The same careful rigour imposed on the design of phase III randomised controlled trials is not always applied to medical research in other areas such as trials conducted at earlier stages of drug development. With the emphasis that is now placed on evidence-based medicine, such care and rigour will inevitably impact on these areas with increasing attention turned to the quality of design. This title describes what principles can be used to structure research effectively allowing for the required degree of accuracy. Written by two best selling authors, this book includes many examples from medical literature and will be of great value to all groups conducting studies at the interface of clinical and laboratory research.
An important milestone in medicine has been the recent completion of the Human Genome Project. The identification of 30,000 genes and their regulatory proteins provides the framework for understanding the metabolic basis of disease. This advance has also laid the foundation for a broad range of genomic tools that have opened the way for targeted genetic testing in a number of medical disorders. This book is designed to be the first major text to discuss genomics-based advances in disease susceptibility, diagnosis, prognostication,and prediction of treatment outcomes in various areas of medicine. After building a strong underpinning in the basic concepts of genomics, the authors of this book, all leaders in the field, proceed to discuss a wide range of clinical areas and the applications now afforded by genomic analysis.
Full-color, step-by-step guidance on reconstructive procedures Authored by top experts in the field, Current Reconstructive Surgery is a comprehensive resource that prepares you for the most challenging cases, while giving you a solid grasp of the fundamentals. The content of the book—logically organized by anatomic region—is supported by more than 1,300 state-of-the-art illustrations and photographs, nearly all of which are in full color. Current Reconstructive Surgery begins with a valuable review of the principles of wound healing and wound repair. Its subsequent chapters meticulously examine pertinent reconstructive topics and present the latest surgical protocols for all injuries and disabilities, from burn reconstruction and skull base surgery to the management of hand infections. Current Reconstructive Surgery delivers insights derived from the authors’ vast experience as practitioners, combined with data from new and landmark studies. This one-of-a-kind guide has everything you need to confidently perform both common and uncommon reconstructive procedures—so you can improve function and approximate a normal appearance for your patients. Each chapter covers: Patient evaluation and selection: Proven diagnostic strategies that elucidate the nature of the disorder, including onset and duration Patient preparation: Details the preoperative plan, including anesthesia considerations, grafts or flaps used in reconstruction, and patient positioning Techniques: Evidence-based surgical approaches for each type of surgery Incisive coverage of postoperative management: Important steps that physicians and patients must take to promote healing and restore function Overview of complications: Such as infection, fistulae, the risk of secondary procedures due to unsatisfactory results, and post-surgical psychological problems related to the patient’s self-image
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