Genetically modified animals were created about 30 years ago, and are considered good models of human diseases. In this chapter, the types of genetically engineered mice, such as transgenic, knockout conditional knockout, and knockin animals, and the general techniques on how to obtain them are described. In addition, the available genetically modified models for genetic diseases, multifactorial and polygenic (complex) disorders, neurodegenerative, inflammatory diseases, besides cancer models, are presented. The aim of the chapter is to help investigators to find out the best models for their studies.
Written by current and former surgical oncology fellows of the world-renowned M.D. Anderson Cancer Center, this portable handbook is a practical guide to established surgical oncology principles for each organ system. Maximize your surgical oncology skills with comprehensive coverage, multidisciplinary perspectives, proven therapeutic strategies, useful algorithms, and recommended readings. Concise chapters illustrated with algorithms and line drawings outlining the essential elements of diagnosis, staging, and clinical management of solid tumors treated in surgical practice.
Taking the place of the multiple texts traditionally needed to cover visual anatomy and physiology, Clinical Anatomy and Physiology of the Visual System, 3rd Edition dramatically lightens your load by providing one book that covers it all! This concise, well-referenced resource contains information on the clinical anatomy of the eye, its adnexa and visual pathways, histologic information, plus newly added content on physiology of the human ocular structures. Vivid illustrations complement the text and provide clinical information on diseases and disorders that represent departures from normal clinical anatomy. - Comprehensive physiology coverage clarifies the integration between structure and function, eliminating your need for multiple books on the anatomy and physiology of the visual system. - An emphasis on clinical application helps you better understand the processes that occur in disease and dysfunction. - Genetic information keeps you current with the latest developments in visual anatomy and physiology. - Full-color illustrations throughout the text enhance your understanding of anatomical and clinical information. - UNIQUE! Clinical Comment sections provide a solid foundation for recognizing and understanding clinical situations, conditions, diseases, and treatments. - Photos of normal eye structures illustrate clinical appearance and demonstrate how appearance is directly related to structure. - Geriatric coverage, including aging changes in ocular tissue and the visual pathway, keeps you up-to-date with the expanding field of geriatric care. - UNIQUE! Expert coverage written by an actual optometrist gives you a practical framework for recognizing and understanding clinical situations, problems, and treatments.
The standard location tool for full-length plays published in collections and anthologies in England and the United States since the beginning of the 20th century, Ottemiller's Index to Plays in Collections has undergone seven previous editions, the latest in 1988, covering 1900 through 1985. In this new edition, Denise Montgomery has expanded the volume to include collections published in the entire English-speaking world through 2000 and beyond. This new volume lists more than 3,500 new plays and 2,000 new authors, as well as birth and/or death information for hundreds of authors. Representing the largest expansion between editions, this updated volume is a valuable resource for libraries worldwide.
Despite the rise of the Hollywood system and hostility to Asian migrant communities in the early twentieth-century United States, Japanese Americans created a thriving cinema culture that produced films and established theaters and exhibition companies to facilitate their circulation between Japan and the United States. Drawing from a fascinating multilingual archive including the films themselves, movie industry trade press, Japanese American newspapers, oral histories, and more, this book reveals the experiences of Japanese Americans at the cinema and traces an alternative network of film production, exhibition, and spectatorship. In doing so,Denise Khor recovers previously unknown films such as The Oath of the Sword(1914), likely one of the earliest Asian American film productions, and illuminates the global circulations that have always constituted the multifaceted history of American cinema. Khor opens up transnational lines of inquiry and draws comparisons between early Japanese American cinema and Black cinema to craft a broad and expansive history of a transnational public sphere shaped by the circulation and exchange of people, culture, and ideas across the Pacific.
First published more than 20 years ago, Special Tests for Orthopedic Examination, now in its Fourth Edition, continues to follow the authors’ initial goals of providing a simple, pocket-sized manual for practical learning purposes. The Fourth Edition provides critical and invaluable information on the most current and practical special tests used during an orthopedic examination. The efficient user-friendly, spiral-bound format allows for easy access to individualized special tests. Special Tests for Orthopedic Examination, Fourth Edition includes 160 special tests, 6 of which are new: Ballottement Test Gerber’s Test (Lift-Off Test) Painful Arc Sign Thessaly Test Quad Active Test Lelli Test for Anterior Cruciate Ligament (ACL) Injuries Inside Special Tests for Orthopedic Examination Fourth Edition, Jeff G. Konin, Denise Lebsack, Alison R. Snyder Valier, and Jerome A. Isear, Jr. have included a new section on evidence, where the authors have highlighted systematic reviews, meta-analyses, or single articles to address reliability, sensitivity, and specificity of the special tests, where available. What is new and updated in the Fourth Edition: Includes a video website that provides visually enhanced dimensional and motion analysis of each special test performed Includes 160 special tests, 6 of which are new to this edition Includes information on reliability, sensitivity, and specificity presented in a table format New evidence section highlight systematic reviews, meta-analyses, or single articles for special tests, where available New color images for each test Updated references for all tests Bonus Material! Special Tests for Orthopedic Examination, Fourth Edition includes a video website with each new book purchase. This video website offers a unique approach that provides a visually enhanced dimensional and motion analysis of each special test performed. The video segments will help students and clinicians better understand the test motion in order to perform the test accurately during an orthopedic examination. The simple yet succinct information provided throughout the manual and on the video website will help clinicians make informed decisions during an orthopedic examination, from understanding to performing and evaluating the special tests. Special Tests for Orthopedic Examination, Fourth Edition will carry on the tradition of past editions as being the premier resource for thousands of students, clinicians, and rehabilitation professionals.
Providing the ocular anatomy and physiology content needed for a thorough comprehension of this complex field, Clinical Anatomy and Physiology of the Visual System, 4th Edition, offers a solid foundation for recognizing and understanding specific clinical situations and how they relate to anatomic structure. This concise, well-referenced resource covers the clinical anatomy of the eye, its adnexa and visual pathways, and histologic information—the information you need for success in coursework, certification exams, and clinical practice. - Features vivid, full-color illustrations that help you visualize the clinical anatomy of the eye along with the cellular physiology behind diseases and disorders of the visual system. - Emphasizes clinical application throughout, helping you better understand the processes that occur in disease and dysfunction. Clinical Comment sections offer a unique focus on clinical situations, conditions, diseases, and treatments. - Contains new OCT, OCTA, MRI, and CT images that demonstrate clinical views of ocular anatomy. OCT technology is incorporated to describe the retinal layers, newly described anatomical components of the vitreous, corneal and anterior chamber angle anatomy, and the choroidal and retinal vasculature. - Covers current topics such as genes essential in eye development, scleral and choroidal changes occurring with myopia progression, limbal stem cells, age-related macular degeneration and VEGF therapies, and microinvasive glaucoma surgical procedures. - Includes updated concepts and terminology: Edinger Westfall preganglionic cells, sensory innervation to the cornea, knees of Wilbrand, intrinsically photosensitive retinal ganglion cells, and more. - Provides expert coverage by a practicing optometrist, giving you a practical framework for recognizing and understanding clinical situations, problems, and treatments. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
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