Publisher's Note: Products purchased from 3rd Party sellers are not guaranteed by the Publisher for quality, authenticity, or access to any online entitlements included with the product. Master the unique, multi-faceted role of the Canadian nurse. Confidently embark on a lifelong learning journey and prepare for the daily realities of Canadian nursing practice this with comprehensive, Canadian-focused text. Developed specifically for your needs by talented Canadian students, practicing nurses, scholars, and educators, Fundamentals: Perspectives on the Art and Science of Canadian Nursing, 2nd Edition, delivers an integrated understanding of nursing fundamentals through a continuum that guides you from one chapter to the next and from learning to understanding. New! Inter-Professional Practice helps you achieve positive patient outcomes through effective collaboration with the healthcare team. New! Diversity Considerations alert you to important patient care considerations related to culture, sexuality, gender, economics, visible minorities, and religious beliefs. New! NCLEX®-style questions at the end of each chapter test your retention and ready you for success on your exams. Revised! Skills chapters familiarize you with a wide variety of advanced skills to broaden your clinical capabilities. Enhanced focus on LGBTQ-related considerations, demographic shifts in Canadian society, end-of-life/palliative care, substance abuse crises, and refugee communities helps you ensure confident care across diverse Canadian populations. Case Studies place chapter content in a realistic context for the most practical understanding. Think Boxes encourage critical thinking and challenge you to apply your knowledge to different situations. Through the Eyes features familiarize you with patients’ perspectives to help you provide thoughtful and effective care interventions. Research equips you with the latest and most relevant Canadian healthcare findings based on clinical evidence. Critical Thinking Case Scenarios strengthen your clinical focus and critical thinking through real-life situations.
The science of toxicology has progressed considerably since Molecular Toxicology was first published in 1997. New advances in biochemical and molecular biological experimental techniques have helped researchers understand the precise effects of toxins and foreign compounds on living things atthe molecular, cellular, and organismal levels. Breakthrough research has recently been completed illuminating the human genome and the role of enzymes in toxic biochemical reaction mechanisms. Toxicology now covers drug metabolism and design, carcinogenesis, programmed cell death, and DNA repair,among other subjects. The second edition captures these and other advances, and broadens its scope to address the experimental science of toxicology. The first edition of Molecular Toxicology has become an indispensable resource for graduate students in molecular and biochemical toxicology courses,as well as academic researchers and industrial researchers in toxicology. Rigorously updated and revised, the new edition commands an unrivaled authority in the field of molecular toxicology.
Cognitive Neuroscience of Language provides an up-to-date, wide-ranging, and pedagogically practical survey of the most important developments in this exciting field. It guides students through all of the major areas of investigation, beginning with the fundamental aspects of brain structure and function and then following with key topics such as classic and progressive aphasia syndromes; speech perception and production; the meanings of object nouns, action verbs, and abstract words; the formulation and comprehension of complex expressions, including grammatically inflected words, complete sentences, and entire stories; and several other domains of neurolinguistic research, including reading and writing, sign language, and the bilingual brain. Drawing heavily on prominent theoretical models, the core chapters illustrate how such frameworks are supported, and sometimes challenged, by experiments employing diverse brain mapping techniques. This edition has been thoroughly updated throughout, and now includes a dedicated chapter on the neural substrates of bilingualism. Chapters have been revised to reflect the most salient developments in the field, and the book has undergone a thoughtful restructure to mirror course teaching. While the study of language can be challenging, the text has been written accessibly and requires no previous knowledge of either neuroscience or linguistics and includes definitions of technical terms and explanations of important principles from both disciplines along the way. Accompanied by online resources for students and instructors, it is an essential companion for graduate or upper-level undergraduate students.
Modeling schizophrenia in animals represents a formidable challenge because the most characteristic symptoms of this disorder, auditory hallucinations and delusional beliefs, cannot be directly modeled in animals. Furthermore, limited current understanding of the etiology and pathophysiology underlying the clinical features of this disorder greatly hinders the ability to develop valid models based on those aspects. To circumvent these issues, investigators have attempted to recreate the leading candidate biochemical, neuroanatomical, and genetic abnormalities for this disorder in animals using pharmacological, developmental, neurotoxic, genetic engineering, and other methods. The validity of these animal preparations as animal models for schizophrenia is generally based upon the extent to which they induce measurable behavioral changes that are homologous or analogous to the core clinical features or the information-processing endophenotypes (presymptom phenotypes) that are seen in schizophrenia. The utility of any animal model to serve as a screen for novel treatments is considered related to the extent to which the schizophrenia-relevant behaviors it exhibits can be ameliorated by drugs with known efficacy in schizophrenia but not by drugs known to be therapeutic for brain disorders other than schizophrenia.
The impending energy crisis brought on by the running out of finite and non-homogenously distributed fossil fuel reserves and the worldwide increase in energy demand has prompted vast research in the development of sustainable energy technologies in the last few decades. However, the efficiency of most of these new technologies is relatively small and therefore it needs to be increased to eventually replace conventional technologies based on fossil fuels. The required efficiency increase primarily relies on the ability to improve the performance of the functional materials which are at the heart of these technologies. The purpose of this book is to give a unified and comprehensive presentation of the fundamentals and the use and design of novel materials for efficient sustainable energy applications, such as conversion, storage, transmission, and consumption. The book presents general coverage of the use and design of advanced materials for sustainable energy applications. Thus, the book addresses all the relevant aspects, such as materials for energy conversion, storage, transmission, and consumption.
One of the major experimental difficulties in studying materials at extreme temperatures is unwanted contamination of the sample through contact with the container. This can be avoided by suspending the sample through levitation. This technique also makes metastable states of matter accessible, opening up new avenues of scientific enquiry, as well as possible new materials for technological applications. This book describes several methods of levitation, the most important being aerodynamic, electromagnetic and electrostatic. It summarizes the state-of-the-art of the measurement of structural, dynamic and physical properties with levitation techniques, the considerable progress made in this field in the past two decades, and prospects for the future. It also explores the concepts behind the experiments and associated theoretical ideas. Aimed at researchers in physics, physical chemistry and materials science, the book is also of interest to professionals working in high-temperature materials processing and the aerospace industry.
Excavation of seven turf buildings at Lair in Glen Shee confirms the introduction of Pitcarmick buildings to the hills of north-east Perth and Kinross in the early 7th century AD. Clusters of these at Lair, and elsewhere in the hills, are interpreted as integrated, spatially organised farm complexes comprising byre-houses and outbuildings.
Over the past two decades a number of attempts have been made, with varying degrees of success, to collect in a single treatise available information on the basic and applied pharmacology and biochemical mechanism of action of antineoplastic and immunosuppressive agents. The logarithmic growth of knowledge in this field has made it progressively more difficult to do justice to all aspects of this topic, and it is possible that the present handbook, more than four years in preparation, may be the last attempt to survey in a single volume the entire field of drugs employed in cancer chemotherapy and immunosuppression. Even in the present instance, it has proved necessary for practical reasons to publish the material in two parts, although the plan of the work constitutes, at least in the editors' view, a single integrated treatment of this research area. A number of factors have contributed to the continuous expansion of research in the areas of cancer chemotherapy and immunosuppression. Active compounds have been emerging at ever-increasing rates from experimental tumor screening systems maintained by a variety of private and governmental laboratories through out the world. At the molecular level, knowledge of the modes of action of established agents has continued to expand, and has permitted rational drug design to play a significantly greater role in a process which, in its early years, depended almost completely upon empirical and fortuitous observations.
To address the growing complexities of childhood cancer, Nathan and Oski’s Hematology and Oncology of Infancy and Childhood has now been separated into two distinct volumes. With this volume devoted strictly to pediatric oncology, and another to pediatric hematology, you will be on the cutting edge of these two fields. This exciting new, full-color reference provides you with the most comprehensive, authoritative, up-to-date information for diagnosing and treating children with cancer. It brings together the pathophysiology of disease with detailed clinical guidance on diagnosis and management for the full range of childhood cancers, including aspects important in optimal supportive care. Written by the leading names in pediatric oncology, this resource is an essential tool for all who care for pediatric cancer patients. Offers comprehensive coverage of all pediatric cancers, including less common tumors, making this the most complete guide to pediatric cancer. Covers emerging research developments in cancer biology and therapeutics, both globally and in specific pediatric tumors. Includes a section on supportive care in pediatric oncology, written by authors who represent the critical subdisciplines involved in this important aspect of pediatric oncology. Uses many boxes, graphs, and tables to highlight complex clinical diagnostic and management guidelines. Presents a full-color design that includes clear illustrative examples of the relevant pathology and clinical issues, for quick access to the answers you need. Incorporates the codified WHO classification for all lymphomas and leukemias.
In this paper, we survey the rapidly developing literature on macroprudential stress-testing models. The scope of the survey includes models of contagion between banks, models of contagion within the wider financial system including non-bank financial institutions such as investment funds, and models that emphasise the two-way interaction between the financial sector and the real economy. Our aim is two-fold: first, to provide a reference guide of the state-of-the-art for those developing such models; second, to distil insights from this endeavour for policy-makers using these models. In our view, the modelling frontier faces three main challenges: (a) our understanding of the potential for amplification in sectors of the non-bank financial system during periods of stress, (b) multi-sectoral models of the non-bank financial system to analyse the behaviour of the overall demand and supply of liquidity under stress and (c) stress testing models that incorporate comprehensive two-way interactions between the financial system and the real economy. Emerging lessons for policy-makers are that, for a given-sized shock hitting the system, its eventual impact will depend on (a) the size of financial institutions' capital and liquidity buffers, (b) the liquidation strategies financial institutions adopt when they need to raise cash, and (c) the topology of the financial network.
This handbook is a comprehensive collection of measures and assessment tools intended for use by researchers and clinicians that work with people with problem eating behaviors, obese clients, and the associated psychological issues that underlie these problems.
Health and Safety Communication: A Practical Guide Forward is an easy introduction to the principles and practice of health and safety communications, providing all you need to know to design and implement communications efforts on a wide range of health and safety topics and issues. Whether you're a student grappling with a health communications course or a professional wishing to learn how to communicate health and safety messages effectively to a range of audiences using a variety of communications media, Health and Safety Communication is all you'll need. This book incorporates two broad sections: the grounding and the applications. The model articulates a planning approach for designing, implementing and reviewing a range of communications approaches. The applications segment specifies numerous approaches, including workshops, print materials, campaigns, the media, public speaking and social media that can be used to convey what the health and safety specialist wants the audience to "know, feel and do" as a result of engagement with the communications approach. Health and Safety Communication blends sound foundations with practical strategies for health and safety communication so that messages can be communicated more effectively; after all, for changes to occur, the message must be received and respected. Unique features of this book include a wide range of approaches and strategies, with numerous examples and tips provided throughout. "Messages from the field" incorporate examples and samples from over 30 individuals and organizations, offering their insights and suggestions. The applied approach of this definitive guide is designed to enhance the competence and confidence of those currently in health or safety arenas, as well as those seeking to incorporate health or safety messages in other settings such as businesses or communities.
Lost City, Found Pyramid: Understanding Alternative Archaeologies and Pseudoscientific Practices explores the phenomenon of pseudoarchaeology in popular culture and the ways that professional archaeologists can respond to sensationalized depictions of archaeology and archaeologists.
Intending this work as a companion to his textbook Essentials of International Management: A Cross-Cultural Perspective (Sage, 2001), Thomas (Simon Frazer U.) groups his collection of 18 readings and 21 case studies around the same themes as the earlier textbook: the influence of culture on internat
DNA in the nucleus of plant and animal cells is stored in the form of chromatin. Chromatin and the chromatin remodelling enzymes play an important role in gene transcription. - Genetic assays of chromatin modification and remodeling - Histone modifying enzymes - ATP-dependent chromatin remodeling enzymes
Authored by two leading investigators, this book presents a thorough and authoritative overview of this multifaceted field of science. Pathogenic bacteria have been evolving and spreading resistance to diverse classes of antibiotics. As a result, we risk losing our ability to control and treat infectious diseases. Understanding antibiotic resistance, therefore, is becoming increasingly essential for a broad audience of healthcare professionals, biomedical and public health researchers, students, and policymakers. The authors answer questions such as: What is resistance? How does it emerge? How do common human activities contribute to resistance? What can we do about it? How can we strengthen our “first lines of defense” against resistance? Are there better ways to discover new antibiotics? What unique issues are associated with MRSA and viral influenza? In addition to defining and evaluating one of the most important emerging threats to public health, the authors explain what can be done to minimize risks to public health, and to preserve and extend the effectiveness of existing and new antibiotics.
This issue of Veterinary Clinics of North America: Food Animal Practice focuses on Bovine Surgery. Article topics include: Local, regional, and spinal anesthesia in ruminants; Field sedation and anesthesia of ruminants; Respiratory Surgery; Surgery of the sinuses and eyes; Surgical procedures of the forestomachs; Surgical Management of Abomasal disease; Intestinal surgery; Surgery of the Umbilicus and Related Structures; Female reproductive surgery; Male reproductive surgery; Surgical management of the teats and udder; and more!
This book examines young people's involvement in crime (including crimes of violence, vandalism, shoplifting, burglary and car crime) as both victims and offenders. Although adolescence is the time when involvement in crime peaks, few previous UK-based studies have attempted to provide a methodical and comprehensive understanding of adolescent offending on a city-wide basis. This book seeks a better understanding of adolescent crime by studying the relationship between individual characteristics (social bonds and morality and self-control) and lifestyles (as defined by delinquent peers, substance use and exposure to risky behaviour settings) and their joint influence on adolescent involvement in crime, against the backdrop of the juveniles' social context - taking into account family, school and neighbourhood influences. The findings of this study suggest the existence of three main groups of adolescent offenders; propensity induced offenders, life-style dependent offenders and situationally limited offenders, groups of offenders having different causal backgrounds to their crime involvement, and who therefore may warrant different strategies for effective prevention.
One of the most problematic areas in the teaching and development of literacy appears to concern children's interactions with non-fiction books. Many surveys and reports have commented on the tendency for children to do little more than copy out sections of non-fiction texts. The Exeter Extending Literacy (EXEL) project was set up with the aim of exploring ways in which non-fiction might be used more effectively and profitably than this. In this book David Wray and Maureen Lewis outline the thinking behind the project and describe in detail the many useful teaching strategies and approaches which were developed in collaboration with primary teachers across the country. Teachers of children from five to fourteen will find this book both a stimulating account of a very influential development project and a useful source of practical teaching ideas.
Children and adolescents with intellectual and developmental disabilities are at high risk of co-morbid emotional, behavioural, and psychiatric problems that may further reduce their functional abilities. For the clinicians who support them and their families, meeting the needs of children and adolescents with intellectual and developmental disabilities and mental health problems is challenging. In this book, clinicians who work with young people with intellectual and developmental disabilities and mental health problems will find a comprehensive framework for how their complex needs might best be addressed. Relevant biological, developmental, family, educational, social, and cultural factors are integrated. The evolution of developmental sequence is seen as vital to understanding the mental health problems of young people with disabilities. This view informs multi-dimensional assessment of behaviour, and addresses conceptual confusion in defining behaviour problems, developmental disorders, mental disorders, and serious mental illnesses. Evidence-based interventions to promote skill development and mental health in young people with disabilities are described. A model for how interdisciplinary and multi-agency collaboration and co-ordination might be facilitated is outlined. Parents’ perspectives are also presented. Fundamentally, though, this is a book by clinicians, for clinicians. All clinicians and other professionals who work to improve mental health outcomes and quality of life more generally for young people who have intellectual and developmental disabilities - paediatricians, child psychiatrists, psychologists, speech pathologists, occupational therapists, social workers, behaviour clinicians, counsellors, teachers, agency managers, among others – will find the book invaluable.
Inspired by a collection of reflective blog posts on patient safety and quality improvement shared by medical and nursing education participants as a result of attending the Academy for Emerging Leaders in Patient Safety's four-day summer immersion "camp" called the Telluride Experience (TTE). Program's goal is to help fill gaps in health science education curriculum and to prepare future health care leaders in making sustainable improvements in patient care throughout their careers.
An expert guide to targeting protein kinases in cancer therapy Research has shown that protein kinases can instigate the formation and spread of cancer when they transmit faulty signals inside cells. Because of this fact, pharmaceutical scientists have targeted kinases for intensive study, and have been working to develop medicinal roadblocks to sever their malignant means of communication. Complete with full-color presentations, Targeting Protein Kinases for Cancer Therapy defines the structural features of protein kinases and examines their cellular functions. Combining kinase biology with chemistry and pharmacology applications, this book enlists emerging data to drive the discovery of new cancer-fighting drugs. Valuable information includes: Comprehensive overviews of the major kinase families involved in oncology, integrating protein structure and function, and providing important tools to assist pharmaceutical researchers to understand and work in this dynamic area of cancer drug research Focus on small molecule inhibitors as well as other therapeutic modalities Discussion of kinase inhibitors that have entered clinical trials for the treatment of cancer, with an emphasis on molecules that have progressed to late stage clinical trials and, in a few cases, to market Providing a platform for further study, this important work reviews both the successes and challenges of kinase inhibitor therapy, and provides insight into future directions in the war against cancer.
This book highlights the results from over a year of ethnobotanical research in a rural and an urban community in Jamaica, where we interviewed more than 100 people who use medicinal plants for healthcare. The goal of this research was to better understand patterns of medicinal plant knowledge, and to find out which plants are used in consensus by local people for a variety of illnesses. For this book, we selected 25 popular medicinal plant species mentioned during fieldwork. Through individual interviews, we were able to rank plants according to their frequency of mention, and categorized the medicinal uses for each species as “major” (mentioned by more than 20% of people in a community) or “minor” (mentioned by more than 5%, but less than 20% of people). Botanical identification of plant specimens collected in the wild allowed for cross-linking of common and scientific plant names. To supplement field research, we undertook a comprehensive search and review of the ethnobotanical and biomedical literature. Our book summarizes all this information in detail under specific sub-headings.
Clinical information for Otolaryngologists is provided in topics that include: Imaging and Anatomy; Genetics of Hearing Loss, Testing and Relevance to Cochlear Implantation; Candidacy Evaluation, Medical and Surgical Considerations, expanding criteria in Children; Surgical Technique and Accepted Variations in Children; Bilateral Cochlear Implantation; Implanting Obstructed and Malformed Cochleae; Device Programming NRT, NRI, Streamlined programming; Cochlear Implants and Music; Rehabilitation and Educational Considerations; Outcomes and Variables Affecting Outcomes; Language Development and Cochlear Implantation; New Frontiers in Cochlear Implantation, electroacoustic, hearing preservation, etc; Revision Cochlear Implantation in Children; and Current and Future Device Options.
Entrepreneurship is a key element in the development of market based economies and one of the potential drivers of change in countries that are in the process of transformation to market based systems. This book describes and critically assesses the nature and extent of female entrepreneurship in European economies that until 1990 were operating under central planning. At the core of the book are 7 country based chapters which provide an overview of the development of entrepreneurship and small firms since 1990, including a review of the institutional and policy context; an assessment of the role of women within the society during the socialist period; and any major changes afterwards. Each chapter also includes a thematic section (each one addressing a different issue) based on unique empirical data drawn from original research.
This popular and well received standard text on Entrepreneurship has been completely revised and updated for the second edition. The text retains the favourably reviewed features of the first edition which include the importance of context, diversity and differing international entrepreneurial practice, yet is underpinned by coverage and application of relevant theory. In particular, the text now contains important and entirely new sections on entrepreneurship in the face of multiple global crises, evidence on entrepreneurial resilience, new case study material on examples of international entrepreneurship from developing countries including a new section on Entrepreneurship in Sub-Saharan Africa, new case material on ‘clean technology’ entrepreneurship and on green finance, and a new chapter on Indigenous Entrepreneurship. All chapters have been completely updated to reflect increased diversity and the place of Entrepreneurship in the context of multiple global crises. The text retains the pedagogic features of the first edition which are consistent throughout the text and include learning outcomes, boxed case studies with discussion questions, policy and practical issues, summaries of each chapter, recommended reading and suggested assignments. The text is complemented by online support material for tutors.
Breast Cancer, Second Editionis intended to provide a comprehensive description of current and evolving aspects of breast cancer including the biologic basis of disease, epidemiology, risk assessment, diagnostic evaluation, treatment strategies, and surveillance measures. The second edition expands considerably on the first edition, containing greater emphasis on issues relevant to medical oncology and the broader oncology community. New to this edition are chapters on the male breast, breast cancer in the augmented breast and breast cancer in multiethnic/multiracial populations. Part of the American Cancer Society’s acclaimedAtlas of Clinical Oncology series, this volume offers an expert overview of breast cancer. Topics range from epidemiology and genetics to diagnosis, management and reconstruction. Post-treatment care, as well as male breast cancer, is also discussed.
Biochemistry: The Chemical Reactions of Living Cells is a well-integrated, up-to-date reference for basic chemistry and underlying biological phenomena. Biochemistry is a comprehensive account of the chemical basis of life, describing the amazingly complex structures of the compounds that make up cells, the forces that hold them together, and the chemical reactions that allow for recognition, signaling, and movement. This book contains information on the human body, its genome, and the action of muscles, eyes, and the brain.* Thousands of literature references provide introduction to current research as well as historical background* Contains twice the number of chapters of the first edition* Each chapter contains boxes of information on topics of general interest
Focused on the practical management of patients with common clinical conditions In the Clinic offers evidence-based answers to frequently asked questions about screening, prevention, diagnosis, therapy, and patient education and provides physicians with tools to improve the quality of care.
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