Numerical Optimization presents a comprehensive and up-to-date description of the most effective methods in continuous optimization. It responds to the growing interest in optimization in engineering, science, and business by focusing on the methods that are best suited to practical problems. For this new edition the book has been thoroughly updated throughout. There are new chapters on nonlinear interior methods and derivative-free methods for optimization, both of which are used widely in practice and the focus of much current research. Because of the emphasis on practical methods, as well as the extensive illustrations and exercises, the book is accessible to a wide audience. It can be used as a graduate text in engineering, operations research, mathematics, computer science, and business. It also serves as a handbook for researchers and practitioners in the field. The authors have strived to produce a text that is pleasant to read, informative, and rigorous - one that reveals both the beautiful nature of the discipline and its practical side.
Various imperfections in existing market systems prevent the free market from serving as a truly efficient allocation mechanism, but optimization of economic activities provides an effective remedial measure. Cooperative optimization claims that socially optimal and individually rational solutions to decision problems involving strategic action over time exist. To ensure that cooperation will last throughout the agreement period, however, the stringent condition of subgame consistency is required. This textbook presents a study of subgame consistent economic optimization, developing game-theoretic optimization techniques to establish the foundation for an effective policy menu to tackle the suboptimal behavior that the conventional market mechanism fails to resolve.
Durable strategies that have prolonged effects are prevalent in real-world situations. Revenue-generating investments, toxic waste disposal, long-lived goods, regulatory measures, coalition agreements, diffusion of knowledge, advertisement and investments to accumulate physical capital are concrete and common examples of durable strategies. This book provides an augmentation of dynamic game theory and advances a new game paradigm with durable strategies in decision-making schemes. It covers theories, solution techniques, and the applications of a general class of dynamic games with multiple durable strategies. Non-cooperative equilibria and cooperative solutions are derived, along with advanced topics including random termination, asynchronous game horizons, and stochastic analysis. The techniques presented here will enable readers to solve numerous practical dynamic interactive problems with durable strategies. This book not only expands the scope of applied dynamic game theory, but also provides a solid foundation for further theoretical and technical advancements. As such, it will appeal to scholars and students of quantitative economics, game theory, operations research, and computational mathematics. "Not too many new concepts have been introduced in dynamic games since their inception. The introduction of the concept of durable strategies changes this trend and yields important contributions to environmental and business applications." Dušan M Stipanović, Professor, University of Illinois at Urbana-Champaign "Before this book, the field simply did not realize that most of our strategies are durable and entail profound effects in the future. Putting them into the mathematical framework of dynamic games is a great innovative effort." Vladimir Turetsky, Professor, Ort Braude College “Durable-strategies Dynamic Games is truly a world-leading addition to the field of dynamic games. It is a much needed publication to tackle increasingly crucial problems under the reality of durable strategies.” Vladimir Mazalov, Director of Mathematical Research, Russian Academy of Sciences & President of the International Society of Dynamic Games
Strategic behavior in the human and social world has been increasingly recognized in theory and practice. It is well known that non-cooperative behavior could lead to suboptimal or even highly undesirable outcomes. Cooperation suggests the possibility of obtaining socially optimal solutions and the calls for cooperation are prevalent in real-life problems. Dynamic cooperation cannot be sustainable if there is no guarantee that the agreed upon optimality principle at the beginning is maintained throughout the cooperation duration. It is due to the lack of this kind of guarantees that cooperative schemes fail to last till its end or even fail to get started. The property of subgame consistency in cooperative dynamic games and the corresponding solution mechanism resolve this “classic” problem in game theory. This book is a comprehensive treatise on subgame consistent dynamic cooperation covering the up-to-date state of the art analyses in this important topic. It sets out to provide the theory, solution techniques and applications of subgame consistent cooperation in a wide spectrum of paradigms for analysis which includes cooperative dynamic game models with stochastic state dynamics, with uncertain future payoffs, with asynchronous players’ horizons, with random cooperation duration, with control spaces switching and with transferable and nontransferable payoffs. The book would be a significant research reference text for researchers in game theory, economists, applied mathematicians, policy-makers, corporate decision-makers, and graduate students in applied mathematics, game theory, decision sciences, economics and management sciences.
This book develops a new and interesting approach to the valuation of foreign exchange options. The authors synthesise international monetary theory with the Samuelson-Black-Scholes insight that assets prices follow diffusion processes, and obtain a system of stochastic differential equations to model exchange rate dynamics under the influence of purchasing power parity. An exact formula to price foreign currency options is obtained, which incorporates the influence of its purchasing power parity. The book is essential to advanced undergraduate and graduate students who wish to learn about the modern theory of foreign exchange options. Since its results are completely operational, the book will also prove to be invaluable for practitioners in the financial markets.
This comprehensive text presents a critical discussion of the scopes and limitations of various organic synthetic methodologies that are available for performing asymmetric transformations. In addition to purely chemical methods, the book covers applications of new enzymes and other biological systems that are increasingly useful in asymmetric methodology.
Stay on the cutting edge of today’s most promising trends in complementary and alternative medical treatments with Dr. David Rakel’s Integrative Medicine, 4th Edition. Written by physicians who are experts in both traditional and integrative medicine, this highly regarded, evidence-based reference covers therapies such as botanicals, supplements, mind-body, lifestyle choices, nutrition, exercise, spirituality, and more. Integrative Medicine, 4th Edition uses a clinical, disease-oriented approach, offering practical guidance for reducing costs and improving patient care. Helps you safely and effectively incorporate complementary and alternative therapies into your everyday practice, while focusing on prevention and wellness for a better quality of life. Uses the reliable SORT method (Strength of Recommendation Taxonomy) to provide evidence-based ratings, grading both the evidence and the relative potential harm. Explains how to make the best use of integrative medicine and the mechanisms by which these therapeutic modalities work, keeping you at the forefront of the trend toward integrative health care. Includes 13 brand-new chapters, covering hot topics such as personalized medicine, MTHFR mutation, food allergy and intolerance, the gut-immune influence on systemic inflammation and disease, chelation therapy, testosterone deficiency, adrenal fatigue, and much more. Features more than 100 significantly revised chapters and hundreds of new figures and tables throughout.
Stuttering and Cluttering provides a clear, accessible and wide-ranging overview of both the theoretical and clinical aspects of two disorders of fluency: stuttering and cluttering. This edition remains loyal to the idea that stuttering and cluttering can best be understood by first considering various overarching frameworks which can then be expanded upon, and provides a clear position from which to disentangle the often complex interrelationships of these frameworks. The book is divided into two parts, the first of which mainly deals with theory and aetiology, while the second focuses on clinical aspects of assessment, diagnosis and treatment. The book also provides frequent references across Parts I and II to help link the various areas of investigation together. This revised edition of Stuttering and Cluttering reflects the major changes in thinking regarding both theory and therapy that have taken place since the publication of the first edition. As well as those who stutter and clutter, the book will be invaluable for speech language therapy/speech language pathology students, practicing clinicians, psychologists and linguists around the world.
The good news of Jesus spread like wildfire through the Roman Empire in the decades between his death and the writing of the first gospels—but how? What exactly did the first Christians say about Jesus? In From Good News to Gospels David Wenham delves into the gospels, the book of Acts, and the writings of Paul to uncover evidence of a strong and substantial oral tradition in the early church. This book will inform, engage, and challenge readers, inspiring them to better understand and appreciate the earliest gospel message.
The only narrative about Jesus by eyewitnesses, this is also one of the world's greatest literary works. The unfinished text was spirited off to Sinope when the author was sent into exile. Even there the hand of Rome nearly destroyed it. Rescued 35 years later, the author's spiritual heirs published it. While in Sinope some pages got lost or disordered. After publication various editors changed the manuscript repeatedly to suit the changing doctrines of early Christianity, even adding spurious new material. Thus the standard text is an inspiring mess, but still a mess. This translation restores not the unfinished original text, but the masterpiece the author sought to compose: a first-hand account of a real man sent to urge humanity to accept God's will, set down before doctrine repackaged him as an incarnate deity. Volume One contains the carefully restored text and a history of the gospel. Volume Two includes commentaries that burnish this masterpiece for the modern reader.
Stuttering and Cluttering provides a comprehensive overview of both theoretical and treatment aspects of disorders of fluency: stuttering (also known as stammering) and the lesser-known cluttering. The book demonstrates how treatment strategies relate to the various theories as to why stuttering and cluttering arise, and how they develop. Uniquely, it outlines the major approaches to treatment alongside alternative methods, including drug treatment and recent auditory feedback procedures. Part one looks at different perspectives on causation and development, emphasizing that in many cases these apparently different approaches are inextricably intertwined. Part two covers the assessment, diagnosis, treatment, and evaluation of stuttering and cluttering. In addition to chapters on established approaches, there are sections on alternative therapies, including drug therapy, and auditory feedback, together with a chapter on counselling. Reference is made to a number of established treatment programs, but the focus is on the more detailed description of specific landmark approaches. These provide a framework from which the reader may not only understand others’ treatment procedures, but also a perspective from which they can develop their own. Offering a clear, accessible and comprehensive account of both the theoretical underpinning of stammering therapy and its practical implications, the book will be of interest to speech language therapy students, as well as qualified therapists, psychologists, and to those who stutter and clutter.
The author argues that the roles of human resource professionals must be redefined to meet the competitive challenges organizations face today and into the future. He provides a framework that identifies four distinct roles of human resource professionals: strategic player, administrative expert, employee champion, and change agent. He includes many examples to demonstrate that human resource professionals must operate in all four areas simultaneously in order to contribute fully. He urges a shift of these professionals' mentality from "what I do" to "what I deliver" and makes specific recommendations for how individuals in human resources can partner with line managers to make organizations more competitive.
I am unaware of any textbook which provides such comprehensive coverage of the field and doubt that this work will be surpassed in the foreseeable future, if ever!' From the foreword by Robert C. Moellering, Jr., M.D, Shields Warren-Mallinckrodt Professor of Medical Research, Harvard Medical School, USA Kucers' The Use of Antibiotics is the leading major reference work in this vast and rapidly developing field. More than doubled in length compared to the fifth edition, the sixth edition comprises 3000 pages over 2-volumes in order to cover all new and existing therapies, and emerging drugs not yet fully licensed. Concentrating on the treatment of infectious diseases, the content is divided into 4 sections: antibiotics, anti-fungal drugs, anti-parasitic drugs and anti-viral drugs, and is highly structured for ease of reference.Within each section, each chapter is structured to cover susceptibility, formulations and dosing (adult and paediatric), pharmacokinetics and pharmacodynamics, toxicity and drug distribution, detailed discussion regarding clinical uses, a feature unique to this title. Compiled by an expanded team of internationally renowned and respected editors, with a vast number of contributors spanning Europe, Africa, Asia, Australia, South America, the US and Canada, the sixth edition adopts a truly global approach. It will remain invaluable for anyone using antimicrobial agents in their clinical practice and provides in a systematic and concise manner all the information required when treating infections requiring antimicrobial therapy. Kucers' The Use of Antibiotics is available free to purchasers of the books as an electronic version on line or on your desktop: It provides access to the entire 2-volume print material It is fully searchable, so you can find the relevant information you need quickly Live references are linked to PubMed referring you to the latest journal material Customise the contents - you can highlight sections and make notes Comments can be shared with colleagues/tutors for discussion, teaching and learning The text can also be reflowed for ease of reading Text and illustrations copied will be automatically referenced to Kucers' The Use of Antibiotics
This book explains the anatomy and physiology of cartilage tissue in an integrated way. The emphasis is on how cartilage tissue functions and maintains homeostasis in a challenging mechanical environment. Supported by hundreds of references, the book posts new hypotheses explaining how cartilage adapts and achieves homeostasis in vivo, and tests them against available data. This exploratory approach creates a sense of discovery that the reader can join, or perhaps test themselves through their own research. The main benefit will be obtained by research students and professors looking to understand the deeper concepts that will further their own research, or clinicians (including health professionals and surgeons) who want to gain a deeper physiological understanding of cartilage tissue, which can then serve as a basis for more rational clinical decision-making they need to make on a daily basis. To help bridge the gap between basic science and clinically relevant joint disease, applications and interpretations of key physiological concepts are discussed in the context of osteoarthritis at the end of most chapters.
An unprecedented rereading of the passages from the New Testament and other early Christian writings that ascribe saving significance to Jesus' death on the basis of an in-depth study of second-temple Jewish thought regarding atonement, sacrifice, suffering, and death. This 2-volume work is the result of over 40 years of research on the subject.
A state-of-the-art guide on oral cancer management from distinguished experts! Oral Cancer: Evaluation, Therapy, and Rehabilitation edited by prominent Johns Hopkins clinicians and educators Carole Fakhry, Karen Pitman, Ana Kiess, and David Eisele provides a comprehensive, state-of-the-art review on the diagnosis and management of oral cancer. This unique resource fills a void in the literature by exploring surgical and reconstructive issues specific to each subsite of the oral cavity. Important pre- and post-treatment evaluations by dental, speech language pathology, and the oncologic care team are reviewed. The comprehensive book is divided into 10 sections, each focused on different facets of the patients' trajectory. The text starts with epidemiology of oral cavity cancer and discussion of patient populations at increased risk of oral cavity cancer. The book details pre-cancers, multidisciplinary diagnostic evaluations, treatment, post-treatment, recurrent and metastatic oral cancer, and palliative care, concluding with future directions such as chemoprevention. A full spectrum of oral neoplasms are covered in depth, including different types of squamous cell cancer, primary malignancies of the mandible, and sublingual and minor salivary gland malignancies. Key Features All oral cavity subsites are approached from both an ablative and reconstructive standpoint, with dedicated chapters focused on specific oral cancer reconstructive techniques Discussion of oncologic considerations encompassing radiation and medical oncology including definitive radiation therapy, brachytherapy, adjuvant radiation therapy, and adjuvant chemotherapy/novel therapeutics Clinical pearls cover complications of both surgery and radiation therapy, as well as psychological and dental implications of therapy High-quality illustrations, photographs, and videos further elucidate impacted anatomy and techniques Residents and clinicians in otolaryngology-head and neck surgery, oral and maxillofacial surgery, head and neck reconstructive surgery, medical oncology, and radiation oncology will benefit from reading this excellent resource. Dentists who wish to further their knowledge about oral cancers will also find it an invaluable reference.
Balancing basic science with clinical coverage, this book offers students, residents and practitioners with an understanding of the mechanisms and clinical management of acid-base disorders.
An authoritative guide to understanding and treating depression in the medically ill Depression in Medical Illness is based on the fact that depression and medical illness are inextricably bound together and must be viewed through a single lens in order to truly understand, diagnose, and treat them. Throughout the book, the authors emphasize not simply a critical distillation and balanced summary of the available empirical data, but equally important, an active synthesis, formulation, and analysis of that evidence.This informs a contemporary biomedical understanding, as well as diagnostic and therapeutic approaches. All of the chapters are authored by members of the Department of Psychiatry at the world-renowned Brigham and Women’s Hospital. In chapters devoted to specific medical disorders, psychiatrists with particular expertise in those areas have been joined by other eminent Brigham medical and surgical specialists or subspecialists. This makes these chapters valuable not just to psychiatrists and other mental health professionals, but to a wide range of medical specialists as well. Logically Organized Into Five Sections: Core Concepts – provides a conceptual and intellectual framework for understanding depressive illness in the context of medical illness Assessment and Treatment of Depression in Medically Ill Patients – discusses the general principles of depression diagnosis and treatment Depression in Medical Illness – Assesses what we know about depression when it is comorbid with the full range of major medical disorders Special Populations and Settings – Is devoted to special patient populations and the importance of the settings in which care is delivered New Directions – A fascinating glimpse into the future of the care of medically ill patients who are depressed
The first two editions of this manual have been mainstays of molecular biology for nearly twenty years, with an unrivalled reputation for reliability, accuracy, and clarity. In this new edition, authors Joseph Sambrook and David Russell have completely updated the book, revising every protocol and adding a mass of new material, to broaden its scope and maintain its unbeatable value for studies in genetics, molecular cell biology, developmental biology, microbiology, neuroscience, and immunology. Handsomely redesigned and presented in new bindings of proven durability, this three–volume work is essential for everyone using today’s biomolecular techniques. The opening chapters describe essential techniques, some well–established, some new, that are used every day in the best laboratories for isolating, analyzing and cloning DNA molecules, both large and small. These are followed by chapters on cDNA cloning and exon trapping, amplification of DNA, generation and use of nucleic acid probes, mutagenesis, and DNA sequencing. The concluding chapters deal with methods to screen expression libraries, express cloned genes in both prokaryotes and eukaryotic cells, analyze transcripts and proteins, and detect protein–protein interactions. The Appendix is a compendium of reagents, vectors, media, technical suppliers, kits, electronic resources and other essential information. As in earlier editions, this is the only manual that explains how to achieve success in cloning and provides a wealth of information about why techniques work, how they were first developed, and how they have evolved.
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