For two decades in Long Beach, California, August Hunter operates as one of the city's most powerful gang lords. But as his life alternates between the violence of the streets and the brutality of the California prison system, Hunter struggles in his heart and mind with the senselessness of the gang scene. Hunter finally surrenders to the greater forces that have been at work in his life, and he encounters the real "Lord of Long Beach." The book reads like a modern-day urban Exodus, from his bitter childhood in the housing projects of New Orleans, to his move with his mother to Long Beach and his rise through the youth gangs, to the pinnacle of his power in the adult gangs and the suffering of three prison terms, and finally to his emotional collapse and rebirth. Hunter's story is a valuable one-for young men and women at risk on the streets, for those in our prisons and jails who find little hope there, and for anyone seeking to make a stronger connection between their everyday life and their faith.
Scientists are deciphering the biology of the tumor cell at a level of detail that would have been hard to imagine just a decade or so ago. The development of high-throughput DNA sequencing and genomics technologies have allowed an understanding of the development, growth, survival, and spread of cancer cells in the body. From this information, we now have a basic blueprint or roadmap of how a single damaged cell can develop into a pre-malignant lesion, a primary tumor, and finally, a lethal tumor that may spread throughout the body and resist both medical therapy and host immune responses. In this book, we provide an overview of our current understanding of this cancer blueprint, which has been aided both by the study of familial cancer syndromes, in vitro studies of cancer cells, and animal models. Three classes of genes have emerged from these studies: tumor suppressor genes needed for normal growth control and DNA repair; oncogenes that regulate cell growth and survival, and epigenetic modifiers, enzymes that regulate the modification of DNA and the proteins that form chromatin. Each of these three classes of genes is mutated or altered at least once in virtually all malignant cancer cells. Current technologies permit the DNA sequencing of cancer exomes (coding gene sequencing), whole genomes, transcriptome (all expressed genes), and DNA methylation profiling. These studies show that all tumors have unique constellations of mutated, rearranged, amplified, and deleted genes. Single-cell sequencing further shows that there is extensive variation in individual cells in the tumor; that cancers evolve, and have many of the properties of a multi-cellular entity. Lastly, cancer cells, through mutations in epigenetic modifiers, can reprogram the genome and unlock entire developmental and gene expression pathways to adapt and survive in changing conditions. This reprogramming allows the tumor to elude the host body's defenses, radiotherapy, chemotherapy, and targeted therapy that we use in cancer treatment. Understanding this cancer blueprint paves the way for the development of future therapies to treat and eliminate cancer.
Lecture provides an overview of the progress made in molecular medicine applying genetics and genomics to the understanding, diagnosis, and treatment of human diseases. Specifically, the methods for identifying genes involved in human diseases are described. Examples from 10 genes and diseases will be provided, drawing on the author's research. Topics include examples from simple Mendelian diseases, such as cystic fibrosis, inherited cancers, oncogenes activated by chromosomal translocations, host genes involved in infectious disease, genes identified via genomewide association studies, pathogens causing cancer, and gene families contributing to multiple diseases. For each example, historical details will be provided as background for readers to understand the context and process of the discoveries, technologies explained, and current understanding and treatment implications detailed.
Inflammatory and infectious diseases in the eye often present very challenging diagnostic dilemmas and are difficult to manage. Despite advances in anti-inflammatory and immunomodulatory therapy, permanent structural changes can occur in the eye because of intraocular inflammation or infection. These are best managed with surgery. Modern treatment of these inflammations and infections involves novel drug therapy and retina-vitreous surgical procedures. This is the first book to review the recent surgical protocols used in the management of intraocular inflammation and infection, and covers indications, pre-procedure therapy, surgical procedure, and complications. Key Points First book to review the latest surgical intervention procedures to manage inflammation and infection of the eye Covers indications, accompanying therapy, techniques, and complications Contributing team of leading US experts
This text critically examines the shortcomings of psychiatry; the flawed development of the diagnostic system, including the DSM-5; and the failure to advance the effectiveness of antipsychotics and antidepressants. Starting with an overview of the evolution of psychiatry, Dean explores the creation, use, and misuse of medications, a process largely driven by drug companies. Other chapters describe the benefits and risks of medications, the problems associated with rational prescribing, and the embrace of so-called novel therapies including hallucinogenic drugs and opioids. Chapters end with a set of clinical notes that provide specific recommendations to clinicians, families, patients, and other providers, emphasizing the risks and benefits of treatment with medications but also stressing alternative approaches. This book will challenge clinicians to think critically about the DSM-5 and the current systems of diagnosis and treatment of mental illnesses in the hopes of ultimately improving the lives of people with mental illnesses.
Transform methods provide a bridge between the commonly used method of separation of variables and numerical techniques for solving linear partial differential equations. While in some ways similar to separation of variables, transform methods can be effective for a wider class of problems. Even when the inverse of the transform cannot be found ana
Although Jews in early modern Germany produced little in the way of formal historiography, Jews nevertheless engaged the past for many reasons and in various and surprising ways. They narrated the past in order to enforce order, empower authority, and record the traditions of their communities. In this way, Jews created community structure and projected that structure into the future. But Jews also used the past as a means to contest the marginalization threatened by broader developments in the Christian society in which they lived. As the Reformation threw into relief serious questions about authority and tradition and as Jews continued to suffer from anti-Jewish mentality and politics, narration of the past allowed Jews to re-inscribe themselves in history and contemporary society. Drawing on a wide range of sources, including chronicles, liturgical works, books of customs, memorybooks, biblical commentaries, rabbinic responsa and community ledgers, this study offers a timely reassessment of Jewish community and identity during a frequently turbulent era. It engages, but then redirects, important discussions by historians regarding the nature of time and the construction and role of history and memory in pre-modern Europe and pre-modern Jewish civilization. This book will be of significant value, not only to scholars of Jewish history, but anyone with an interest in the social and cultural aspects of religious history.
In Biblical Hebrew Grammar Visualized, Andersen and Forbes approach the grammar of Biblical Hebrew from the perspective of corpus linguistics. Their pictorial representations of the clauses making up the biblical texts show the grammatical functions (subject, object, and so on) and semantic roles (surrogate, time interval, and so on) of clausal constituents, as well as the grammatical relations that bind the constituents into coherent structures. The book carefully introduces the Andersen-Forbes approach to text preparation and characterization. It describes and tallies the kinds of phrases and clauses encountered across all of Biblical Hebrew. It classifies and gives examples of the major constituents that form clauses, focusing especially on the grammatical functions and semantic roles. The book presents the structures of the constituents and uses their patterns of incidence both to examine constituent order (“word order”) and to characterize the relations among verb corpora. It expounds in detail the characteristics of quasiverbals, verbless clauses, discontinuous and double-duty clausal constituents, and supra-clausal structures. The book is intended for students of Biblical Hebrew at all levels. Beginning students will readily grasp the basic grammatical structures making up the clauses, because these are few and fairly simple. Intermediate and advanced students will profit from the detailed descriptions and comparative analyses of all of the structures making up the biblical texts. Scholars will find fresh ways of addressing open problems, while gaining glimpses of new research approaches and topics along the way.
This Volume aims to provide an analysis of problems and challenges relating to the creation of a legal infrastructure that meets the needs and capabilities of emerging market economies in the light of the privatisation process.
Americans love to colonize their beaches. But when storms threaten, high-ticket beachfront construction invariably takes precedence over coastal environmental concerns—we rescue the buildings, not the beaches. As Cornelia Dean explains in Against the Tide, this pattern is leading to the rapid destruction of our coast. But her eloquent account also offers sound advice for salvaging the stretches of pristine American shore that remain. The story begins with the tale of the devastating hurricane that struck Galveston, Texas, in 1900—the deadliest natural disaster in American history, which killed some six thousand people. Misguided residents constructed a wall to prevent another tragedy, but the barrier ruined the beach and ultimately destroyed the town's booming resort business. From harrowing accounts of natural disasters to lucid ecological explanations of natural coastal processes, from reports of human interference and construction on the shore to clear-eyed elucidation of public policy and conservation interests, this book illustrates in rich detail the conflicting interests, short-term responses, and long-range imperatives that have been the hallmarks of America's love affair with her coast. Intriguing observations about America's beaches, past and present, include discussions of Hurricane Andrew's assault on the Gulf Coast, the 1962 northeaster that ravaged one thousand miles of the Atlantic shore, the beleaguered beaches of New Jersey and North Carolina's rapidly vanishing Outer Banks, and the sand-starved coast of southern California. Dean provides dozens of examples of human attempts to tame the ocean—as well as a wealth of lucid descriptions of the ocean's counterattack. Readers will appreciate Against the Tide's painless course in coastal processes and new perspective on the beach.
More than an introductory text, Respiratory Care: Principles and Practice, Fourth Edition by Dean Hess is a comprehensive resource will be referenced and utilized by students throughout their educational and professional careers.
A new edition of the classic text, is for respiratory care students who desire a complete and up to date exploration of the technical and professional aspects of respiratory care. With foundations in evidence-based practice, this resource reviews respiratory assessment, respiratory therapeutics, respiratory diseases, basic sciences and their application to respiratory care, the respiratory care profession, and much more. Edited and authored by leading experts, it incorporates the latest information on the practice of respiratory care into a well-organized, reader-friendly guide to help students learn to develop care plans, critical thinking skills, strong communication and patient education skills, and the clinical leadership skills needed to succeed. This text provides essential information in a practical and manageable format for optimal learning and retention. Features include Clinical Practice Guidelines, Key Points, and Respiratory Recaps to help students apply knowledge to practice and retain key information, as well as hundreds of glossary terms with clear definitions, and concise explanations of important concepts and equations. Also includes full color photos and illustrations, and content cross-referencing the NBRC examination matrices.
Murray and Nadel’s Textbook of Respiratory Medicine has long been the definitive and comprehensive pulmonary disease reference. Robert J. Mason, MD now presents the fifth edition in full color with new images and highlighted clinical elements. The fully searchable text is also online at www.expertconsult.com, along with regular updates, video clips, additional images, and self-assessment questions. This new edition has been completely updated and remains the essential tool you need to care for patients with pulmonary disease. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Compatible with Kindle®, nook®, and other popular devices. Master the scientific principles of respiratory medicine and its clinical applications. Work through differential diagnosis using detailed explanations of each disease entity. Learn new subjects in Pulmonary Medicine including Genetics, Ultrasound, and other key topics. Grasp the Key Points in each chapter. Search the full text online at expertconsult.com, along with downloadable images, regular updates, more than 50 videos, case studies, and self-assessment questions. Consult new chapters covering Ultrasound, Innate Immunity, Adaptive Immunity, Deposition and Clearance, Ventilator-Associated Pneumonia. Find critical information easily using the new full-color design that enhances teaching points and highlights challenging concepts. Apply the expertise and fresh ideas of three new editors—Drs. Thomas R. Martin, Talmadge E. King, Jr., and Dean E. Schraufnagel. Review the latest developments in genetics with advice on how the data will affect patient care.
A crisis is coming for everyone who uses math and science. For decades now, the classical model of probability (the indifference principle and the Gaussian distribution) has been breaking down and revealing its limitations in fields from economics to epidemiology. Now a new approach has revealed the underlying non-classical principle behind all these 'anomalous' laws: — Pareto’s law of elite incomes — Zipf’s law of word frequencies — Lotka’s law of scientific publications — Kleiber’s law of metabolic rates — the Clausewitz-Dupuy law of combat friction — Moore’s law of computing costs — the Wright-Henderson cost law — Weibull’s law of electronics failures — the Flynn Effect in IQ scores — Benford’s law of digit frequencies — Farr’s law of epidemics — Hubbell’s neutral theory of biodiversity — Rogers’ law of innovation classes — Wilson’s law of island biogeography — Smeed’s law of traffic fatalities The general law behind all these particular laws (and countless others) is the "decline effect". As a system ages or grows in size, the rules of probability subtly change. Entropy increases, rare items become rarer, and average performance measures decline. The human meaning of a decline may be positive (decreasing costs, falling epidemic mortality) or negative (lower customer loyalty, decreasing efficiency), but the mathematical pattern is always the same. The implications are enormous, as these examples show: All epidemic diseases decline in infectiousness and in lethality. HIV-AIDS went from a highly infectious, 95-percent fatal disease, to a survivable condition with a latency of decades. COVID-19 went from a death rate of 7 percent in early 2020, to under 2 percent in 2022. Hereditary dynasties around the world declined smoothly in lifespan, from hundreds of years to tens of years. When democracies replaced monarchies, the decline (in spans of party control) continued.
Providing a solid foundation in cardiovascular and pulmonary physiology and rehabilitation, Cardiovascular and Pulmonary Physical Therapy: Evidence and Practice, 5th Edition uses the latest scientific literature and research in covering anatomy and physiology, assessment, and interventions. A holistic approach addresses the full spectrum of cardiovascular and pulmonary physical therapy from acute to chronic conditions, starting with care of the stable patient and progressing to management of the more complex, unstable patient. Both primary and secondary cardiovascular and pulmonary disorders are covered. In this edition, updates include new, full-color clinical photographs and the most current coverage of techniques and trends in cardiopulmonary physical therapy. Edited by Donna Frownfelter and Elizabeth Dean, recognized leaders in cardiovascular and pulmonary rehabilitation, this resource is ideal for clinicals and for practice. - Evidence-based practice is demonstrated with case studies, and the latest research supports PT decision-making. - Real-life clinical cases show the application of concepts to evidence-based practice. - Holistic approach supports treating the whole person rather than just the symptoms of a disease or disorder, covering medical, physiological, psychological, psychosocial, therapeutic, practical, and methodological aspects. - Coverage includes both primary and secondary cardiovascular and pulmonary conditions. - An integrated approach to oxygen transport demonstrates how the cardiovascular and pulmonary systems function together. - Emphasis on the terminology and guidelines of APTA's Guide to Physical Therapist Practice keeps the book consistent with the standards for practice in physical therapy. - Key terms and review questions in each chapter focus your learning on important concepts. - The Evolve companion website includes additional resources such as a case study guide, Archie animations, color images, video clips, WebLinks, and references with links to MEDLINE abstracts. - Full-color photos and illustrations enhance your understanding of the book's concepts. - Two new Mobilization and Exercise chapters cover physiologic principles along with application to practice. - Information on airway clearance techniques is revised and condensed into one comprehensive chapter. - New reference style makes it easier to find resources by replacing the old author-date references with numbered superscripts linked to MEDLINE abstracts.
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