Foundations of Biochemical Psychiatry provides information pertinent to the development of biochemical psychiatry, including biochemical studies of psychiatric patients before and after pharmacological intervention and genetic studies. This book discusses the development of biochemical psychiatry as a significant experimental and conceptual approach to understanding mental illness. Organized into 24 chapters, this book begins with an overview of the neurochemical processes involved in the elaboration of a behavior and the extent to which alterations in those processes are responsible for behavioral differences. This text then discusses the clinical characteristics of schizophrenia, including common symptoms, natural history, and subtypes. Other chapters consider the contribution of genetic factors to the etiology of schizophrenia. This book discusses as well the similarities among hallucinations, dreams, and primary process thinking. The final chapter deals with the factors that may influence the neuroendocrine system. This book is a valuable resource for psychiatrists, neuropharmacologists, neurobiologists, behavioral biologists, and psychoanalysts.
Laying the foundation for an understanding of US-Israeli relations, this lively and accessible book provides critical background on the origins and development of the 'special' relations between Israel and the United States. Questioning the usual neo-realist approach to understanding this relationship, David Tal instead suggests that the relations between the two nations were constructed on idealism, political culture, and strategic ties. Based on a diverse range of primary sources collected in archives in both Israel and the United States, The Making of an Alliance discusses the development of relations built through constant contact between people and ideas, showing how presidents and Prime Ministers, state officials, and ordinary people from both countries, impacted one another. It was this constancy of religion, values, and history, serving the bedrock of the relations between the two countries and peoples, over which the ephemeral was negotiated.
Social Movements in Global Politics is a timely new account of the unconventional, ‘extra-institutional’ activities of social movements. In the face of impending global crises and stubborn conflicts, a conventional view of politics risks leaving us confused and fatalistic, feeling powerless because we are unaware of all that can be achieved by political means. By contrast, a variety of recent social movements, ranging from those of women, gays and lesbians and anti-racists, to environmentalists, the Occupy movement and the Arab Spring, demonstrate the enormous potential of political action beyond the institutional sphere of politics. At the same time, religious fundamentalists, racial supremacists and ultra-nationalists make clear that movements are not necessarily progressive and are often at odds with one another. West highlights the many ways in which national and global institutions depend on a broader context of extra-institutional action or what is, in effect, the formative dimension of politics. He explores some of the major contributions of social movements: from the genealogy of liberal democratic nation-states, sixties’ radicalism and the ‘new social movements’ to the politics of sexuality, gender and identity, the politicization of nature and climate, and alter-globalization. The book also considers current theoretical approaches and sets out the basis for a critical theory of social movements. This is a fresh and original account of social movements in politics and will be essential reading for any students and scholars interested in the challenges and the unpredictable potential of political action.
Metabolic Pathways, Third Edition: Volume VII: Metabolism of Sulfur Compounds deals with various aspects of the metabolism and biosynthesis of sulfur compounds such as coenzyme A, biotin, thiamine, and lipoic acid. The biochemistry of glutathione and the sulfur cycle is also discussed, together with sulfate activation and transfer; oxidative metabolism of cysteine and cystine in animal tissues; and enzyme defects in sulfur amino acid metabolism in humans. This volume is comprised of 15 chapters and begins with a discussion on the pathways of biosynthesis and dissimilation of coenzyme A, as well as the metabolic fate of exogenous coenzyme A in animals. The reader is then introduced to the chemistry, biosynthesis, metabolism, biological role, and biodegradation of biotin; the biosynthesis and function of thiamine; and the biosynthesis, dissimilation, and metabolic role of lipoic acid. Other sulfur compounds considered in this text are glutathione, cysteine and cystine, riboflavin, thiosulfate sulfurtransferase, mercaptopyruvate sulfurtransferase, and methionine. The final chapter is devoted to human diseases associated with enzyme defects in sulfur amino acid metabolism. This book will be a useful resource for biologists and biochemists.
Strategic Management for Travel and Tourism is the must-have text for students studying travel and tourism. It brings theory to life by using industry-based case studies, and in doing so, 'speaks the language' of the Travel and Tourism student. Among the new features and topics included in this edition are: * international case studies from large-scale businesses such as Airtours, MyTravel and South West Airlines * user-friendly applications of strategic management theory, such as objectives, products and markets and strategic implementation, together with illustrative case studies, and longer case studies for seminar work and summaries * contemporary strategic issues affecting travel and tourism organizations, such as vertical integration and strategic alliances Strategic Management for Travel and Tourism is a well-rounded book, ideal for all undergraduate and postgraduate students focusing on strategy in travel and tourism.
The second edition of this popular text features a team of international experts who discuss all aspects of travel medicine-from immunizations and pre-travel advice for adults and children...to the latest information on cruise travel, bird flu, and SARS...to the essentials of post-travel screening. It reflects current ‘best practices’ and remains both the leading comprehensive reference text on the principles and practice of travel medicine and a rich resource of practical guidance that you can use daily. And, as an Expert Consult title, this thoroughly updated second edition comes with access to the complete contents online, fully searchable-enabling you to consult it rapidly from any computer with an Internet connection. Discusses common travel illnesses, including traveler’s diarrhea and malaria to help you treat whatever you see. Addresses environmental problems such as altitude sickness, extremes in temperatures, and sun exposure to help your patients prepare for high-risk activites in extreme environments. Offers advice on establishing and running a travel clinic. Provides access to the complete contents online, fully searchable, enabling you to consult it rapidly from any computer with an Internet connection. Features revised chapters to reflect current best practices as well as completely updated chapters, keeping you abreast of this rapidly changing field. Presents a new chapter on cruise travel to help you provide complete travel medicine advice. Provides cross references for the ISTM “body of knowledge? to specific chapters and/or passages in the book to help you prepare for the ISTM travel medicine examination. Uses a new logical organization that speeds you to the information you need. Provides cross references for the ISTM “body of knowledge? to specific chapters and/or passages in the book to help you prepare for the ISTM travel medicine examination.
Teaching students with learning challenges just got easier with this groundbreaking guide! More and more students are having difficulty acquiring basic reading, writing, and computation skills. If you seek effective strategies to meet their needs, look no further! Use this updated third edition from education expert David A. Sousa to explore the causes of many common learning disorders and discover how to identify, accommodate, and motivate your students. Dr. Sousa answers your questions about common disabilities and provides the latest alternative instructional approaches to ensure mastery occurs. Discover cutting-edge brain research and innovative instructional strategies to help you: Improve your understanding of the learning process Understand genetic and environmental triggers of learning problems Effectively instruct students with ADHD, LD, dyslexia, writing disabilities, autism, emotional and behavioral challenges, and more Utilize assistive technologies to remove barriers to learning Differentiate instruction in speech, reading, writing, and mathematics Learn how the brain works and the practical know-how to transfer that knowledge to the classroom for the benefit of all students. This expert resource shows you how! "By providing the specific neurological processes behind learning difficulties, Dr. Sousa gives teachers and teacher candidates a useful resource to understand and respond to challenges experienced by students with learning difficulties and special educational needs." Gina Garner, Assistant Professor of Education, Learning Disabilities Program Director Aquinas College "This book provides knowledge of the neurological basis of learning without inundating the reader with complex terminology. The author arms the reader with strategies to address various disabilities and a plethora of ways to support their learning and emotional needs. The teacher-friendliness of this book makes it stand out." Francine Del Vecchio, Associate Professor Division of Education, Caldwell University
This is a new book on the integrated management of vulvovaginal disease. The authors come from a variety of backgrounds - gynaecology, dermatology, pathology and psychology - and describe a multidisciplinary approach to these conditions. The book has the most complete classification of vulvovaginal disease published, based on the etiology of 275 conditions; coverage includes benign, malignant, and functional (including psychosexual) diseases. Each disease has a descriptive summary, pathological features, and treatment guidelines. The book is illustrated in full color throughout.
Long was I hugg'd close-long and long. Immense have been the preparations for me, Faithful and friendly the arms that have help'd me. Cycles ferried my cradle, rowing and rowing like friendly boatmen. For room to me stars kept aside in their own rings, They sent influences to look after what was to hold me. Before I was born out of my mother, generations guided me, My embryo has never been torpid, nothing could overlay it. -Walt Whitman, "Song of Myself" The womb is the seat of all mammalian life. In pregnancy, the uterus acquires this impor tance with the arrival of the fertilized egg, which takes up residence for periods ranging from about 2 weeks in the opossum to about 2 years in the elephant. The arrival of the embryo signals a crucial time for the establishment of pregnancy. For several days the blas tocyst remains free in the uterine lumen, where it depends on uterine secretions for its sur vival and differentiation. During this time, essential changes in the endometrium take place in preparation for attachment of the blastocyst and implantation. Early embryonic loss is an economic problem of global proportions in animal husbandry, where, in pigs and cattle for example, some 30% of all fertilizations fail to result in a pregnancy. In humans this figure may be even higher, and estimates of early spontaneous abortions range from 40 to 60% of all conceptions.
For review see: Roderick A. McDonald, in The economic historic review : a journal of economic and social history, vol. 44, no. 4 (November 1991); p. 765-766.
This book examines the rise of cultural studies and evaluates its strengths and weaknesses. The author raises searching questions about the originality of cultural studies and its political motivation. Written with zest and a judicious sense of purpose it is a landmark work in cultural studies media and the sociology of culture.
Managing the Drug Discovery Process, Second Edition thoroughly examines the current state of pharmaceutical research and development by providing experienced perspectives on biomedical research, drug hunting and innovation, including the requisite educational paths that enable students to chart a career path in this field. The book also considers the interplay of stakeholders, consumers, and drug firms with respect to a myriad of factors. Since drug research can be a high-risk, high-payoff industry, it is important to students and researchers to understand how to effectively and strategically manage both their careers and the drug discovery process. This new edition takes a closer look at the challenges and opportunities for new medicines and examines not only the current research milieu that will deliver novel therapies, but also how the latest discoveries can be deployed to ensure a robust healthcare and pharmacoeconomic future. All chapters have been revised and expanded with new discussions on remarkable advances including CRISPR and the latest gene therapies, RNA-based technologies being deployed as vaccines as well as therapeutics, checkpoint inhibitors and CAR-T approaches that cure cancer, diagnostics and medical devices, entrepreneurship, and AI. Written in an engaging manner and including memorable insights, this book is aimed at anyone interested in helping to save countless more lives through science. A valuable and compelling resource, this is a must-read for all students, educators, practitioners, and researchers at large—indeed, anyone who touches this critical sphere of global impact—in and around academia and the biotechnology/pharmaceutical industry. Considers drug discovery in multiple R&D venues - big pharma, large biotech, start-up ventures, academia, and nonprofit research institutes - with a clear description of the degrees and training that will prepare students well for a career in this arena Analyzes the organization of pharmaceutical R&D, taking into account human resources considerations like recruitment and configuration, management of discovery and development processes, and the coordination of internal research within, and beyond, the organization, including outsourced work Presents a consistent, well-connected, and logical dialogue that readers will find both comprehensive and approachable Addresses new areas such as CRISPR gene editing technologies and RNA-based drugs and vaccines, personalized medicine and ethical and moral issues, AI/machine learning and other in silico approaches, as well as completely updating all chapters
Designed for graduate level courses in adult psychopathology, the Second Edition of this book incorporates the newly released (2013) DSM-5 . Unique in its approach, this text presents a historical context in which current diagnoses are made. Presenting an overview of the issues and methodologies of conducting assessments, each of the major psychological disorders is discussed in a standard format in the chapter dealing with that disorder. The text includes new chapters on nonalcohol substance abuse and contextual factors affecting diagnoses. Each chapter covers: description from DSM, using case examples; epidemiology; basic research, including neurobiology and neuroscience of the disorder; prevalence and consequences of the disorder; behavioral, social, cognitive, and emotional aspects of the disorder; and treatment of the disorder, using clinical examples showing how psychopathology and assessment influence treatment"--
This volume offers a comprehensive history of the Mount Desert Island Biological Laboratory (MDIBL), one of the major marine laboratories in the United States and a leader in using marine organisms to study fundamental physiological concepts. Beginning with its founding as the Harpswell Laboratory of Tufts University in 1898, David H. Evans follows its evolution from a teaching facility to a research center for distinguished renal and epithelial physiologists. He also describes how it became the site of major advances in cytokinesis, regeneration, cardiac and vascular physiology, hepatic physiology, endocrinology and toxicology, as well as studies of the comparative physiology of marine organisms. Fundamental physiological concepts in the context of the discoveries made at the MDIBL are explained and the social and administrative history of this renowned facility is described.
The National Book Award–winning biography that tells the story of how young Teddy Roosevelt transformed himself from a sickly boy into the vigorous man who would become a war hero and ultimately president of the United States, told by master historian David McCullough. Mornings on Horseback is the brilliant biography of the young Theodore Roosevelt. Hailed as “a masterpiece” (John A. Gable, Newsday), it is the winner of the Los Angeles Times 1981 Book Prize for Biography and the National Book Award for Biography. Written by David McCullough, the author of Truman, this is the story of a remarkable little boy, seriously handicapped by recurrent and almost fatal asthma attacks, and his struggle to manhood: an amazing metamorphosis seen in the context of the very uncommon household in which he was raised. The father is the first Theodore Roosevelt, a figure of unbounded energy, enormously attractive and selfless, a god in the eyes of his small, frail namesake. The mother, Mittie Bulloch Roosevelt, is a Southerner and a celebrated beauty, but also considerably more, which the book makes clear as never before. There are sisters Anna and Corinne, brother Elliott (who becomes the father of Eleanor Roosevelt), and the lovely, tragic Alice Lee, TR’s first love. All are brought to life to make “a beautifully told story, filled with fresh detail” (The New York Times Book Review). A book to be read on many levels, it is at once an enthralling story, a brilliant social history and a work of important scholarship which does away with several old myths and breaks entirely new ground. It is a book about life intensely lived, about family love and loyalty, about grief and courage, about “blessed” mornings on horseback beneath the wide blue skies of the Badlands.
THE NEW YORK TIMES BESTSELLER Unlock the secret to extraordinary health by reducing high uric acid levels—the hidden risk you didn't know you had—by the author of Grain Brain and Brain Wash. What do obesity, insulin resistance, diabetes, fatty liver disease, hypertension, cardiovascular disease, stroke, neurological disorders, and premature death have in common? All can be stoked by high uric acid levels. Our most respected scientific literature is bursting with evidence that elevated uric acid levels lie at the root of many pervasive health conditions, but mainstream medicine for the most part remains unaware of this connection. This is especially alarming because a large number of Americans don’t know they are suffering from increased levels, putting them at risk for developing or exacerbating potentially life-threatening illnesses. Offering an engaging blend of science and practical advice, Drop Acid exposes the deadly truth about uric acid and teaches invaluable strategies to manage its levels, including how to: Reduce fructose and foods high in “purines” through simple dietary edits Lower uric acid levels through natural hacks like consuming tart cherries, vitamin C, quercetin, and coffee Identify common pharmaceuticals that threaten to increase uric acid Implement lifestyle interventions, like restorative sleep and exercise Easily test your uric acid levels at home—a test routinely performed in your doctor’s office during regular check-ups but typically ignored Featuring the groundbreaking “LUV” (Lower Uric Values) diet, 35 delicious recipes, self-assessment quizzes, and a 21-day program for dropping levels, Drop Acid empowers readers with the information they need to address this hidden danger and live longer, leaner, and healthier lives.
The second edition of this comprehensive textbook for students of Neuropsychology gives a thorough overview of the complex relationship between brain and behaviour. With an excellent blend of clinical, experimental and theoretical coverage, it draws on the latest research findings from neuroscience, cognitive neuroscience, neurochemistry, clinical neuropsychology and neuropsychology to provide students with new insights in this fast moving field. The book is organised around the main neuropsychological disorders in the areas of perception, executive dysfunction, attention, memory, cerebral asymmetry, language, emotion and consciousness. There is a clear emphasis on bridging the gap between theory and practice with links throughout to clinical issues of both assessment and rehabilitation to build a clear understanding of the application of the theoretical issues. The final section in each chapter illustrates the importance of a more systematic approach to intervention, which takes into account theoretical views of recovery from brain damage. New to this edition: A new chapter format that includes a "basic topic" section, which contains up-to-date essential knowledge of the topic and a "further topics" section for a more advanced treatment of the area. A new section on neuroscientific approaches to rehabilitation in each chapter to make links between scientific knowledge and clinical treatment. A brand new chapter on consciousness A new full colour layout with increased pedagogical features, including key terms, section summaries, ‘study questions’ and improved presentation of figures and brain diagrams A companion website including related weblinks, guidance on answering the ‘study questions’, and flashcards. This book will be invaluable for undergraduate students in Neuropsychology and students who wish to take the subject further to the various clinical fields.
Cometography is a multi-volume catalog of every comet observed from ancient times up to the 1990s, when the internet took off as a medium of scientific record. It uses the most reliable orbits known to determine the distances from the Earth and Sun at the time of discovery and last observation, as well as the largest and smallest angular distance to the Sun, most northerly and southerly declination, closest distance to the Earth, and other details, to enable the reader to understand each comet's physical appearance. Volume 6, the final volume in the catalog, covers the observations and pertinent calculations for every comet seen between 1983 and 1993. The comets are listed in chronological order, with complete references to publications relating to each comet and physical descriptions of each comet's development throughout its apparition. Cometography is the definitive reference on comets through the ages, for astronomers and historians of science.
Now in its third edition, The Brain and Behavior continues on its mission to present a simplified and accessible introduction to behavioral neuroanatomy. Human behavior is a direct reflection of the anatomy of the central nervous system, and it is the goal of the behavioral neuroscientist to uncover its neuroanatomical basis. Much of the new content in this edition reflects advances in functional magnetic resonance imaging. The text is presented in a highly structured and organized format to help the reader distinguish between issues of anatomical, behavioral and physiological relevance. Simplified and clear diagrams are provided throughout the chapters to illustrate key points. Case examples are explored to set the neuroanatomy in the context of clinical experience. This will be essential reading for behavioral clinicians including psychiatrists, neuropsychiatrists, neurologists, psychologists and clinical neuroscientists.
Tumourigenesis is the formation of tumours in the body, often caused by oncogenes. These tumours are the result of uncontrollable reproduction (cell division) due to alterations in the cell's genetic code, creating lesions in the tissue where they reside. Tumourigenesis can be divided into tumour initiation, promotion and progression. Oncogenomics often studies tumours caused by such a condition in hope of pinpointing genes -- pieces of genetic information -- that are susceptible to being changed (mutated) by external factors like ultraviolet light, toxic chemicals, and other carcinogens. The range of normal genetic alterations that a person's DNA undergoes over time is extraordinarily large, so it is hard to detect exactly what cause tumourigenesis. This book presents the latest research advances in the field.
From “America’s most beloved biographer, David McCullough” (Time)—a collection of his bestselling biographies of American Presidents. This ebook box set features David McCullough’s award-winning biographies of American Presidents. John Adams is the magisterial, Pulitzer Prize–winning biography of the independent, irascible Yankee patriot, one of our nation’s founders and most important figures, who became our second president. Mornings on Horseback is the brilliant National Book Award–winning biography of young Theodore Roosevelt’s metamorphosis from sickly child to a vigorous, intense man poised to become a national hero and then president. Truman is the Pulitzer Prize–winning biography of Harry Truman, the complex and courageous man who rose from modest origins to make momentous decisions as president, from dropping the atomic bomb to going to war in Korea. Including a special bonus: The Course of Human Events. In this Jefferson Lecture in the Humanities, David McCullough draws on his personal experience as a historian to acknowledge the crucial importance of writing in history’s enduring impact and influence, and he affirms the significance of history in teaching us about human nature through the ages.
Biofluid Mechanics: An Introduction to Fluid Mechanics, Macrocirculation, and Microcirculation, Third Edition shows how fluid mechanics principles can be applied not only to blood circulation, but also to air flow through the lungs, joint lubrication, intraocular fluid movement, renal transport, and other specialty circulations. This new edition contains new homework problems and worked examples, including MATLAB-based examples. In addition, new content has been added on such relevant topics as Womersley and Oscillatory Flows. With advanced topics in the text now denoted for instructor convenience, this book is particularly suitable for both senior and graduate-level courses in biofluids. Uses language and math that is appropriate and conducive for undergraduate and first-year graduate learning Contains new worked examples and end-of-chapter problems Covers topics in the traditional biofluids curriculum, also addressing other systems in the body Discusses clinical applications throughout the book, providing practical applications for the concepts discussed Includes more advanced topics to help instructors teach an undergraduate course without a loss of continuity in the class
The updated fourth edition of this comprehensive, highly respected reference covers all you need to know about obstetric anesthesia-from basic science to various anesthesia techniques to complications. The editorial team of leading authorities in the field now features Drs. Linda S. Polley, Lawrence C. Tsen, and Cynthia A. Wong and presents the latest on anesthesia techniques for labor and delivery and medical disorders that occur during pregnancy. This edition features two new chapters and rewritten versions of key chapters such as Epidural and Spinal Analgesia and Anesthesia. Emphasizes the treatment of the fetus and the mother as separate patients with distinct needs to ensure the application of modern principles of care. Delivers contributions from many leaders in the fields of obstetric anesthesia and maternal-fetal medicine from all over the world. Offers abundant figures, tables, and boxes that illustrate the step-by-step management of a full range of clinical scenarios. Presents key point summaries in each chapter for quick, convenient reference. Features new chapters on Patient Safety and Maternal Mortality to address the latest developments in the field and keep you current. Presents completely rewritten chapters on Epidural and Spinal Analgesia and Anesthesia, Anesthesia for Cesarean Section, and Hypertension Disorders, updated by new members of the editorial team-Drs. Linda S. Polley, Lawrence C. Tsen, and Cynthia A. Wong, for state-of-the-art coverage of key topics and new insights. Covers all the latest guidelines and protocols for safe and effective practice so you can offer your patients the very best.
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