essence, the book establishes that success in Bollywood is not a matter of chance or blind luck, but the reward for following a methodical and deliberated approach to cinema, backed by sound scientific reasoning and historically irrefutable facts.
On a Caribbean island, the morning after a full moon, Felix Hobain tears through the market in a drunken rage. Taken away to sober up in jail, all that night he is gripped by hallucinations: the impoverished hermit believes he has become a healer, walking from village to village, tending to the sick, waiting for a sign from God. In this dream, his one companion, Moustique, wants to exploit his power. Moustique decides to impersonate a prophet himself, ignoring a coffin-maker who warns him he will die and enraging the people of the island. Hobain, half-awake in his desolate jail cell, terrorized by the specter of his friend's corruption, clings to his visionary quest. He will try to transform himself; to heal Moustique, his jailer, and his jail-mates; and to be a leader for his people. Dream on Monkey Mountain was awarded the 1971 Obie Award for a Distinguished Foreign Play when it was first presented in New York, and Edith Oliver, writing in The New Yorker, called it "a masterpiece." Three of Derek's Walcott's most popular short plays are also included in this volume: Ti-Jean and His Brothers; Malcochon, or The Six in the Rain; and The Sea at Dauphin. In an expansive introductory essay, "What the Twilight Says," the playwright explains his founding of the seminal dramatic company where these works were first performed, the Trinidad Theatre Workshop. First published in 1970, Dream on Monkey Mountain and Other Plays is an essential part of Walcott's vast and important body of work.
From acclaimed author and screenwriter Derek Haas comes a unique and thrilling twist on a family story—what happens when an elite assassin becomes a father? Now a new dad, the infamous Silver Bear finds himself staying up late to give a bottle and changing diapers—all while leading the double life of a contract killer. The struggle is not with his conscience. He enjoys his gig. But a child forces him to weigh selfishness versus safety. Continue in his line of work, and he’ll always wonder if he's putting his child’s life at risk. When the next assignment comes, both Columbus and his partner Risina are surprised to find that the mark is another assassin: a brash, young man named Castillo. An assassin on the rise, he’s responsible for slaying a high profile CEO. As Columbus closes in on his target, he realizes that Castillo is a younger version of himself. It's almost like looking in a mirror. Castillo has even studied Columbus' work. Yet as much as Columbus sees himself in this young man, his assignment is clear. Then, Castillo learns that his hero and unwitting mentor has a family—a revelation with enormous ramifications. Now that he knows Columbus’s weakness, he will go after it and exploit it. Just as Columbus would have done...
In 1941 air gunner Sergeant Jack Newton’s Wellington is hit by flak on his first bombing raid over Germany. Miraculously, the skipper makes an emergency landing on a German-occupied Belgian airfield, narrowly avoiding Antwerp Cathedral.Having torched the plane, the crew give the unsuspecting Germans the slip and are hidden by the Resistance. Hoping to make it to the coast and back across the Channel, the airmen are surprised when the 23-year-old female leader of the Comete Escape Line, Andree de Jongh – codenamed Dedee – has other plans for them.Full of terrifying and humorous moments, this is the story of the epic journey of the first British airman to escape occupied Europe during the Second World War.
Your Solar Energy Home: Including Wind and Methane Applications considers the worldwide domestic use of solar energy. This book is divided into 18 chapters that also cover the consumption of wind energy and methane. The opening chapters present data on solar energy usage in various countries, including the United States, United Kingdom, Europe, Australia, New Zealand, South Africa, and Canada. The succeeding chapters deal with the collection and storage of solar energy, as well as the design and production of solar collector. Other chapters describe scheme for solar home heating and solar domestic hot water. These topics are followed by discussions of wind and water power schemes. The final chapters highlight the production, use, and economics of methane gas.
Brokehill Manor, an out-of-the-way pile in a state of gentle dilapidation, is a house with a secret. Its gentleman owner’s peace and tranquility is suddenly interrupted late one autumn by the arrival of a larger-than-life widowed sister whose sole agenda is change. With history on his side and in the company of a one-time Detective Agency bloodhound, a distinctly laid-back Persian cat and the feisty support of a loyal grand-daughter, Edward Brimble sets out to rebuff his sister’s unwarranted demands. A cleverly crafted and compelling novel, The Last Defender is aimed at an open audience, from teenagers up to the age of 80. The novel, which tells of the manor’s historic link with the beginning of the English Civil War, will appeal particularly to fans of sport and history. Derek is inspired by different authors; Charles Dickens for his structure, characters and dialogue, John Fowles for introspection and historicity, James Joyce for his more ‘bizarre moments’.
Histopathology Reporting: Guidelines for Surgical Cancer provides an easily comprehensible and practicable framework for standardised histopathology reports in surgical cancer. The book details the gross description, histological classification, tumour differentiation, extent of local tumour spread, involvement of lymphovascular channels, lymph nodes and excision margins of the common carcinomas and also summarises non-carcinomatous malignancies. The 5th edition TNM classification of cancers is incorporated, with comments on any associated pathology, diagnostic clues and prognostic criteria. Staging information is supplemented visually by line diagrams. The aim of Histopathology Reporting: Guidelines for Surgical Cancer is to be educative and applied. The book: * emphasises those gross and histological features that are relevant to clinical management and prognosis. * uses a systematic and analytical approach to the description of surgical pathology specimens resulting in focused histopathology reports. * acts as a companion or aide-memoire for routine reporting of the common cancers and also lists diagnostic options and summary features of rarer cancers. * facilitates audit of specimen type and quality and gives guidance for pathological, surgical and oncological practice. Derek Allen is Honorary Senior Lecturer and Consultant in Histopathology and Cytology at the Belfast City Hospital, Belfast, UK
The poems in Derek Henderson’s Songs are “translations” of a film cycle of the same name, shot by American filmmaker Stan Brakhage (1933–2003) to document his and his family’s life in Colorado in the mid-1960s. Where Brakhage’s films provide a subjective visual record of his experience bewildered by the eye, these poems let language bewilder the space a reader enters through the ear. Henderson tenders the visual experience of Brakhage’s films—films of the domestic and the wild, the private and political, the local and global—into language that insists on the ultimate incapacity of language—or of image—to fully document the comfort and the violence of intimacy. Songs expresses the ecstasy we so often experience in the company of family, but it just as urgently attests to ecstasy’s turbulent threat to family’s stability. Like Brakhage’s films, Henderson’s poems carry across into language and find family in every moment, even the broken ones, all of them abounding in hope.
This work is Derek Rosser's autobiography. It tells how he was born in 1930, the year the airship R101 made its final disastrous voyage, when life was exciting but very different to that experienced by today's youngsters. Rosser gives the reader an insight into the life and emotions of a boy born in the inter war years.
King Edward VII School, 1965 - 1970, in Apartheid Johannesburg was a stick-wielding, traditional boys school of its times. But the Establishment did not count on a cohort that displayed an over-developed spirit of rebellion. In this unofficial, unauthorized and somewhat scandalous account, over 70 schoolmates used the Covid-19 lockdown to describe their complicated relationship with the institution that helped shape their lives over the last 50 years. Anyone who has ever reflected on their own schooldays will enjoy the humour and escapades of a group determined to resist the rules and constraints of a very rigid society.
Written by Derek Black, one of the nation’s foremost experts in education law and policy, and Education Law Association’s 2015 Goldberg Award for Most Significant Publication in Education Law recipient, this third edition casebook develops Education Law through the themes of equality, fairness, and reform. The book focuses on the laws of equal educational opportunity for various disadvantaged student populations, recent reform movements designed to improve education, and the general constitutional rights that extend to all students. New to the Third Edition: Updates on litigation regarding the fundamental right to education, school funding, and their intersection with COVID-19 issues New cases and analysis on the rights of LGBTQ youth, including Bostock v. Clayton County Department of Education’s new regulatory structure for investigating and resolving sexual harassment claims Two new U.S. Supreme Court special education cases defining the meaning of “free and appropriation public education” and the intersection of Rehabilitation Act with the Individuals with Disabilities in Education Act New cases on student walkouts and protests New U.S. Supreme Court case, Espinoza v. Montana, on vouchers and the free exercise of religion New analysis and updates on the Every Student Succeeds Act New materials on the U.S. Supreme Court’s decision striking down mandatory teacher union fees Professors and student will benefit from: Efficient presentation of cases—to permit more comprehensive inclusion of case law and issues Problems—which can be modified for group exercises, in-class discussion, or out-of-class writing assignments Contextualization and situation of case law in the broader education world—by including edited versions of federal policy guidelines, seminal law review articles, social science studies, and organization reports and studies Careful editing of cases and secondary sources—for ease of reading and comprehension Narrative introductions to every chapter, major section, and case—synthesize and foreshadow the material to improve student comprehension and retention Teaching materials Include: Teacher’s Manual
In 1901 Emil von Behring received the first Nobel Prize in med. for serum therapy against diphtheria, a disease that killed thousands of infants annually. Diphtheria serum was the first major cure of the bacteriological era and its develop. generated procedures for testing, standardizing, and regulating drugs. Emphasizes Behring's contrib. to the study of infectious disease, the formation of modern immunology, and research on remedies and vaccines against microbial infections. Explores his relations to the rival bacteriological schools of Robert Koch and Louis Pasteur, the emergent German pharmaceutical industry, and the institutionalization of experimental therapeutic research. Also contains translations of 13 key articles by Behring and his assoc.
Both Sides Now is a thought-provoking collection of short stories by Vancouver Island writers Derek Hanebury, Vicki Drybrough, and Libbie Morin. Ranging in time from the 1950s to the present, these stories will draw the reader in to the world of a boy and his younger brother who struggle to find the perfect gift for their ailing grandfather, a troubled veteran who tries to escape the past by settling in a small community, and a young girl who goes to the circus alone and encounters more than she imagined. From beginning to end, you will enjoy stories that are crafted with empathy and insight to give the reader a satisfying experience.
With lucid text, four-color illustrations, and abundant examples, Criminal Evidence follows the path of evidence From Crime Scene to Courtroom. Focusing on the Federal Rules of Evidence and their state counterparts, Derek Regensburger offers a clear introduction to the principles of evidence and instructions for collecting, preserving, and presenting evidence in a criminal case. The book surveys the major concepts of evidence law such as relevance and burden of proof, discovery, admission of expert witness testimony, impeachment of witnesses, character evidence, hearsay, authentication of physical evidence, and more. Actual trials and news excerpts bring the material to life as they illustrate the role of evidence in real cases. Videos of mock trial scenes on the book’s website reinforce students’ understanding of key concepts. New to the Third Edition: A new chapter on trial practice and witness preparation Streamlined discussions of the exclusionary rule, Miranda rights, and rape shield laws Updated material on eyewitness identification and admission of confessions, particularly the modification of the corpus delicti rule by many state courts Changes concerning the reliability of forensic evidence due to the release of the 2016 report on the issue authored by the President’s Council on Science and Technology, including the FBI’s rejoinder to that report New and expanded sections on bloodstain pattern analysis, arson investigation, and handwriting analysis New and updated practical examples and Evidence in Action articles to feature more recent events, including the Kyle Rittenhouse trial Professors and students will benefit from: Straightforward text that follows the evidence from collection to trial Accessible three-part organization I. The Collection and Preservation of Evidence II. Pretrial Matters III. Admissibility of Evidence Four-color photographs and exhibits that illustrate evidentiary concepts Evidence in Action, observed in real trials and news excerpts Practical examples that apply legal concepts through hypothetical scenarios Review questions and application problems at the end of each chapter test students’ mastery of the material Short mock trial scenes on the companion website that illustrate key concepts discussed in the text
What starts out as a covert military operation to exterminate all the Taliban goat herds in Afghanistan quickly ends up going badly awry! The dead goats suddenly reanimate and begin attacking their herders. Soon the entire Afghan population becomes an army of undead, spreading fear and devastation throughout the region. Stick close to a special Ranger unit as they flee from Afghanistan, traveling through Turkmenistan to Kazakhstan and into southern Russia, where they sneak aboard the Trans-Siberian Express to Vladivostok. These men unknowingly carry with them the possible cure to the rampant plague. However, before they reach their destination, they are joined by a veteran US Army colonel and a beautiful female US Navy ensign who have their own agendas. This unlikely band of Americans eventually seizes a Russian trawler to make their way to Alaska, where even more surprises await them while crossing Canada to the US border.
This six-volume anthology documents the history of women's drama throughout the 18th century, starting with the emergence in 1695-6 of the second generation of women dramatists to Aphra Benn. It includes the work of Catherine Trotter, Mary Pix, Eliza Haywood and Elizabeth Griffith.
This new textbook is the definitive evidence-based resource for pediatric critical care. It is the first ostensibly evidence-based pediatric critical care textbook and will prove an invaluable resource for critical care professionals across the globe.
First published in 1988, this classic text is established as one of the most important discussions of the language of literature. Re-issued as a result of recent critical interest, this edition includes a new preface by the author.
MRI Atlas of Pediatric Brain Maturation and Anatomy provides rapid decision support during the interpretation of pediatric brain MRI when assessment of myelination and maturation present special challenges. Reference images are annotated to highlight key developmental features in the first three years of life for efficient, confident, reliable, and clinically valuable MRI interpretations.
Hot on the heels of Killing at its Very Extreme, Dublin: October 1917 – November 1920, Someone Has to Die for This, Dublin: November 1920 – July 1921 wrenches the reader into the final frenetic months of Dublin's War of Independence, in uncompromising, unflinching, and unprecedented detail. The reader will follow in the footsteps of IRA assassination units on Bloody Sunday, witness the hellish conditions in Croke Park, taste the gripping tension that stalked the city as intelligence services battled it out over the winter, while equally clandestine peace feelers were set in play. The pressure ratchets up in 1921 as surging IRA Active Service Units take the fight to the Auxiliaries, police and military in Dublin. Swathes of the country erupt into violent attacks and barbarous reprisals. Killings escalate in daily ambushes. Prison escapes are vividly detailed, as are the Mountjoy hangings. Shuttle diplomacy intensifies as a settlement is desperately sought, but fault lines develop among the Republican leadership. Street-battles paralyse the city with civilians bearing a brutal burden; the IRA relentlessly presses on. The devastating Custom House attack precedes the war's ferocious final weeks, culminating in a near bloodbath that almost scuppered the truce. Experience these breathtaking events through the eyes of their participants. This is an unforgettable story, its style providing long-overdue justice.
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