An expert guide to targeting protein kinases in cancer therapy Research has shown that protein kinases can instigate the formation and spread of cancer when they transmit faulty signals inside cells. Because of this fact, pharmaceutical scientists have targeted kinases for intensive study, and have been working to develop medicinal roadblocks to sever their malignant means of communication. Complete with full-color presentations, Targeting Protein Kinases for Cancer Therapy defines the structural features of protein kinases and examines their cellular functions. Combining kinase biology with chemistry and pharmacology applications, this book enlists emerging data to drive the discovery of new cancer-fighting drugs. Valuable information includes: Comprehensive overviews of the major kinase families involved in oncology, integrating protein structure and function, and providing important tools to assist pharmaceutical researchers to understand and work in this dynamic area of cancer drug research Focus on small molecule inhibitors as well as other therapeutic modalities Discussion of kinase inhibitors that have entered clinical trials for the treatment of cancer, with an emphasis on molecules that have progressed to late stage clinical trials and, in a few cases, to market Providing a platform for further study, this important work reviews both the successes and challenges of kinase inhibitor therapy, and provides insight into future directions in the war against cancer.
In the first social history of what happened to public schools in those "years of the locust," the authors explore the daily experience of schoolchildren in many kinds of communities--the public school students of working-class northeastern towns, the rural black children of the South, the prosperous adolescents of midwestern suburbs. How did educators respond to the fiscal crisis, and why did Americans retain their faith in public schooling during the cataclysm? The authors examine how New Dealers regarded public education and the reaction of public school people to the distinctive New Deal style in programs such as the National Youth Administration. They illustrate the story with photographs, cartoons, and vignettes of life behind the schoolhouse door. Moving from that troubled period to our own, the authors compare the anxieties of the depression decade with the uncertainties of the 1970s and 1980s. Heirs to an optimistic tradition and trained to manage growth, school staff have lately encountered three shortages: of pupils, money, and public confidence. Professional morale has dropped as expectations and criticism have mounted. Changes in the governing and financing of education have made planning for the future even riskier than usual. Drawing on the experience of the 1930s to illuminate the problems of the 1980s, the authors lend historical perspective to current discussions about the future of public education. They stress the basic stability of public education while emphasizing the unfinished business of achieving equality in schooling.
Thank you for visiting our website. Would you like to provide feedback on how we could improve your experience?
This site does not use any third party cookies with one exception — it uses cookies from Google to deliver its services and to analyze traffic.Learn More.