Since the 1840s, critics have lambasted Wagner for lacking the ability to compose melody. But for him, melody was fundamental - 'music's only form'. This incongruity testifies to the surprising difficulties during the nineteenth century of conceptualizing melody. Despite its indispensable place in opera, contemporary theorists were unable even to agree on a definition for it. In Wagner's Melodies, David Trippett re-examines Wagner's central aesthetic claims, placing the composer's ideas about melody in the context of the scientific discourse of his age: from the emergence of the natural sciences and historical linguistics to sources about music's stimulation of the body and inventions for 'automatic' composition. Interweaving a rich variety of material from the history of science, music theory, music criticism, private correspondence and court reports, Trippett uncovers a new and controversial discourse that placed melody at the apex of artistic self-consciousness and generated problems of urgent dimensions for German music aesthetics.
The first book entirely dedicated to the topic emphasizes the relation between basic research and actual processing technologies. As such, it covers complex microstructures down to the nanometer scale, structure/property relationships and potential applications in key industries. From the contents: * Constitution * Thermophysical Constants * Phase Transformations and Microstructures * Deformation Behaviour * Strengthening Mechanisms * Creep * Fracture Behaviour * Fatigue * Oxidation Resistance and Related Issues * Alloy Design * Ingot Production and Component Casting * Powder Metallurgy * Wrought Processing * Joining * Surface Hardening * Applications and Component Assessment
Here, from historian David Ross Campbell, are the extraordinary stories of five of the most important of the independent monarchs who ruled parts of Germany during the many centuries before it finally united into a single nation. From bloody battles to fairy-tale castles, from brutal madness to patronage of the arts, each of these kings - Otto the Great, Albert of Bavaria, Augustus the Strong, Frederick the Great, and Mad King Ludwig - played a vital role in creating the Germany that exists today.
The present volume, Thorium C5, deals with the compounds of thorium and sulfur, selenium, tellurium, and boron, as well as with oxoacid compounds of the three chalcogen elements. Thorium borates have already been treated in Thorium C2. In contrast to the corresponding compounds of uranium the thorium sulfides, etc. , do not show any nuclear or other technological application; they are only of academic interest, despite some very interest ing electronic properties, especially of the 1 : 1 compounds. The thorium-sulfur and the thorium boron systems in particular were studied in detail, so that we have a clear picture of them, whereas there are still a lot of open questions in the systems Th-Se and Th-Te - not very different from other metal chalcogenide systems. Thorium sulfates are of some technological importance because they are formed in solution during recovery of thorium from monazite by sulfuric acid leaching. The very detailed and critical treatment of the chemical and physical properties of the compounds discussed also enables us to find gaps still remaining in our knowledge and thus to initiate new research in this field. I want to thank the two authors, Dr. Horst Wedemeyer (Karlsruhe) and Dr. David Brown (Harwell), for their excellent contributions, the "Literaturabteilung" of the Karlsruhe Nuclear Research Center for its help in providing reports and other documents difficult to procure, as well as the staff of the Gmelin-Institute, especially to Dr. K. -C.
One morning a child gazes through a bedroom window and watches as amazing things happen. The backyard is transformed to reveal what lived there hundreds, thousands, and millions of years ago.
Written by the leading names in pediatric oncology and hematology, Nathan and Oski's Hematology and Oncology of Infancy and Childhood offers you the essential tools you need to overcome the unique challenges and complexities of childhood cancers and hematologic disorders. Meticulously updated, this exciting full-color set brings together the pathophysiology of disease with detailed clinical guidance to provide you with the most comprehensive, authoritative, up-to-date information for diagnosing and treating children. - Form a definitive diagnosis and create the best treatment plans possible with comprehensive coverage of all pediatric cancers, including less-common tumors, as well as all hematologic disorders, including newly recognized ones. - Develop a thorough, understanding of the underlying science of diseases through summaries of relevant pathophysiology balanced with clear, practical clinical guidance. Nathan and Oski's is the only comprehensive product on the market that relates pathophysiology in such depth to hematologic and oncologic diseases affecting children. - Quickly and effortlessly access the key information you need with the help of a consistent organization from chapter to chapter and from volume to volume. - Stay at the forefront of your field thanks to new and revised chapters covering topics such as paroxysmal nocturnal hemoglobinuria, lysosomal storage diseases, childhood genetic predisposition to cancer, and oncology informatics. - Learn about the latest breakthroughs in diagnosis and management, making this the most complete guide in pediatric hematology and oncology. - Discover the latest in focused molecularly targeted therapies derived from the exponential growth of knowledge about basic biology and genetics underlying the field. - Rely on it anytime, anywhere! Access the full text, images, and more at Expert Consult.
Luchino Visconti's trilogy of films Ludwig, Death in Venice and The Damned explore the complex relationship between the themes and ideals of German Romanticism and their impact on the catastrophe of the Third Reich. The personality and works of Richard Wagner to a large extent epitomize German Romanticism as a whole, while the writings of Thomas Mann and Friedrich Nietzsche provide the greatest critique of this dark and troubled but sublime and emotionally overwhelming culture. Along with contrasting approaches to this subject by other filmmakers such as Hans-Jurgen Syberberg, Ken Russell and Tony Palmer, this book explores how the preoccupations of the German Romantic movement led to Nazism, and contrasts the ways in which filmmakers have presented this continuum. The book also discusses the impact of Wagner's musical dramas on the art form of the cinema itself.
This two-volume text provides a summary of studies relating to the use of photosensitizing agents in the diagnosis and therapy of cancer. This interesting work describes synthesis of new sensitizers, photochemical and photobiological properties of dyes currently used for photodynamic therapy, plus those being examined with a view toward providing therapeutic advantages. It contains results and methodology from leading experts on the use of porphyrins and other photosensitizers for detection of neoplastic disease and for photodynamic therapy of neoplastic disease. The volumes focus on the major clinical and pre-clinical research groups. They also include an appended bibliography which lists all pertinent publications in this field. This easy-to-understand book is written for all workers in the field of photodynamic therapy and provides an introduction to those beginning research on some aspect of tumor photosensitization.
Ventilator Management for the Cardiac Patient; Management of Post-Operative Complications in the Cardiac Surgery Patient; Guidelines Relevant to Care in the Cardiac Intensive Care Unit--to keep the book and you up to date. yPresents the text in a new, full-color design and layout for a more visually-appealing and accessible format that makes finding the information you need quick and easy.
Offered in print, online, and downloadable formats, this updated edition of Stroke: Pathophysiology, Diagnosis, and Management delivers convenient access to the latest research findings and management approaches for cerebrovascular disease. Picking up from where J. P. Mohr and colleagues left off, a new team of editors - Drs. Grotta, Albers, Broderick, Kasner, Lo, Mendelow, Sacco, and Wong - head the sixth edition of this classic text, which is authored by the world's foremost stroke experts. Comprehensive, expert clinical guidance enables you to recognize the clinical manifestations of stroke, use the latest laboratory and imaging studies to arrive at a diagnosis, and generate an effective medical and surgical treatment plan. Abundant full-color CT images and pathology slides help you make efficient and accurate diagnoses. Data from late-breaking endovascular trials equips you with recent findings. Includes comprehensive coverage of advances in molecular biology of cell death; risk factors and prevention; advances in diagnostics and stroke imaging; and therapeutic options, including a thorough review of thrombolytic agents and emerging data for endovascular therapy. Features brand-new chapters on Intracellular Signaling: Mediators and Protective Responses; The Neurovascular Unit and Responses to Ischemia; Mechanisms of Cerebral Hemorrhage; Stroke Related to Surgery and Other Procedures; Cryptogenic Stroke; and Interventions to Improve Recovery after Stroke. Highlights new information on genetic risk factors; primary prevention of stroke; infectious diseases and stroke; recovery interventions such as robotics, brain stimulation, and telerehabilitation; and trial design. Details advances in diagnostic tests, such as ultrasound, computed tomography (including CT angiography and CT perfusion), MRI (including MR perfusion techniques), and angiography. Includes extracted and highlighted evidence levels. Expert Consult eBook version included with print purchase. This enhanced eBook experience allows you to search all of the text, figures, and references on a variety of devices. The content can also be downloaded to tablets and smart phones for offline use. Combat stroke with the most comprehensive and updated multimedia resource on the pathophysiology, diagnosis, and management of stroke from leaders in the field
*Brings the story of the Cassini-Huygens mission and their joint exploration of the Saturnian system right up to date. *Combines a review of previous knowledge of Saturn, its rings and moons, including Titan, with new spacecraft results in one handy volume. *Provides the latest and most spectacular images, which will never have appeared before in book form. *Gives a context to enable the reader to more easily appreciate the stream of discoveries that will be made by the Cassini-Huygens mission. *Tells the exciting story of the Huygens spacecraft’s journey to the surface of Titan.
Renowned international experts Peter B. Smith, Mark F. Peterson, and David C. Thomas, editors of the The Handbook of Cross-Cultural Management, have drawn together scholars in the field of management from around the world to contribute vital information from their cross-national studies to this innovative, comprehensive tome. Chapters explore links between people and organizations, providing useful cultural perspectives on the most significant topics in the field of organizational behavior—such as motivation, human resource management, and leadership —and answering many of the field's most controversial methodological questions. Key Features Presents innovative perspectives on the cultural context of organizations: In addition to straightforward coverage of structures and processes, this Handbook addresses locally distinctive, indigenous views of organizational processes from around the world and considers the interplay of climate and wealth when analyzing how organizations operate. Offers an integrated theoretical framework: At the start of each substantive section, the Editors provide context for the upcoming chapters by discussing how prevalent cultures in different parts of the world place emphasis on particular aspects of organizational processes and outcomes. Boasts a global group of contributing scholars: This Handbook features contributing authors from around the world who represent an outstanding mix of respected, long-standing scholars in cross-cultural management as well as newer names already impacting the literature. Provides an authoritative agenda for the future development of the field: All chapters conclude with a list of promising avenues for further research and a focus on issues that remain unresolved. Intended Audience This Handbook is an ideal resource for researchers, instructors, professionals, and graduate students in fields of business, management, and psychology.
American histories have long held that in May 1637---"Connecticut's Birthday"---a small force of English colonists guided by Mohegan Native allies set out to break the back of Pequot dominion in New England. According to Alfred E. Cave's The Pequot War and other accounts, the English and Mohegans supposedly marched "undetected" across multiple Indian territories, and at the Pequot village of Missituc on the Mystic River, trapped and killed between 300 and 700 men, women and children---thus launching the northern English colonies' first "total war" against Native Americans. What new understandings emerge when, for the first time, readers can examine these records and traditions against the actual landscape? What were the realities of New England tribal life, and of Native American war, in the 1600s? If the colonists of Massachusetts Bay and Hartford were in their own words "altogether ignorant" of how to locate, identify, fight, and control Native peoples, how did thoroughly-intermarried Pequots, Mohegans, Narragansetts and others exploit these crucial English blind-spots with astonishing, subtle and yet plainly visible counter-strategies? Why were guns, armor and European assault-tactics the wrong means of war in New England? What were the consequences near and far of the colonies' refusals to adjust? Tracking every step of The Pequot War from its origins to its aftermath and influences, Mystic Fiasco is its most comprehensive and detailed study. Its basis in the landscape exposes the fundamental but unexamined paradigms that hard-wired the American colonial psyche from those days to these. With user-friendly maps and illustrations by renowned historical artist David R. Wagner and the documentary expertise of historian Jack Dempsey, Mystic Fiasco is filled with resources that empower you to go and discover this "Mystic Massacre" and Pequot War for yourself.
Now thoroughly updated to include new advances in the field,and with regular content updates to the eBook, Principles and Practice of Pediatric Oncology, 7th Edition remains the gold standard text for the care and research of children with cancer. This authoritative reference is the single most comprehensive resource on the biology and genetics of childhood cancer and the diagnosis, multimodal treatment, and long-term management of young patients with cancer. Also addressed are a broad array of topics on the supportive and psychosocial aspects of care of children and families. Covering virtually every aspect of the breadth and depth of childhood cancer, this 7th Edition provides expert guidance on state-of-the-art, multidisciplinary care for children and families. Stay up to date with the most recent advances in the field with the contributions by new and returning contributors, including the perspective from patients and parents in the chapter titled “The Other Side of the Bed.” Reference your eBook version for key updates in the field during the life of the edition! Chapters included on palliative care and education. Supportive care is covered broadly and specifically – in contexts such as emergencies, infectious disease, and nutrition. The most updated and authoritative information is provided by the leading experts in the field. Gain a thorough understanding of every aspect of pediatric oncology, with comprehensive information regarding basic science, diagnostic tools, principles of treatment, and clinical trials, as well as highly detailed, definitive coverage of each pediatric malignancy. Collaborate more effectively with others on the cancer care team to enhance quality-of-life issues for patients and families. Understand the cooperative nature of pediatric oncology as a model for cancer research with information from cooperative clinical trial groups and consortia.
The updated third edition of the definitive guide to water treatment engineering, now with all-new online content Stantec's Water Treatment: Principles and Design provides comprehensive coverage of the principles, theory, and practice of water treatment engineering. Written by world-renowned experts in the field of public water supply, this authoritative volume covers all key aspects of water treatment engineering, including plant design, water chemistry and microbiology, water filtration and disinfection, residuals management, internal corrosion of water conduits, regulatory requirements, and more. The updated third edition of this industry-standard reference includes an entirely new chapter on potable reuse, the recycling of treated wastewater into the water supply using engineered advanced treatment technologies. QR codes embedded throughout the book connect the reader to online resources, including case studies and high-quality photographs and videos of real-world water treatment facilities. This edition provides instructors with access to additional resources via a companion website. Contains in-depth chapters on processes such as coagulation and flocculation, sedimentation, ion exchange, adsorption, and gas transfer Details membrane filtration technologies, advanced oxidation, and potable reuse Addresses ongoing environmental concerns, pharmacological agents in the water supply, and treatment strategies Describes reverse osmosis applications for brackish groundwater, wastewater, and other water sources Includes high-quality images and illustrations, useful appendices, tables of chemical properties and design data, and more than 450 exercises with worked solutions Stantec's Water Treatment: Principles and Design, Updated Third Edition remains an indispensable resource for engineers designing or operating water treatment plants, and is an essential textbook for students of civil, environmental, and water resources engineering.
This note raises the IMF’s profile on a number of issues related to inequality, unemployment, governance, etc. It builds on earlier empirical work that examined correlations between growth downbreaks/duration of growth spells and a range of macro/policy/institutional factors. This paper is designed to be more accessible, more policy oriented, and focused squarely on the issue of inequality and the sustainability of growth. It will reference the literature that has gained prominence in the wake of the global crisis, and the possible links between the crisis and rising inequality in countries at the epicenter of the crisis. The analytical findings will also be connected to real world policy narratives in certain countries, to provide texture to the results and enhance policy relevance. The paper will argue that, based on the empirical findings, more equality in the income distribution is associated with longer-lived growth spells. Broad redistributive policies are not necessarily pro-growth, however, as these can have strong disincentive effects. The paper’s policy discussion is appropriately cautious, therefore, offering only tentative ideas, for example, active labor market policies and more attention to human capital investments designed to avoid conflicts between efficiency and equity perspectives.
This book makes a substantial collection of Vaughan Williams's writings widely available to music lovers, students, and researchers alike. It comprises 102 items written by the composer between 1897 and the year of his death, 1958, including articles for musical magazines, transcripts of broadcasts, obituary notices and program notes. The great majority of items in this anthology have been unavailable since their initial publication, some have never been published, and very few have been reprinted. Vaughan Williams reveals the many roles he played during his life in the pages of this book: he was an active supporter of amateur music-makers, a leader in the folksong revival, educator, performer, campaigner for English music, and polemicist. Through all these perspectives, the words are unmistakably those of a composer who came to believe it his duty to build an active and cohesive musical community within his native country.
This practical book focuses on humanistic counselling as an evidence-based psychological intervention and it is an essential read for trainees wishing to work in public health settings. Coverage includes: evidence-based practice and person-centered and experiential therapies the counselling for depression competence framework in-depth case studies illustrating Counselling for Depression in practice training, supervision and research The book also includes research data supporting the approach, and sources used in developing the humanistic competence framework. Vital reading for those taking counselling for depression training or a humanistic counselling and psychotherapy course, as well as for those already working within the NHS and wish to enhance their practice.
Over the past two decades a number of attempts have been made, with varying degrees of success, to collect in a single treatise available information on the basic and applied pharmacology and biochemical mechanism of action of antineoplastic and immunosuppressive agents. The logarithmic growth of knowledge in this field has made it progressively more difficult to do justice to all aspects of this topic, and it is possible that the present handbook, more than four years in preparation, may be the last attempt to survey in a. single volume the entire field of drugs em ployed in cancer chemotherapy and immunosuppression. Even in the present instance, it has proved necessary for practical reasons to publish the material in two parts, although the plan of the work constitutes, at least in the editors' view, a single integrated treatment of this research area. A number of factors have contributed to the continuous expansion of research in the areas of cancer chemotherapy and immunosuppression. Active compounds have been emerging at ever-increasing rates from experimental tumor screening systems maintained by a variety of private and governmental laboratories through out the world. At the molecular level, knowledge of the modes of action of estab lished agents has continued to expand, and has permitted rational drug design to playa significantly greater role in a process which, in its early years, depended almost completely upon empirical and fortuitous observations.
As a result of the molecular genetic analysis of development similar mechanisms for the regulation of gene expression are found in a wide range of organisms. In "Development - the Molecular Genetic Approach" these common mechanisms as well as the specific events leading to a differentiated cell are described. Particular items treated are, for example, how asymmetry is achieved, how cell size is determined, how cell division is controlled, how cell lineage influences development, how cells know their position, and how cells communicate during development.
Completely revised and updated, this text provides an easy-to-read guide to the concept of mass spectrometry and demonstrates its potential and limitations. Written by internationally recognised experts and utilising "real life" examples of analyses and applications, the book presents real cases of qualitative and quantitative applications of mass spectrometry. Unlike other mass spectrometry texts, this comprehensive reference provides systematic descriptions of the various types of mass analysers and ionisation, along with corresponding strategies for interpretation of data. The book concludes with a comprehensive 3000 references. This multi-disciplined text covers the fundamentals as well as recent advance in this topic, providing need-to-know information for researchers in many disciplines including pharmaceutical, environmental and biomedical analysis who are utilizing mass spectrometry
In spite of improved access to psychosocial interventions, many people with psychosis continue to experience persistent problems which act as significant barriers to their recovery. This book investigates risk and problem behaviours in psychosis, including staff and service factors that can impede the delivery of effective care. Problematic and Risk Behaviours in Psychosis provides a new approach for assessment, formulation and intervention within such problem behaviours in a team context. Of particular interest will be: an outline of the SAFE (Shared Assessment, Formulation and Education) approach an integrative model for understanding risk and problematic behaviour shared risk assessment and management processes approaches to reducing team and carer barriers to effective care the use of CBT in day-to-day interactions with clients a set of formulation-driven strategies for managing problematic behaviours case studies and vignettes providing guidance and highlighting the benefits of the approach. This book will have particular appeal to professionals working in specialist community, hospital-based and residential services who often struggle to help those with the most complex mental health problems who are hardest to reach. It is also an excellent resource for those engaged in training in psychological therapies, risk assessment and management.
Dr. George P. Thomon, Nobel Laureate in Physics said, "We have labelled civilizations by the main materials which they have used: The Stone Age, the Bronze Age and the Iron Age ••• a civilization is both developed and limited by the materials at its disposal. Today, man lives on the boundary between the Iron Age and a New Materials Age." The ever more stringent requirements for materials to accomplish specific functions and withstand extreme conditions, as dictated by the needs of industry and defense, con tinue to spur ever more intensive research in Materials Science. According to the recent report "Trends and Opportunities in Materials Research" a vital goal of materials research is to design synthesize and fabricate in high yield, new materials with properties that can be pre dicted, varied and controlled. In the past this has been a fairly empirical process, but as we gain more comprehensive understanding of the behavior of matter on an atomic and molecular scale this goal becomes ever more attain able. An important recent trend is the increasing sophistication and power of theoretical approaches. Aided by the development of computers and versa tile numerical techniques, as well as concepts from statistical mechanics, theorists are beginning to confront the complexity of real materials. Important advances are expected through a concentrated attack on model systems in which the theorist, experimental scientist and engineer all work together towards designing new materials and controlling their properties.
In connection with the recent treatment of radium and the actinides, the Gmelin Institute is carrying out the description of thorium and its compounds. The supplement volumes A 2, A 3 and A 4 with the history, isotopes, uses, the recovery of thorium and general properties of thorium atom and ions, the thermodynamics of its compounds and solutions, and spectroscopic data have already been published. The supplement vol- umes C 1, C 2 and C 3 describing the compounds with the noble gases, hydrogen, oxygen compounds and nitrogen compounds are also available; also has been pu- blished Supplement Volume C 5 describing the compounds with sulfur, selenium, tellurium, and boron. The Supplement Volume D 1 and D 2 describing the properties of thorium ions in solution and the solvent extraction of thorium as well as Supplement Volume E de- scribing the coordination compounds also have been published. The present supplement volume A 5 of the Gmelin Handbook "Thorium" is devoted to the analytical chem- istry of this element, to its biological behavior and to health protection and safety control, including the monitoring of occupational exposure received by personnel. The analytical chemistry of thorium relies mainly on the so-called "classical" determination methods like gravimetric, volumetric, and spectrometric methods. Radiometric methods find also large application in the analytical chemistry of thorium. Presently we have a good understanding of the biological behavior of this danger- ous radioelement, together with a broad knowledge of its metabolism and its effects on humans. The therapeutic decorporation of thorium is also treated in this volume.
As the definitive reference for clinical chemistry, Tietz Textbook of Clinical Chemistry and Molecular Diagnostics, 5th Edition offers the most current and authoritative guidance on selecting, performing, and evaluating results of new and established laboratory tests. Up-to-date encyclopedic coverage details everything you need to know, including: analytical criteria for the medical usefulness of laboratory procedures; new approaches for establishing reference ranges; variables that affect tests and results; the impact of modern analytical tools on lab management and costs; and applications of statistical methods. In addition to updated content throughout, this two-color edition also features a new chapter on hemostasis and the latest advances in molecular diagnostics. Section on Molecular Diagnostics and Genetics contains nine expanded chapters that focus on emerging issues and techniques, written by experts in field, including Y.M. Dennis Lo, Rossa W.K. Chiu, Carl Wittwer, Noriko Kusukawa, Cindy Vnencak-Jones, Thomas Williams, Victor Weedn, Malek Kamoun, Howard Baum, Angela Caliendo, Aaron Bossler, Gwendolyn McMillin, and Kojo S.J. Elenitoba-Johnson. Highly-respected author team includes three editors who are well known in the clinical chemistry world. Reference values in the appendix give you one location for comparing and evaluating test results. NEW! Two-color design throughout highlights important features, illustrations, and content for a quick reference. NEW! Chapter on hemostasis provides you with all the information you need to accurately conduct this type of clinical testing. NEW! Six associate editors lend even more expertise and insight to the reference. NEW! Reorganized chapters ensure that only the most current information is included.
This companion to Brenner and Rector's The Kidney offers a state-of-the-art summary of the most recent advances in renal genetics. Molecular and Genetic Basis for Renal Disease provides the nephrologist with a comprehensive look at modern investigative tools in nephrology research today, and reviews the molecular pathophysiology of the nephron as well as the most common genetic and acquired renal diseases. A comprehensive clinical review of Medelian renal disease is also be included. Detailed review of the molecular anatomy and pathophysiology of the nephron that provides relevant basic science to consider when diagnosing and managing patients with these disorders.
A wide range of topics are covered, including articles on nucleic acid structure, through their interactions with proteins to the control of gene expression. A number of authors address the subject of RNA, including the difficult but important subject of its chemical synthesis, the complexities of its structures and the mechanisms of transcript splicing. The probing of DNA structure is reviewed in papers on the application of hydroxyl radical and 1,10 phenanthroline copper cleavages. A number of important DNA-protein interactions are discussed, including DNA polymerase, the tryptophan and deoR repressors, and the resolvase enzymes which cleave Holliday junctions in recombination. Gene transcription is also covered, from the points of view of DNA methylation, mammalian ribosomal and avian lysozyme genes, and the control of transcription in the proto-oncogene c-fos. Finally, the plant kingdom has not been forgotten with articles on development and transposition in plants.
Winner of the BMA 2011 book awards: psychiatry category Winner of the Australian Journal of Ageing book of the year award This definitive work on dementia and related disorders has been fully updated and revised to reflect recent advances in this fast-moving field. The incidence of dementia continues to rise as the population of the world ages, and the condition represents one of the most significant challenges facing societies and health professionals in the next half-century. In this, the most comprehensive single volume work available on the subject, the editors have met this challenge by assembling a team of the world's leading experts on all aspects of the condition, from history, epidemiology and social aspects to the latest neurobiological research and advanced therapeutic strategies.
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