An expert guide to targeting protein kinases in cancer therapy Research has shown that protein kinases can instigate the formation and spread of cancer when they transmit faulty signals inside cells. Because of this fact, pharmaceutical scientists have targeted kinases for intensive study, and have been working to develop medicinal roadblocks to sever their malignant means of communication. Complete with full-color presentations, Targeting Protein Kinases for Cancer Therapy defines the structural features of protein kinases and examines their cellular functions. Combining kinase biology with chemistry and pharmacology applications, this book enlists emerging data to drive the discovery of new cancer-fighting drugs. Valuable information includes: Comprehensive overviews of the major kinase families involved in oncology, integrating protein structure and function, and providing important tools to assist pharmaceutical researchers to understand and work in this dynamic area of cancer drug research Focus on small molecule inhibitors as well as other therapeutic modalities Discussion of kinase inhibitors that have entered clinical trials for the treatment of cancer, with an emphasis on molecules that have progressed to late stage clinical trials and, in a few cases, to market Providing a platform for further study, this important work reviews both the successes and challenges of kinase inhibitor therapy, and provides insight into future directions in the war against cancer.
Based on nearly five decades of research, this magisterial work is a biographical register and analysis of the people who most directly influenced the course of the Civil War, its high commanders. Numbering 3,396, they include the presidents and their cabinet members, state governors, general officers of the Union and Confederate armies (regular, provisional, volunteers, and militia), and admirals and commodores of the two navies. Civil War High Commands will become a cornerstone reference work on these personalities and the meaning of their commands, and on the Civil War itself. Errors of fact and interpretation concerning the high commanders are legion in the Civil War literature, in reference works as well as in narrative accounts. The present work brings together for the first time in one volume the most reliable facts available, drawn from more than 1,000 sources and including the most recent research. The biographical entries include complete names, birthplaces, important relatives, education, vocations, publications, military grades, wartime assignments, wounds, captures, exchanges, paroles, honors, and place of death and interment. In addition to its main component, the biographies, the volume also includes a number of essays, tables, and synopses designed to clarify previously obscure matters such as the definition of grades and ranks; the difference between commissions in regular, provisional, volunteer, and militia services; the chronology of military laws and executive decisions before, during, and after the war; and the geographical breakdown of command structures. The book is illustrated with 84 new diagrams of all the insignias used throughout the war and with 129 portraits of the most important high commanders.
A compilation of 45 African-American cemeteries in Jackson and Sandy Ridge Townships in Union Co., NC, with eight surrounding townships, in North and South Carolina.
In an eclectic and highly original study, Turnbull brings together traditions as diverse as cathedral building, Micronesian navigation, cartography and turbulence research. He argues that all our differing ways of producing knowledge - including science - are messy, spatial and local. Every culture has its own ways of assembling local knowledge, thereby creating space thrugh the linking of people, practices and places. The spaces we inhabit and assemblages we work with are not as homogenous and coherent as our modernist perspectives have led us to believe - rather they are complex and heterogeneous motleys.
Volume Four of this series contains the alphabetical rosters of each of the 144 cemeteries in the study area of Jackson and Sandy Ridge Townships, Union Co., NC. It includes over 27,524 graves.
A comprehensive overview of clinically important infections of the urinary tract Urinary tract infections (UTIs) continue to rank among the most common infectious diseases of humans, despite remarkable progress in the ability to detect and treat them. Recurrent UTIs are a continuing problem and represent a clear threat as antibiotic-resistant organisms and infection-prone populations grow. Urinary Tract Infections: Molecular Pathogenesis and Clinical Management brings the scientific community up to date on the research related to these infections that has occurred in the nearly two decades since the first edition. The editors have assembled a team of leading experts to cover critical topics in these main areas: clinical aspects of urinary tract infections, including anatomy, diagnosis, and management, featuring chapters on the vaginal microbiome as well as asymptomatic bacteriuria, prostatitis, and urosepsis the origins and virulence mechanisms of the bacteria responsible for most UTIs, including uropathogenic Escherichia coli, Proteus mirabilis, and Klebsiella pneumoniae the host immune response to UTIs, the rise of antibiotic-resistant strains, and the future of therapeutics This essential reference serves as both a resource and a stimulus for future research endeavors for anyone with an interest in understanding these important infections, from the classroom to the laboratory and the clinic.
Interactive Exercises for Cross-Cultural Psychology provides material for interactive discussion of a range of topics in cross-cultural psychology, including regional and indigenous psychology; symbolic and expressive psychology; identity; social perception and cognition; interpersonal interaction; emotion, motivation, and health; development and family; government and law; economics and work; environmental psychology; animals and other species; and the psychology of recreation and sport. It will help students apply cultural psychology to social issues, and makes these issues relevant to students in health, forensic, organizational, sport and exercise, and other applied psychology fields. It offers suggestions for exposition, simulation, and confrontation of important cultural issues that matter to students, while allowing for maximum creativity in instructional design. Thoroughly and currently referenced, with connections to a wide range of accessible web-based and open-source materials, it is user-friendly across a spectrum of classroom and workshop applications, including online delivery.
Baptists have a long and rich heritage of congregational song. The hymns Baptists have sung and the books from which they have sung them have been shaping forces for Baptist theology, worship, and piety. Baptist authors and composers have provided songs that have made an impact not only among Baptists in America but also across denominational and geographic lines. Congregational singing continues to be a key component of Baptist worship in the twenty-first century. Beginning with an overview of the British background, this book is a survey of the history of Baptist hymnody in America from Baptist beginnings in the New World to the present. Its intent is to help the reader better understand the background against which current Baptist congregational song practices operate. Unlike earlier writings on the subject, this book provides both comprehensive coverage and a continuous narrative. It gives thorough attention to the major Baptist bodies in America as well as calling attention to the contributions of significant smaller groups. The British Baptist background is dealt with in an introductory section. The book also includes many texts and tunes as illustrations of the topics being discussed and focuses on some of the contributions of Baptist authors and composers to the repertory of congregational song. Book jacket.
Figures of Time proposes radically new ideas about the very poetic ground of culture. Presenting unique close readings of six modern poets—Wallace Stevens, W. B. Yeats, H. D. (Hilda Doolittle), Ezra Pound, Langston Hughes, and T. S. Eliot—David Ben-Merre brings recent theoretical questions about the rhetoric of modernism and poetic figuration into current discussions in critical theory. He argues that poetic spaces, often disjunctions of sound and sense, disrupt our culturally inherited notions of time, reimagining with an often irrational and anachronistic backward glance what we take to be historical chronologies, psychological perceptions of time, and collective scripts about causality.
An important milestone in medicine has been the recent completion of the Human Genome Project. The identification of 30,000 genes and their regulatory proteins provides the framework for understanding the metabolic basis of disease. This advance has also laid the foundation for a broad range of genomic tools that have opened the way for targeted genetic testing in a number of medical disorders. This book is designed to be the first major text to discuss genomics-based advances in disease susceptibility, diagnosis, prognostication,and prediction of treatment outcomes in various areas of medicine. After building a strong underpinning in the basic concepts of genomics, the authors of this book, all leaders in the field, proceed to discuss a wide range of clinical areas and the applications now afforded by genomic analysis.
In-depth study of internet-enhanced healthcare services Complete and thorough survey of the most promising e-health technologies Presents numerous real world examples Emphasis on international health-informatics topics, such as better access of states / countries to modern e-health technologies developed by leading centers
Newly updated, this full-color text offers a rich array of features to help you develop your musculoskeletal assessment skills. Orthopedic Physical Assessment, 6th Edition provides rationales for various aspects of assessment and covers every joint of the body, as well as specific topics including principles of assessment, gait, posture, the head and face, the amputee, primary care, and emergency sports assessment. Artwork and photos with detailed descriptions of assessments clearly demonstrate assessment methods, tests, and causes of pathology. The text also comes with an array of online learning tools, including video clips demonstrating assessment tests, assessment forms, and more. Thorough, evidence-based review of orthopedic physical assessment covers everything from basic science through clinical applications and special tests. 2,400 illustrations include full-color clinical photographs and drawings as well as radiographs, depicting key concepts along with assessment techniques and special tests. The use of icons to show the clinical utility of special tests supplemented by evidence - based reliability & validity tables for tests & techniques on the Evolve site The latest research and most current practices keep you up to date on accepted practices. Evidence-based reliability and validity tables for tests and techniques on the EVOLVE site provide information on the diagnostic strength of each test and help you in selecting proven assessment tests. A Summary (Précis) of Assessment at the end of each chapter serves as a quick review of assessment steps for the structure or joint being assessed. Quick-reference data includes hundreds of at-a-glance summary boxes, red-flag and yellow-flag boxes, differential diagnosis tables, muscle and nerve tables, and classification, normal values, and grading tables. Case studies use real-world scenarios to help you develop assessment and diagnostic skills. Combined with other books in the Musculoskeletal Rehabilitation series - Pathology and Intervention, Scientific Foundations and Principles of Practice, and Athletic and Sport Issues - this book provides the clinician with the knowledge and background necessary to assess and treat musculoskeletal conditions. NEW! Online resources include video clips, assessment forms, text references with links to MEDLINE® abstracts, and more. NEW! Video clips demonstrate selected movements and the performance of tests used in musculoskeletal assessment. NEW! Text references linked to MEDLINE abstracts provide easy access to abstracts of journal articles for further review. NEW! Forms from the text with printable patient assessment forms can be downloaded for ease of use. NEW! Updated information in all chapters includes new photos, line drawings, boxes, and tables. NEW! The use of icons to show the clinical utility of special tests supplemented by evidence - based reliability & validity tables for tests & techniques on the Evolve site.
The seventh edition of this classic text champions healthy aging by demonstrating how to prevent or manage disease and make large-scale improvements toward health and wellness in the older adult population. The text synthesizes state-of-the-art research findings—providing convincing evidence that health promotion truly works—with practical, effective strategies. Encompassing important research results that supplant prior recommendations, this new edition provides updated best practices and strategies to ensure the active participation of older adults in all aspects of life. Completely reorganized for ease of use, this textbook features updated demographics and rankings for leading causes of death, new blood pressure screening guidelines and data on obesity and diabetes, updated exercise regimens, older-driver statistics and innovations such as the driverless car, cautions regarding ineffective brain-training programs, and more. Highly practical, the text includes health-promoting tools, resource lists, assessment tools, illustrations, checklists, and tables. Additionally, the book includes key terms and learning objectives at the start of each chapter, along with thought-provoking questions and reflection boxes. An Instructor’s Manual and PowerPoint slides are available to facilitate teaching. New to the Seventh Edition: Provides updated blood pressure, cholesterol, Ductal Carcinoma In Situ (DCIS), and lung cancer screening guidelines Presents updates on exercise regimens ranging from yoga to the tango Expands and updates section on emotional regulation and conflict resolution skills with aging Discusses Boomer Entrepreneurism Provides new policy recommendations including student loan debt among older adults Expands gerotechnology and smart home innovations Updates on “Obamacare” and health care delivery recommendations Addresses “Buyer Beware” regarding brain-training programs Expands global aging and LGBT aging content
America’s First Aircraft Carrier tells the remarkable story of the USS Langley. The narrative provides an in-depth discussion of the ship’s origins as the collier USS Jupiter, which was built with a “first of” propulsion system that has been adapted for use in present-day Ford-class carriers. Author David F. Winkler considers the post–World War I debate for procuring carriers, the decision to convert Jupiter, and the identification of constructor Clayton Simmers as the father of the American aircraft carrier. The evolution of the Langley as an experimental ship was tied to the introduction of new doctrine for the United States. Promoting an independent naval air arm against Brig. Gen. Billy Mitchell’s vision of an independent air force, the U.S. Navy saw Langley as an operational aircraft carrier that would change the way the Navy fought wars at sea. While the story of Langley is that of the origins of naval air combat, it is also a record of the vessel’s service in World War II until the ship’s final posting to the Asiatic Fleet, where she met her demise on February 27, 1942, off the southern coast of Java. Many of the U.S. Navy’s pioneering naval aviators are closely associated with this ship, including Kenneth Whiting, John H. Towers, Godfrey DeCourcelles Chevalier, Virgil C. Griffith, Mel Pride, Patrick N. L. Bellinger, Joseph M. Reeves, Gerald Bogan, Aubrey Fitch, Felix Stump, Ernest J. King, Warren G. Child, Dan Gallery, and Frank D. Wagner. A number of these individuals would go on to play critical roles during World War II. Langley’s story is their story. Aircraft carriers remain the centerpiece of American sea power projection. America’s First Aircraft Carrier provides the context on how CV 1, the “Covered Wagon,” and carrier development and utilization came to be.
lt is a tremendous achievement to have provided this highly comprehensive but readable text, which informs such a large group of researchers and clinicians." Christopher Kennard, PhD, FRCP, FMedSci, Professor of Clinical Neurology, Head, Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom. "A monograph written with deep knowledge, understanding, wisdom, clarity, intelligibility - the superlatives could go on and on... A remarkable achievement and a great gift to all of us from the two modern giants of eye movement disorders." Michael Halmagyi, MD, Eye and Ear Research Unit, Neurology Department, Royal Prince Alfred Hospital, The University of Sydney, Australia. "The fifth edition of The Neurology of Eye Movements is a must for all neurologists and neuroscientists interested in how the human vestibular and oculomotor systems adapt to movement in space and to optimally viewing the world and its contents." Louis R. Caplan, MD, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
This paper identifies the factors linked to cross-country differentials in growth performance in the aftermath of social conflict for 30 sub-Saharan African countries using panel data techniques. Our results show that changes in the terms of trade are the most important correlate of economic performance in post-conflict environments. This variable is typically associated with an increase in the marginal probability of positive economic performance by about 30 percent. Institutional quality emerges as the second most important factor. Foreign aid is shown to have very limited ability to explain differentials in growth performance, and other policy variables such as trade openness are not found to have a statistically significant effect. The results suggest that exogenous factors ("luck") are an important factor in post-conflict recovery. They also highlight the importance in post-conflict settings of policies to mitigate the macroeconomic impact of terms of trade volatility (including countercyclical macroeconomic policies and innovative financing instruments) and of policies to promote export diversification.
This book provides a theoretical background of branching processes and discusses their biological applications. Branching processes are a well-developed and powerful set of tools in the field of applied probability. The range of applications considered includes molecular biology, cellular biology, human evolution and medicine. The branching processes discussed include Galton-Watson, Markov, Bellman-Harris, Multitype, and General Processes. As an aid to understanding specific examples, two introductory chapters, and two glossaries are included that provide background material in mathematics and in biology. The book will be of interest to scientists who work in quantitative modeling of biological systems, particularly probabilists, mathematical biologists, biostatisticians, cell biologists, molecular biologists, and bioinformaticians. The authors are a mathematician and cell biologist who have collaborated for more than a decade in the field of branching processes in biology for this new edition. This second expanded edition adds new material published during the last decade, with nearly 200 new references. More material has been added on infinitely-dimensional multitype processes, including the infinitely-dimensional linear-fractional case. Hypergeometric function treatment of the special case of the Griffiths-Pakes infinite allele branching process has also been added. There are additional applications of recent molecular processes and connections with systems biology are explored, and a new chapter on genealogies of branching processes and their applications. Reviews of First Edition: "This is a significant book on applications of branching processes in biology, and it is highly recommended for those readers who are interested in the application and development of stochastic models, particularly those with interests in cellular and molecular biology." (Siam Review, Vol. 45 (2), 2003) “This book will be very interesting and useful for mathematicians, statisticians and biologists as well, and especially for researchers developing mathematical methods in biology, medicine and other natural sciences.” (Short Book Reviews of the ISI, Vol. 23 (2), 2003)
Textbook of Assisted Reproductive Technologies is a truly comprehensive manual for the whole team at the IVF clinic. Information is presented in a highly visual manner, allowing both methods and protocols to be consulted easily. The text provides clinical and scientific teams with the A to Zs of setting up an embryology laboratory, gives research fellows insight into technical developments, and supplies seasoned professionals with a review of the latest techniques and advances. New to the Third Edition: fully revised and expanded chapters, with new information on: single embryo transfer artificial gametes pharmacogenetics
Reclaiming 42 centers on one of America’s most respected cultural icons, Jackie Robinson, and the forgotten aspects of his cultural legacy. Since his retirement in 1956, and more strongly in the last twenty years, America has primarily remembered Robinson’s legacy in an oversimplified way, as the pioneering first black baseball player to integrate the Major Leagues. The mainstream commemorative discourse regarding Robinson’s career has been created and directed largely by Major League Baseball (MLB), which sanitized and oversimplified his legacy into narratives of racial reconciliation that celebrate his integrity, character, and courage while excluding other aspects of his life, such as his controversial political activity, his public clashes with other prominent members of the black community, and his criticism of MLB. MLB’s commemoration of Robinson reflects a professional sport that is inclusive, racially and culturally tolerant, and largely postracial. Yet Robinson’s identity—and therefore his memory—has been relegated to the boundaries of a baseball diamond and to the context of a sport, and it is within this oversimplified legacy that history has failed him. The dominant version of Robinson’s legacy ignores his political voice during and after his baseball career and pays little attention to the repercussions that his integration had on many factions within the black community. Reclaiming 42 illuminates how public memory of Robinson has undergone changes over the last sixty-plus years and moves his story beyond Robinson the baseball player, opening a new, broader interpretation of an otherwise seemingly convenient narrative to show how Robinson’s legacy ultimately should both challenge and inspire public memory.
This book focuses on the World Bank projects, led by the author, based on computable general equilibrium models of international trade policy. The chapters show an unusual combination of policy relevance, advice and impact, with academic rigor and international trade theory insights. The author discusses some of the policy contexts for the requests from developing and transition countries to the World Bank, the key trade theory or policy insights, policy recommendations and conclusions, and the policy impacts.
Back cover: How is God revealed through the life of a human community? Dietrich Bonhoeffer's theological ethics begins from the claim to 'Christ existing as community', which David Robinson presents as one of several critical and politically astute variations on G.W.F. Hegel's philosophy of religion.
This book guides readers to the mastery of a wide array of practical analytic techniques useful to local governments. Written in an easy-to-read style with an emphasis on providing practical assistance to students, local government practitioners, and others interested in local government performance, this updated third edition features analytic methods selected for their relevance to everyday problems encountered in city and county governments. The authors outline a variety of practical techniques including the simplest that the fields of management, public administration, policy analysis, and industrial engineering have to offer. Each analytic technique is introduced in the context of a fictitious case presented over a few pages at the beginning of that technique’s chapter. Contents include demand analysis, work distribution analysis, process flow-charting, inflation adjustments, annualizing capital costs, staffing analysis, identifying full costs of a program or service, present value analysis, life-cycle costing, lease/buy analysis, cost-effectiveness analysis, benchmarking analysis, and more. This updated third edition features a dramatic expansion of Excel-based applications, plus templates and exercises accompanying many of the chapters and available online. New chapters prepare readers to: • use statistical tests to identify significant differences in performance averages; • construct Pareto charts; • develop cause-and-effect diagrams; • prepare control charts; • detect possible discrimination in hiring and appointment practices; and • present analytic evidence more effectively. This book is an essential resource for students and instructors of public administration courses on analysis, methods, evaluation, productivity improvement, and service delivery. Online resources for this book, including Excel templates, are available at https://toolsfordecisionmaking.sog.unc.edu
This clear and intuitive introduction to care planning for nurses explains the benefits of holistic, individualised care planning from a professional and clinical perspective. Using the ASPIRE model, it guides the reader step-by-step through a problem-solving approach to care, from assessing patients and identifying their needs, to planning goals and interventions, and evaluating progress. The book is structured to explain the theory of care planning in relation to a number of common nursing models and then show how the theory can best be put into practice. It draws on recent research to show how nurses can develop individualised care plans from scratch or use and adapt a range of ‘off-the-shelf’ tools. It is written in a clear, succinct and down-to-earth writing style, which will put students immediately at their ease, and is rich with pedagogic features, including: ‘Stop and think’ boxes to check understanding; boxed ‘Practice examples’ to illustrate points made; ‘Research summary’ boxes to highlight relevant and important studies; ‘What have you learnt so far?’ features to recap on key points of discussion; mini care plans; regular activities to encourage the reader to apply what they have learnt to particular practice scenarios. This is a go-to text for all pre-registration nursing students taking courses on the theory and practice of effective healthcare delivery.
The Story of Australia provides a fresh, engaging and comprehensive introduction to Australia’s history and geography. An island continent with distinct physical features, Australia is home to the most enduring Indigenous cultures on the planet. In the late eighteenth century newcomers from distant worlds brought great change. Since that time, Australia has been shaped by many peoples with competing visions of what the future might hold. This new history of Australia integrates a rich body of scholarship from many disciplines, drawing upon maps, novels, poetry, art, music, diaries and letters, government and scientific reports, newspapers, architecture and the land itself, engaging with Australia in its historical, geographical, national and global contexts. It pays particular attention to women and Indigenous Australians, as well as exploring key themes including invasion/colonisation, land use, urbanisation, war, migration, suburbia and social movements for change. Elegantly written, readers will enjoy Australia’s story from its origins to the present as the nation seeks to resolve tensions between Indigenous dispossession, British tradition and multicultural diversity while finding its place in an Asian region and dealing with global challenges like climate change. It is an ideal text for students, academics and general readers with an interest in Australian history, geography, politics and culture.
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