We are a nation that loves its ancient woods and trees. But in the space of just 40 years, more than a third of our ancient woods were destroyed. How and why did this happen? A Tale of Trees is the untold story of how we nearly lost our greatest national treasure.
Mechatronics as a discipline has an ever growing impact on engineering and engineering education as a defining approach to the design, development, and operation of an increasingly wide range of engineering systems. The increasing scope and complexity of mechatronic systems means that their design and development now involve not only the technical aspects of its core disciplines, but also aspects of organization, training, and management. Mechatronics and the Design of Intelligent Machines and Systems reflects the significant areas of development in mechatronics and focuses on the higher-level approaches needed to support the design and implementation of mechatronic systems. Throughout the book, the authors emphasize the importance of systems integration. Each chapter deals with a particular aspect of the design and development process, from the specification of the system to software design and from the human-machine interface to the requirements for safe operation and effective manufacture. Notable among this text's many features is the use of a running case study-the autonomous and robotic excavator LUCIE-to illustrate points made in various chapters. This, combined with the authors' clear prose, systematic organization, and generous use of examples and illustrations provides students with a firm understanding of mechatronics as a discipline, some of the problems encountered in its various areas, and the developing techniques used to solve those problems.
This book is the first text to provide a comprehensive assessment of the application of fundamental principles of dissolution and drug release testing to poorly soluble compounds and formulations. Such drug products are, vis-à-vis their physical and chemical properties, inherently incompatible with aqueous dissolution. However, dissolution methods are required for product development and selection, as well as for the fulfillment of regulatory obligations with respect to biopharmaceutical assessment and product quality understanding. The percentage of poorly soluble drugs, defined in classes 2 and 4 of the Biopharmaceutics Classification System (BCS), has significantly increased in the modern pharmaceutical development pipeline. This book provides a thorough exposition of general method development strategies for such drugs, including instrumentation and media selection, the use of compendial and non-compendial techniques in product development, and phase-appropriate approaches to dissolution development. Emerging topics in the field of dissolution are also discussed, including biorelevant and biphasic dissolution, the use on enzymes in dissolution testing, dissolution of suspensions, and drug release of non-oral products. Of particular interest to the industrial pharmaceutical professional, a brief overview of the formulation and solubilization techniques employed in the development of BCS class 2 and 4 drugs to overcome solubility challenges is provided and is complemented by a collection of chapters that survey the approaches and considerations in developing dissolution methodologies for enabling drug delivery technologies, including nanosuspensions, lipid-based formulations, and stabilized amorphous drug formulations.
Going round the world" is an idea that has excited people ever since it was realized that the earth was a sphere. The appeal has something to do with encompassing all the known environment and exploring the unknown, not only on the surface of the planet but within the spirit of the explorer. The story of circumnavigation is thus a long saga of human adventure, travel and discovery. Beginning with the fateful day in 1521 when Ferdinand Magellan was speared to death on Mactan and Juan de Elcano took up the challenge of bringing his surviving companions home, the story continues through four centuries crammed with astonishing exploits by men and women of many nations. Some of the names that feature are well-known, others less so.
In America after the Civil War, the emancipation of four million slaves and the explosion of Chinese immigration fundamentally challenged traditional ideas about who belonged in the national polity. As Americans struggled to redefine citizenship in the United States, the "Negro Problem" and the "Chinese Question" dominated the debate. During this turbulent period, which witnessed the Supreme Court's Plessy v. Ferguson decision and passage of the Chinese Exclusion Act, among other restrictive measures, American Baptists promoted religion instead of race as the primary marker of citizenship. Through its domestic missionary wing, the American Baptist Home Missionary Society, Baptists ministered to former slaves in the South and Chinese immigrants on the Pacific coast. Espousing an ideology of evangelical nationalism, in which the country would be united around Christianity rather than a particular race or creed, Baptists advocated inclusion of Chinese and African Americans in the national polity. Their hope for a Christian nation hinged on the social transformation of these two groups through spiritual and educational uplift. By 1900, the Society had helped establish important institutions that are still active today, including the Chinese Baptist Church and many historically black colleges and universities. Citizens of a Christian Nation chronicles the intertwined lives of African Americans, Chinese Americans, and the white missionaries who ministered to them. It traces the radical, religious, and nationalist ideology of the domestic mission movement, examining both the opportunities provided by the egalitarian tradition of evangelical Christianity and the limits imposed by its assumptions of cultural difference. The book further explores how blacks and Chinese reimagined the evangelical nationalist project to suit their own needs and hopes. Historian Derek Chang brings together for the first time African American and Chinese American religious histories through a multitiered local, regional, national, and even transnational analysis of race, nationalism, and evangelical thought and practice.
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