In the last decade, researchers working in the field of cancer biology have shifted their focus from genetic defects to epigenetic dysregulation, especially that of non-coding RNAs (ncRNAs). This book encompasses a comprehensive review of the transcriptional landscape of the cell and its involvement in the cancer pathophysiology. The first two chapters elucidate the basics of biosynthesis, mechanism of action and modulation of the epigenetic regulation of gene expression by coding as well as non-coding RNAs. The third chapter discusses the aberrant expression of the cellular RNome in the cancer cells and highlights its role in the orchestration of processes involved in evolution as well as the sustenance of cancer cells. The fourth chapter describes the recent advances in the field of translating the transcriptome into diagnostic/prognostic biomarkers and as targets for novel anti-cancer therapies. The final chapter then reviews the emerging experimental approaches to screen, identify and explore the functions of ncRNAs. Providing valuable insights into the field of RNome in the context of cancer, this book is helpful to students, researchers and clinicians..
In the last decade, researchers working in the field of cancer biology have shifted their focus from genetic defects to epigenetic dysregulation, especially that of non-coding RNAs (ncRNAs). This book encompasses a comprehensive review of the transcriptional landscape of the cell and its involvement in the cancer pathophysiology. The first two chapters elucidate the basics of biosynthesis, mechanism of action and modulation of the epigenetic regulation of gene expression by coding as well as non-coding RNAs. The third chapter discusses the aberrant expression of the cellular RNome in the cancer cells and highlights its role in the orchestration of processes involved in evolution as well as the sustenance of cancer cells. The fourth chapter describes the recent advances in the field of translating the transcriptome into diagnostic/prognostic biomarkers and as targets for novel anti-cancer therapies. The final chapter then reviews the emerging experimental approaches to screen, identify and explore the functions of ncRNAs. Providing valuable insights into the field of RNome in the context of cancer, this book is helpful to students, researchers and clinicians..
Jinnah's Fatal Handicap looks at Mr. Jinnah's inflexible demand for the creation of a separate Islamic state through the prism of the disease that killed him in 1948, a year after the creation of Pakistan. Mr. Jinnah, a brilliant barrister, possessing one of the sharpest minds of his time, was unable or unwilling to get his hands on streptomycin, the first antibiotic discovered for the treatment of tuberculosis, the disease that eventually consumed him. This book dwells on the notion that if Mr. Jinnah had been less unbending and more inclined towards medical treatment, he could have provided a more enduring democratic legacy to the nation, which he singlehandedly carved out in 1947. Mr. Jinnah refused to reveal that he was suffering from tuberculosis right till the end. There is considerable scientific evidence that chronic disease significantly impairs cognition. It is tempting to speculate that Pakistan would not be tottering on the verge of collapse had Mr. Jinnah been of sounder health. The world today is more dangerous than ever. We should not permit wily politicians to splinter us based on religion or creed to accomplish their geopolitical agenda. All mankind belongs to a single species.
Deepak Gupta did his BA from Allahabad, MA from St Stephen’s college and MPhil in International relations from JNU. From the IAS batch of 1974, he has spent many years in the field in the erstwhile state of Bihar, including two districts (Saharsa 1979–80; Rohtas 1986–88) as Collector. He served in many departments in state and center and was also posted in India Trade Centre, Brussels and spent a year as WHO Advisor on TB in Delhi. He retired in 2011 as Secretary, Ministry of New and Renewable Energy. After retirement he consulted with the World Bank and UNIDO and writes on issues of energy and sustainable development. He was Chairman of UPSC from November 2014 to September 2016. His published works include Documentation of Participatory Irrigation Management, Covering a Billion with DOTS, Achieving Universal Energy Access in India: Challenges and Way Forward, and Caught by the Police.
The objective of this book is to provide complete course content of beverage processing related subjects in ICAR, CSIR and UGC institutions in Food Technology, Dairy Technology, Food & Nutrition, Post Harvest Technology, Agricultural and Food Process Engineering discipline. The book contains fourteen chapters on the topics such as Introduction to Beverages, Role of Ingredients and Additives in Beverages, Fruit Juice Processing, Processing of Specific Fruits & Vegetables Juices, Cereal Based Beverages, Soft Carbonated Beverages, Alcoholic Beverages, Dairy Based Beverages, Sports Beverages, Tea Processing, Technology of Coffee Manufacture, Cocoa and Chocolate Based Beverages, Packaging of Beverages & Functional Beverages. The content of the book will be helpful for B.Tech, M.Tech, M.Sc. & Ph.D. students of above mentioned disciplines. These topics will also be helpful for the students preparing for competitive exams.
The book first explains the dynamics of cultural heritage with its authenticity underpinnings, marketing, and tourism, and proposes a strategic praxis drawn from core sustainable principles.
30 Solved Papers (2018-07) for SSC Junior Engineer Mechanical Exam is a comprehensive book prepared using authentic papers of the SSC exam. The book contains 12 sets of 2018 paper & 8 sets of 2017 paper. The book also contains 10 more Solved Papers from 2016 to 2007 (2 sets of 2014 paper). Detailed Solutions to all the papers are provided at the end of each paper.
This book provides a summarized information related to the global herbal drug market and its regulations, ethnopharmacology of traditional crude drugs, isolation of phytopharmaceuticals, phytochemistry, standardization, and quality assessment of crude drugs. Natural products science has constantly been developing with comprehensive data contemplating different parts of natural drugs, such as global trade, quality control and regulatory concerns, traditional medicine systems, production and utilization of drugs, and utilization of medicinal and aromatic plants. This broad information about crude drugs gives rise to a subject that is now recognized as advance natural products science. By contemplating all of this thorough knowledge of the areas, this book is intended to provide considerably to the natural products science. The area of natural products science involves a broad range of topics, such as the pharmacognostical, phytochemical, and ethno-pharmacological aspects of crude drugs. Each chapter gives a sufficient understanding to academicians and researchers in the respective topic. This book includes 40 illustrations and descriptions of roughly 80 medicinal plants used for herbal medicine. The book is an imperative source for all researchers, academicians, students, and those interested in natural products science. FEATURES Includes advance knowledge and detailed developments in natural products science Discusses the most important phytopharmaceuticals used in the pharmaceutical industry Explores the analysis and classification of novel plant-based medicinal compounds Includes standardization, quality control, and global trade of natural products Gives a deep understanding related to recent advances in herbal medicines to treat various ailments Discusses national and WHO regulations and policies related to herbal medicines Covers the complete profile of some important traditional medicinal plants, especially their historical background, biology, and chemistry
Coronavirus disease 2019 (COVID-19) has emerged as a global health threat. Unfortunately, there are very limited approved therapeutics available with established efficacy and safety profiles against SARS-CoV-2. COVID-19 vaccines aim to actively induce systemic immunization; however, the possibility or fear of side effects decreases or discourages their use. Alternative therapy via natural products, especially essential oils, could be considered safe and effective to improve health, cure ailments, and soothe your body and mind. Essential oils, which have been known for their anti-inflammatory, immunomodulatory, bronchodilatory, and antiviral properties, could possibly be useful for the symptomatic management of COVID-19. This book is vital in respect of designing approaches to protect humanity from further losses and harm due to SARS-CoV-2 infection. Role of Essential Oils in the Management of COVID-19 offers a complete outline of the recent novel coronavirus (SARS-CoV-2) infection, its biology, and associated challenges for the prevention and treatment of novel COVID-19, with a prime focus on the possible role of essential oils in the prevention and treatment of COVID-19. This book is written for everyone who needs to be thoroughly familiar with the appropriate and safe use of essential oils in COVID-19 therapy. As per the objectives of the book: The first seven chapters cover various aspects of COVID-19 infection, including epidemiology, origin, morphology, genome organization, pathogenesis, clinical manifestations, diagnostic approaches, preventive measures, and treatment strategies. The remaining chapters elaborate on the various aspects related to essential oils, such as chemistry, extraction methods, dispensing methods, stability, quality control, mechanism of action, therapeutic effects, pharmacokinetics, aromatherapy, and safety profiles. Prof. Ahmed Al-Harrasi is Vice Chancellor for Graduate Studies, Research and External Relations, Natural and Medical Sciences Research Center, and Professor of Organic Chemistry, University of Nizwa, Oman. Prof. Ahmed received his M.Sc. degree in Chemistry followed by his Ph.D. in Organic Chemistry from the University of Berlin. He then pursued his postdoctoral research at Cornell University. Afterward, he continued his research rigor at the University of Nizwa, where he founded the Natural and Medical Sciences Research Center, which has now become a center of excellence in natural and medical sciences. While enduring his research aptitude, he has authored and co-authored more than 400 scientific papers, 2 books, and 12 book chapters of high repute. Dr. Saurabh Bhatia graduated from Kurukshetra University, followed by postgraduation from Bharati Vidyapeeth University. He received his Ph.D in Pharmaceutical Technology at Jadavpur University. He now works as an Associate Professor at Natural and Medical Sciences Research Center, University of Nizwa, Oman. He has 12 years of academic experience; has authored 75 articles and 9 books of repute; and filed 11 patents.
This book presents recent advances in renewable energy scenarios for future Indian smart cities including technologies and devices at the scales of both experimental and theoretical models for Industry 4.0, the concept of automated and computerized industrial manufacturing and practices. The current Indian economy is inclined towards smart urban cities, but the energy deficit in modern society is not well recognized. As a result, there is an enormous need to explore alternative avenues of energy for future smart cities. Because such cities depend significantly on technologies and devices that comprise Industry 4.0, the synthesis of energy scenarios enables an understanding of the technology, applications and devices that contribute immensely to the textile, construction, cosmetics, biomedical and environmental industries, among others. These industrial areas are the key starting points for a wide range of applications, consequently becoming top priorities for science and technology policy development. Such advances already have been adopted in various contemporary services and products, especially in the fields of electronics, health care, chemicals, cosmetics, composites and energy. This book is a valuable resource for practising energy planners, citizens and professionals such as businesspeople, bureaucrats from all levels of government, employees from nongovernmental public organizations and their volunteers and other individuals who have stakes in the development of their city-region.
In this issue, guest editors bring their considerable expertise to this important topic. Provides in-depth reviews on the latest updates in the field, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.
This primer offers a concise introduction to Loop Quantum Gravity (LQG) - a theoretical framework for uniting Quantum Mechanics (QM) with General Relativity (GR). The emphasis is on the physical aspects of the framework and its historical development in terms of self-dual variables, still most suited for a first, pedagogical encounter with LQG. The text starts by reviewing GR and the very basics of Quantum Field Theory (QFT), and then explains in a concise and clear manner the steps leading from the Einstein-Hilbert action for gravity to the construction of the quantum states of geometry, known as spin-networks, and which provide the basis for the kinematical Hilbert space of quantum general relativity. Along the way the various associated concepts of tetrads, spin-connection and holonomies are introduced. Having thus provided a minimal introduction to the LQG framework, some applications to the problems of black hole entropy and of quantum cosmology are briefly surveyed. Last but not least, a list of the most common criticisms of LQG is presented, which are then tackled one by one in order to convince the reader of the physical viability of the theory. A set of appendices provides accessible introductions to several key notions such as the Peter-Weyl theorem, duality of differential forms and Regge calculus, among others. The presentation is aimed at graduate students and researchers who have some familiarity with the tools of QM and GR, but are intimidated by the technicalities required to browse through the existing LQG literature. This primer aims at making the formalism appear a little less bewildering to the uninitiated and helps lower the barrier for entry into the field.
Tailored to be relevant to the real-life medical practice of interns, residents, and students, this handbook is designed to condense the most current information in internal medicine into one concise volume. The text is written so that upon receiving a consult, the user can simply turn to the relevant section and follow the text to learn what physical findings to look for, what questions to ask during the patient history, what labs to order and their interpretation, and the various treatment regimens and outcomes. Already "road-tested" at the Vanderbilt University Medical Center and the University of Virginia Medical School and Hospital, The Internal Medicine Peripheral Brain has already garnered praise for its straightforward approach to clinical practice and the breadth of its information.
Acute coronary syndromes are one of the leading causes of morbidity and mortality in the world. This work assembles a group of international experts to deliver a concise handbook on the pathophysiology, epidemiology, and treatment of ACS.
SECTION 1: Sepsis Diagnosis and Management 1. Precision Medicine in Septic Shock 2. Optimal Blood Pressure Target in Patients with Septic Shock 3. The Surviving Sepsis Campaign Guidelines in 2022: What is New and what has Changed? 4. Individualizing Hemodynamics in Septic Shock 5. Adjunctive Therapies in Sepsis: Current Status 6. Refractory Septic Shock: What are the Options 7. Steroids in Sepsis and Clinical Outcomes 8. Candida auris: Detection, Prevention, and Management 9. Empirical Antifungal Treatment: Is It Justified? 10. Role of Steroids in Severe Community acquired Pneumonia 11. Procalcitonin: Can It Differentiate Bacterial versus Fungal Infection SECTION 2: Antimicrobial Therapy in ICU 12. Optimizing Antimicrobial Dosing in the Intensive Care Unit 13. Antibiotic within 1 hour: Should this be Applied to all Patients with Sepsis? 14. Dark Side of Antibiotics 15. Optimal Duration of Antibiotic Therapy 16. Cefiderocol: Is this the Answer to Multidrug-resistant Gram-negative Infection? SECTION 3: Respiratory Critical Care 17. Management of Pneumonia in Intensive Care 18. Reverse Triggering during Controlled Ventilation: A Frequent Dysynchrony with Various Consequences 19. Use of Multiplex Polymerase Chain Reaction in Pneumonia 20. Management of Complicated Pleural Effusion 21. Hepatic Hydrothorax 22. Submassive Pulmonary Embolism 23. Role of Magnesium in Respiratory Failure 24. ARDS in Children: How is it Different? 25. Safe Tracheal Intubation in Intensive Care Unit 26. Lateral Positioning: Does it Work? 27. Dyspnea in Patients on Invasive Ventilation: Clinical Impact 28. Complications of Noninvasive Ventilation Failure SECTION 4: Mechanical Ventilation 29. Setting Optimum PEEP 30. Open Lung or Keep Lung Closed: Which Strategy to Choose? 31. Driving Pressure or Mechanical Power: Which One to Monitor? 32. Measuring Respiratory Drive and Muscle Effort 33. Oxygenation Targets in Mechanically Ventilated Critically-ill Patients 34. Ventilatory Ratio: A New Monitoring Tool 35. Helmet NIV: Is it a Game Changer? 36. Electrical Impedance Tomography: Current Application 37. Automatic Tube Compensation: Does it have a Role? 38. High-frequency Oscillatory Ventilation in Pediatric Acute Respiratory Distress Syndrome 39. Noninvasive Ventilation in Pediatrics: Current Status SECTION 5: Cardiovascular Critical Care 40. Crystalloid Resuscitation: Finding the Balance 41. Artificial Intelligence Tools to Optimize Hemodynamics in the ICU 42. Aggressive or Restrictive Fluid Resuscitation 43. Predicting Hypotension: Is It Useful? 44. Vasopressors: How Early? 45. Myocardial Injury after Noncardiac Surgery 46. Use of Vasopressin during Cardiac Arrest SECTION 6: Echocardiography and Ultrasound 47. Advances in Intensive Care Unit Echocardiography 48. Transesophageal Echocardiography: Is It Preferable in the Intensive Care Unit? 49. ECHO Features of Pulmonary Hypertension and Increased Left Atrial Pressures 50. Role of Echocardiography in Shock State 51. Use of Echocardiography in Assessing Fluid Responsiveness 52. Venous Excess Ultrasound Score (VExUS) SECTION 7: Nephrology, Fluids, Acid-Base Balance and Electrolytes Balance 53. Fluid Management in Acute Kidney Injury 54. Sepsis-associated Acute Kidney Injury: Common but Poorly Understood 55. Delayed versus Very Delayed Renal Replacement Therapy 56. Plasma Exchange in Intensive Care Unit: Current Status 57. Acute Kidney Injury Care Bundle 58. Biomarker-driven Therapy in AKI 59. How to Approach Dyselectrolytemias in a Patient on CRRT? SECTION 8: Neurocritical Care 60. Prognostication in
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