I am unaware of any textbook which provides such comprehensive coverage of the field and doubt that this work will be surpassed in the foreseeable future, if ever!' From the foreword by Robert C. Moellering, Jr., M.D, Shields Warren-Mallinckrodt Professor of Medical Research, Harvard Medical School, USA Kucers' The Use of Antibiotics is the leading major reference work in this vast and rapidly developing field. More than doubled in length compared to the fifth edition, the sixth edition comprises 3000 pages over 2-volumes in order to cover all new and existing therapies, and emerging drugs not yet fully licensed. Concentrating on the treatment of infectious diseases, the content is divided into 4 sections: antibiotics, anti-fungal drugs, anti-parasitic drugs and anti-viral drugs, and is highly structured for ease of reference.Within each section, each chapter is structured to cover susceptibility, formulations and dosing (adult and paediatric), pharmacokinetics and pharmacodynamics, toxicity and drug distribution, detailed discussion regarding clinical uses, a feature unique to this title. Compiled by an expanded team of internationally renowned and respected editors, with a vast number of contributors spanning Europe, Africa, Asia, Australia, South America, the US and Canada, the sixth edition adopts a truly global approach. It will remain invaluable for anyone using antimicrobial agents in their clinical practice and provides in a systematic and concise manner all the information required when treating infections requiring antimicrobial therapy. Kucers' The Use of Antibiotics is available free to purchasers of the books as an electronic version on line or on your desktop: It provides access to the entire 2-volume print material It is fully searchable, so you can find the relevant information you need quickly Live references are linked to PubMed referring you to the latest journal material Customise the contents - you can highlight sections and make notes Comments can be shared with colleagues/tutors for discussion, teaching and learning The text can also be reflowed for ease of reading Text and illustrations copied will be automatically referenced to Kucers' The Use of Antibiotics
Religion in Sociological Perspective introduces students to the systems of meaning, structure, and belonging that make up the complex social phenomena we know as religion. Authors Keith A. Roberts and David Yamane use an active learning approach to illustrate the central theories and methods of research in the sociology of religion and show students how to apply these analytical tools to new groups they encounter.
Founding the Far West is an ambitious and vividly written narrative of the early years of statehood and statesmanship in three pivotal western territories. Johnson offers a model example of a new approach to history that is transforming our ideas of how America moved west, one that breaks the mold of "regional" and "frontier" histories to show why Western history is also American history. Johnson explores the conquest, immigration, and settlement of the first three states of the western region. He also investigates the building of local political customs, habits, and institutions, as well as the socioeconomic development of the region. While momentous changes marked the Far West in the later nineteenth century, distinctive local political cultures persisted. These were a legacy of the pre-Civil War conquest and settlement of the regions but no less a reflection of the struggles for political definition that took place during constitutional conventions in each of the three states. At the center of the book are the men who wrote the original constitutions of these states and shaped distinctive political cultures out of the common materials of antebellum American culture. Founding the Far West maintains a focus on the individual experience of the constitution writers—on their motives and ambitions as pioneers, their ideological intentions as authors of constitutions, and the successes and failures, after statehood, of their attempts to give meaning to the constitutions they had produced.
(Book). You may not have heard of them, but you have certainly heard their songs! From the lo-fidelity origins of early pioneers to today's dazzling technocrats, the role of the music producer is as murkily undefined as it is wholly essential. Sonic Alchemy: Visionary Music Producers and Their Maverick Recordings is an exploration of the influence of the often colorful, idiosyncratic and visionary music producers through popular music and the fascinatingly crucial role they have played in shaping the way we hear pop music today. Sonic Alchemy is nothing short of the secret history of the music producer.
After losing a loved one, "pay attention to the ways in which your relationship continues." So advised Sarah Horowitz in an interview she gave the day before her unexpected death. In A Cracking of the Heart, David Horowitz explores the legacy of his extraordinary daughter's short life, and narrates his quest for a deeper understanding of the child he lost. A remarkable woman and gifted writer, Sarah was afflicted with a birth condition that, while complicating and ultimately shortening her life, never affected her dreams. From an early age, she displayed inspiring courage in facing her own difficulties and boundless compassion. Alternately searing and uplifting, this book reconciles what could have been with what is, taking the reader through a father's love, frustration, admiration, and grief, to what lies beyond.
“When Meadows’s men set sail, it’s sure to be a mission like no other.”—W.E.B. Griffin Over the waters off the Ivory Coast, a routine exercise turns into a mysterious disaster, when a flight of F-22 fighters simply vanishes. Someone has gotten hold of an experimental weapon being developed by the American Missile Defense Office—and all signs point to the French. And when a secret mission to destroy the weapon goes wrong, it leads to a covert battle along the coast of Africa that could bring the world to war. Praise for David E. Meadows: “On a par with Tom Clancy.”—Milos Stankovic “Not only does the author know his subject but [his] fiction could readily become fact.”—John Tegler, host of the syndicated television show, Capital Conversation
The One Best System presents a major new interpretation of what actually happened in the development of one of America's most influential institutions. At the same time it is a narrative in which the participants themselves speak out: farm children and factory workers, frontier teachers and city superintendents, black parents and elite reformers. And it encompasses both the achievements and the failures of the system: the successful assimilation of immigrants, racism and class bias; the opportunities offered to some, the injustices perpetuated for others. David Tyack has placed his colorful, wide-ranging view of history within a broad new framework drawn from the most recent work in history, sociology, and political science. He looks at the politics and inertia, the ideologies and power struggles that formed the basis of our present educational system. Using a variety of social perspectives and methods of analysis, Tyack illuminates for all readers the change from village to urban ways of thinking and acting over the course of more than one hundred years.
Hollywood's first sex symbol, the ' It ' girl, Clara Bow was born in the slums of Brooklyn in a family plagued with alcoholism and insanity. She catapulted to fame after winning Motion Picture magazine's 1921 " Fame and Fortune" contest. The greatest box-office draw of her day—she once received 45,000 fan letters in a single month, Clara Bow's on screen vitality and allure that beguiled thousands, however, would be her undoing off-camera. David Stenn captures her legendary rise to stardom and fall from grace, her success marred by studio exploitation and sexual scandals.
Compared to insects, fossil spiders have received only scant attention in the literature. Previously, the only works available were numerous scientific papers, many published in foreign languages. Most of these are basic descriptive taxonomic works, with very few considering broader biological concepts. Despite a significant increase in the discovery and description of fossil spiders within the last quarter Century this void remained unfilled. Thus, this short monograph aims to achieve several objectives. Firstly, to provide general and up to date background information on the overall importance and diversity of fossils spiders, including an indication of those groups for which the taxonomy is spurious and in need of reassessment. Secondly, to discuss the techniques available for working with fossil spiders and some of the problems encountered by palaeoarachnologists, including bias and limitations of the spider fossil record. Thirdly, the overall evolutionary history of spiders is summarized in the form of an evolutionary tree, which is subsequently used to address key issues of broad interest, such as origins, diversifications and extinctions, including the effects of mass extinctions and predator-prey co-radiations. Finally, the contribution that fossil data can make to understanding the past and present biogeography of the order is considered. This book should be of interest to both amateur and professional arachnologists and palaeontologists and will also serve as a general palaeontological reference work for neonologists studying extant spiders.
The theme of this book is an exposition of connections between representations of finite partially ordered sets and abelian groups. Emphasis is placed throughout on classification, a description of the objects up to isomorphism, and computation of representation type, a measure of when classification is feasible. David M. Arnold is the Ralph and Jean Storm Professor of Mathematics at Baylor University. He is the author of "Finite Rank Torsion Free Abelian Groups and Rings" published in the Springer-Verlag Lecture Notes in Mathematics series, a co-editor for two volumes of conference proceedings, and the author of numerous articles in mathematical research journals.
For over two hundred years, the Catskill Mountains have been repeatedly and dramatically transformed by New York City. In Making Mountains, David Stradling shows the transformation of the Catskills landscape as a collaborative process, one in which local and urban hands, capital, and ideas have come together to reshape the mountains and the communities therein. This collaboration has had environmental, economic, and cultural consequences. Early on, the Catskills were an important source of natural resources. Later, when New York City needed to expand its water supply, engineers helped direct the city toward the Catskills, claiming that the mountains offered the purest and most cost-effective waters. By the 1960s, New York had created the great reservoir and aqueduct system in the mountains that now supplies the city with 90 percent of its water. The Catskills also served as a critical space in which the nation's ideas about nature evolved. Stradling describes the great influence writers and artists had upon urban residents - especially the painters of the Hudson River School, whose ideal landscapes created expectations about how rural America should appear. By the mid-1800s, urban residents had turned the Catskills into an important vacation ground, and by the late 1800s, the Catskills had become one of the premiere resort regions in the nation. In the mid-twentieth century, the older Catskill resort region was in steep decline, but the Jewish "Borscht Belt" in the southern Catskills was thriving. The automobile revitalized mountain tourism and residence, and increased the threat of suburbanization of the historic landscape. Throughout each of these significant incarnations, urban and rural residents worked in a rough collaboration, though not without conflict, to reshape the mountains and American ideas about rural landscapes and nature.
Temple Mount is believed by some Jews to be the locus of their ancient Temple. Known to Muslims as Haram al-Sharif (the Noble Sanctuary), this site is home to two mosques, one of which is the third most holy shrine in all of Islam. Jewish fundamentalists want to destroy the mosques on Temple Mount and rebuild the Temple. Christian apocalypticists are financing and supporting their efforts. If the mosques are destroyed, Islamic fundamentalists have vowed to destroy Israel, resulting in the possibility of nuclear war. This book addresses the idea that the recent rise of militant Christian, Jewish, and Muslim fundamentalisms and their interaction are endangering peace in the Middle East. It fully examines the thesis that apocalypticist fundamentalists--Christians in America, Jews in Israel and America--are working together to hasten the coming of the Messiah by instigating a Holy War in the Middle East. Several chapters focus on three U.S. political figures--Jerry Falwell, Ronald Reagan, and Pat Robertson--who helped bring Christian fundamentalism into the mainstream of American politics. One chapter tells of Jewish preparations for rebuilding the Temple on Temple Mount. Other chapters document the rise of religious fundamentalism in Israel since 1967, Haram al-Sharif-Temple Mount crises involving Christian-Jewish cooperation, and the rise of Islamic fundamentalism. Separate chapters are devoted to Israel's nuclear program and political psychology, and the fact that nuclear weapons are leaving Russia and finding their way to Islamic nations and Islamic terrorists.
With emphasis on practical classroom application, this up-to-date and refreshingly honest collection of essays is a wonderful resource for teaching creative writing. The original and utterly contemporary essays that accurately portray the reality of the teaching experience.
The Cinema of Errol Morris offers close analyses of the director's films—from box office successes like The Thin Blue Line and The Fog of War to Morris's early works like Vernon, Florida and controversial films like Standard Operating Procedure. Film scholar David Resha's reappraisal of Morris's films allows us to rethink the traditional distinction between stylistically conservative documentaries, which are closely invested in evidence and reality, and stylistically adventurous films, which artfully call to question such claims of nonfiction and truth. According to Resha, Errol Morris does not fit neatly in this division of the documentary tradition. Rather, his experiments with documentary conventions constitute another way to investigate reality—in particular, to examine the ways in which his subjects understand, and misunderstand, themselves and the world around them. Seen within the nonfiction tradition, an Errol Morris documentary is a flexible form of lively, engaging storytelling and shrewd, cutting, in-depth reportage. Hardcover is un-jacketed.
The New Testament epistles are much more than just a historical record of the early church -- they are also the heart and center of Christian proclamation, helping us to clearly understand how the life, death, and resurrection of Jesus Christ is part of God's cosmic plan of salvation. In this outstanding anthology of sermons based on the Second Readings from Cycle A of the Revised Common Lectionary, five distinguished preachers bring their insight to the pastoral letters and draw valuable lessons for the complex challenges posed by life in the 21st century. Each thought-provoking message is filled with compelling stories and illustrations, and offers a clear and authentic vision of Christian faith in the context of daily life. With material for every Sunday and major celebration throughout the entire church year, this resource provides abundant seeds for preaching, teaching, and meditation, and will become a treasured addition to anyone's reference library. This essential resource is useful for: - Fresh homiletical approaches to the lectionary texts - Inspiring preaching illustrations and sermon starters - Understanding scripture passages - Adult study and discussion groups - Personal devotions and Bible study John N. Brittain is Dean of the Chapel at Houghton College in Houghton, New York. A magna cum laude graduate of Brown University, Brittain has also earned degrees from Methodist Theological School in Delaware, Ohio (M.Div.) and St. Mary's Seminary and University in Baltimore, Maryland (D.Min.). David O. Bales was a Presbyterian minister for 33 years. Recently retired as the pastor of Bethany Presbyterian Church in Ontario, Oregon, he is also a freelance writer and editor for Stephen Ministries and Tebunah Ministries. Bales is a graduate of the University of Portland and San Francisco Theological Seminary. Steven E. Albertin is the pastor of Christ Lutheran Church of Zionsville, Indiana. Albertin has received degrees from Concordia College (B.A.), Concordia Seminary in Exile, St. Louis (M.Div.), Christ Seminary - Seminex (S.T.M.), and the Lutheran School of Theology at Chicago (D.Min.). Larry Lange and his wife, Julie Wrubbel-Lange, serve as the pastors of Grace Lutheran Church in Green Bay, Wisconsin. Lange is a graduate of Carthage College (B.A.), the University of Wisconsin-Milwaukee (M.A. in English), the Lutheran School of Theology at Chicago (M.Div.), and the Association of Chicago Theological Schools (D.Min. in Preaching). Mary S. Lautensleger is the pastor of Stony Hill United Methodist Church in Albemarle, North Carolina. Lautensleger is a graduate of the College-Conservatory of Music at the University of Cincinnati (B.M., M.M), United Theological Seminary (M.A. in theological studies), and Trinity Lutheran Seminary (M.Div.), and she is a D.Min. candidate at Hood Theological Seminary.
Now in four convenient volumes, Field’s Virology remains the most authoritative reference in this fast-changing field, providing definitive coverage of virology, including virus biology as well as replication and medical aspects of specific virus families. This volume of Field’s Virology: RNA Viruses, Seventh Edition covers the latest information on RNA viruses, how they cause disease, how they can cause epidemics and pandemics, new therapeutics and vaccine approaches, as provided in new or extensively revised chapters that reflect these advances in this dynamic field. Bundled with the eBook, which will be updated regularly as new information about each virus is available, this text serves as the authoritative, up-to-date reference book for virologists, infectious disease specialists, microbiologists, and physicians, as well as medical students pursuing a career in infectious diseases.
Some researchers in the field of suicidology think that the old theories of suicide are too constraining and impede advances in the understanding of suicide. However the book’s authors are not quite so critical of past theories. In the book they review the classic theories of suicide, both psychological and sociological, because they are the foundation of our current theories and also propose the skeletons of possible future theories. The goal of the text is to present researchers with theories to guide their research, encourage them to modify these theories, perhaps meld them together in some cases, and think how they might propose new theories. Presented in three sections, the first reviews significant psychological theories including: Suicide as Escape; Interpersonal-Psychological theory; The Role of Defeat and Entrapment in Suicidal Behavior; Suicide, Ethology and Sociobiology; Stress-Diatheses; Cognitive Theories; Learning Perspective on Suicide; Theories of Personality and Suicide; Typological Theories; and the Pathophysiology of Suicide. The second section of the text addresses Sociological and Economic Theories including: Suicide as Deviance, Naroll’s Thwarting Disorientation Theory, three classic sociological theories as well as several minor theories. A comprehensive chapter on economic theories is offered by Bijou Yang. The final section concentrates on Critical Thoughts About Theories of Suicide, a new and growing influence in academia and scholarship.
Jean Harlow was an enigma, the original Blonde Bombshell, completely uninhibited. She made no secret of the fact that she never wore underwear, bleached her pubic hair to match that on her head – and was never afraid of showing this to journalists, if they asked. On the screen she epitomised the fun-loving, wise-cracking tart-with-a-heart yet away from the spotlight she was nothing like the public perceived her to be. In this new biography, David Bret uncovers an unhappy upbringing by an unloving mother and sexually abusive step-father, her love of older men and the mistreatment she suffered at their hands, her progression from movie slut to screwball comedy star, her special relationship with William Powell, how she was ripped off by the studios, and more. Jean Harlow: Tarnished Angel is a compelling portrayal of the enigmatic star. David Bret was born in Paris. His acclaimed books include biographies of Marlene Dietrich, Morrissey, Freddie Mercury and Edith Piaf among many others.
The Common Good and Christian Ethics rethinks the ancient tradition of the common good in a way that addresses contemporary social divisions, both urban and global. David Hollenbach draws on social analysis, moral philosophy, and theological ethics to chart new directions in both urban life and global society. He argues that the division between the middle class and the poor in major cities and the challenges of globalisation require a new commitment to the common good and that both believers and secular people must move towards new forms of solidarity.
Understanding Physics is a completely revised, updated, and expanded e- tion of the Project Physics Course. It is an integrated introductory physics course, developed with funding from the Carnegie Corporation and the Sloan Foundation and with the close cooperation of Springer-Verlag New York. In approach and content, Understanding Physics follows the trail blazed by the earlier versions, but it includes more recent developments in physics and a stronger emphasis on the relationships among physics, technology, and society. We have sought especially to incorporate the salient lessons of recent physics education research and practical experience gained in the classroom. The Audience Understanding Physics is written primarily for undergraduate college s- dents not intending (at least initially) to enter careers in science or en- neering. These may include liberal-arts students, business majors, prelegal, and prospective architecture students. We have found that when the course is taken with laboratory work, it has been deemed suitable by medical schools for premedical students.
Between 1980 and 1996 the number of arrests has increased considerably for offenders ages 12 and under. This increase is a cost to society in two ways: the cost of the crime and the cost of multiple agencies involved with these children. Several questions have developed due to this increase: How does the juvenile justice system deal with child delinquents? Is child delinquency a predictor of serious, violent, and chronic offending? How early can we predict, and what are early warning signs? In an effort to develop answers for these questions and many more, editors Rolf Loeber and David Farrington organized a study group on Very Young offenders comprising 39 experts on juvenile delinquency and child problem behavior. Over a two-year period of intense and collaborative work these individuals have produced the book Child Delinquents: Development, Intervention, and Service Needs. Presenting empirically derived insights, Child Delinquents is the definitive statement to date on the working knowledge of prevalence, development, risk and protective factors, and optimal intervention with preteen offenders. This book is an excellent source for a broad audience of researchers, scholars, psychiatry, and practitioners at the administrative level.
The wickedly entertaining, hunger-inducing, behind-the-scenes story of the revolution in American food that has made exotic ingredients, celebrity chefs, rarefied cooking tools, and destination restaurants familiar aspects of our everyday lives. Amazingly enough, just twenty years ago eating sushi was a daring novelty and many Americans had never even heard of salsa. Today, we don't bat an eye at a construction worker dipping a croissant into robust specialty coffee, city dwellers buying just-picked farmstand produce, or suburbanites stocking up on artisanal cheeses and extra virgin oils at supermarkets. The United States of Arugula is a rollicking, revealing stew of culinary innovation, food politics, and kitchen confidences chronicling how gourmet eating in America went from obscure to pervasive—and became the cultural success story of our era.
Also Available: Orchestral Music Online This fourth edition of the highly acclaimed, classic sourcebook for planning orchestral programs and organizing rehearsals has been expanded and revised to feature 42% more compositions over the third edition, with clearer entries and a more useful system of appendixes. Compositions cover the standard repertoire for American orchestra. Features from the previous edition that have changed and new additions include: · Larger physical format (8.5 x 11 vs. 5.5 x 8.5) · Expanded to 6400 entries and almost 900 composers (only 4200 in 3rd Ed.) · Merged with the American Symphony Orchestra League's OLIS (Orchestra Library Information Service) · Enhanced specific information on woodwind & brass doublings · Lists of required percussion equipment for many works · New, more intuitive format for instrumentation · More contents notes and durations of individual movements · Composers' citizenship, birth and death dates and places, integrated into the listings · Listings of useful websites for orchestra professionals
This book is the first to provide both a broad overview of the current methodologies being applied to drug design and in-depth analyses of progress in specific fields. It details state-of-the-art approaches to pharmaceutical development currently used by some of the world's foremost laboratories. The book features contributors from a variety of fields, new techniques, previously unpublished data, and extensive reference lists.
The book is designed to allow readers to study issues in isolation or as part of a course or a module. The five main parts are Relationships in Sport, Coach Leadership and Group Dynamics, Motivational Climate, Key Social and Cognitive Processes in Sport, and The Athlete in the Wider Sport Environment. Each chapter is cross-referenced and provides a clear description of the topic and a concise theoretical overview along with a discussion of existing research. The chapters also introduce new research ideas, suggest practical research applications, and conclude with summaries and questions to help instructors engage the class in discussion and to help students follow the key points."--Publisher's website.
From the publishers of The Unofficial Guide to Walt Disney World "A Tourist's Best Friend!" —Chicago Sun-Times "Indispensable" —The New York Times The Top 10 Ways The Unofficial Guide to Chicago Can Help You Have the Perfect Trip: Information that's candid, critical, and totally objective Hotels reviewed and ranked for value and quality—plus secrets for getting the lowest possible rate More than 70 restaurants reviewed and profiled, with listings for dozens more A complete guide to Chicago's sights—museums, architecture, ethnic neighborhoods, and more Complete information on Chicago's lakefront beaches and parks The inside story on shopping—where to get the best for less, on and off the Magnificent Mile All the details on Chicago's nightlife—jazz and blues clubs, dance clubs, concerts, theater, and more The best places to play golf and tennis, ride a bike, go boating, and work out Tips on enjoying Chicago with your kids Advice on how to plan and make the most of your business trip Get the unbiased truth on hundreds of hotels, restaurants, attractions, and more in The Unofficial Guide to Chicago—the resource that helps you save money, save time, and make your trip the best it can be.
Cancer Therapy with Radiolabeled Antibodies explores the most current experimental and clinical advances in the newly emerging field of cancer radioimmunotherapy (RAIT). Providing a multidisciplinary and international context, some of the world's leading experts examine the problems and prospects of RAIT from radiation, immunological, chemical, physical, physiological, and clinical perspectives with both overviews and original research. Discussions cover the up-to-date clinical results in the RAIT of ovarian, breast, colorectal, and brain cancers, as well as the current status of RAIT in the management of B cell lymphomas. Radiobiology, dosimetry, radiochemistry, targeting biology in experimental models, clinical experiences in hematopoietic and solid tumors, and new approaches to improve cancer radioimmunotherapy are also discussed. In addition, new dosimetry concepts, new labeling methods, new concepts of antibody pharmacokinetics, and new methods to enhance selective cancer radioimmunotherapy are included.
The authors of the best-selling The Worst-Case Scenario Survival Handbook are back—and they've brought a date. Whatever your own dating nightmares are, take it from the professionals, things can get worse. Just in time for Valentine's Day, here are dozens of scenarios covering every phase of the romantic—or not so romantic—turn of events. Learn how to remove stubborn articles of clothing, slip away from a blind date, and get rid of unsightly stains. Discover the secrets of dealing with a bad kisser and of surviving a meeting with your date's parents. Hands-on, step-by-step illustrated instructions help guide you through these and many more perils d'amor. Tasteful and useful, and with an appendix of great pickup lines, breakup lines, and all-purpose excuses, this is the book you need when you wake up next to someone whose name you can't remember.
Children and adolescents with moderate and severe disabilities often have communication challenges that lead them to use problem behavior to convey their desires. This is the most comprehensive contemporary volume on functional communication training (FCT)--the individualized instructional approach that teaches a child socially acceptable communicative alternatives to aggression, tantrums, self-injury, and other unconventional behaviors. The expert authors provide accessible, empirically based guidelines for implementing FCT, and tips for overcoming obstacles. Grounded in the principles of applied behavior analysis, the book includes detailed strategies for developing a support plan, together with illustrative case examples. ÿ
Metabolic Pathways, Third Edition: Volume VII: Metabolism of Sulfur Compounds deals with various aspects of the metabolism and biosynthesis of sulfur compounds such as coenzyme A, biotin, thiamine, and lipoic acid. The biochemistry of glutathione and the sulfur cycle is also discussed, together with sulfate activation and transfer; oxidative metabolism of cysteine and cystine in animal tissues; and enzyme defects in sulfur amino acid metabolism in humans. This volume is comprised of 15 chapters and begins with a discussion on the pathways of biosynthesis and dissimilation of coenzyme A, as well as the metabolic fate of exogenous coenzyme A in animals. The reader is then introduced to the chemistry, biosynthesis, metabolism, biological role, and biodegradation of biotin; the biosynthesis and function of thiamine; and the biosynthesis, dissimilation, and metabolic role of lipoic acid. Other sulfur compounds considered in this text are glutathione, cysteine and cystine, riboflavin, thiosulfate sulfurtransferase, mercaptopyruvate sulfurtransferase, and methionine. The final chapter is devoted to human diseases associated with enzyme defects in sulfur amino acid metabolism. This book will be a useful resource for biologists and biochemists.
Eastern Air Lines began in 1926 when aviation pioneer Harold Pitcairn started the first carrier air mail route from New York to Atlanta under his company, Pitcairn Aviation. Clement Keys of National Air Transport bought the company in 1929, changed the name to Eastern Air Transport and began passenger service the next year on daily round trips between New York and Richmond. The growing airline was purchased by General Motors and became Eastern Air Lines in 1934. World War I flying ace Edward V. Rickenbacker purchased the airline four years later and led it to become by the 1950s the most profitable airline in the United States. Former astronaut Frank Borman became president of Eastern in 1975 and tried to manage the airline through deregulation, labor union conflict, and heavy debt, ending with the sale of Eastern to Frank Lorenzo and Texas Air in 1986. The airline entered bankruptcy in March 1989 and ended service in less than two years. This detailed history follows Eastern from start to finish, studying such corporate decision-making as aircraft purchases and route expansions, as well as the personalities that shaped the airline throughout its history.
Given a set of objects and a pairwise similarity measure between them, the goal of correlation clustering is to partition the objects in a set of clusters to maximize the similarity of the objects within the same cluster and minimize the similarity of the objects in different clusters. In most of the variants of correlation clustering, the number of clusters is not a given parameter; instead, the optimal number of clusters is automatically determined. Correlation clustering is perhaps the most natural formulation of clustering: as it just needs a definition of similarity, its broad generality makes it applicable to a wide range of problems in different contexts, and, particularly, makes it naturally suitable to clustering structured objects for which feature vectors can be difficult to obtain. Despite its simplicity, generality, and wide applicability, correlation clustering has so far received much more attention from an algorithmic-theory perspective than from the data-mining community. The goal of this lecture is to show how correlation clustering can be a powerful addition to the toolkit of a data-mining researcher and practitioner, and to encourage further research in the area.
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