As the great Mel Brooks said, “ Humor is just another defense against the universe” — and in these chaotic times, an irreverent and chaotic book like When the Rains Came, will definitely help you gird your loins AND laugh your head off. This entertaining collection of flash fiction, has been mysteriously spun out of the very deep, extended, chaotic, intense, personal experiences of a unique, one-of-a-kind person. David Wolinsky is a retired army officer, an entertainment attorney, restaurateur, businessman, a former memeber of Mensa, and currently, a writer who lives in the Pacific Northwest with his cat Barney.If you are seeking a Zagat-style description, Wolinsky' s work has been described as, “ well-crafted,” “ surprising,” and “ highly entertaining.” He' s been compared to Mel Brooks, and it has been said that he offers “ some of the best Jewish humor of recent times.” His “ brand of funny” was so good it even caused someone to “ publicly snort chicken noodle soup out of my nose.”
An incisive oral history that brings together the voices of major figures in gaming, tech, media, and politics to reflect on the long shadow of Gamergate With The Hivemind Swarmed, oral historian and documentary researcher David Wolinsky invites readers to sit in on a series of urgent, intimate conversations between some of the most distinguished voices across entertainment and media as they reflect on the longstanding impact of Gamergate. What went wrong, and what can we learn from Gamergate to help us build a more equitable online world? The backstory: 10 years ago, a disgruntled software developer named Eron Gjoni posted online to accuse his ex-girlfriend, game developer Zoë Quinn, of sleeping with game critics in exchange for positive reviews. He offered no evidence to back up his claims. However, his posts were picked up by extremists in the gaming community who built a vicious online movement targeting women, minorities, and progressive voices. Rallying under the hashtag #gamergate, they sent their victims round-the-clock death and rape threats. Game companies, for the most part, declined to take action as their female employees were harassed out of their jobs. The FBI launched an investigation but found "no true threat." Gamergate holds the grim distinction of being the first modern online harassment campaign. It arguably served as a model for the alt-right movement that would help propel Donald Trump to the White House. And it highlighted a toxic media culture—not just in gaming, but in film, TV, journalism, and more—in which leaders, through their passivity, took the side of the oppressor. Now, ten years later—in the wake of #MeToo, Charlottesville, the Trump years, and the January 6 insurrection—the questions discussed here are more important than ever.
As the great Mel Brooks said, “ Humor is just another defense against the universe” — and in these chaotic times, an irreverent and chaotic book like When the Rains Came, will definitely help you gird your loins AND laugh your head off. This entertaining collection of flash fiction, has been mysteriously spun out of the very deep, extended, chaotic, intense, personal experiences of a unique, one-of-a-kind person. David Wolinsky is a retired army officer, an entertainment attorney, restaurateur, businessman, a former memeber of Mensa, and currently, a writer who lives in the Pacific Northwest with his cat Barney.If you are seeking a Zagat-style description, Wolinsky' s work has been described as, “ well-crafted,” “ surprising,” and “ highly entertaining.” He' s been compared to Mel Brooks, and it has been said that he offers “ some of the best Jewish humor of recent times.” His “ brand of funny” was so good it even caused someone to “ publicly snort chicken noodle soup out of my nose.”
An incisive oral history that brings together the voices of major figures in gaming, tech, media, and politics to reflect on the long shadow of Gamergate With The Hivemind Swarmed, oral historian and documentary researcher David Wolinsky invites readers to sit in on a series of urgent, intimate conversations between some of the most distinguished voices across entertainment and media as they reflect on the longstanding impact of Gamergate. What went wrong, and what can we learn from Gamergate to help us build a more equitable online world? The backstory: 10 years ago, a disgruntled software developer named Eron Gjoni posted online to accuse his ex-girlfriend, game developer Zoë Quinn, of sleeping with game critics in exchange for positive reviews. He offered no evidence to back up his claims. However, his posts were picked up by extremists in the gaming community who built a vicious online movement targeting women, minorities, and progressive voices. Rallying under the hashtag #gamergate, they sent their victims round-the-clock death and rape threats. Game companies, for the most part, declined to take action as their female employees were harassed out of their jobs. The FBI launched an investigation but found "no true threat." Gamergate holds the grim distinction of being the first modern online harassment campaign. It arguably served as a model for the alt-right movement that would help propel Donald Trump to the White House. And it highlighted a toxic media culture—not just in gaming, but in film, TV, journalism, and more—in which leaders, through their passivity, took the side of the oppressor. Now, ten years later—in the wake of #MeToo, Charlottesville, the Trump years, and the January 6 insurrection—the questions discussed here are more important than ever.
Sponsored by the National Council on Family Relations, the Sourcebook of Family Theory and Research is the reference work on theory and methods for family scholars and students around the world. This volume provides a diverse, eclectic, and paradoxically mature approach to theorizing and demonstrates how the development of theory is crucial to the future of family research. The Sourcebook reflects an interactive approach that focuses on the process of theory building and designing research, thereby engaging readers in "doing" theory rather than simply reading about it. An accompanying Web site, http://www.ncfr.org/sourcebook, offers additional participation and interaction in the process of doing theory and making science.
Clinicians and those in health sciences are frequently called upon to measure subjective states such as attitudes, feelings, quality of life, educational achievement and aptitude, and learning style in their patients. This fifth edition of Health Measurement Scales enables these groups to both develop scales to measure non-tangible health outcomes, and better evaluate and differentiate between existing tools. Health Measurement Scales is the ultimate guide to developing and validating measurement scales that are to be used in the health sciences. The book covers how the individual items are developed; various biases that can affect responses (e.g. social desirability, yea-saying, framing); various response options; how to select the best items in the set; how to combine them into a scale; and finally how to determine the reliability and validity of the scale. It concludes with a discussion of ethical issues that may be encountered, and guidelines for reporting the results of the scale development process. Appendices include a comprehensive guide to finding existing scales, and a brief introduction to exploratory and confirmatory factor analysis, making this book a must-read for any practitioner dealing with this kind of data.
The Protein Myth illustrates how we can avoid the major killer diseases by eliminating animal products from the diet. It challenges the healthcare establishment to stop ignoring the scientific evidence that a diet based on animal protein costs millions of lives. For example, why do the National Cancer Institute and the American Cancer Society turn a blind eye to the scientific facts that avoiding animal protein could prevent many women from getting breast cancer by lowering their oestrogen levels? The book links the Western diet to major problems facing the world such as 1) animal cruelty on factory farms, 2) the pollution of our atmosphere, rivers and streams, 3) obesity in children, 4) the needless vivisection of animals at university laboratories for the purpose of getting billions of tax dollars from the public, 5) the manufacture of drugs to treat counterfeit diseases, and 6) the creation of poverty in the developing world. The Protein Myth makes a compelling case that the way to a healthier life and a better world is to end our abuse and exploitation of animals.
This book comprehensively summarizes the adverse effects of tobacco smoking on human health. The current second edition has integrated a large set of new data that have been published in numerous scientifc studies and meta-analyses over the past few years. Unfortunately, the harmful sequelae of tobacco smoking are played down by the ind- try and politicians in many industrialized countries. However, about 800,000 people/year in the EU die from the immediate consequences of smoking. The particularly insidious feature of tobacco consumption is that smoking-attributable harmful effects on health do not generally become apparent until three or four decades after smoking initiation. Although some positive changes in the legislative handling of tobacco have appeared in the past fve years, we still need to form a pact, sealed by politicians, the medical prof- sionals, teachers and the media, to target the problem across nations. In this respect, a minority of countries, including the US and the UK, have given positive examples. There are four areas that need to be improved in future: (1) strict bans on tobacco adv- tisement on a global level, (2) better measures to protect against side-stream (passive) smoke exposure, (3) establishment of prevention programs, especially for children and (4) tre- ment of tobacco addiction.
Orthopedic Trauma Call for the Attending Surgeon is a clinically focused book that will help guide the orthopedic surgeon through the most commonly encountered injuries when on call. Drs. David J. Hak, Kyros R. Ipaktchi and Steven Morgan are joined by over 50 leading experts to provide a succinct and quick review of the key points that will allow you to provide patients with expert and immediate care. Inside Orthopedic Trauma Call for the Attending Surgeon each chapter is written in an easy to read bulleted format that will allow for a quick review of the key facts you need to know while taking call. Chapters also cover emergent and definitive management and provide guidelines for when to consider referral to a higher level of care. The authors also share their tips and tricks for successful outcomes, while highlighting potential pitfalls and how to avoid them. Since it can be difficult to find time to read a traditional textbook or review article, Orthopedic Trauma Call for the Attending Surgeon is perfect for orthopedic surgeons, physician assistants, extenders who cover ER call, and orthopedic trainees.
Henry Friendly is frequently grouped with Oliver Wendell Holmes, Louis Brandeis, Benjamin Cardozo, and Learned Hand as the best American jurists of the twentieth century. In this first, comprehensive biography of Friendly, Dorsen opens a unique window onto how a judge of this caliber thinks and decides cases, and how Friendly lived his life.
Ce document tente de fournir la somme des informations recueillies par l'auteur sur les aspects psychologiques touchant les personnes atteintes du syndrome de Down. Il décrit alors le développement psychologique des individus, les caractéristiques de l'intelligence, une analyse comparative de la personnalité, l'adaptation sociale, les aptitudes que les personnes peuvent développer, le développement cognitif, le langage et la communication. Il termine en portant son regard particulièrement sur la modification de comportement.
Textbook of Clinical Neuropsychiatry provides a comprehensive, encyclopedic and up to date coverage of the complete range of neuropsychiatric disorders. The text is clearly written and well organized, utilizing a consistent and easy to read format throughout. Part I describes the diagnostic assessment of patients and details the interview, mental s
A political history of environmental policy and regulation in California, from the Gold Rush to the present Over the course of its 150-year history, California has successfully protected its scenic wilderness areas, restricted coastal oil drilling, regulated automobile emissions, preserved coastal access, improved energy efficiency, and, most recently, addressed global climate change. How has this state, more than any other, enacted so many innovative and stringent environmental regulations over such a long period of time? The first comprehensive look at California's history of environmental leadership, California Greenin' shows why the Golden State has been at the forefront in setting new environmental standards, often leading the rest of the nation. From the establishment of Yosemite, America's first protected wilderness, and the prohibition of dumping gold-mining debris in the nineteenth century to sweeping climate- change legislation in the twenty-first, David Vogel traces California's remarkable environmental policy trajectory. He explains that this pathbreaking role developed because California had more to lose from environmental deterioration and more to gain from preserving its stunning natural geography. As a result, citizens and civic groups effectively mobilized to protect and restore their state's natural beauty and, importantly, were often backed both by business interests and bystrong regulatory authorities. Business support for environmental regulation in California reveals that strict standards are not only compatible with economic growth but can also contribute to it. Vogel also examines areas where California has fallen short, particularly in water management and the state's dependence on automobile transportation. As environmental policy debates continue to grow more heated, California Greenin' demonstrates that the Golden State's impressive record of environmental accomplishments holds lessons not just for the country but for the world.
Social relations are crucial for understanding diverse economic actions and a network perspective is central to that explanation. Simple exchanges involving money, labor, and commodities combine into complexly connected systems. Economic networks span many levels of analysis, from persons (consumers, employees), to groups (households, workteams), organizations (corporations, interest groups), populations (industries, markets) and the rapidly expanding global economic system. David Knoke blends network theories from a range of disciplines and empirical studies of domestic and international economies to illuminate how economic activity is embedded in and constrained by social ties among economic actors. Social capital, in the form of connections to others holding valuable resources, is vital for finding a job, buying a car, creating a new industry, or triggering a global financial crisis. In nontechnical terms the author explicates the core network concepts, measures, and analysis methods behind these phenomena. The book also includes many striking network diagrams to provide visual insights into complex structural patterns. This accessible book offers an invaluable critique for both undergraduate and graduate students in economic sociology and social network analysis courses who seek a better understanding of the multifaceted economic webs in which we are all entangled.
This volume contains 30 chapters that provide an up-to-date account of key topics and areas of research in political psychology. In general, the chapters apply what is known about human psychology to the study of politics. Chapters draw on theory and research on biopsychology, neuroscience, personality, psychopathology, evolutionary psychology, social psychology, developmental psychology, cognitive psychology, and intergroup relations. Some chapters address the political psychology of political elites-their personality, motives, beliefs, and leadership styles, and their judgments, decisions, and actions in domestic policy, foreign policy, international conflict, and conflict resolution. Other chapters deal with the dynamics of mass political behavior: voting, collective action, the influence of political communications, political socialization and civic education, group-based political behavior, social justice, and the political incorporation of immigrants. Research discussed in the volume is fuelled by a mix of age-old questions and recent world events"--
More than ever, society faces painful choices in the allocation of resources for health care. How it makes these choices, and how wise they are, will determine the quality and character of health care for years to come. David Mechanic examines existing and impending dilemmas the American health care system must manage as it confronts these choices. He explores conceptual approaches to health and health care, showing how these translate into research, and defines a strategy for informed choice. The result is a masterful volume by one of our leading medical sociologists at the peak of his career. Mechanic looks at the continuing emphasis on biomedical technology in the context of growing economic, constraints, as medical care becomes more expensive and demands become greater. He examines the discrepancy between public expectations and how health care is actually provided, and points out increasing discordance between demographic trends and disease patterns and the medical system's emphasis on acute care. Of particular concern is the enormous gap between entitlements for medical care and the increasing need for long-term care. This gap is of particular concern because of the United States's enormous investment in health care, which now consumes 11 percent of the Gross National Product, Although there is no particular consensus on what is an appropriate level of investment in health, policymakers are impatient with the medical system's apparent inability to control costs, and are concerned as well about the competition for resources between health and other sectors. Mechanic examines new trends, such as managed care, and transformation of the role of those who provide health care from patient advocates to allocators of services-a crucial distinction. The choices that will have to be made in the next decades are difficult They will also be painful, but they are inevitable. The key challenge will be to respond to the anxieties of the 37 million uninsured children and adults, the growing numbers of frail elderly, and the needs of patients with serious mental illness and other chronic disabilities. All of this must be accomplished while maintaining a high level of service for the rest of the population, and without breaking the bank. To achieve this, Mechanic argues, health services must be shaped to enhance function and quality of life, and not simply in response to technological imperatives. In its profound understanding of the social and political context, in which competitive initiative, the growth of regulation, new health care systems, and approaches for making research sensitive to patients are all evident, "Painful Choices "provides a framework for responsive and meaningful policy analysis.
Highly Commended, BMA Medical Book Awards 2013Previously published as Textbook of Clinical Neuropsychiatry, this book has been re-titled and thoroughly updated, redesigned, and enhanced to include the fundamentals of neuroscience. This highly acclaimed text provides a definitive, clinically oriented, yet comprehensive book covering neuropsychiatry
The fourth edition of this highly successful text has been extensively revised and restructured to take account of the many recent advances in the subject and bring it right up to date. The classic observations of recent years can now be interpreted with the powerful new techniques of molecular biology. Consequently there is much new material throughout the book, including many new illustrations and extensive references to recent work. Its essential philosophy remains the same, though: fundamental concepts are clearly explained, and key experiments are examined in some detail. This textbook will be used by students of physiology, neuroscience, cell biology and biophysics. Specializing undergraduates and graduates as well as lecturers and researchers will find the text thorough and clearly written.
Originally published in 1985, and authored by an epidemiologists, a medical immunologist, a chemist and a clinical psychologist, this books shows that unravelling the links between diet and disease is a very complex task, and while the evidence is strong in many cases, in others if is of doubtful validity. Many of the diseases prevalent in developed countries are discussed here: cancer, arterial heart disease, food allergies and intolerances as well as the impact of diet on mental health.
The best journalists are masters at their craft. With a comma and a colon, a vivid verb and a colorful adjective, they not only convey important information but also create a sense of place and evoke powerful emotions. A compelling story can shape_for good or ill_the way a reader understands people, events, and issues. The Ethics of the Story examines the ethical implications of narrative techniques commonly used in journalism, not just literary journalism but also news and feature writing. The book draws on interviews with 60 talented journalists, including Pulitzer Prize winners, to offer practical advice about ethical choices in writing and editing. Much has been written about journalism ethics, but the discussion has often focused on spectacularly bad decisions_such as Jayson BlairOs and Jack KelleyOs use of fraudulent narrative_rather than the ethical dimension of day-to-day choices about the building blocks of journalistic storytelling. The Ethics of the Story fills a gap in current work on ethics, writing, and editing. It will enlighten any serious wordsmith with a story to tell.
The Wage Curve casts doubt on some of the most important ideas in macroeconomics, labor economics, and regional economics. According to macroeconomic orthodoxy, there is a relationship between unemployment and the rate of change of wages. According to orthodoxy in labor economics and regional economics an area's wage is positively related to the amount of joblessness in the area. The Wage Curve suggests that both these beliefs are incorrect. Blanchflower and Oswald argue that the stable relationship is a downward-sloping convex curve linking local unemployment and the level of pay. Their study, one of the most intensive in the history of social science, is based on random samples that provide computerized information on nearly four million people from sixteen countries. Throughout, the authors systematically present evidence and possible explanations for their empirical law of economics.
Here is a work that emphasizes the full view of the lives of those young people that Gacy took. . . . It is essentially the Gacy story in reverse. Victims first." —Jeff Coen, author of Murder in Canaryville As investigators brought out the bagged remains of several dozen young men from a small Chicago ranch home and paraded them in front of a crowd of TV reporters and spectators, attention quickly turned to the owner of the house. John Gacy was an upstanding citizen, active in local politics and charities, famous for his themed parties and appearances as Pogo the Clown. But in the winter of 1978–79, he became known as one of many so-called "sex murderers" who had begun gaining notoriety in the random brutality of the 1970s. As public interest grew rapidly, victims became footnotes and statistics, lives lost not just to violence, but to history. Through the testimony of siblings, parents, friends, lovers, and other witnesses close to the case, Boys Enter the House retraces the footsteps of these victims as they make their way to the doorstep of the Gacy house itself.
Political scientists use models to investigate and illuminate causal mechanisms, generate comparative data, and more. But how do we justify and rationalize the method? Why test predictions from a deductive, and thus truth-preserving, system? Primo and Clarke tackle these central questions in this novel work of methodology.
Developed and developing economies alike face increased resource scarcity and competitive rivalry. In this context, science and technology appear as an essential source of competitive and sustainable advantage at national and regional levels. However, the key determinant of their efficacy is the quality and quantity of entrepreneurship-enabled innovation that unlocks and captures the benefits of the science enterprise in the form of private, public or hybrid goods. Linking basic and applied research with the market, via technology transfer and commercialization mechanisms, including government-university-industry partnerships and capital investments, constitutes the essential trigger mechanism and driving force of sustainable competitive advantage and prosperity. In this volume, the authors define the terms and principles of knowledge creation, diffusion, and use, and establish a theoretical framework for their study. In particular, they focus on the “Quadruple Helix” model, through which government, academia, industry, and civil society are seen as key actors promoting a democratic approach to innovation through which strategy development and decision making are exposed to feedback from key stakeholders, resulting in socially accountable policies and practices.
Tissue Engineering is a comprehensive introduction to the engineering and biological aspects of this critical subject. With contributions from internationally renowned authors, it provides a broad perspective on tissue engineering for students and professionals who are developing their knowledge of this important topic. Key topics covered include stem cells; morphogenesis and cellular signaling; the extracellular matrix; biocompatibility; scaffold design and fabrication; controlled release strategies; bioreactors; tissue engineering of skin, cartilage, bone and organ systems; and ethical issues. - Covers all the essentials from tissue homeostasis and biocompatibility to cardiovascular engineering and regulations - 22 chapters from internationally recognized authors, provide a comprehensive introduction for engineers and life scientists, including biomedical engineers, chemical and process engineers, materials scientists, biologists and medical students - Full colour throughout, with clear development of understanding through frequent examples, experimental approaches and the latest research and developments
Our fear of cancer causes great harm to individual health and to society. The fear of cancer is understandable. But that fear is in some ways outdated, as it fails to account for the medical progress made against this family of diseases. In Curing Cancerphobia, David Ropeik reveals the fascinating historical and psychological roots of our fear of cancer and documents the dramatic health and financial harms caused when that fear exceeds the risk. Fear of cancer drives millions for whom screening is not recommended to screen for the disease anyway, producing tens of thousands of emotionally damaging false positives and costing the US health care system an estimated $9.2 billion a year. At the same time, fear of cancer also causes many people for whom screening is recommended to avoid it altogether. Modern screening technologies often identify cancers that do not spread or that grow so slowly they almost certainly will never cause harm in a person's lifetime. Yet many of these people, frightened by the word "cancer" in their diagnosis, understandably choose more aggressive and risky treatments than their clinical conditions require. These unnecessary treatments kill hundreds of people, cause severe side effects in thousands, and cost the health care system at least $5.2 billion a year. Additionally, consumers spend billions of dollars on vitamins and supplements, organic food, and other products that promise to reduce our risk of cancer but do not actually reduce it. And an excessive fear of cancer causes resistance to potentially beneficial technologies like nuclear power and fluoridation of tap water. After documenting these harms, Ropeik offers tools and suggestions to help reduce the negative impacts of cancerphobia. Based on extensive research including interviews with experts and cancer patients, Curing Cancerphobia confronts our emotional relationship with the disease we fear more than any other.
This accessibly written book introduces readers to DNA—one of the most important technologies for the manipulation of all forms of life, from simple bacteria to plants and animals. It also addresses the most important social, ethical, political, economic, and other issues raised by this form of technology. The great strides made in our understanding of the structure and function of DNA in recent decades have led to applying this invaluable knowledge to use in serving humanity. For example, recent discoveries in the field of genetic editing have created the potential for the creation of life forms de novo, a possibility that results in profound ethical issues for the human race that are just beginning to be discussed. What other positive—and potentially negative—developments are coming our way with continuing advancements in DNA research? DNA Technology: A Reference Handbook provides an up-to-date historical overview and general technical background to the topic as well as a broad introduction to current issues related to the development of DNA technology, such as genetically modified organisms, the use of DNA technology in the forensic sciences, and genetic testing and genetic therapy. Written by David E. Newton, an author and former teacher who has dedicated a lifetime to authoring educational texts on science and technology, this book examines the history of DNA technology from its discovery in the 1950s to the present day and covers recent advances, such as new methods for gene editing, including CRISP-Cas9 technology. Readers need to have little or no background knowledge of the technology of genetic engineering to improve their understanding of DNA-based technologies and how DNA research influences many current issues and debates in agriculture, food science, forensics, public health, and other fields. The single-volume work is particularly well-suited to students and young adults because of the range of references included that serve further study, such as a glossary of terms, a chronology, and an extensive annotated bibliography.
Over the past thirty years, urban economic theory has been one of the most active areas of urban and regional economic research. Just as static general equilibrium theory is at the core of modern microeconomics, so is the topic of this book - the static allocation of resources within a city and between cities - at the core of urban economic theory. An Essay on Urban Economic Theory well reflects the state of the field. Part I provides an elegant, coherent, and rigorous presentation of several variants of the monocentric (city) model - as the centerpiece of urban economic theory - treating equilibrium, optimum, and comparative statistics. Part II explores less familiar and even some uncharted territory. The monocentric model looks at a single city in isolation, taking as given a central business district surrounded by residences. Part II, in contrast, makes the intra-urban location of residential and non-residential activity the outcome of the fundamental tradeoff between the propensity to interact and the aversion to crowding; the resulting pattern of agglomeration may be polycentric. Part II also develops models of an urbanized economy with trade between specialized cities and examines how the market-determined size distribution of cities differs from the optimum. This book launches a new series, Advances in Urban and Regional Economics. The series aims to provide an outlet for longer scholarly works dealing with topics in urban and regional economics.
A cutting-edge introduction to key topics in modern economic theory for first-year graduate students in economics and related fields Volume II of Microeconomic Foundations introduces models and methods at the center of modern microeconomic theory. In this textbook, David Kreps, a leading economic theorist, emphasizes foundational material, concentrating on seminal work that provides perspective on how and why the theory developed. Because noncooperative game theory is the chief tool of modeling and analyzing microeconomic phenomena, the book stresses the applications of game theory to economics. And throughout, it underscores why theory is most useful when it supports rather than supplants economic intuition. Introduces first-year graduate students to the models and methods at the core of microeconomic theory today Covers an extensive range of topics, including the agency theory, market signaling, relational contracting, bilateral bargaining, auctions, matching markets, and mechanism design Stresses the use—and misuse—of theory in studying economic phenomena and shows why theory should support, not replace, economic intuition Includes extensive appendices reviewing the essential concepts of noncooperative game theory, with guidance about how it should and shouldn’t be used Features free online supplements, including chapter outlines and overviews, solutions to all the problems in the book, and more
The idea for publishing these books on the mechanism of action and on the biosynthesis of antibiotics was born of frustration in our attempts to keep abreast of the literature. Gone were the years when we were able to keep a biblio graphy on antibiotics and feel confident that we could find everything that was being published on this subject. These fields of investigation were moving for ward so rapidly and were encompassing so wide a range of specialized areas in microbiology and chemistry that it was almost impossible to keep abreast of developments. In our naivete and enthusiasm, however, we were unaware that we were toying with an idea that might enmesh us, that we were creating an entity with a life of its own, that we were letting loose a Golom who instead of being our servant would be our master. That we set up ideals for these books is obvious; they would be current guides to developments and information in the areas of mechanism of action and bio synthesis of antibiotics. For almost every subject, we wished to enlist the aid of an investigator who himself had played a part in determining the nature of the phenomena that were being discussed. One concept for the books was that they include only antibiotics for which a definitive, well-documented mechanism of action or biosynthetic pathway was known.
Dave Eberly's 3D Game Engine Design was the first professional guide to the essential concepts and algorithms of real-time 3D engines and quickly became a classic of game development. Dave's new book 3D Game Engine Architecture continues the tradition with a comprehensive look at the software engineering and programming of 3D engines. This book is
This work explains that equilibrium is the long-run outcome of a process in which non-fully rational players search for optimality over time. The models they e×plore provide a foundation for equilibrium theory and suggest ways for economists to evaluate and modify traditional equilibrium concepts.
An authoritative investigation of the sources andtreatment of osteoarthritic joint pain Millions of people throughout the world suffer from osteoarthritis (OA)—a medical condition causing its sufferers excruciating pain that is often disabling. This is the first book to offer clinicians an in-depth understanding of the biological sources of osteoarthritic pain and how they can be treated. Here, a team of leading international authorities has contributed state-of-the-art information on: The Neuroscience of Articular Pain—spinal and peripheral mechanisms of joint pain; experimental models for the study of osteoarthritic pain; inflammatory mediators and nociception in arthritis; phantoms in rheumatology; and more Osteoarthritis and Pain—joint mechanisms and neuromuscular aspects of OA; bone pain and pressure in OA joints; structural correlates of OA pain; and more Treatment of Osteoarthritic Pain—general approaches to treatment; treatments targeting pain receptors; treatments targeting biomechanical abnormalities; and treatments targeting inflammation Whether you're a medical professional, researcher, student, or a generalist or specialist focusing on pain or arthritis, this is your one-stop reference for understanding and treating joint pain in osteoarthritis.
Venomous" Bites from "Non-Venomous" Snakes, Second Edition thoroughly examines the potential hazards associated with bites by non-front-fanged snakes (popularly, but inaccurately, called "rear-fanged snakes"). This diverse group contains approximately 80% of living snake species (approximately 2,900 species). A large proportion of these snakes were previously assigned to the family Colubridae but, as a consequence of expanding systematics investigations, have been split into multiple families and subfamilies. Many of these snakes produce venoms or oral secretions that contain toxins and other biologically active substances. A large variety of non–front-fanged snakes figure in the pet industry, yet little documented information or formal study of their potential medical importance has been published. Therefore, although the possible medical importance of many of these species has been subjected to speculation since the mid-19th century, there is a limited amount of useful descriptive information regarding the real hazard (or lack thereof) of this wide variety of snakes. The first edition of this book provided "one-stop shopping" by offering information regarding their possible toxicity and clinical relevance as well as recommendations for medical management of their bites. The second edition expands and updates the content with detailed information about the effects and medical management of bites by a broad representation of non–front-fanged species. The hypothetical venomous nature of some lizards considered as non-venomous such as the Komodo monitor or dragon and their allies, as well as the medical effects of their bites, is also examined. The dynamic taxonomy of advanced snakes is updated, and the bases for some of these fluid changes are discussed. Likewise, terminology is also updated in order to reflect the ongoing debates regarding the definition of "venom" and the balanced reinforcement of nonmedical criteria used to define the biological basis of the term "venomous." - Fills a gap in toxicological, medical, and herpetological literature by providing a comprehensive review of this entire assemblage of non–front-fanged snakes, with particular attention given to their capacity to cause harm to humans - Offers a patient-centered, evidence-based approach which is applied to analyzing documented case reports of bites inflicted by a broad representation of species - Provides expanded and updated detailed information on the clinical management of medically significant bites from non–front-fanged snakes, which is also methodically reviewed, and specific recommendations are provided - Includes updates of the fluid taxonomy of advanced snakes and also of terminology with particular regard to the definition of "venom" and the nonmedical criteria used to define the biological basis of the "venomous condition" in snakes and lizards
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