Molecular Biology, Second Edition, examines the basic concepts of molecular biology while incorporating primary literature from today's leading researchers. This updated edition includes Focuses on Relevant Research sections that integrate primary literature from Cell Press and focus on helping the student learn how to read and understand research to prepare them for the scientific world.The new Academic Cell Study Guide features all the articles from the text with concurrent case studies to help students build foundations in the content while allowing them to make the appropriate connections to the text. Animations provided deal with topics such as protein purification, transcription, splicing reactions, cell division and DNA replication and SDS-PAGE. The text also includes updated chapters on Genomics and Systems Biology, Proteomics, Bacterial Genetics and Molecular Evolution and RNA. An updated ancillary package includes flashcards, online self quizzing, references with links to outside content and PowerPoint slides with images.This text is designed for undergraduate students taking a course in Molecular Biology and upper-level students studying Cell Biology, Microbiology, Genetics, Biology, Pharmacology, Biotechnology, Biochemistry, and Agriculture. - NEW: "Focus On Relevant Research" sections integrate primary literature from Cell Press and focus on helping the student learn how to read and understand research to prepare them for the scientific world - NEW: Academic Cell Study Guide features all articles from the text with concurrent case studies to help students build foundations in the content while allowing them to make the appropriate connections to the text - NEW: Animations provided include topics in protein purification, transcription, splicing reactions, cell division and DNA replication and SDS-PAGE - Updated chapters on Genomics and Systems Biology, Proteomics, Bacterial Genetics and Molecular Evolution and RNA - Updated ancillary package includes flashcards, online self quizzing, references with links to outside content and PowerPoint slides with images - Fully revised art program
A valuable resource to help beginners and intermediates get in on the craze. With computer-generated illustrations that show every step, it introduces all the key construction procedures, including the proper methods of winding, opening and closing the metal rings.
In The Formation of the Hebrew Bible David Carr rethinks both the methods and historical orientation points for research into the growth of the Hebrew Bible into its present form. Building on his prior work, Writing on the Tablet of the Heart (Oxford, 2005), he explores both the possibilities and limits of reconstruction of pre-stages of the Bible. The method he advocates is a ''methodologically modest'' investigation of those pre-stages, utilizing criteria and models derived from his survey of documented examples of textual revision in the Ancient Near East. The result is a new picture of the formation of the Hebrew Bible, with insights on the initial emergence of Hebrew literary textuality, the development of the first Hexateuch, and the final formation of the Hebrew Bible. Where some have advocated dating the bulk of the Hebrew Bible in a single period, whether relatively early (Neo-Assyrian) or late (Persian or Hellenistic), Carr uncovers specific evidence that the Hebrew Bible contains texts dating across Israelite history, even the early pre-exilic period (10th-9th centuries). He traces the impact of Neo-Assyrian imperialism on eighth and seventh century Israelite textuality. He uses studies of collective trauma to identify marks of the reshaping and collection of traditions in response to the destruction of Jerusalem and Babylonian exile. He develops a picture of varied Priestly reshaping of narrative and prophetic traditions in the Second Temple period, including the move toward eschatological and apocalyptic themes and genres. And he uses manuscript evidence from Qumran and the Septuagint to find clues to the final literary shaping of the proto-Masoretic text, likely under the Hasmonean monarchy.
CO-PUBLISHED BY SINAUER ASSOCIATES, INC., AND W. H. FREEMAN AND COMPANY. LIFE HAS EVOLVED. . . from its original publication to this dramatically revitalized Eighth Edition. LIFE has always shown students how biology works, offering an engaging and coherent presentation of the fundamentals of biology by describing the landmark experiments that revealed them. This edition builds on those strengths and introduces several innovations.. As with previous editions, the Eighth Edition will also be available in three paperback volumes: • Volume I The Cell and Heredity, Chapters 1-20 • Volume II Evolution, Diversity and Ecology, Chapters 1, 21-33, 52-57 • Volume III Plants and Animals, Chapters 1, 34-51
This volume describes the elaborate surveillance systems and various DNA repair mechanisms that ensure accurate passage of genetic information onto daughter cells. In particular, it narrates how the cell cycle checkpoint and DNA repair machineries detect and restore DNA damages that are embedded in millions to billions of normal base pairs. The scope of the book ranges from biochemical analyses and structural details of DNA repair proteins, to integrative genomics and population-based studies. It provides a snapshot of current understanding about some of the major DNA repair pathways, including base-excision repair, nucleotide excision repair, mismatch repair, homologous recombination, and non-homologous end-joining as well as cell cycle checkpoints and translesion DNA synthesis. One of the particular emphases of the book is the link between inherited DNA repair deficiencies and susceptibility to cancer in the general population. For the first time, the book brings together a collection of review articles written by a group of active and laboratory-based investigators who have a clear understanding of the recent advances in the fields of DNA damage repair and genomic stability and their implications in carcinogenesis, new approaches in cancer therapy, and cancer prevention.
Perform genome analysis and sequencing of data with Amazon Web Services Genomics in the AWS Cloud: Analyzing Genetic Code Using Amazon Web Services enables a person who has moderate familiarity with AWS Cloud to perform full genome analysis and research. Using the information in this book, you'll be able to take a FASTQ file containing raw data from a lab or a BAM file from a service provider and perform genome analysis on it. You'll also be able to identify potentially pathogenic gene sequences. Get an introduction to Whole Genome Sequencing (WGS) Make sense of WGS on AWS Master AWS services for genome analysis Some key advantages of using AWS for genomic analysis is to help researchers utilize a wide choice of compute services that can process diverse datasets in analysis pipelines. Genomic sequencers that generate raw data files are located in labs on premises and AWS provides solutions to make it easy for customers to transfer these files to AWS reliably and securely. Storing Genomics and Medical (e.g., imaging) data at different stages requires enormous storage in a cost-effective manner. Amazon Simple Storage Service (Amazon S3), Amazon Glacier, and Amazon Elastics Block Store (Amazon EBS) provide the necessary solutions to securely store, manage, and scale genomic file storage. Moreover, the storage services can interface with various compute services from AWS to process these files. Whether you're just getting started or have already been analyzing genomics data using the AWS Cloud, this book provides you with the information you need in order to use AWS services and features in the ways that will make the most sense for your genomic research.
The Thrive in Bioscience revision guides are written to help undergraduate students achieve exam success in all core areas of bioscience. They communicate all the key concepts in a succinct, easy-to-digest way, using features and tools - both in the book and in digital form - to make learning even more effective.
Unlike most biotechnology textbooks, Dr. David P. Clark's Biotechnology approaches modern biotechnology from a molecular basis, which grew out of the increasing biochemical understanding of physiology. Using straightforward, less-technical jargon, Clark manages to introduce each chapter with a basic concept that ultimately evolves into a more specific detailed principle. This up-to-date text covers a wide realm of topics, including forensics and bioethics, using colorful illustrations and concise applications.This book will help readers understand molecular biotechnology as a scientific discipline, how the research in this area is conducted, and how this technology may impact the future.· Up-to-date text focuses on modern biotechnology with a molecular foundation· Basic concepts followed by more detailed, specific applications · Clear, color illustrations of key topics and concepts · Clearly written without overly technical jargon or complicated examples
Ideal text for undergraduate and graduate students in advanced cell biology courses Extraordinary technological advances in the last century have fundamentally altered the way we ask questions about biology, and undergraduate and graduate students must have the necessary tools to investigate the world of the cell. The ideal text for students in advanced cell biology courses, Lewin's CELLS, Third Edition continues to offer a comprehensive, rigorous overview of the structure, organization, growth, regulation, movements, and interactions of cells, with an emphasis on eukaryotic cells. The text provides students with a solid grounding in the concepts and mechanisms underlying cell structure and function, and will leave them with a firm foundation in cell biology as well as a "big picture" view of the world of the cell. Revised and updated to reflect the most recent research in cell biology, Lewin's CELLS, Third Edition includes expanded chapters on Nuclear Structure and Transport, Chromatin and Chromosomes, Apoptosis, Principles of Cell Signaling, The Extracellular Matrix and Cell Adhesion, Plant Cell Biology, and more. All-new design features and a chapter-by-chapter emphasis on key concepts enhance pedagogy and emphasize retention and application of new skills. Thorough, accessible, and essential, Lewin's CELLS, Third Edition, turns a new and sharper lens on the fundamental units of life
For sample chapters, a video interview with David Hillis, and more information, visit www.whfreeman.com/hillispreview. Sinauer Associates and W.H. Freeman are proud to introduce Principles of Life. Written in the spirit of the reform movement that is reinvigorating the introductory majors course, Principles of Life cuts through the thicket of excessive detail and factual minutiae to focus on what matters most in the study of biology today. Students explore the most essential biological ideas and information in the context of the field’s defining experiments, and are actively engaged in analyzing research data. The result is a textbook that is hundreds of pages shorter (and significantly less expensive) than the current majors introductory books.
Authored by two leading investigators, this book presents a thorough and authoritative overview of this multifaceted field of science. Pathogenic bacteria have been evolving and spreading resistance to diverse classes of antibiotics. As a result, we risk losing our ability to control and treat infectious diseases. Understanding antibiotic resistance, therefore, is becoming increasingly essential for a broad audience of healthcare professionals, biomedical and public health researchers, students, and policymakers. The authors answer questions such as: What is resistance? How does it emerge? How do common human activities contribute to resistance? What can we do about it? How can we strengthen our “first lines of defense” against resistance? Are there better ways to discover new antibiotics? What unique issues are associated with MRSA and viral influenza? In addition to defining and evaluating one of the most important emerging threats to public health, the authors explain what can be done to minimize risks to public health, and to preserve and extend the effectiveness of existing and new antibiotics.
The 411 currently recognized and described species of tiger-moths of the Afrotropical Region are catalogued in this book. Fourteen new synonymies are established together with 44 new combinations and 8 reversions to original combinations of genus group and species group names. Six generic and 7 species group names are removed from synonymy and re-established as valid names. One name has been changed in status from species to subspecies, and another the reverse. The diagnostic features of each genus are presented and a brief summary is given of species that are probably wrongly placed generically. The male genitalia of type species of most genera are illustrated by half-tone photographs and the whole moth by colour photographs. Twenty genera have been removed from the Arctiidae and placed in the families Noctuidae, Lymantriidae or Geometridae. One species has been transferred to the Notodontidae.
This book is based on the papers presented at the conference on "Mecha nisms of DNA Damage and Repair: Implications for Carcinogenesis and Risk Assessment," held at the National Bureau of Standards on June 2-7, 1985, This volume deals with mechanisms of DNA damage and repair at the molecular level; consequences of unrepaired or misrepaired damage, with major emphasis on carcinogenesis; drugs which bind selectively to altered and potentially damaging DNA sequences; and potential utilization of DNA damage as an endpoint for assessing risks of UV light, ionizing radiations, chemicals, drugs, and hazardous agents in foods. Because the induction of mutations by radiation and genotoxic chemicals has been observed to follow one-hit kinetics in some instances, it is generally assumed that any level of exposure to a DNA-damaging agent may increase the risk of genetic disease or cancer in an exposed population. At the same time, however, there is evidence that although the DNA of living cells is continually damaged by natural background radiation, free radicals, and other naturally occurring processes, most of the damage is normally repaired.
Microbiology is a comprehensive textbook that facilitates a thorough understanding of the scope, nature, and complexity of the science of microscopic organisms. It gives a balanced presentation of foundational concepts, real-world applications, and current research and experimentation. The text approaches the subject within the context of exploration and experimentation, integrating a wealth of classroom-tested pedagogical features. The material is organized around the three pillars of physiology, ecology, and genetics -- helping students appreciate the interconnected and dynamic nature of microbiology and explore the relationship between different types of microbes, other organisms, and the environment. This international adaptation contains up-to-date coverage of topics including DNA replication and gene expression, viral pathogenesis, microbial biotechnology, adaptive immunity, the control of infectious diseases, and the microbiology of food and water. It also offers integrated coverage of SARS-CoV-2 and the impacts of COVID-19, relating it to the importance of an interdisciplinary response to a global pandemic. It also focuses on strengthening the organization of the content and updating the end of chapter problems
This book provides an analysis of the nature vs. nuture debate, arguing for an end to the 'either/or' nature of the discussions in favor of a recognition that environmental and genetic factors interact throughout life to form human traits.
The foundational textbook on the study of virology Basic Virology, 4th Edition cements this series’ position as the leading introductory virology textbook in the world. It’s easily read style, outstanding figures, and comprehensive coverage of fundamental topics in virology all account for its immense popularity. This undergraduate-accessible book covers all the foundational topics in virology, including: The basics of virology Virological techniques Molecular biology Pathogenesis of human viral disease The 4th edition includes new information on the SARS, MERS and COVID-19 coronaviruses, hepatitis C virus, influenza virus, as well as HIV and Ebola. New virological techniques including bioinformatics and advances in viral therapies for human disease are also explored in-depth. The book also includes entirely new sections on metapneumoviruses, dengue virus, and the chikungunya virus.
BIOS Instant Notes in Biochemistry, Fourth Edition, is the perfect text for undergraduates looking for a concise introduction to the subject, or a study guide to use before examinations. Each topic begins with a summary of essential factsan ideal revision checklistfollowed by a description of the subject that focuses on core information, with clear, simple diagrams that are easy for students to understand and recall in essays and exams. BIOS Instant Notes in Biochemistry, Fourth Edition, is fully up-to-date and covers: Cells; Amino acids and proteins; Studying proteins; Enzymes; Membranes and cell signalling; DNA structure and replication; RNA synthesis and processing; Protein synthesis; Recombinant DNA technology; Carbohydrate metabolism; Lipid metabolism; Respiration and energy; Nitrogen metabolism.
Since its inception, Introduction to Genetic Analysis (IGA) has been known for its prominent authorship including leading scientists in their field who are great educators. This market best-seller exposes students to the landmark experiments in genetics, teaching students how to analyze experimental data and how to draw their own conclusions based on scientific thinking while teaching students how to think like geneticists. Visit the preview site at www.whfreeman.com/IGA10epreview
Molecular biology is one of the most rapidly developing and at the same time most exciting disciplines. The key to molecular biology lies in the understanding of nucleic acids - their structure, function, and interaction with proteins. Nucleic Acids and Molecular Biology keeps scientists informed of the explosively growing information and complies with the great interest in this field by offering a continued high standard of review. A substantial part of this volume has been devoted to the analysis of different aspects of nucleic acid-protein-interactions including RNA-protein-interaction.
This study presents the basic models for discrete and continuous particle laden flow simulation. An overview of the two main approaches, the Lagrangian discrete particle model and the Eulerian granular phase model is given. Moreover these two approaches are combined to a hybrid model to use the benefits of the discrete and continuous description. This safes computational time and increase the efficiency of particle laden flow simulations. Furthermore the models are extended to poly-disperse particles including a simple agglomeration model based on a population balance equation. Finally the usability of the models is shown at a pneumatic particle transport system including particle strand building and the separation of particles using an industrial cyclone.
A comprehensive overview of clinically important infections of the urinary tract Urinary tract infections (UTIs) continue to rank among the most common infectious diseases of humans, despite remarkable progress in the ability to detect and treat them. Recurrent UTIs are a continuing problem and represent a clear threat as antibiotic-resistant organisms and infection-prone populations grow. Urinary Tract Infections: Molecular Pathogenesis and Clinical Management brings the scientific community up to date on the research related to these infections that has occurred in the nearly two decades since the first edition. The editors have assembled a team of leading experts to cover critical topics in these main areas: clinical aspects of urinary tract infections, including anatomy, diagnosis, and management, featuring chapters on the vaginal microbiome as well as asymptomatic bacteriuria, prostatitis, and urosepsis the origins and virulence mechanisms of the bacteria responsible for most UTIs, including uropathogenic Escherichia coli, Proteus mirabilis, and Klebsiella pneumoniae the host immune response to UTIs, the rise of antibiotic-resistant strains, and the future of therapeutics This essential reference serves as both a resource and a stimulus for future research endeavors for anyone with an interest in understanding these important infections, from the classroom to the laboratory and the clinic.
This social history of 20th-century show business and the new American public that assembled in the parks, theatres and dance halls argues that an otherwise disparate 'white' audience was united by the exclusion and stigmatisation of African Americans.
Principles of Physical Chemistry, Second Edition uniquely uses simple physical models as well as rigorous treatments for understanding molecular and supramolecular systems and processes. In this way the presentation assists students in developing an intuitive understanding of the subjects as well as skill in quantitative manipulations. The unifying nature of physical chemistry is emphasized in the book by its organization - beginning with atoms and molecules, and proceeding to molecular assemblies of increasing complexity, ending with the emergence of matter that carries information, i.e. the origin of life, a physicochemical process of unique importance. The aim is to show the broad scope and coherence of physical chemistry.
The fall of the Berlin Wall in 1989 came to symbolize the dawn of a new era of openness and connectivity. Yet today, the world is ever more divided, demarcated, and – quite literally – fortified. We are living in a guarded age. Why and how has this happened? Where will it take us? In this book, David J. Betz explores the expansion of fortified physical infrastructure at every level of the global political economy. In cities, where security is increasingly ‘designed in’ to public buildings and spaces as they are reshaped to mitigate mass terror attacks. Within corporations, who are burying their electronic assets in deep underground caverns and behind the leaded walls of ex-nuclear war bunkers against a range of threats and feared contingencies. In many urban areas, where the default condition of civil life is to be walled, gated, watched, and guarded. Year after year, hundreds of miles of linear obstacles – walls, ditches, and watchtowers – are added to national borders. Practically everywhere you look there are signs of innovative fortification, often designed to be overlooked. The Guarded Age reveals the barriers which most have observed but few – until reading this book – have truly seen.
This book collects and republishes 14 key academic works by Dai Morgan Evans FSA (1944–2017). Spanning early medieval studies, the management and conservation of ancient monuments, histories of antiquarianism, and the Welsh church of Llangar, the chapters have been freshly edited and published together for the first time with new illustrations.
The science of toxicology has progressed considerably since Molecular Toxicology was first published in 1997. New advances in biochemical and molecular biological experimental techniques have helped researchers understand the precise effects of toxins and foreign compounds on living things atthe molecular, cellular, and organismal levels. Breakthrough research has recently been completed illuminating the human genome and the role of enzymes in toxic biochemical reaction mechanisms. Toxicology now covers drug metabolism and design, carcinogenesis, programmed cell death, and DNA repair,among other subjects. The second edition captures these and other advances, and broadens its scope to address the experimental science of toxicology. The first edition of Molecular Toxicology has become an indispensable resource for graduate students in molecular and biochemical toxicology courses,as well as academic researchers and industrial researchers in toxicology. Rigorously updated and revised, the new edition commands an unrivaled authority in the field of molecular toxicology.
The critically acclaimed laboratory standard, Methods in Enzymology, is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. The series contains much material still relevant today - truly an essential publication for researchers in all fields of life sciences.RNA Interference will cover RNAi in non-vertebrates (plants, C. elegans, drosophila, and S. pombe), and Mammalian systems (human and non-human cells). This volume discusses extensive methodology related to delivery methods high throughput strategies and prospects as a human therapy agent.* One of the most highly respected publications in the field of biochemistry since 1955 * Frequently consulted, and praised by researchers and reviewers alike * Truly an essential publication for anyone in any field of the life sciences
For almost twenty years, from the publication of his seminal and highly influential collection of poems Hush to the appearance of the stunning Study for the World's Body: New and Selected Poems, David St. John has been considered one of the most accomplished and innovative of all American poets. Here, for the first time, David St. John has selected from essays and reviews written over the course of his career--about many of the major figures of our time: W. S. Merwin, Philip Levine, Mark Strand, Charles Wright, Donald Hall, Marvin Bell, Donald Justice, Jorie Graham, and dozens of others--and brought them together with six uncompromising and refreshingly candid interviews about the craft of poetry and the state of poetry today. Always passionate about the poets he loves and always provocative in his poetic judgements, David St. John has given us a lucid and exciting volume of prose that all readers of poetry can turn to for both pleasure and instruction."-- Back cover.
Get a comprehensive guide to this important literary figure and his author. A classic literary character, Sherlock Holmes has fascinated readers for decades -- from his repartee with Dr. Watson and his unparalleled powers of deduction to the settings, themes, and villains of the stories. Now, this friendly guide offers a clear introduction to this beloved figure and his author, Sir Arthur Conan Doyle, presenting new insight into the detective stories and crime scene analysis that have has made Sherlock Holmes famous. Inside you'll find easy-to-understand yet thorough information on the characters, recurring themes, and locations, and social context of the Sherlock Holmes stories, the relationship of these stories to literature, and the forensics and detective work they feature. You'll also learn about the life of the author. Better understand and enjoy this influential literary character with this plain-English guide. Gain insight on these classic Doyle tales -- from the classic Hound of the Baskervilles to the lesser-known short stories to Holmes stories written by other mystery writers. Explore the appearance of Sherlock Holmes on film, TV, and stage. Examine Holmes today -- from the ever-expanding network of fans worldwide to story locations that fans can visit. It's elementary! Sherlock Holmes For Dummies is an indispensable guide for students and fans alike!
Now in four convenient volumes, Field’s Virology remains the most authoritative reference in this fast-changing field, providing definitive coverage of virology, including virus biology as well as replication and medical aspects of specific virus families. This volume of Field’s Virology: RNA Viruses, Seventh Edition covers the latest information on RNA viruses, how they cause disease, how they can cause epidemics and pandemics, new therapeutics and vaccine approaches, as provided in new or extensively revised chapters that reflect these advances in this dynamic field. Bundled with the eBook, which will be updated regularly as new information about each virus is available, this text serves as the authoritative, up-to-date reference book for virologists, infectious disease specialists, microbiologists, and physicians, as well as medical students pursuing a career in infectious diseases.
Authors Dave Nelson and Mike Cox combine the best of the laboratory and best of the classroom, introducing exciting new developments while communicating basic principles of biochemistry.
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