Crime in England 1688-1815 covers the ‘long’ eighteenth century, a period which saw huge and far-reaching changes in criminal justice history. These changes included the introduction of transportation overseas as an alternative to the death penalty, the growth of the magistracy, the birth of professional policing, increasingly harsh sentencing of those who offended against property-owners and the rapid expansion of the popular press, which fuelled debate and interest in all matters criminal. Utilising both primary and secondary source material, this book discusses a number of topics such as punishment, detection of offenders, gender and the criminal justice system and crime in contemporaneous popular culture and literature. This book is designed for both the criminal justice history/criminology undergraduate and the general reader, with a lively and immediately approachable style. The use of carefully selected case studies is designed to show how the study of criminal justice history can be used to illuminate modern-day criminological debate and discourse. It includes a brief review of past and current literature on the topic of crime in eighteenth-century England and Wales, and also emphasises why knowledge of the history of crime and criminal justice is important to present-day criminologists. Together with its companion volumes, it will provide an invaluable aid to both students of criminal justice history and criminology.
Presents the principles of human gene evolution in a concise and easy to understand fashion. Uses examples of how evolutionary processes have molded present day genes, drawn from the evolution of humans and other primates, as well as from more primitive organisms. With increasing attention in this expanding area, this review forms a timely publication of our current knowledge of this important field. Structure and function in the human genome The evolution of gene structure Mutational mechanisms in evolution
Natural Autoantibodies provides an in-depth analysis of all aspects of natural antibodies. The book examines the advantages and pitfalls of every type of technique that is widely used for detecting autoantibodies. It also covers the sequencing of human autoantibody genes, discussing how sequencing is undertaken and the genetic clues available to elucidate the genetic origins of autoimmunity. Animal models of autoimmunity are also covered, and the up-to-date account provided in this book explains how natural autoantibodies have important regulatory functions and also occasionally serve as templates for autoimmunity. Other topics examined in Natural Autoantibodies: Their Physiological Role and Regulatory Significance include idiotypes of natural autoantibodies; the pathogenic role of natural autoantibodies; and methods to measure the effects of genetic and sex hormones, as well as aging, on natural autoantibodies. The book will be an excellent research tool and reference for immunologists, rheumatologists, and others interested in the topic.
Molecular biology has always been a discipline of rapid development. Despite this, we are presently experiencing a period of unprecedented proliferation of information in nucleic acid studies and molecular biology. These areas are intimately interwoven, so that each influences the other to their mutual benefit. The rapid growth in information leads to ever-increasing specialization, so that it becomes increasingly difficult for a scientist to keep abreast of developments in all the various aspects of the field, although an up-to-date knowledge of the field as a whole is highly desirable. With this background in mind we present the series Nucleic Acids and Molecular Biology. It comprises focused review articles by active researchers who report on the newest developments in their areas of particular interest.
Frederick Rennie Emerson (1895-1972) was a dynamic presence in the cultural and intellectual life of Newfoundland and Labrador for much of the twentieth century. A musician, lawyer, educator, and folklore enthusiast, Emerson was a central figure in the preservation and mediation of Newfoundland culture in the tumultuous decades prior to and following Confederation with Canada in 1949. Glenn Colton shows how Emerson fostered greater awareness and understanding of Newfoundland's cultural heritage in local, national, and international contexts. His collaboration with song collector Maud Karpeles in the late 1920s preserved some of the most cherished folk songs in the English language, and a decade later, his lectures at Memorial University College emphasized folk traditions and classical repertoire to inspire cultural discovery for an entire generation. As Newfoundland's representative on the first Canada Council and vice-president of the Canadian Folk Music Society, he played a crucial role in shaping Canadian cultural policy during the transformative years of the mid-twentieth century. Colton also reveals the meaningful creative works Emerson composed in response to the same cultural heritage he documented and preserved: his one-act drama Proud Kate Sullivan (1940) is a pioneering depiction of Newfoundland life, and the folk-inspired Newfoundland Rhapsody (1964) is one of few examples of symphonic music composed by a Newfoundlander of his generation. Newfoundland Rhapsody explores Newfoundland society, Canada's emerging arts scene, and the international folk music community to offer a new lens through which to view the cultural history of twentieth-century Newfoundland and Canada.
These are the memoirs of Dr. David R. Glover's professional career in pharmaceutical medicine. His formative school and undergraduate years led to a unique and remarkable journey through medicine and medicines. Like many medical careers there were a number of twists and turns which encompassed clinical and academic medicine, clinical research and drug development. He touched upon or was deeply involved with most types of medicines from simple pills and potions through to stem cells. He has recalled many anecdotes relating to the drugs, the people and the events that enriched his career and included some rarely seen illustrations of old medicines and personal photographs. This is not an in-depth pharmacological treatise but it is sufficiently detailed where merited, particularly regarding the infamous "clinical trial that went wrong" in 2006. In his Vie D’or the reader will find that he enjoyed more than his fifteen minutes of fame.
Throughout the twentieth century architectural models served as the miniature playgrounds in which the future of Britain’s built environment was imagined, and in drawing from the evidence provided by those models today, this book considers how architects, planners, and civil engineers thought about that future by presenting a history of yesterday’s dreams of tomorrow, told through architectural models. Focused not on the making of architectural models but rather the optimistic and utopian visions they were made to communicate, this book examines the possible futures put forward by 120 models made by Thorp, the oldest and most prolific firm of architectural modelmakers in Britain, in order to reveal a century of evolving ideas about how we might live, work, relax, and move. From depictions of unbuilt city masterplans to those of seemingly ordinary shopping centres and motorways, the models featured trace a progression of the architectural, social, political, technological, and economic influences that shaped the design of Britain’s buildings, transport infrastructure, and its towns and cities during a century of relentless change. Illustrated with over 130 photographs, this book will appeal to academics and historians, as well as anyone with an interest in architectural models and the history of Britain’s twentieth century built environment.
This is an ornithological bibliography for the counties of England, Wales, and Scotland and for the Isle of Man. It includes all known books, pamphlets and papers which contain substantial studies of the birds of local areas, from a county down to a back garden or a gravel pit. Each county has an introduction on its boundaries and the history of its ornithology. There has been no comprehensive national publication of this kind since Mullens, Swann and Jourdain's Geographical Bibliography in 1920. The volume also provides a detailed record of the many county and local bird reports and of the ever-increasing number of area surveys produced by statutory and voluntary bodies. The material is arranged by the pre-1974 counties and takes the record up to 1995. There are maps to show the many changes in county boundaries since 1800.The book will be a standard reference work for libraries and collectors, and for anyone interested in the rich and diverse development of local ornithology in its homeland.
Police officers, firefighters, and other public safety workers face exceptionally high rates of injury and fatality relative to the general workforce. This document provides an analysis of the risk factors associated with different aspects of public safety occupations, to help policymakers in their efforts to improve the health and safety of these employees.
Gene therapy was conceived during the early and mid part of the 20th century. At first, it was considered a revolutionary biomedical procedure, which could potentially cure any disease for which the molecular bases were understood. Since then, gene therapy has gone through many stages and has evolved from a nearly unrealistic perspective to a real life application. Clinical efficacy in humans was demonstrated at the beginning of this century after its successful application in small-scale clinical trials to cure severe immunodeficiency in children. However, their successes were overshadowed some time later by the occurrence of vector-related leukaemia in a number of treated children. It is in this context that lentiviral vectors have appeared, with improved efficiency and, possibly, increased biosafety. Very recently, the first clinical trials with lentivectors have been carried out with some success. This Brief firstly defines gene therapy, and places lentivectors within this fascinating therapeutic strategy. Then follows a comprehensive description of the development of retroviral and lentiviral vectors and how to specifically target distinct cell types and tissues. The authors also discuss the application of lentivector gene therapy for the treatment of cancer and autoimmune diseases, ending with the application of lentivectors in human gene therapy clinical trials.
This lucid, well structured and jargon-free book provides an up-to-date and comprehensive account of the processes involved in gene expression and the mechanisms by which such expression is regulated. New information on how viruses modify host gene regulation has been included in this new edition. Methods used to analyze gene expression have also been given more attention, with a new section added on methods for examining DNA binding by transcriptional factors.
This book is a completely revised new edition of the definitive reference on disorders of hemoglobin. Authored by world-renowned experts, the book focuses on basic science aspects and clinical features of hemoglobinopathies, covering diagnosis, treatment, and future applications of current research. While the second edition continues to address the important molecular, cellular, and genetic components, coverage of clinical issues has been significantly expanded, and there is more practical emphasis on diagnosis and management throughout. The book opens with a review of the scientific underpinnings. Pathophysiology of common hemoglobin disorders is discussed next in an entirely new section devoted to vascular biology, the erythrocyte membrane, nitric oxide biology, and hemolysis. Four sections deal with α and β thalassemia, sickle cell disease, and related conditions, followed by special topics. The second edition concludes with current and developing approaches to treatment, incorporating new agents for iron chelation, methods to induce fetal hemoglobin production, novel treatment approaches, stem cell transplantation, and progress in gene therapy.
Now thoroughly updated to include new advances in the field,and with regular content updates to the eBook, Principles and Practice of Pediatric Oncology, 7th Edition remains the gold standard text for the care and research of children with cancer. This authoritative reference is the single most comprehensive resource on the biology and genetics of childhood cancer and the diagnosis, multimodal treatment, and long-term management of young patients with cancer. Also addressed are a broad array of topics on the supportive and psychosocial aspects of care of children and families. Covering virtually every aspect of the breadth and depth of childhood cancer, this 7th Edition provides expert guidance on state-of-the-art, multidisciplinary care for children and families. Stay up to date with the most recent advances in the field with the contributions by new and returning contributors, including the perspective from patients and parents in the chapter titled “The Other Side of the Bed.” Reference your eBook version for key updates in the field during the life of the edition! Chapters included on palliative care and education. Supportive care is covered broadly and specifically – in contexts such as emergencies, infectious disease, and nutrition. The most updated and authoritative information is provided by the leading experts in the field. Gain a thorough understanding of every aspect of pediatric oncology, with comprehensive information regarding basic science, diagnostic tools, principles of treatment, and clinical trials, as well as highly detailed, definitive coverage of each pediatric malignancy. Collaborate more effectively with others on the cancer care team to enhance quality-of-life issues for patients and families. Understand the cooperative nature of pediatric oncology as a model for cancer research with information from cooperative clinical trial groups and consortia.
This textbook provides a concise overview of malignant haematology, including reviews of cell and molecular biology, and implications for new trends in treatment.
Biochemistry: The Chemical Reactions of Living Cells is a 16-chapter reference source on chemical structures and reactions of living cells. The first three chapters of this book contain introductory material on cell structure, molecular architecture, and energetic. The subsequent chapters examine the allosteric effect of the binding structures of oligomeric enzymes, microtubules, viruses, and muscle. These chapters also describe the structures and chemical properties of membranes and of the surrounding cell coats. The discussions then shift to the general properties of enzymes, the kinetics of chemical reactions, and the various mechanisms employed in enzymatic catalysis. Considerable chapters are devoted to the reaction sequences found in metabolism. These chapters particularly examine the carbohydrate and lipid metabolism; photosynthesis; and biosynthesis and catabolism of an enormous number of nitrogenous compounds. The final chapters highlight the genetic and hormonal control of metabolism, development, and brain function. Biochemistry teachers and students will find this book of great value.
Since the publication of High-Resolution Electrophorsesis and Immunofixation 2e, there have been ever-increasing advances in the analyses of proteins, by electrophoresis in particular. Protein Electrophoresis in Clinical Diagnosis shows the changes in both techniques and interpretation, presenting a comprehensive review of serum protein techniques, immunofixation techniques, approaches to pattern interpretation, and pattern interpretation in both cerebralspinal fluid and urine. Conditions associated with Monoclunal Gammopathies are considered, as are the appropriate strategies for their detection. David Keren is well-known as the leader in this field, his work on guidelines becoming the benchmark for all those involved in protein detection in serum and urine. Dr Keren's book will be essential in every laboratory, and read by pathologists, chemical chemists, medical technicians and clinicians (particularly hematologists and oncologists).
In recent years, the assumption that traditional songs originated from a primarily oral tradition has been challenged by research into ’street literature’ - that is, the cheap printed broadsides and chapbooks that poured from the presses of jobbing printers from the late sixteenth century until the beginning of the twentieth. Not only are some traditional singers known to have learned songs from printed sources, but most of the songs were composed by professional writers and reached the populace in printed form. Street Ballads in Nineteenth-Century Britain, Ireland, and North America engages with the long-running debate over the origin of traditional songs by examining street literature’s interaction with, and influence on, oral traditions.
Exploring the chromosomal imbalance (aneuploidy) theory of cancer, this volume describes how cancer is initiated and why progression takes years to decades. It clarifies why cancer cells often become drug resistant, provides objective, quantitative measures for detecting cancer and monitoring its progression, and suggests non-toxic strategies of ca
Zakim and Boyer's Hepatology-the defining work in hepatology-presents comprehensive coverage of both basic science and clinically relevant developments so you can provide the best possible patient care. Drs. Thomas Boyer, Michael Manns, and Arun Sanyal have reorganized and updated the contents of this trusted global reference to reflect today's more clinical approach to hepatology. They bring you up to date on hot topics including HIV Co-Infection Drug Toxicity, Hepatocellular Carcinoma (HCC), and much more. This new streamlined edition is now a single volume with access to the fully searchable contents and an image bank online at www.expertconsult.com making it easier to find the treatment information you need. Effectively treat all liver diseases currently seen in clinical practice with authoritative guidance from leading international authorities. Reinforce your foundation in basic science with the concise Pathophysiology of Therapeutic Targets section. See clear presentations of liver disease through hundreds of detailed, color illustrations. Explore topics further with up-to-date references that direct you to the significant literature. Access the complete, fully searchable contents of the book online at www.expertconsult.com, along with a downloadable image bank and complete list of references. Stay current on new developments in the field through five new chapters on Pathogenesis Liver Injury in HBV, HCV; HCC; Imaging and Non-Invasive DX Liver Disease CT, US, Fibroscan, MRI; HIV Co-Infection Drug Toxicity; and HBC, HCV in Non-Liver Transplant Patients, plus comprehensive updates throughout. Apply best practices with reorganized and updated content that reflects today's need for a more clinical approach to hepatology. Reference key information more easily thanks to streamlined content that now fits into one volume.
Consulting Editor, Dr. Bonita Stanton has worked closely with Guest Editors Drs. David R. Rosenberg and Leslie H. Lundahl to create a current issue devoted to substance abuse in children. Expert authors have written clinical review articles with the goal of providing the pediatrician with the latest information on substances and addiction medicine. The first half of the issue focuses on the following substances: Nicotine Use Disorders in Adolescents; Alcohol Use Disorders in Adolescents; Cannabis Use and Consequences; Medical and Non-Medical Use of Opiates; Stimulant Use and Cognitive Enhancement; and Club Drugs. The second half of the issue focuses on special topics important to pediatricians: Contingency Management for Substance Use Disorders; Behavioral Addictions: Gambling, Gaming, Internet; Juvenile Drug Court: Novel Approach to Treatment; Computer-Assisted Approaches to Substance Abuse Treatment; Co-Morbid Substance Use and Other Psychiatric Disorders; and Drug Use in Pregnant Teens. Readers will come away with the information they need to stay current on this changing field and to improve patient outcomes.
**Selected for Doody's Core Titles® 2024 with "Essential Purchase" designation in Pediatrics** As the #1 title in the pediatric nursing market for over 40 years, Wong's Essentials of Pediatric Nursing, 11th Edition continues to leverage its trademark developmental approach as it equips readers with the very latest research and guidelines for treating children today. The text utilizes a highly-readable writing style and encourages a whole-body approach — beginning with child development and health promotion to better understand the later chapters on specific health problems. This new eleventh edition also features Next Generation NCLEX®-style case studies and questions, a new chapter covering all systems cancers, additional case studies within the nursing care plans, and updated and expanded evidence-based content throughout to best reflect the latest standards and trends impacting pediatric nursing care today. - Developmental approach clearly identifies developmental tasks and influences at each stage of a child's growth. - Emphasis on wellness features health promotion chapters for each developmental stage of childhood. - Critical thinking case studies with answers are found throughout the text. - Quality patient outcomes are highlighted within nursing management discussions for major diseases and disorders. - Drug alerts draw attention to potential safety issues, reflecting QSEN safety initiative. - Family focus includes a separate family chapter as well as family content and Family-Centered Care boxes integrated throughout the text. - Community Focus boxes provide resources and guidance on caring for children outside the clinical setting. - Evidence-Based Practice boxes focus attention on the application of research and critical thought processes to support and guide the outcomes of nursing care. - Chapter on complementary & alternative therapy cover timely topics to aid in providing complete, comprehensive care. - Nursing care plans provide a model for planning patient care and include rationales that provide the "why." - Research Focus boxes highlight current studies that impact pediatric nursing today. - Cultural content and Cultural Considerations boxes are integrated throughout the text to draw attention to customs and beliefs of different cultures that influence childcare. - Atraumatic Care boxes contain techniques for care that minimize pain, discomfort, or stress. - Nursing tips offer helpful hints and practical, clinical information of a non-emergency nature. - Nursing alerts feature critical information that MUST BE considered in providing care. - Emergency Treatment sections provide a quick reference in critical situations. - Nursing care guidelines provide clear, step-by-step instructions for performing specific skills or procedures.
**Selected for Doody's Core Titles® 2024 with "Essential Purchase" designation in Pediatric Surgery** Now in brilliant full color and reflecting recent significant changes in the field, Critical Heart Disease in Infants and Children, 3rd Edition, keeps you abreast of the skills and knowledge required to safely care for children with congenital and acquired heart disease in the ICU. Pediatric intensivists, cardiologists, cardiac surgeons, and anesthesiologists from leading centers around the world provide a well-rounded perspective on basic scientific principles, medical and pharmacologic treatments, surgical techniques, and equipment. - Features comprehensive updates throughout the text, including indications, techniques, potential complications in perioperative management of patients, and surgical techniques for congenital heart disease. - Covers recent advances in the treatment of pulmonary hypertension, developments in mechanical assist devices, heart and lung transplantation, and interventional cardiac catheterization. - Features an all-new, full-color format that speeds navigation and helps clarify complex concepts. - Contains 27 new chapters with an emphasis on the team approach to patient care in the ICU including creating multidisciplinary teams, quality and performance improvement, training , and challenges and solutions to developing a cohesive team environment. - Includes a detailed chapter on bedside ultrasound, walking you through the techniques you're most likely to encounter in the ICU. - Employs well-documented tables, text boxes, and algorithms to make clinical information easy to access, and more than two dozen video clips provide a more complete understanding of echocardiography, imaging modalities, pulmonary hypertension, and more. - Describes the basic pharmacology and clinical applications of new pharmacologic agents. - Examines issues affecting adults with congenital heart disease. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices. - Offers four completely new chapters: Cardiac Trauma, Congenital Heart Disease in the Adult, Congenitally Corrected Transposition of the Great Arteries, and Outcome Evaluation. - Describes the basic pharmacology and clinical applications of all of the new pharmacologic agents. - Details important refinements and developments in surgical techniques, including the Ross pulmonary autograft replacement of the aortic valve, video-assisted fluoroscopy, and the extracardiac Fontan connection, and discusses their indications and potential complications. - Explores the latest advances in the treatment of pulmonary hypertension, new developments in mechanical assist devices, heart and lung transplantation, and interventional cardiac catheterization. - Examines issues affecting adults with congenital heart disease.
There has been a recent explosion of knowledge in the field of respiratory genetics. This authoritative text brings together current knowledge in respiratory genetics in a single volume. The book includes a comprehensive introductory section to provide guidance and aid understanding of key basic concepts in respiratory genetics, including statistic
To address the growing complexities of childhood cancer, Nathan and Oski’s Hematology and Oncology of Infancy and Childhood has now been separated into two distinct volumes. With this volume devoted strictly to pediatric oncology, and another to pediatric hematology, you will be on the cutting edge of these two fields. This exciting new, full-color reference provides you with the most comprehensive, authoritative, up-to-date information for diagnosing and treating children with cancer. It brings together the pathophysiology of disease with detailed clinical guidance on diagnosis and management for the full range of childhood cancers, including aspects important in optimal supportive care. Written by the leading names in pediatric oncology, this resource is an essential tool for all who care for pediatric cancer patients. Offers comprehensive coverage of all pediatric cancers, including less common tumors, making this the most complete guide to pediatric cancer. Covers emerging research developments in cancer biology and therapeutics, both globally and in specific pediatric tumors. Includes a section on supportive care in pediatric oncology, written by authors who represent the critical subdisciplines involved in this important aspect of pediatric oncology. Uses many boxes, graphs, and tables to highlight complex clinical diagnostic and management guidelines. Presents a full-color design that includes clear illustrative examples of the relevant pathology and clinical issues, for quick access to the answers you need. Incorporates the codified WHO classification for all lymphomas and leukemias.
High-Resolution Electrophoresis and Immunofixation: Techniques and Interpretation acquaints the reader with the available methodologies and instrumentation for performing high-resolution electrophoresis and immunofixation. This text presents the use of procedures of high-resolution electrophoresis and immunofixation to facilitate the diagnosis of a variety of serum protein abnormalities. It also provides case examples to illustrate the uses of these procedures and their possible caveats. The book contains chapters devoted to the methods and rationale for high-resolution electrophoresis; interpretation of high-resolution electrophoresis patterns in serum, urine, and cerebrospinal fluid; the immunofixation technique; and strategies for diagnosing monoclonal gammopathies. Medical technologists, physicians, and pathologists will find the book invaluable.
This book covers a wide range of novel biochemical targets that appear to be the best leads in terms of designing novel targets for anticancer drug design. New Molecular Targets for Cancer Chemotherapy is a unique, multi-disciplinary effort, with internationally respected authors from the fields of growth factor-receptor interaction, phosphoinositide and phospholipase signal transduction, and DNA-drug binding interactions. The science is placed in clinical context and illustrations explain how clinicians can incorporate a mechanistic, pharmacodynamic approach into early clinical trial design.
Extensively updated, this edition offers readers a carefully structured approach to learning the building blocks of the immune system, cells, organs and major receptor molecules, as well as initiation and actions of the immune response, especially in a clinical context.
To address the exponential growth in the fields of pediatric hematology and oncology, this classic reference has been separated into two distinct volumes. With this volume, devoted strictly to pediatric hematology, and another to pediatric oncology, you'll keep you on the cutting-edge of these two specialties. The completely revised 7th edition of Nathan and Oski's Hematology of Infancy and Childhood is now in full color, and provides you with the most comprehensive, authoritative, up-to-date information for diagnosing and treating children with hematologic disorders. It brings together the pathophysiology of disease with detailed clinical guidance on diagnosis and management for the full range of blood diseases that you encounter in everyday practice. Written by the leading names in pediatric hematology, this resource is an essential tool for anyone involved in caring for children with hematologic disorders. And, as an Expert Consult title, this thoroughly updated 7th edition comes with access to the complete contents online, fully searchable. Balances summaries of relevant pathophysiology with clear, practical clinical guidance to help you thoroughly understand the underlying science of diseases. Offers comprehensive coverage of all hematologic disorders, including newly recognized ones, along with the latest breakthroughs in diagnosis and management. Uses many boxes, graphs, and tables to highlight complex clinical diagnostic and management guidelines at a glance. Presents an all-new full-color design that includes clear illustrative examples of relevant science and clinical problems for quick access to the answers you need. Provides access to the complete contents online, fully searchable, enabling you to consult it rapidly from any computer with an Internet connection. Your purchase entitles you to access the web site until the next edition is published, or until the current edition is no longer offered for sale by Elsevier, whichever occurs first. If the next edition is published less than one year after your purchase, you will be entitled to online access for one year from your date of purchase. Elsevier reserves the right to offer a suitable replacement product (such as a downloadable or CD-ROM-based electronic version) should access to the web site be discontinued.
To address the exponential growth in the fields of pediatric hematology and oncology, this classic reference has been separated into two distinct volumes. With this volume, devoted strictly to pediatric hematology, and another to pediatric oncology, you’ll keep you on the cutting-edge of these two specialties. The completely revised 7th edition of Nathan and Oski’s Hematology of Infancy and Childhood is now in full color, and provides you with the most comprehensive, authoritative, up-to-date information for diagnosing and treating children with hematologic disorders. It brings together the pathophysiology of disease with detailed clinical guidance on diagnosis and management for the full range of blood diseases that you encounter in everyday practice. Written by the leading names in pediatric hematology, this resource is an essential tool for anyone involved in caring for children with hematologic disorders. Balances summaries of relevant pathophysiology with clear, practical clinical guidance to help you thoroughly understand the underlying science of diseases. Offers comprehensive coverage of all hematologic disorders, including newly recognized ones, along with the latest breakthroughs in diagnosis and management. Uses many boxes, graphs, and tables to highlight complex clinical diagnostic and management guidelines at a glance. Presents an all-new full-color design that includes clear illustrative examples of relevant science and clinical problems for quick access to the answers you need.
Written with useful practicality in mind, Breast Pathology, 3rd Edition, provides surgical pathologists with authoritative guidance on the selection and best use of proper diagnostic techniques when reporting on breast specimens. Dr. David J. Dabbs and a team of internationally acclaimed pathologists incorporate genomic and molecular information, gross and microscopic findings, radiologic and laboratory diagnosis, theranostics, and immunohistochemistry to cover every aspect of benign and malignant lesions of the breast, helping you minimize diagnostic variation and error in the sign-out room. - Brings you fully up to date with recent advances, including new molecular information for breast entities, new surgical techniques, more widely used multigene prognostic tests, and assays used to determine treatment, such as PD-L1 as a new immunotherapy biomarker for triple-negative breast cancer. - Incorporates the latest classifications of breast pathology and molecular diagnosis. - Organizes each topical chapter around relevant genomic and molecular information, clinical presentation, gross and microscopic pathologic findings and diagnostic and molecular immunohistochemistry. - Maps immunohistochemistry for each entity according to diagnostic, theranostic, and genomic applications, with specific regard to disease entities in each chapter. - Discusses breast specimen handling in detail to assure proper sampling and processing for optimal molecular and immunohistochemistry resulting. - Supplies a convenient quick reference at the beginning of each chapter that includes all relevant diagnostic, theranostic, and genomic data for fast retrieval. - Features approximately 2,000 full-color pathological images that clearly depict clinical, radiological, molecular, immunohistochemical, and theranostic aspects of disease. - Includes biomarker guideline updates throughout. - Reflects updates to new tumor staging data in the American Joint Committee on Cancer (AJCC) 8th Edition and updated ASCO/CAP guidelines for interpreting HER2 assays.
Written by the leading names in pediatric oncology and hematology, Nathan and Oski's Hematology and Oncology of Infancy and Childhood offers you the essential tools you need to overcome the unique challenges and complexities of childhood cancers and hematologic disorders. Meticulously updated, this exciting full-color set brings together the pathophysiology of disease with detailed clinical guidance to provide you with the most comprehensive, authoritative, up-to-date information for diagnosing and treating children. - Form a definitive diagnosis and create the best treatment plans possible with comprehensive coverage of all pediatric cancers, including less-common tumors, as well as all hematologic disorders, including newly recognized ones. - Develop a thorough, understanding of the underlying science of diseases through summaries of relevant pathophysiology balanced with clear, practical clinical guidance. Nathan and Oski's is the only comprehensive product on the market that relates pathophysiology in such depth to hematologic and oncologic diseases affecting children. - Quickly and effortlessly access the key information you need with the help of a consistent organization from chapter to chapter and from volume to volume. - Stay at the forefront of your field thanks to new and revised chapters covering topics such as paroxysmal nocturnal hemoglobinuria, lysosomal storage diseases, childhood genetic predisposition to cancer, and oncology informatics. - Learn about the latest breakthroughs in diagnosis and management, making this the most complete guide in pediatric hematology and oncology. - Discover the latest in focused molecularly targeted therapies derived from the exponential growth of knowledge about basic biology and genetics underlying the field. - Rely on it anytime, anywhere! Access the full text, images, and more at Expert Consult.
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