This is the fifth edition of a very successful textbook on clinical trials methodology, written by recognized leaders who have long and extensive experience in all areas of clinical trials. The three authors of the first four editions have been joined by two others who add great expertise. A chapter on regulatory issues has been included and the chapter on data monitoring has been split into two and expanded. Many contemporary clinical trial examples have been added. There is much new material on adverse events, adherence, issues in analysis, electronic data, data sharing and international trials. This book is intended for the clinical researcher who is interested in designing a clinical trial and developing a protocol. It is also of value to researchers and practitioners who must critically evaluate the literature of published clinical trials and assess the merits of each trial and the implications for the care and treatment of patients. The authors use numerous examples of published clinical trials to illustrate the fundamentals. The text is organized sequentially from defining the question to trial closeout. One chapter is devoted to each of the critical areas to aid the clinical trial researcher. These areas include pre-specifying the scientific questions to be tested and appropriate outcome measures, determining the organizational structure, estimating an adequate sample size, specifying the randomization procedure, implementing the intervention and visit schedules for participant evaluation, establishing an interim data and safety monitoring plan, detailing the final analysis plan and reporting the trial results according to the pre-specified objectives. Although a basic introductory statistics course is helpful in maximizing the benefit of this book, a researcher or practitioner with limited statistical background would still find most if not all the chapters understandable and helpful. While the technical material has been kept to a minimum, the statistician may still find the principles and fundamentals presented in this text useful.
This textbook provides a concise overview of malignant haematology, including reviews of cell and molecular biology, and implications for new trends in treatment.
I am unaware of any textbook which provides such comprehensive coverage of the field and doubt that this work will be surpassed in the foreseeable future, if ever!' From the foreword by Robert C. Moellering, Jr., M.D, Shields Warren-Mallinckrodt Professor of Medical Research, Harvard Medical School, USA Kucers' The Use of Antibiotics is the leading major reference work in this vast and rapidly developing field. More than doubled in length compared to the fifth edition, the sixth edition comprises 3000 pages over 2-volumes in order to cover all new and existing therapies, and emerging drugs not yet fully licensed. Concentrating on the treatment of infectious diseases, the content is divided into 4 sections: antibiotics, anti-fungal drugs, anti-parasitic drugs and anti-viral drugs, and is highly structured for ease of reference.Within each section, each chapter is structured to cover susceptibility, formulations and dosing (adult and paediatric), pharmacokinetics and pharmacodynamics, toxicity and drug distribution, detailed discussion regarding clinical uses, a feature unique to this title. Compiled by an expanded team of internationally renowned and respected editors, with a vast number of contributors spanning Europe, Africa, Asia, Australia, South America, the US and Canada, the sixth edition adopts a truly global approach. It will remain invaluable for anyone using antimicrobial agents in their clinical practice and provides in a systematic and concise manner all the information required when treating infections requiring antimicrobial therapy. Kucers' The Use of Antibiotics is available free to purchasers of the books as an electronic version on line or on your desktop: It provides access to the entire 2-volume print material It is fully searchable, so you can find the relevant information you need quickly Live references are linked to PubMed referring you to the latest journal material Customise the contents - you can highlight sections and make notes Comments can be shared with colleagues/tutors for discussion, teaching and learning The text can also be reflowed for ease of reading Text and illustrations copied will be automatically referenced to Kucers' The Use of Antibiotics
Acute Pain brings coverage of this diverse area together in a single comprehensive clinical reference, from the basic mechanisms underlying the development of acute pain, to the various treatments that can be applied to control it in different clinical settings. Much expanded in this second edition, the volume reflects the huge advances that continue to be made in acute pain management. Part One examines the basic aspects of acute pain and its management, including applied physiology and development neurobiology, the drugs commonly used in therapy, assessment, measurement and history-taking, post-operative pain management and its relationship to outcome, and preventive analgesia. Part Two reviews the techniques used for the management of acute pain. Methods of drug delivery and non-pharmacological treatments including psychological therapies in adults and children and transcutaneous electrical nerve stimulation are considered here. Part Three looks at the many clinical situations in which acute pain can arise, and the methods of treatment that may be suitable in each circumstance, whether the patient is young or old, has pain due to surgery, trauma, medical illness or childbirth, or is undergoing rehabilitation. Issues specific to the management of acute pain in the developing world are also covered here.
Now thoroughly updated to include new advances in the field,and with regular content updates to the eBook, Principles and Practice of Pediatric Oncology, 7th Edition remains the gold standard text for the care and research of children with cancer. This authoritative reference is the single most comprehensive resource on the biology and genetics of childhood cancer and the diagnosis, multimodal treatment, and long-term management of young patients with cancer. Also addressed are a broad array of topics on the supportive and psychosocial aspects of care of children and families. Covering virtually every aspect of the breadth and depth of childhood cancer, this 7th Edition provides expert guidance on state-of-the-art, multidisciplinary care for children and families. Stay up to date with the most recent advances in the field with the contributions by new and returning contributors, including the perspective from patients and parents in the chapter titled “The Other Side of the Bed.” Reference your eBook version for key updates in the field during the life of the edition! Chapters included on palliative care and education. Supportive care is covered broadly and specifically – in contexts such as emergencies, infectious disease, and nutrition. The most updated and authoritative information is provided by the leading experts in the field. Gain a thorough understanding of every aspect of pediatric oncology, with comprehensive information regarding basic science, diagnostic tools, principles of treatment, and clinical trials, as well as highly detailed, definitive coverage of each pediatric malignancy. Collaborate more effectively with others on the cancer care team to enhance quality-of-life issues for patients and families. Understand the cooperative nature of pediatric oncology as a model for cancer research with information from cooperative clinical trial groups and consortia.
Revised, extended and updated, this edition will continue as the core textbook for students of interpersonal communication as well as for professional groups such as counsellors, doctors, nurses, social workers and psychologists.
A state-of-the-art reference, drawing on key contemporary research to provide an in-depth, international, and competencies-based approach to the psychology of coaching and mentoring. Puts cutting-edge evidence at the fingertips of organizational psychology practitioners who need it most, but who do not always have the time or resources to keep up with scholarly research Thematic chapters cover theoretical models, efficacy, ethics, training, the influence of emerging fields such as neuroscience and mindfulness, virtual coaching and mentoring and more Contributors include Anthony Grant, David Clutterbuck, Susan David, Robert Garvey, Stephen Palmer, Reinhard Stelter, Robert Lee, David Lane, Tatiana Bachkirova and Carol Kauffman With a Foreword by Sir John Whitmore
An easy-to-use illustrated guide to building codes for residential structures As the construction industry moves to a single set of international building codes, architects and construction professionals need an interpretive guide to understand how the building code affects the early design of specific projects. This newest addition to Wiley’s series of focused guides familiarizes code users with the 2009 International Residential Code® (IRC) as it applies to residential buildings. The book provides architects, engineers, and other related building professionals with an understanding of how the International Residential Code was developed, and how it is likely to be interpreted when applied to the design and construction of residential buildings. • User-friendly visual format that makes finding the information you need quick and easy • The book’s organization follows the 2009 International Residential Code itself • Nearly 900 illustrations, by architectural illustrator Steven Juroszek in the style of noted illustrator and author Frank Ching, visualize and explain the codes • Text written by experienced experts who have been instrumental in gaining acceptance for the new unified building code This book is an essential companion to the IRC for both emerging practitioners and experienced practitioners needing to understand the new IRC.
Now more than ever, architects need an interpretive guide to understand how the building code affects the early design of specific projects. This easy-to-use, illustrative guide is part of a new series covering building codes based on the International Building Code for 2006. This book presents the complex code issues inherent to elementary and secondary school design in a clear, easily understandable format.
A compelling account of how incorporating play into work can help us overcome the uncertainty and turbulence that surrounds work How can we learn to deal with uncertainty at work? The answer, as Dodgson and Gann eloquently portray in this pathfinding book, is to learn from the adaptive behaviors of entrepreneurs. Play, the authors show, is a crucial component of this. It encourages exploration, experimentation, and curiosity while it also challenges established practices and orthodoxies. It facilitates change in people and organizations. Drawing on in-depth interviews with entrepreneurs and innovators, this book explains why we should incorporate play into work, what play looks like, and how to encourage playfulness in individuals and organizations. Dodgson and Gann identify four key behaviors that endorse, encourage, and guide play: grace, craft, fortitude, and ambition, and provide a blueprint for an alternative way of working that fosters resilience and encourages innovation and growth in difficult times.
The discipline of silviculture is at a crossroads. Silviculturists are under increasing pressure to develop practices that sustain the full function and dynamics of forested ecosystems and maintain ecosystem diversity and resilience while still providing needed wood products. A Critique of Silviculture offers a penetrating look at the current state of the field and provides suggestions for its future development. The book includes an overview of the historical developments of silvicultural techniques and describes how these developments are best understood in their contemporary philosophical, social, and ecological contexts. It also explains how the traditional strengths of silviculture are becoming limitations as society demands a varied set of benefits from forests and as we learn more about the importance of diversity on ecosystem functions and processes. The authors go on to explain how other fields, specifically ecology and complexity science, have developed in attempts to understand the diversity of nature and the variability and heterogeneity of ecosystems. The authors suggest that ideas and approaches from these fields could offer a road map to a new philosophical and practical approach that endorses managing forests as complex adaptive systems. A Critique of Silviculture bridges a gap between silviculture and ecology that has long hindered the adoption of new ideas. It breaks the mold of disciplinary thinking by directly linking new ideas and findings in ecology and complexity science to the field of silviculture. This is a critically important book that is essential reading for anyone involved with forest ecology, forestry, silviculture, or the management of forested ecosystems.
Endocrinology: Adult and Pediatric: Reproductive Endocrinology is a new eBook from the same experts responsible for the highly acclaimed two-volume Endocrinology clinical reference book. It puts all of the latest advances in adult and pediatric reproductive endocrinology at your fingertips, instantly accessible on your favorite eReader - so you can give your patients the benefit of today’s best know-how. Stay abreast of the newest knowledge in reproductive endocrinology, including endocrinology of sexual behavior and gender identity; genetic pathways that control gonadal development and sex differentiation; management of PCOS and hirsutism; management of male androgen deficiency; management of gynecomastia; and much more. Effectively review the causes and management of precocious or delayed puberty. Count on all the authority that has made Endocrinology, 6th Edition, edited by leading endocrinologists Drs. Jameson and DeGroot, the go-to clinical reference for endocrinologists worldwide. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Compatible with Kindle®, nook®, and other popular devices.
Publisher's Note: Products purchased from 3rd Party sellers are not guaranteed by the Publisher for quality, authenticity, or access to any online entitlements included with the product. For more than 30 years, Perez and Brady's Principles and Practice of Radiation Oncology has been the must-have standard reference for radiation oncologists and radiation oncology residents who need a comprehensive text covering both the biological and physical science aspects of this complex field as well as disease site-specific information on the integrated, multidisciplinary management of patients with cancer. The book has established itself as the discipline’s "text-of-record," belonging on the shelf of all of those working in the field. The Seventh Edition continues this tradition of excellence with extensive updates throughout, many new chapters, and more than 1,400 full-color illustrations that highlight key concepts in tumor pathogenesis, diagnosis, and targeted radiation therapy.
Perhaps no other public policy issue has greater potential to affect some of the most significant economic, political, social, and ethical changes of the 21st century than global health. In this book, a scholar/physician team authors a comprehensive introduction to global health issues and emphasises the potential of public health intervention to improve the longevity and quality of human life across the globe. The authors have lived and worked in Africa as well as in medically underserved areas of the United States, so they write with firsthand experience and authority. Using themes of interconnectedness, globalisation, and united concern from citizens, this book encourages readers to consider the role that they might play as engaged citizens in taking on the global public health challenges of the 21st century including everything from AIDs and flu to tobacco, obesity, and threats in conflict zones.
This book is a unique treatment manual which looks at the assessment of BDD, offering an treatment model in the form of CBT and pharmacotherapy Summarises the current knowledge and theoretical perspectives about BDD Covers the practical aspects of assessment, engagement, and therapy Uses a number of practical resources, including client handouts
Now more than ever, architects need an interpretive guide to understand how the building code affects the early design of specific projects. This easy-to-use, illustrative guide is part of a new series covering building codes based on the International Building Code for 2006. This book presents the complex code issues inherent to healthcare facility design in a clear, easily understandable format.
This new edition fills an important gap in the literature by providing a concise treatment of pediatric neurology that focuses on the most commonly seen diseases with clinical guidelines that help today« busy practitioner find answers quickly. The book is divided into three sections starting with the tools required for a pediatric neurologic evaluation, then moving through classic disease states and disorders with the last section focusing on approaches to key clinical problems in children and adolescents. Each section is edited by the key opinion leaders in the field with dynamic features that get to the information quickly including: Tools for diagnosis Chapter opening outlines Disease "Features" tables "Pearls and Perils" boxes "Consider Consultation When« " boxes Selected annotated bibliographies Key Clinical Questions
lt is a tremendous achievement to have provided this highly comprehensive but readable text, which informs such a large group of researchers and clinicians." Christopher Kennard, PhD, FRCP, FMedSci, Professor of Clinical Neurology, Head, Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom. "A monograph written with deep knowledge, understanding, wisdom, clarity, intelligibility - the superlatives could go on and on... A remarkable achievement and a great gift to all of us from the two modern giants of eye movement disorders." Michael Halmagyi, MD, Eye and Ear Research Unit, Neurology Department, Royal Prince Alfred Hospital, The University of Sydney, Australia. "The fifth edition of The Neurology of Eye Movements is a must for all neurologists and neuroscientists interested in how the human vestibular and oculomotor systems adapt to movement in space and to optimally viewing the world and its contents." Louis R. Caplan, MD, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
Textbook of Assisted Reproductive Technologies is a truly comprehensive manual for the whole team at the IVF clinic. Information is presented in a highly visual manner, allowing both methods and protocols to be consulted easily. The text provides clinical and scientific teams with the A to Zs of setting up an embryology laboratory, gives research fellows insight into technical developments, and supplies seasoned professionals with a review of the latest techniques and advances. New to the Third Edition: fully revised and expanded chapters, with new information on: single embryo transfer artificial gametes pharmacogenetics
Since the publication of the first edition of Chemistry of Protein Conjugation and Cross-Linking in 1991, new cross-linking reagents, notably multifunctional cross-linkers, have been developed and synthesized. The completion of the human genome project has opened a new area for studying nucleic acid and protein interactions using nucleic acid cross
Long recognized as the standard general reference work providing a complete overview of contemporary gynaecological practice, this new edition of Shaw, Gynaecology provides all the information that trainees need to master in order to successfully take their professional certification exams as well as providingthe practicing gynaecologist with an accessible overview of the "state of play" of diagnostic and therapeutic procedures. Totally rewritten, it gives a succinct but comprehensive account of all currently available resources in the management of gynaecological disorders. Comprehensive overview of contemporary gynaecological practice with a clinically focused approach. It covers all of the areas that a gynaecologist covers on a day-to-day basis and helps in the formulation and implementation of the most effective treatment. Details the use of various imaging modalities and investigative techniques as they relate to specific diseases in order to provide a solid foundation for clinical practice. User-friendly features such as chapter outlines, summary tables, key point boxes incorporated throughout.Provides quick access to the most necessary information for practitioners needing a quick consult or trainees preparing for exams. Copiously illustrations clarify and enhance the text whenever appropriate. Highly selective and current list of references quickly directs the reader to further investigations. New full colour illustrations incorporated throughout to accurately depict the full range of both common and rare disorders. Details up-to-date investigative and minimally invasive therapeutic techniques to keep the user abreast of the latest diagnostic and management options. Enhanced emphasis on surgical outcomes to help the user select the most appropriate procedure for any given patient. Two brand new editors and many brand new contributors provide a fresh perspectives on gynaecological oncology, reproductive and urogynaecological conditions.
The Eerdmans Dictionary of the Bible gathers nearly 5,000 alphabetically ordered articles that thoroughly yet clearly explain all the books, persons, places, and significant terms found in the Bible. The Dictionary also explores the background of each biblical book and related writings and discusses cultural, natural, geographical, and literary phenomenae matters that Bible students at all levels may encounter in reading or discussion. Nearly 600 first-rate Bible authorities have contributed to the Eerdmans Dictionary of the Bible. Intended as a tool for practical Bible use, this illustrated dictionary reflects recent archaeological discoveries and the breadth of current biblical scholarship, including insights from critical analysis of literary, historical, sociological, and other methodological issues. The editorial team has also incorporated articles that explore and interpret important focuses of biblical theology, text and transmission, Near Eastern archaeology, extrabiblical writings, and pertinent ecclesiastical traditions - all of which help make the Eerdmans Dictionary of the Bible the most comprehensive and up-to-date one-volume Bible dictionary on the market today.
Clinical application of antithrombotic therapy in both arterial disease (acute coronary syndromes, acute MI, peripheral arterial disease, valvular heart disease, atrial fibrillation) and venous disease, (venous thromboembolic disease and pulmonary embolism). Results of major clinical trials and their implications for clinical practice.
Acute Pain brings coverage of this diverse area together in a single comprehensive clinical reference, from the basic mechanisms underlying the development of acute pain, to the various treatments that can be applied to control it in different clinical settings. Much expanded in this second edition, the volume reflects the huge advances that contin
Praised by JAMA as "The most complete description of the development, structure, function, pathophysiology, and treatment of the retina and its diseases to be found anywhere," this monumental three-volume work puts all of today's scientific and clinical knowledge of the retina at readers' fingertips. The New Edition has been comprehensively updated and reorganized to reflect all of the very latest scientific and genetic discoveries, diagnostic imaging methods, drug therapies, treatment recommendations, and surgical techniques. The result is an indispensable reference and diagnostic tool for generalists and specialists alike. Delivers the editorial expertise of four highly respected authorities, as well as contributions from internationally recognized leaders in visual science, ophthalmology, and vitreoretinal studies. Presents more than 3,400 superb illustrations (2,200 in full color) that capture all forms of retinal disease from every perspective. Offers the very latest information on the genetic basis of retinal disease, diagnostic retinal imaging, photodynamic therapy, and age-related macular degeneration. Examines the most recent advances in diagnostic indocyanine green angiography � optical coherence tomography (OCT) and quantitative fluoroscein angiography � macular translocation with 360� peripheral retinectomy � surgery for diffuse macular edema due to multiple causes, including proliferative vitreoretinopathy � artificial vision � and much more. Features a completely restructured section on age-related macular degeneration that includes epidemiology and risk factors � prophylaxis and prevention knowledge gained from large clinical trials like AREDS � proven and experimental treatments for AMD � and pharmacotherapy. Incorporates a multitude of new full-color images, 2200 in all.
The new edition of Cardiac Intensive Care—the only textbook dedicated to cardiac intensive care medicine—chronicles the progress made in the diagnosis, assessment, and treatment of patients with critical cardiac illness. Editors Allen Jeremias, MD, MSc and David L. Brown, MD present the landmark discoveries, greater understanding of syndromes, and technological advancements that have helped make clinical cardiology a progressive and interventional field. You’ll get coverage of the plethora of noncoronary diseases in the CICU, as well as a complete compendium of up-to-date pharmacologic agents. The new full-color design and layout and nine new chapters give you the latest theoretical, technical, diagnostic, and therapeutic advances in an accessible and visually appealing format. Features the authoritative perspectives of a stellar group of contributors—many of whom are the pioneers in the fields they cover—for the best available guidance. Provides the basic science framework for the clinical material through a section on the scientific foundation of cardiac intensive care to give you the complete picture. Presents a pharmacological introduction to the classes of drugs so you know which are most commonly used in the CICU. Covers which noncoronary diseases frequently result in admittance to the CICU to prepare you for those diagnoses that are not of a cardiac nature. Features nine new chapters—Quality Assurance and Improvement in the Cardiac Intensive Care Unit; Physical Examination in the CICU; Mechanical Treatments for Acute ST-Elevation MI; Non-ST Elevation Myocardial Infarction: Diagnosis, Prognosis, Risk Stratification, and Management; Glycoprotein IIb/IIIa Inhibitors; Vascular Access Procedures; Ventilator Management for the Cardiac Patient; Management of Post-Operative Complications in the Cardiac Surgery Patient; Guidelines Relevant to Care in the Cardiac Intensive Care Unit—to keep the book and you up to date. Presents the text in a new, full-color design and layout for a more visually-appealing and accessible format that makes finding the information you need quick and easy.
Textbook of Assisted Reproductive Technologies is a truly comprehensive manual for the whole team at the IVF clinic. Information is presented in a highly visual manner, allowing both methods and protocols to be consulted easily. The text provides clinical and scientific teams with the A to Zs of setting up an embryology laboratory, gives research fellows insight into technical developments, and supplies seasoned professionals with a review of the latest techniques and advances. New to the Third Edition: fully revised and expanded chapters, with new information on: single embryo transfer artificial gametes pharmacogenetics
Social Justice and Counseling represents the intersection between therapy, counseling, and social justice. The international roster of contributing researchers and practitioners demonstrate how social justice unfolds, utterance by utterance, in conversations that attend to social inequities, power imbalances, systemic discrimination, and more. Beginning with a critical interrogation of the concept of social justice itself, subsequent sections cover training and supervising from a social justice perspective, accessing local knowledge to privilege client voices, justice and gender, and anti-pathologizing and the politics of practice. Each chapter concludes with reflection questions for readers to engage experientially in what authors have offered. Students and practitioners alike will benefit from the postmodern, multicultural perspectives that underline each chapter.
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