Ernest Hemingway spent about one-third of his life in Cuba and grew to love the country and its people. This travel narrative follows a journey across the island in search of Hemingway's Cuba and how it influenced some of his writings. The author seeks out Hemingway's haunts in Old Havana and his home in Finca Vigia and explores the north coast fishing village of Cojimar, his setting for The Old Man and the Sea. Along the way there are glimpses of Cuban geography and history, as well as the lives of modern Cubans.
The final novel in the award-winning George Miles Cycle. “A triumphant finale to one of the most intense series of novels ever written” (Mondo). The stunning conclusion to Dennis Cooper’s five-book cycle, Period earned its author the accolade “a disquieting genius” by Vanity Fair and praise for his “elegant prose and literary lawlessness” from The New York Times. Breathtaking and mesmerizing, it is the culmination of Cooper’s explorations into sex and death, youth culture, and the search for the ineffable object of desire. Cooper has taken his familiar themes—strangely irresistible and interchangeable young men, passion that crosses into murder, the lure of drugs, the culpabilities of authorship, and the inexact, haunting communication of feeling—and melded them into a novel of flawless form and immense power. Set in a spare, smoke-and-mirror-filled world of secret websites, Goth bands, Satanism, pornography, and outsider art, Period is a literary disappearing act as mysterious as it is logical. Obsessive, beautiful, and darkly comic, Period is a stunning achievement from one of America’s finest writers. “A fascinating, intricately crafted jewel of a book . . . It’s a book one could read over and over and never exhaust.” —San Francisco Chronicle Book Review “To read Period (a book so intricate, it comes with its own strategy guide) is to witness the idea of the novel itself imploding; to glimpse the end of language; to become aware of literature’s dizzying possibilities.” —The Guardian “An elegy to the nature of obsessive love, the need to feel . . . [Cooper] is a profoundly original American visionary, and the most important transgressive literary artist since Burroughs.” —Salon “Haunting.” —Details
And I thought I knew this crazy-brave black boy who bolted out of a Harlem ghetto into a white prep school and bobbed and weaved his way across the treacherous divide between black and white America. But Dennis Watlington's life story is even more astonishing than I knew. He emerges a no-jive black integrationist who is proud of the slave ancestry that makes him a solid American foreperson." -Gail Sheehy, bestselling author of Passages and Understanding Men's Passages Chasing America is a rollercoaster ride through promise and poverty, affirmative action and addiction, and a powerful story that captures a life and an era that is seminally American. Born in Harlem in 1952, Dennis developed a heroin habit at the age of 14, kicked it, and received a scholarship to the Hotchkiss School where he was elected president of his class. He went on to NYU, became involved in film and theater (he had a small role in The Deerhunter and gave Bruce Willis his start in a play called Bullpen), got addicted to crack, kicked that, and became an Emmy winning television writer. Chasing America shows us the best and worst that America offers to a Black man--from the Jim Crow South to boarding school life in New England to backstage at the Fillmore East to a holding cell in Bellevue Hospital. Part Ellison, part Exley, Chasing America is an amazing story.
Choral Repertoire is the definitive and comprehensive one-volume presentation of the most significant composers and compositions of choral music from the Western Hemisphere throughout recorded history. The book is designed for multiple uses-as a programming guide for practicing conductors, instructional resource for students and teachers of choral music, historic and stylistic reference for choral singers, and source of information about composers and compositions for choral enthusiasts-and as such, the book intends to further and make accessible important information relevant to the vast scope of choral music. Organized by era (Medieval, Renaissance, Baroque, Classical, and Modern), Choral Repertoire covers general characteristics of each historical era, trends and styles unique to various countries, biographical sketches of more than six hundred composers, and performance annotations of more than five thousand individual works. Of the composers, there is substantive coverage of women and composers of color, and of the repertoire, there is inclusion of lesser-known works as well as those works that are considered standard"--
When I split with my wife ten years ago, my antidote for the resulting feeling of loss and the negative emotions that a marriage breakup engenders was to be dramatically life altering. At the age of fifty-five I planned to teach English in Asia and South America. However, the road from plan to realization was littered with mental and physical obstacles, some of which almost proved fatal. Somehow surving these setbacks, I completed my quest by backpacking through Laos, Thailand, Cambodia, South America, Central America, and Burma. This is a tale about my physical, emotional, and psychological journey.
Seinfeld Ultimate Episode Guide is written by an authoritative expert who penned the most comprehensive reference book ever written about the show—Seinfeld Reference: The Complete Encyclopedia. The latest effort, Seinfeld Episode Guide, is the best source for little-known facts, details and information about the sitcom voted The #1 Greatest TV Series of All-Time by TV Guide. This type of episodic thoroughness cannot be found anywhere else in the entire Seinfeld Universe. Each episode is summarized in detail with supporting credits, such as writer, director, guest actors, bit players, extras, and uncredited actors. The best part is insider information about each episode, as well as little-known facts and unique trivia. There is even a section detailing some of the best known acting credits of every character who appeared in a Seinfeld episode. Everything you need to know about each episode and actor is in this book. Seinfeld Episode Guide provides insight into how some of the plots and subplots originated. The writer prove how art imitates life. Discover cast changes that occurred over the years, staff and crew members that made onscreen appearances, and so much more. There is even a section devoted to awards won by the series, creators, actors and other noteworthy individuals. Diehard fans will love the section devoted to technical credits for each season of the show. It has all the names, titles, and details of every significant crew member who worked behind the scene to make this the best show on TV. Find out which crew members made secret episode appearances as characters or extras. Seinfeld Episode Guide is an essential book for every fan of the show. If there is a question about an episode, actor, or character, this book will provably provide the answer. Photos included, 367 pages paperback and digital.
Provides a case-based approach to clinical exercise practice for students and therapists delivering exercise as therapy and is the first text of its kind focusing on clinical exercise service delivery. Cameron, Australian Catholic University; Selig & Hemphill, Victoria University, Australia.
A stimulating collection of essays about our environment, nature, and wildlife by world-renowned naturalist and conservationist Roy Dennis. A new collection of vibrant essays to inform, stimulate and inspire every nature lover. Times of darkness offer opportunities to reflect. In Mistletoe Winter, Roy Dennis offers his reflections on the natural world from the past year—from the welcome signs of change to the ongoing problems we are posing for nature, and what humankind can and must do about them. As in his companion volume, Cottongrass Summer, Roy Dennis balances his alarm at the crisis confronting the natural world with his own sense of optimism that new generations can make crucial changes for the future. One of our most prominent advocates for our planet and its species, he writes with insight and originality. This volume will provide inspiration and ideas for everyone who cares about our planet and its species.
The impact of the Oulipo (Ouvroir de Litterature Potentielle), one of the most important groups of experimental writers of the late twentieth century, is still being felt in contemporary literature, criticism, and theory, both in Europe and the US. Founded in 1960 and still active today, this Parisian literary workshop has featured among its members such notable writers as Italo Calvino, Georges Perec, and Raymond Queneau, all sharing in its light-hearted, slightly boozy bonhomie, the convivial antithesis of the fractious, volatile coteries of the early twentieth-century avant-garde. For the last fifty years the Oulipo has undertaken the same simple goal: to investigate the potential of 'constraints' in the production of literature--that is, formal procedures such as anagrams, acrostics, lipograms (texts which exclude a certain letter), and other strange and complex devices. Yet, far from being mere parlour games, these methods have been frequently used as part of a passionate--though sometimes satirical--involvement with the major intellectual currents of the mid-twentieth century. Structuralism, psychoanalysis, Surrealism, analytic philosophy: all come under discussion in the group's meetings, and all find their way in the group's exercises in ways that, while often ironic, are also highly informed. Using meeting minutes, correspondence, and other material from the Oulipo archive at the Bibliotheque nationale de France, The Oulipo and Modern Thought shows how the group have used constrained writing as means of puckish engagement with the debates of their peers, and how, as the broader intellectual landscape altered, so too would the group's conception of what constrained writing can achieve.
(Limelight). Includes Lillian Gish, Gregory Peck, Jose Ferrer, Sterling Hayden, Danny Kaye, Paul Winfield, Stacy Keach, Jessica Tandy, among others. "Mr. Brown's volume is one of the finest interview collections ever published." Playbill .
1607 vividly tells the story of the founding of Jamestown, recounting the situation of the original Indian inhabitants, the arrival of the British settlers 400 years ago, the building of the town, and modern excavations at the site. Along the way, we meet such familiar figures as King James, John Smith, and Pocahontas. We also come across strange episodes of cannibalism and skullduggery, heroism and romantic love. The book is a compilation of articles from Colonial Williamsburg magazine.
Is abortion ethical? The answer to this question is often obscured by rhetoric, slogans, and politics. And the media message on abortion is often of little help. When the typical American opens up her morning newspaper, she sees the topic debated between pro-lifers and pro-choicers but receives little information that could help her make an informed moral decision. And as she reads further about the subject, it seems that the Christian church, often an ethical guide in many of her decisions, is of no use to her. Sadly, she is told that the church is just as divided as the rest of society on the topic. So our average American is left to fend for herself. She must somehow decide the right answer with little guidance from society, from the church, or even from God himself. But is our average American really without guidance? Has she gotten all the information she needs about abortion, or has she received only the five-second sound bite that leaves her as confused as she was before she heard about the abortion debate? And has God been silent on the abortion question? Has the church really shown a diversity of opinion on the sanctity of life? A Love for Lifewill provide Christians with the biblical and historical information that they need to make an informed decision on the abortion question. It will also take a critical and biblically-based look at the arguments and theologies of todayÕs most prominent pro-choice clergy. And it will determine if abortion really fulfills the will of God, as many pro-choice Christians believe, or whether abortion is a clearly sinful act. In short, readers of A Love for Lifewill discover the realmessage of the church on abortion.
Most of Japan's leading textile firms date back to the turn of the century. Unlike many of their Western competitors, however, Japan's larger companies have survived the "decline" of a sector consumed by fierce international competition. Providing the fullest English-language account of Japanese textiles, Dennis L. McNamara explores the entire sweep of the industry, from factory to high-fashion brokerage to policymaking circle. Tracing the strategies by which the textile industry has survived, he provides a distinctive view of Japanese capitalism in a climate of change. McNamara reconstructs a world riven by the competing interests of state and capital, firm and industry, labor and management, mill and merchant. We encounter giant "mogul" companies and upstart independent "mavericks"—such firms as Toray, Toyobo, Itochu, Tsuzuki, Kondobo, Onward, and Renown—all hustling to restructure for survival. Drawing on extensive interview data as well as recent Japanese and English-language work in political economy and social anthropology, McNamara describes a dynamic of competition between moguls and mavericks in a turbulent business torn by divisions but bound together by compromise. He finds that, despite enormous international pressures, the industry has maintained much of its market share, largely because state bureaucrats and leaders of major firms have managed to create a cooperative politics of adjustment. A corporatist structuring of interests, he concludes, has helped to moderate decline and maintain stability, permitting survival among the moguls without preventing the successful participation of mavericks.
What is the true secret to spiritual growth for couples? Dennis and Barbara Rainey know from experience that the secret is more moments together. When you are lifting up your relationship and the rest of your life together to God, you won’t be able to keep the spiritual growth from happening. In the pages of Moments with You, the Raineys offer just what couples need to get started or to continue growing in their quiet times together. These short but poignant biblical devotions are enjoyable and easy to use, providing a daily discussion point, prayer and Scripture reference. Married couples desiring a deeper spiritual connection with God and their spouse will come to treasure their time spent over Moments with You. For married couples of all ages and at all stages of life.
Come take a stroll down Main Street, Vancouver. Get a coffee at the Grind, head north. Window-watch at The Front, then meander towards Broadway, past clothing stores, restaurants and pet food stores. Stop for a snack, then head towards Cordova for music and a game. It's a great day on Main Street. But wait, there's more. Much more. There's illegal, global-drug business, violence, dysfunction, and games. There's snarky realism, smarmy snips, gritty verite and wicked wit. History and fiction collide into *Tales of Main Street, Vancouver*.
Now in its third edition, this comprehensive text provides an in-depth examination of poverty and its impact on the health and quality of life of Canadians. Considering a broad range of topics, Dennis Raphael covers the central issues of defining and measuring poverty; situational and societal causes of poverty; health and social implications for individuals, communities, and society as a whole; and the means of reducing poverty’s incidence through public policy action. Poverty in Canada will foster greater insight into the repercussions of poverty throughout society, encouraging readers to reflect on provocative questions at the end of each chapter. Well updated to reflect current statistics and recent public policy changes, this new edition explores why specific groups of Canadians are over-represented amongst those living in poverty and provides a more developed analysis of the barriers to reducing poverty, including economic globalization and the increased power and influence of the corporate sector under neo liberalism. Emphasizing the lived experiences of poverty, this interdisciplinary volume is a valuable resource to those studying or working in health studies, social work, sociology, and equity studies.
This highly valuable book provides information on the problem of relapse in alcoholism and drug addiction. Experts address conceptual issues, summarize research on relapse, and explore a variety of theoretical and clinical models of relapse prevention. Several chapters describe practical applications of relapse prevention approaches used in both inpatient and outpatient clinical settings. Rather than adhere to one particular approach, this volume presents diverse viewpoints on clinical applications of relapse prevention. Intended for all professionals in medicine, psychiatry, social work, psychology, and nursing who work with individuals who have alcohol or other drug problems. Of particular interest to clinicians who treat alcoholics and drug abusers as well as administrators or supervisors who wish to develop and implement new types of relapse prevention programs. Unique in that it addressed conceptual, research, and clinical perspectives. Contributors, many who have published extensively on the subject, include a range of individuals, from those involved in academic research to those who work on the front lines in treatment facilities. SOFT BACKCOVER COPYRelapse: Conceptual, Research, and Clinical Perspectives provides new and valuable information on the problem of relapse with alcoholics and drug addicts. Some of the most respected authorities in the field describe practical applications of relapse prevention approaches used in both inpatient and outpatient clinical settings. They also discuss important conceptual issues, review the research on relapse, and explore theoretical and clinical models of relapse prevention. In recent years, increasing attention has been paid to the problem of relapse in chemically dependent individuals. With advanced research into the causes of relapse and the effectiveness of relapse prevention treatment models and new approaches to relapse prevention, more patients and their families are receiving specialized relapse prevention education and treatment focusing on long-term maintenance. Subsequently, all professionals in medicine, psychiatry, social work, psychology, and nursing who work with individuals who have alcohol or other drug problems will find it essential to read this up-to-the-minute volume. Clinicians who treat alcoholics and drug abusers and administrators or supervisors who wish to develop and implement new types of relapse prevention programs will applaud the comprehensive insights and applications featured in Relapse: Conceptual, Research, and Clinical Perspectives. Here's what you will find: A summary of the existing research and literature on relapse and relapse prevention, providing a broad overview of the current state of knowledge A description of four clinical treatment approaches commonly used in the chemical dependency field--the cognitive-behavioral approach based on the self-efficacy theory, the Psychoeducational Model of Relapse Prevention, the Marlatt and Gordon "self-management" approach, and the CENAPS model An examination of the content and structure of relapse prevention programs and the application of various approaches in several clinical contexts, including a six-month outpatient program, an intensive nonresidential rehabilitation program, a 28-day residential program, a therapeutic community, and a program used with adult chronic marijuana users
This is the history of two RAF squadrons who shared many tasks during WWII. Although there was a healthy rivalry between personnel serving on 190 and 620 Squadrons, there was also a deep sense of camaraderie that forged bonds between them.
365 All - New Devotions for Couples What is the true secret to spiritual growth for couples? Dennis and Barbara Rainey know from experience that the secret is more moments together. When you are lifting up your relationship and the rest of your life together to God, you won't be able to keep the spiritual growth from happening. In the pages of More Moments Together for Couples, the Raineys offer just what couples need to get started or to continue growing in their quiet times together. These short but poignant biblical devotions are enjoyable and easy to use, providing a daily discussion point, prayer and Scripture reference. Married couples desiring a deeper spiritual connection with God and their spouse will come to treasure their time spent with More Moments Together for Couples. Promote strong marriages with this outstanding resource for married couples of all ages and at all stages of life.
One of America's greatest writers, William Faulkner wrote fiction that combined spellbinding Southern storytelling with modernist formal experimentation to shape an enduring body of work. In his fictional Yoknapatawpha County—based on the region around his hometown of Oxford, Mississippi—he created an entire world peopled with unforgettable characters linked into an intricate historical and social web. An introduction to the Nobel-Prize-winning author's life and work, this book devotes opening chapters to his biography and literary heritage and subsequent chapters to each of his major works. The analytical chapters start with his most accessible book, The Unvanquished, a Civil-War-era account of a boy's coming of age. The following chapters orient readers to elements of plot, character, and theme in Faulkner's masterpieces: The Sound and the Fury, As I Lay Dying, Light in August, and Absalom, Absalom! Also analyzed and discussed are some of Faulkner's most often anthologized short stories, including A Rose For Emily and Barn Burning, and the longer stories The Bear, Spotted Horses, and The Old Man that were incorporated in the novels Go Down, Moses, The Hamlet, and If I Forget Thee, Jerusalem. Clear, insightful analyses of the elements of Faulkner's fiction are supplemented with alternative readings from a variety of critical approaches including gender, rhetorical, performance, and cultural studies perspectives.
2014 BMA Medical Book Awards Highly Commended in Anaesthesia category! Apply the latest scientific and clinical advances with Wall & Melzack's Textbook of Pain, 6th Edition. Drs. Stephen McMahon, Martin Koltzenburg, Irene Tracey, and Dennis C. Turk, along with more than 125 other leading authorities, present all of the latest knowledge about the genetics, neurophysiology, psychology, and assessment of every type of pain syndrome. They also provide practical guidance on the full range of today's pharmacologic, interventional, electrostimulative, physiotherapeutic, and psychological management options. Benefit from the international, multidisciplinary knowledge and experience of a "who's who" of international authorities in pain medicine, neurology, neurosurgery, neuroscience, psychiatry, psychology, physical medicine and rehabilitation, palliative medicine, and other relevant fields. Access the complete contents online anytime, anywhere at www.expertconsult.com. Translate scientific findings into clinical practice with updates on the genetics of pain, new pharmacologic and treatment information, and much more. Easily visualize important scientific concepts with a high-quality illustration program, now in full color throughout. Choose the safest and most effective management methods with expanded coverage of anesthetic techniques. Stay abreast of the latest global developments regarding opioid induced hyperalgesia, addiction and substance abuse, neuromodulation and pain management, identification of specific targets for molecular pain, and other hot topics.
Most studies of the performance of Shakespeare's work concentrate on how the text has been played and what meanings have been conveyed through acting and interpretive directing. Dennis Kennedy demonstrates that much of audience response is determined by the visual representation, which is normally more immediate and direct than the aural conveyance of a text. Ranging widely over productions in Britain, Europe, Japan and North America, Kennedy gives a thorough account of the main scenographic movements of the century, investigating how the visual relates to Shakespeare on the stage. The second edition of this acclaimed history includes a new chapter on Shakespeare performance in the 1990s, bringing the story up to date by drawing on examples from a wide international field. There are more than twenty new illustrations, some of them in colour (bringing the total number of illustrations to almost 200), and previous references have been updated.
The memoirs of a World War II RAF flying ace who participated in the Battle of Britain and the Battle of France. Born in 1918, with family roots in a coal-mining village near Cardiff, Wales, Dennis “Hurricane” David had a very distinguished war record with the Royal Air Force, particularly during the Battle for France and the Battle of Britain. He also flew in the Burma campaign, and his postwar adventures included personally witnessing the 1956 revolution in Hungary. Written with candor and exciting detail of his aerial adventures, this autobiography covers his flying career until he retired in 1967.
For most Americans, terrorism made the transformation from theoretical threat to frightening reality on September 11, 2001, yet America has been the target of terrorist acts for over four decades. Piszkiewicz recounts the changing political orientation of terrorists and highlights the challenge that faces America and the community of nations in putting terrorists out of business without adopting their tactics. Piszkiewicz tells the history of modern international terrorism from its beginning in 1958 with the Cuban hijacking of an airliner en route from Miami. He recounts the changing political orientation of the enemy, the growing viciousness of their attacks, and the blundering responses by the U.S. government: inaction, impotent verbal assaults, and ill-conceived acts of retaliation. This book highlights the challenge that faces America and the community of nations in putting terrorists out of business without adopting their tactics. The assault began with the hijacking of airliners, but soon included the bombing of embassies, as well as attacks on military units and navy ships. Terrorism has evolved from a disorganized activity of individuals and small groups, through its adoption of political warfare by nationalists, insurgents, and the disenfranchised, to its current incarnation as a weapon of political change used by rogue states and radical religious movements.
They will melt like snowflakes in the sun," said one observer of nineteenth-century Irish emigrants to America. Not only did they not melt, they formed one of the most extensive and persistent ethnic subcultures in American history. Dennis Clark now offers an insightful analysis of the social means this group has used to perpetuate its distinctiveness amid the complexity of American urban life. Basing his study on family stories, oral interviews, organizational records, census data, radio scripts, and the recollections of revolutionaries and intellectuals, Clark offers an absorbing panorama that shows how identity, organization, communication, and leadership have combined to create the Irish-American tradition. In his pages we see gifted storytellers, tough dockworkers, scribbling editors, and colorful actresses playing their roles in the Irish-American saga. As Clark shows, the Irish have defended and extended their self-image by cultivating their ethnic identity through transmission of family memories and by correcting community portrayals of themselves in the press and theatre. They have strengthened their ethnic ties by mutual association in the labor force and professions and in response to social problems. And they have created a network of communications ranging from 150 years of Irish newspapers to America's longest-running ethnic radio show and a circuit of university teaching about Irish literature and history. From this framework of subcultural activity has arisen a fascinating gallery of leadership that has expressed and symbolized the vitality of the Irish-American experience. Although Clark draws his primary material from Philadelphia, he relates it to other cities to show that even though Irish communities have differed they have shared common fundamentals of social development. His study constitutes a pathbreaking theoretical explanation of the dynamics of Irish-American life.
The story is a lively and anecdotal factual account and a cautionary tale of the local and national events that shaped the destiny of late 1900's forest product and fishing industries in Mendocino County and the world we live in. Thus it is a must read for anyone who longs for development of sustainable communities, who would avoid the mistakes of the past, and who would be a partner in the ultimate triumph of conservation.
Volume I examined the policies and actions in the Eisenhower, Kennedy, and Johnson administrations that contributed to the creation of anti-American grievances which in turn fueled the rise of anti-American terrorism overseas and domestically during the Nixon, Ford, and Carter administrations. Volume II chronicles the high-water mark of anti-American terrorism overseas that occurred during the Reagan administration. The litany of terrorist attacks on US targets overseas during this period is well known and unmatched in American history: 1983 suicide attack on US Embassy Beirut, 1983 suicide attack on US Marine Barracks Beirut, 1983 suicide attack on US Embassy Kuwait, 1984 suicide attack on US Embassy Beirut, 1985 assault on the TWA counter at Rome airport, 1985 hijacking of TWA 847, 1986 mid-air bombing of TWA 840, 1988 mid-air bombing of Pan Am 103, and the 1982-1988 kidnappings of 18 Americans in Lebanon. This wave of anti-American terrorist attacks demanded an appropriate response. The Reagan administration proceeded to construct the most ambitious and costly counter-terrorism program in the pre-9/11 era. Although the terrorist threat was perceived to be in decline during the George H W Bush administration, it still had to deal with the potential terrorist threat emanating from the first Gulf War in 1990-1991, two assassination attempts on the president, and the ramifications of the Pan Am 103 bombing.
R. Dennis Bevans started his federal career as a file clerk in 1960, and moved ahead rapidly into senior level positions during the most vibrant period of domestic policy expansion in history, while working closely with high-ranking officials. Over twenty-eight years Bevans helped shape and refine many programs which were based on the broad vision of President J.F.Kennedy, but enacted by Congress as the Great Society due to the imposing legislative skill and initiative of President Lyndon B. Johnson. Never better than when they were first launched, eventually politicians started to apply increasing amounts of money and less management oversight at failing federal programs, and to organizationally elevate agencies for all the wrong reasons. He requested early retirement in 1988 while working within a stalled, impotent, and demoralized Department of Energy. Fast Track Bureaucrat: An Insider's Story of Service, Survival, Success, Solutions provides a unique, compelling look into an incredible career as it unfolds inside numerous executive branch departments and agencies, including the Nixon White House. Learn about Bevans' many insightful suggestions for managerial, program, and civil service reform.
EXTRACTABLES AND LEACHABLES Learn to address the safety aspects of packaged drug products and medical devices Pharmaceutical drug products and medical devices are expected to be effective and safe to use. This includes minimizing patient, user or product exposure to impurities leached from these items when the drug product is administered or when the medical device is used. Clearly, patient or user exposure to leachables must not adversely impact their health and safety. Furthermore, these impurities must not adversely affect key quality attributes of the drug product or medical device, including its manufacturability, stability, efficacy, appearance, shelf-life and conformance to standards. Extractables and leachables are derived from the drug product’s packaging, manufacturing systems and/or delivery systems or from the medical device’s materials of construction. It is imperative to understand and quantify the release of extractables from these items, the accumulation of leachables in drug products and the release of leachables from medical devices. Once extractables and leachables have been discovered, identified and quantified, their effect on the key product or device quality attributes, including safety, must be systematically and scientifically established according to recognized, rigorous and relevant regulatory and compendial standards and industry-driven best practices. In Extractables and Leachables, the chemical compatibility (including safe use) of drugs (and their containers, delivery devices and manufacturing systems) and medical devices is examined at length, focusing particularly on how trace-level extractables and leachables affect the quality and safety of a medical product and how to assess the magnitude of the effect. This is accomplished by addressing the two critical activities required to develop, register and commercialize safe, effective and affordable clinical therapies; measuring extractables and leachables (chemical characterization) and assessing their impact (for example, toxicological safety risk assessment). Each of these activities is addressed in-depth, based on the existing and developing international regulations and guidelines, current published literature and the author’s extensive personal experience. Written by a key contributor to standards, guidelines, recommended practices and the scientific literature, the book provides “insider” insights beyond those gained by merely reading the relevant texts. Given that the rapidly evolving extractables and leachables landscape, this book provides the most current and crucial information on new and forthcoming regulations and best practices. Extractables and Leachables readers will also find: A thorough summary of regulatory and compendial guidelines and the steps required to meet them A detailed and in-depth review of essential scientific principles and recommended best practices for the design, implementation, interpretation and reporting of chemical characterization studies A practical resource for optimizing the development, registration, and commercialization of safe and effective medical products A helpful tool to maximize product development and successful regulatory outcomes Extractables and Leachables is the essential reference for pharmaceutical scientists, analytical chemists, regulatory affairs professionals, engineers, and toxicologists in areas such as product research and development, product registration and approval, regulatory affairs, analytical science, quality control, and manufacturing.
The essential reference book on matrices—now fully updated and expanded, with new material on scalar and vector mathematics Since its initial publication, this book has become the essential reference for users of matrices in all branches of engineering, science, and applied mathematics. In this revised and expanded edition, Dennis Bernstein combines extensive material on scalar and vector mathematics with the latest results in matrix theory to make this the most comprehensive, current, and easy-to-use book on the subject. Each chapter describes relevant theoretical background followed by specialized results. Hundreds of identities, inequalities, and facts are stated clearly and rigorously, with cross-references, citations to the literature, and helpful comments. Beginning with preliminaries on sets, logic, relations, and functions, this unique compendium covers all the major topics in matrix theory, such as transformations and decompositions, polynomial matrices, generalized inverses, and norms. Additional topics include graphs, groups, convex functions, polynomials, and linear systems. The book also features a wealth of new material on scalar inequalities, geometry, combinatorics, series, integrals, and more. Now more comprehensive than ever, Scalar, Vector, and Matrix Mathematics includes a detailed list of symbols, a summary of notation and conventions, an extensive bibliography and author index with page references, and an exhaustive subject index. Fully updated and expanded with new material on scalar and vector mathematics Covers the latest results in matrix theory Provides a list of symbols and a summary of conventions for easy and precise use Includes an extensive bibliography with back-referencing plus an author index
The volume begins with biographical sketches of the First Purchasers, in which the author explains to what extent each man figured in Nantucket's British beginnings and gives an account of that pioneer's immediate family and the circumstances of his death. The First Purchasers included: Thomas Macy, Benjamin Coffin, Tristram Coffin, Edward Starbuck, Richard Swain, William Bunker, John Swain, Thomas Barnard, Robert Barnard, Christopher Hussey, Thomas Mayhew, Peter Coffin, Stephen Greenleaf, William Pile, Robert Pike, Tristram Coffin, Jr., James Coffin, Thomas Coleman, Nathaniel Starbuck, Thomas Look, and John Smith. Many of these founders were well acquainted with one another and, in a number of instances, were connected through intermarriage as well. These relationships are clearly established by Mr. Starbuck's genealogies, which trace the founders from their origins in England through four or five generations to the eve of the American Revolution and beyond.
In the 1960s and 1970s the study of history and sociology was heavily influenced by Marxism and theories of class. But the collapse of Communism and significant changes in culture and society threw the study of class into crisis. Its most basic premises were called into question. More recently accelerating globalisation, proliferating multinational corporations and unbridled free-market capitalism have given the study of class a new significance and caused historians and sociologists to revisit the debate. This book looks at the changes that caused the crisis in the study of class and shows how new, vibrant theories have appeared that will drive forward our understanding of history and sociology.
Henry Allingham is the last British serviceman alive to have volunteered for active duty in the First World War and is one of very few people who can directly recall the horror of that conflict. In Kitchener's Last Volunteer, he vividly recaptures how life was lived in the Edwardian era and how it was altered irrevocably by the slaughter of millions of men in the Great War, and by the subsequent coming of the modern age. Henry is unique in that he saw action on land, sea and in the air with the British Naval Air Service. He was present at the Battle of Jutland in 1916 with the British Grand Fleet and went on to serve on the Western Front. He befriended several of the young pilots who would lose their lives, and he himself suffered the privations of the front line under fire. In recent years, Henry was given the opportunity to tell his remarkable story to a wider audience through a BBC documentary, and he has since become a hero to many, meeting royalty and having many honours bestowed upon him. This is the touching story of an ordinary man's extraordinary life - one who has outlived six monarchs and twenty-one prime ministers, and who represents a last link to a vital point in our nation's history.
Celebrate the special moments of the season with these unique collections of holiday carols by Alfred's favorite piano arrangers. Titles: The Christmas Angels: * Angels from the Realm of Glory * Angels We Have Heard on High * Hark! the Herald Angels Sing (Dennis Alexander) Christmas Bells: * I Heard the Bells on Christmas Day * The Bells on the Sleigh to Grandma's House [Over the River and Through the Wood / Jingle Bells] * Bells Are Ringing [Ding Dong Merrily on High / Ring, Little Bells] (Mary K. Sallee) The Christmas Manger * What Child Is This? * Coventry Carol * Away in a Manger (Tom Gerou) The Christmas Shepherds * How Great Our Joy * It Came Upon the Midnight Clear * The First Noel (Victor Labenske) He Is Born! * Good Christian Men, Rejoice * What Child Is This? * Polish Lullaby * Il est né (Joyce Grill) A Jazzy, Jolly Christmas * Up on the Housetop * Jolly Old St. Nicholas * Jingle Bells (Victor Labenske) The Nativity * Still, Still, Still * Lo, How a Rose E'er Blooming * Joy to the World (Cindy Berry) The Three Kings * March of the Three Kings * We Three Kings of Orient Are * O Come, All Ye Faithful (Robert D. Vandall Three Moods for Christmas * Carol of the Bells * What Child Is This? * We Wish You a Merry Christmas (Sharon Aaronson)
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