Evidence-based medicine has shown for many years that homozygous mutations of the HFE gene H63D are by no means negligible. Not only can it provoke, usually after a second hit, rather mild classical hemochromatosis, but it can also cause numerous other disorders of iron metabolism, such as Oslo-Syndrome. The latter is a severe disease which leads to multiple organ damages and is - for reasons that remain in the dark - not as known as Wilson's disease which is a very similar syndrome caused by copper.
In the quest to remove supply channel costs, streamline channel communications, and link customers to the value-added resources found along the supply chain continuum, Supply Chain Management (SCM) has emerged as a tactical operations tool. The first book to completely define the architecture of the merger of SCM and the Internet, Introduction to e
The concept of adiabatic electronic potential-energy surfaces, defined by the Born?Oppenheimer approximation, is fundamental to our thinking about chemical processes. Recent computational as well as experimental studies have produced ample evidence that the so-called conical intersections of electronic energy surfaces, predicted by von Neumann and Wigner in 1929, are the rule rather than the exception in polyatomic molecules. It is nowadays increasingly recognized that conical intersections play a key mechanistic role in chemical reaction dynamics. This volume provides an up-to-date overview of the multi-faceted research on the role of conical intersections in photochemistry and photobiology, including basic theoretical concepts, novel computational strategies as well as innovative experiments. The contents and discussions will be of value to advanced students and researchers in photochemistry, molecular spectroscopy and related areas.
The Republican Party is the vehicle of an ideological movement whereas the Democratic Party is a coalition of social groups with concrete policy concerns. Democrats prefer a more moderate party leadership that makes compromises, whereas Republicans favor a more conservative party leadership that sticks to principles. Each party finds popular support for its approach because the American public simultaneously favors liberal positions on specific policy issues and conservative views on the broader role of government.
By 2030, 20 percent of the world's drivers, 60 million in all, will be over the age of 65. Consequently, safe and efficient mobility for older adults is a complex and pressing issue. Maintaining Safe Mobility in an Aging Society addresses the complexities surrounding the booming number of aging drivers and practical solutions for sustaining safe tr
Personal Identification: Modern Development and Security Implications, Second Edition explains how personal identification – and REAL ID – became part of the American fabric along with their past century’s historical ID development. The development of the “trusted and secure” personal identification documents began with passports and has continued as social changes made IDs more essential. This book describes the convergence of technologies and hundreds of patents that produced our “trusted and secure” documents and IDs from our past right up through to today. Key factors, that created today’s need for public-issued mass ID, are addressed: Chronicles the effects of large and mobile populations beginning a century ago Chronicles the effects of “impersonal” electronic & computer communications at a distance, and not face-to-face The distribution of services and money by government agencies based on a person’s identity – including “age” and “group” criteria Describes recent national security and terrorism concerns that necessitates the need to know: “You are who you say you are.” Personal identification documents (IDs) and the societal need for “trusted” identification by the public is a relatively new social phenomenon. In 1900, most people did not need or have any IDs until passports, with a photograph of the individual, became mandatory when Great Britain entered World War I in 1914. In the United States, the State-issued driver’s license is probably the only trusted ID in one’s wallet today, but they became “trusted and secure” documents only recently with the requirement for REAL ID. With the first photo driver’s license issued by the State of Colorado in 1959, it took until 1984 for the last State (New York, 25 years later) to comply. As a direct result of 9/11, where terrorists used fake driver’s licenses to board planes, Congress passed the Real ID Act in 2005 to make all State-issued driver’s licenses more trusted, uniform, and tamper-resistant – what is now called the Enhanced Driver’s License with non-drivers being issued Enhanced Identification Cards. And with this, every US citizen can now possess a trusted and secure personal identification document. Personal Identification, Second Edition chronicles the path of personal identification measures – including the latest developments of Real ID. Scholars and professional security managers understand that stability, security, and safety necessitate these identity measures to ensure a safer America. The book explains the various stages and advances, providing readers with a unique study of this fascinating history of the relationship between identity and the means by which one validates and proves their own identity. The enactment of the REAL ID Act of 2005, with more secure and tamper-resistant documents for each citizen of the United States, is being instituted so that one can trust: “you are who you say you are.” The State-issued driver’s license is not a National ID Card – it is a Nationally Recognized ID for each citizen.
Discover how the latest computational tools are building our understanding of particle interactions and leading to new applications With this book as their guide, readers will gain a new appreciation of the critical role that particle interactions play in advancing research and developing new applications in the biological sciences, chemical engineering, toxicology, medicine, and manufacturing technology The book explores particles ranging in size from cations to whole cells to tissues and processed materials. A focus on recreating complex, real-world dynamical systems helps readers gain a deeper understanding of cell and tissue mechanics, theoretical aspects of multiscale modeling, and the latest applications in biology and nanotechnology. Following an introductory chapter, Multiscale Modeling of Particle Interactions is divided into two parts: Part I, Applications in Nanotechnology, covers: Multiscale modeling of nanoscale aggregation phenomena: applications in semiconductor materials processing Multiscale modeling of rare events in self-assembled systems Continuum description of atomic sheets Coulombic dragging and mechanical propelling of molecules in nanofluidic systems Molecular dynamics modeling of nanodroplets and nanoparticles Modeling the interactions between compliant microcapsules and patterned surfaces Part II, Applications in Biology, covers: Coarse-grained and multiscale simulations of lipid bilayers Stochastic approach to biochemical kinetics In silico modeling of angiogenesis at multiple scales Large-scale simulation of blood flow in microvessels Molecular to multicellular deformation during adhesion of immune cells under flow Each article was contributed by one or more leading experts and pioneers in the field. All readers, from chemists and biologists to engineers and students, will gain new insights into how the latest tools in computational science can improve our understanding of particle interactions and support the development of novel applications across the broad spectrum of disciplines in biology and nanotechnology.
Evolvepreneur (After Hours) Show - Volume 1," curated by John North, is a unique anthology that brings together the insights of seven seasoned entrepreneurs, each an expert in their respective field. John North opens the book with his deep understanding of the entrepreneurial landscape, providing a narrative that connects the diverse wisdom of the authors. Mechelle McDonald shares her journey in "Podcasting The Future," where she discusses her role as a communicator, entrepreneur, and growth coach, emphasizing the power of impactful conversations. Richard Wray in "Don’t Mention The Matrix - How A.I. is Democratising Paranoia and Opportunity," offers a unique perspective on Artificial Intelligence, sharing his journey from a small mining town to collaborations with tech giants. Christine Campbell Rapin, in "Get More Podcast Guest Invitations with These 5 Strategies," provides strategic insights into business growth, drawing from her vast experience in marketing, sales, and operations. David Kitchen (Coach Kitch) shares his expertise in sport psychology and leadership in "Laying Bricks: Building a Business Foundation," focusing on developing leaders and cultivating a success-oriented mindset. Manny Skevofilax in "Profitable Growth Is Achievable," provides essential financial strategies, highlighting the importance of sustainable and profitable growth in business. Tamara Pflug offers practical advice in "Self-Coach for Business Growth," focusing on self-coaching techniques for personal and professional development. Tony Pisanelli explores personal branding and career development in "Career By Design." His insights offer valuable strategies for those looking to craft a successful career path. Each chapter in this book provides a unique perspective on entrepreneurship, covering topics from innovative business strategies to digital marketing, financial management, and leadership. This anthology is not just a collection of strategies; it's an exploration of the experiences and insights of successful entrepreneurs. "Evolvepreneur (After Hours) Show - Volume 1" is a must-read for anyone aspiring to succeed in the entrepreneurial world. It's packed with actionable advice and real-life examples, inviting readers to explore the essence of entrepreneurship and unlock their full potential. This book is an essential guide for budding entrepreneurs and seasoned business owners alike, providing a comprehensive look at the path to success in business.
Covers modern photonics accessibly and discusses the basic physical principles underlying all the applications and technology of photonics. This volume covers the basic physical principles underlying the technology and all applications of photonics from statistical optics to quantum optics. The topics discussed in this volume are: Photons in perspective; Coherence and Statistical Optics; Complex Light and Singular Optics; Electrodynamics of Dielectric Media; Fast and slow Light; Holography; Multiphoton Processes; Optical Angular Momentum; Optical Forces, Trapping and Manipulation; Polarization States; Quantum Electrodynamics; Quantum Information and Computing; Quantum Optics; Resonance Energy Transfer; Surface Optics; Ultrafast Pulse Phenomena. Comprehensive and accessible coverage of the whole of modern photonics Emphasizes processes and applications that specifically exploit photon attributes of light Deals with the rapidly advancing area of modern optics Chapters are written by top scientists in their field Written for the graduate level student in physical sciences; Industrial and academic researchers in photonics, graduate students in the area; College lecturers, educators, policymakers, consultants, Scientific and technical libraries, government laboratories, NIH.
Established by Congress in 1901, the National Bureau of Standards (NBS), now the National Institute of Standards and Technology (NIST), has a long and distinguished history as the custodian and disseminator of the United States' standards of physical measurement. Having reached its centennial anniversary, the NBS/NIST reflects on and celebrates its first century with this book describing some of its seminal contributions to science and technology. Within these pages are 102 vignettes that describe some of the Institute's classic publications. Each vignette relates the context in which the publication appeared, its impact on science, technology, and the general public, and brief details about the lives and work of the authors. The groundbreaking works depicted include: A breakthrough paper on laser-cooling of atoms below the Doppler limit, which led to the award of the 1997 Nobel Prize for Physics to William D. Phillips The official report on the development of the radio proximity fuse, one of the most important new weapons of World War II The 1932 paper reporting the discovery of deuterium in experiments that led to Harold Urey's1934 Nobel Prize for Chemistry A review of the development of the SEAC, the first digital computer to employ stored programs and the first to process images in digital form The first paper demonstrating that parity is not conserved in nuclear physics, a result that shattered a fundamental concept of theoretical physics and led to a Nobel Prize for T. D. Lee and C. Y. Yang "Observation of Bose-Einstein Condensation in a Dilute Atomic Vapor," a 1995 paper that has already opened vast new areas of research A landmark contribution to the field of protein crystallography by Wlodawer and coworkers on the use of joint x-ray and neutron diffraction to determine the structure of proteins
For nearly twenty years, Aaron David Miller has played a central role in U.S. efforts to broker Arab-Israeli peace as an advisor to presidents, secretaries of state, and national security advisors. Without partisanship or finger-pointing, Miller records what went right, what went wrong, and how we got where we are today. Here is a look at the peace process from a place at the negotiation table, filled with behind-the-scenes strategy, colorful anecdotes and equally colorful characters, and new interviews with presidents, secretaries of state, and key Arab and Israeli leaders. Honest, critical, and often controversial, Miller’s insider’s account offers a brilliant new analysis of the problem of Arab-Israeli peace and how it still might be solved.
The baseball glove is a ubiquitous item, a crucial piece of equipment in the game of baseball, and it offers the opportunity to examine the production of material culture and social practice at numerous levels. Where and how is a glove made, and how does its manufacture square with the narratives surrounding its place in American cultural life? What are the myths, superstitions, and beliefs surrounding its acquisition, care, use, and significance? How does a glove function as the center of a web of cultural practices that illustrate how individuals relate to a consumer good as a symbol of memory, personal narrative, and national identity? How do the manufacturers of baseball gloves draw upon, promote, and in some sense create these practices? How do these practices and meanings change in other national and cultural contexts? The Baseball Glove offers students the opportunity to examine these questions in an engagingly written and illustrated book that promotes hands-on interaction with a quintessential item of material culture. At the same time, the book gives students the space for critical self-reflection about the place of material goods like sporting equipment in their lives, and it provides the chance to learn different methodological approaches to studying everyday objects.
Describes ways of assessing forensic science evidence and the means of communicating the assessment to a court of law. The aim of this work is to ensure that the courts consider seriously the probability of the evidence of association.
Knowledge in the field of urologic pathology is growing at an explosive pace. Today’s pathologists, specialists, and residents require a comprehensive and authoritative text that examines the full range of urological diseases and their diagnosis. Written by recognized leaders and educators in the field, the text provides readers with a detailed understanding of all diagnostic aspects of urological disease. Inside this unique resource, readers will explore a broad spectrum of practical information—including etiology, diagnostic criteria, molecular markers, differential diagnosis, ancillary tests, and clinical management. This is sure to be the new definitive text for urological pathology!
Lawrie's Meat Science has established itself as a standard work for both students and professionals in the meat industry. Its basic theme remains the central importance of biochemistry in understanding the production, storage, processing and eating quality of meat. At a time when so much controversy surrounds meat production and nutrition, Lawrie's meat science, written by Lawrie in collaboration with Ledward, provides a clear guide which takes the reader from the growth and development of meat animals, through the conversion of muscle to meat, to the point of consumption.The seventh edition includes details of significant advances in meat science which have taken place in recent years, especially in areas of eating quality of meat and meat biochemistry. - A standard reference for the meat industry - Discusses the importance of biochemistry in production, storage and processing of meat - Includes significant advances in meat and meat biochemistry
I am unaware of any textbook which provides such comprehensive coverage of the field and doubt that this work will be surpassed in the foreseeable future, if ever!' From the foreword by Robert C. Moellering, Jr., M.D, Shields Warren-Mallinckrodt Professor of Medical Research, Harvard Medical School, USA Kucers' The Use of Antibiotics is the leading major reference work in this vast and rapidly developing field. More than doubled in length compared to the fifth edition, the sixth edition comprises 3000 pages over 2-volumes in order to cover all new and existing therapies, and emerging drugs not yet fully licensed. Concentrating on the treatment of infectious diseases, the content is divided into 4 sections: antibiotics, anti-fungal drugs, anti-parasitic drugs and anti-viral drugs, and is highly structured for ease of reference.Within each section, each chapter is structured to cover susceptibility, formulations and dosing (adult and paediatric), pharmacokinetics and pharmacodynamics, toxicity and drug distribution, detailed discussion regarding clinical uses, a feature unique to this title. Compiled by an expanded team of internationally renowned and respected editors, with a vast number of contributors spanning Europe, Africa, Asia, Australia, South America, the US and Canada, the sixth edition adopts a truly global approach. It will remain invaluable for anyone using antimicrobial agents in their clinical practice and provides in a systematic and concise manner all the information required when treating infections requiring antimicrobial therapy. Kucers' The Use of Antibiotics is available free to purchasers of the books as an electronic version on line or on your desktop: It provides access to the entire 2-volume print material It is fully searchable, so you can find the relevant information you need quickly Live references are linked to PubMed referring you to the latest journal material Customise the contents - you can highlight sections and make notes Comments can be shared with colleagues/tutors for discussion, teaching and learning The text can also be reflowed for ease of reading Text and illustrations copied will be automatically referenced to Kucers' The Use of Antibiotics
The rising prevalence of dementia in the population continues to pose a serious public health challenge in both the developed and the developing world. Previous editions of Dementia have become acknowledged as a key 'gold standard' work in this field, and have had a genuinely international approach. The third edition has been fully revised and upda
This best-selling book provides you with a comprehensive guide to the diagnostic applications of exfoliative and aspiration cytology. The book takes a systemic approach and covers the recognized normal and abnormal cytological findings encountered in a particular organ. Appropriate histopathological correlations and a consideration of the possible differential diagnosis accompany the cytological findings. The book is lavishly illustrated, making it the perfect practical resource for daily reference in the laboratory. Provides an accessible guide to diagnostic investigation and screening. Includes a summary of major diagnostic criteria and discusses the pitfalls and limitations of cytology. Utilizes a consistent chapter structure to make finding the answers you need quick and easy. Provides updates to crucial chapters to keep you on top of the latest diagnosis and techniques. Incorporates differential diagnosis tables for easy comparison/contrast of diagnoses. Offers more than 1800 full-color images depicting a full range of normal and abnormal findings. Discusses new concepts on molecular basis of neoplasia. Explores the role of cytogenetics in cancer development.
With more than 1,200 detailed monographs, Tatro has designed a quick reference to potentially severe drug-drug and drug-food interactions of more than 700 generic drugs and 70 therapeutic groups.
Drug Interaction Facts™ provides health professionals with a fast and accurate interaction screening tool, with over 12,000 monographs. In just seconds, potential interactions can be reviewed by class, generic drug, or trade name. Comprehensive information on drug/drug or drug/food interactions is provided in a unique and logical quick-reference format to enhance the speed and accuracy of therapeutic decision making. Drug Interaction Facts™ provides information on the onset, severity, and documentation of clinically significant interactions, including a review of their effects, mechanism, and management. Readers will also find discussion and assessment of the data used to document the interaction.
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