Oral Colon-Specific Drug Delivery covers approaches used to deliver a variety of drugs to the colon. Anatomy and physiology of the gastrointestinal tract as it affects colonic drug delivery and pharmacokinetics are reviewed, as well as drug absorption from the colon. The book presents valuable information on a variety of topics, including oral peptide/protein delivery, dextran-based delivery systems, glycoside/glycosidase-based delivery, azo-bond prodrugs, hydroxypropyl methacrylamide copolymers for colonic delivery, and matrices for colonic drug delivery. Special emphasis is placed on delivery systems, especially biochemical approaches to delivery, such as the use of degradable polymers and both low and high molecular weight prodrugs. Oral Colon-Specific Drug Delivery will provide a valuable reference resource for gastroenterologists, pharmaceutical scientists, and other researchers working with drug delivery to the colon.
The Handbook of Crime Correlates, Second Edition summarizes more than a century of worldwide research on traits and social conditions associated with criminality and antisocial behavior. Findings are provided in tabular form, enabling readers to determine at a glance the nature of each association. Within each table, results are listed by country, type of crime (or other forms of antisocial behavior), and whether each variable is positively, negatively, or insignificantly associated with offending behavior. Criminal behavior is broken down according to major categories, including violent crime, property crime, drug offenses, sex offenses, delinquency, and recidivism. This book provides a resource for practitioners and academics who are interested in criminal and antisocial behavior. It is relevant to the fields of criminology/criminal justice, sociology, and psychology. No other publication provides as much information about how a wide range of variables—e.g., gender, religion, personality traits, weapons access, alcohol and drug use, social status, geography, and seasonality—correlate with offending behavior. - Includes 600+ tables regarding variables related to criminal behavior - Consolidates 100+ years of academic research on criminal behavior - Findings are identified by country and world regions for easy comparison - Lists criminal-related behaviors according to major categories - Identifies universal crime correlates
Low-dimensional solids are of fundamental interest in materials science due to their anisotropic properties. Written not only for experts in the field, this book explains the important concepts behind their physics and surveys the most interesting one-dimensional systems and discusses their present and emerging applications in molecular scale electronics. The second edition of this successful book has been completely revised to include the remarkable achievements of the last ten years of research and applications. Chemists, polymer and materials scientists as well as students will find this book a very readable introduction to the solid-state physics of electronic materials.
Over the course of nearly half a century, Sam Edwards has led the field of condensed matter physics into new directions, ranging from the electronic and statistical properties of disordered materials to the mechanical properties of granular materials. Along the way, he has provided seminal contributions to fluid mechanics, polymer science, surface science and statistical mechanics. This volume celebrates the immense scope of his influence by presenting a collection of original articles by recognized leaders in theoretical physics, including two Nobel Laureates and a Fields Medalist, which describe the genesis, evolution and future prospects of the various sub-fields of condensed matter theory, along with reprints of a selection of Edwards' seminal papers that helped give birth to the subject. 'Stealing the Gold', Edwards' favourite caricature of the relationship between theoretical physicists and Nature, will be of singular interest to graduate students looking for an overview of some of the most exciting areas of theoretical physics, as well as to researchers in condensed matter physics looking for a comprehensive, broad and uniquely incisive snapshot of their subject at the dawn of the 21st century.
The Psychopharmacologists 3 completes a trio of interview-based books about the process of therapeutic innovation in clinical psychiatry. David Healy's method is to interview key individuals involved in the discovery and deployment of drugs that have proved useful to psychiatry, and to draw them together within a model of the mechanism and clinical discovery that he uses as an overall framework. These are historical accounts but highly relevant to the clinical psychiatrist of today, emphasising the importance of research, and of the marketing strategies of pharmaceutical companies in formulating disease entities as well as treatments for them.
This is the inaugural volume in the first full-scale scholarly edition of Thoreau's correspondence in more than half a century. When completed, the edition's three volumes will include every extant letter written or received by Thoreau--in all, almost 650 letters, roughly 150 more than in any previous edition, including dozens that have never before been published. Correspondence 1 contains 163 letters, ninety-six written by Thoreau and sixty-seven to him. Twenty-five are collected here for the first time; of those, fourteen have never before been published. These letters provide an intimate view of Thoreau's path from college student to published author. At the beginning of the volume, Thoreau is a Harvard sophomore; by the end, some of his essays and poems have appeared in periodicals and he is at work on A Week on the Concord and Merrimack Rivers and Walden. The early part of the volume documents Thoreau's friendships with college classmates and his search for work after graduation, while letters to his brother and sisters reveal warm, playful relationships among the siblings. In May 1843, Thoreau moves to Staten Island for eight months to tutor a nephew of Emerson's. This move results in the richest period of letters in the volume: thirty-two by Thoreau and nineteen to him. From 1846 through 1848, letters about publishing and lecturing provide details about Thoreau's first years as a professional author. As the volume closes, the most ruminative and philosophical of Thoreau's epistolary relationships begins, that with Harrison Gray Otis Blake. Thoreau's longer letters to Blake amount to informal lectures, and in fact Blake invited a small group of friends to readings when these arrived. Following every letter, annotations identify correspondents, individuals mentioned, and books quoted, cited, or alluded to, and describe events to which the letters refer. A historical introduction characterizes the letters and connects them with the events of Thoreau's life, a textual introduction lays out the editorial principles and procedures followed, and a general introduction discusses the significance of letter-writing in the mid-nineteenth century and the history of the publication of Thoreau's letters. Finally, a thorough index provides comprehensive access to the letters and annotations.
The second Canadian edition of Health Psychology: Biopsychosocial Interactions integrates multidisciplinary research and theory to help students understand the complex connections between psychology and health. This comprehensive yet accessible textbook covers the biopsychosocial factors that impact human health and wellness, placing particular emphasis on the distinctive characteristics of the Canadian health care system, the issues and challenges unique to Canadian culture, and the most recent Canadian research in the field of health psychology. Clear, student-friendly chapters examine topics such as coping with stress and illness, lifestyles for enhancing health and preventing illness, managing pain and discomfort, getting medical treatment, and living with chronic illness. This fully revised second edition features the latest available data and research from across Canada and around the world. New and expanded chapters explore psychosocial factors in aging and dying, legalized marijuana use in Canada, the link between inflammation and depression, Canadian psychosocial models of pain, recent Medical Assistance in Dying (MAiD) legislation, weight control, eating disorders, and exercise, and much more. Throughout the text, updated illustrative examples, cross-cultural references, and real-world cases reinforce key points and strengthen student comprehension, retention, and interest.
Full-color, step-by-step guidance on reconstructive procedures Authored by top experts in the field, Current Reconstructive Surgery is a comprehensive resource that prepares you for the most challenging cases, while giving you a solid grasp of the fundamentals. The content of the book—logically organized by anatomic region—is supported by more than 1,300 state-of-the-art illustrations and photographs, nearly all of which are in full color. Current Reconstructive Surgery begins with a valuable review of the principles of wound healing and wound repair. Its subsequent chapters meticulously examine pertinent reconstructive topics and present the latest surgical protocols for all injuries and disabilities, from burn reconstruction and skull base surgery to the management of hand infections. Current Reconstructive Surgery delivers insights derived from the authors’ vast experience as practitioners, combined with data from new and landmark studies. This one-of-a-kind guide has everything you need to confidently perform both common and uncommon reconstructive procedures—so you can improve function and approximate a normal appearance for your patients. Each chapter covers: Patient evaluation and selection: Proven diagnostic strategies that elucidate the nature of the disorder, including onset and duration Patient preparation: Details the preoperative plan, including anesthesia considerations, grafts or flaps used in reconstruction, and patient positioning Techniques: Evidence-based surgical approaches for each type of surgery Incisive coverage of postoperative management: Important steps that physicians and patients must take to promote healing and restore function Overview of complications: Such as infection, fistulae, the risk of secondary procedures due to unsatisfactory results, and post-surgical psychological problems related to the patient’s self-image
Compiled by scholars with unrivalled knowledge of the sources, this dictionary provides biographies of all musicians and instrument makers employed by the English court from 1485-1714. A number of the musicians featured here have never previously received a dictionary entry. Coverage of these minor figures helps to flesh out the picture of musical life in the court in a way which individual studies of more major composers cannot. In addition to basic biographical details, entries feature information on: appointments; probate material; family background; heraldry; signatures and holograph documents; subscriptions to books; bibliographic references. A finding-list of variant names, details of the succession of court places assumed by musicians and an index of subjects and place names completes this comprehensive reference work.
Using an integrated, "team" approach, leading authority David N. Herndon, MD, FACS explains how to meet the clinical, physical, psychological, and social needs of every burn patient - and thus achieve optimal recovery and rehabilitation. The 3rd Edition of this definitive reference covers all of the latest advances in the treatment of burns...features new a full-color layout with new color illustrations and clinical photographs. Compiled and edited by one of the world's leading authorities on the management of patients with burns. Discusses the management of burn patients from their initial presentation through long-term rehabilitation. Addresses the clinical, physical, and social needs of the burn patient and emphasizes a multi-faceted, "team approach" to treatment. Covers how to devise integrated treatment programs for different groups of patients, such as elderly and pediatric patients. Uses color illustrations and clinical photographs throughout for the first time-incorporating the illustrative strengths of Barret & Herndon's Color Atlas of Burn Care to provide you with a single source of definitive guidance on diagnosis and management. Presents new chapters on barotrauma and inhalation injury - the tissue bank - the role of exercise - and the use of dermal templates and burn scar resurfacing. Offers fresh perspectives from more than 50% new authors. With more than 100 additional contributing experts
Fluid turbulence is often referred to as `the unsolved problem of classical physics'. Yet, paradoxically, its mathematical description resembles quantum field theory. The present book addresses the idealised problem posed by homogeneous, isotropic turbulence, in order to concentrate on the fundamental aspects of the general problem. It is written from the perspective of a theoretical physicist, but is designed to be accessible to all researchers in turbulence, both theoretical and experimental, and from all disciplines. The book is in three parts, and begins with a very simple overview of the basic statistical closure problem, along with a summary of current theoretical approaches. This is followed by a precise formulation of the statistical problem, along with a complete set of mathematical tools (as needed in the rest of the book), and a summary of the generally accepted phenomenology of the subject. Part 2 deals with current issues in phenomenology, including the role of Galilean invariance, the physics of energy transfer, and the fundamental problems inherent in numerical simulation. Part 3 deals with renormalization methods, with an emphasis on the taxonomy of the subject, rather than on lengthy mathematical derivations. The book concludes with some discussion of current lines of research and is supplemented by three appendices containing detailed mathematical treatments of the effect of isotropy on correlations, the properties of Gaussian distributions, and the evaluation of coefficients in statistical theories.
An essential guide to clinical issues encountered during management of patients of varied cultural and economic backgrounds This essential text assists health care students and practitioners in delivering skilled and appropriate care to all patients, no matter their ethnicity, country of origin, cultural history, or access to services. Presenting need-to-know and often hard to find information on differences in access to heath care, immunization histories, disease prevalence, attitudes about health and provision of care, and much more, this resource provides practical, authoritative, and specific guidance.
Booderee National Park at Jervis Bay, 200km south of Sydney, attracts over 450 000 visitors each year. The park has many special features, including dramatic wave cut platforms and sea caves, some of the whitest beach sands in Australia, and very high densities of native predators such as the Powerful Owl and the Diamond Python. This book outlines the biology and ecology of Booderee National Park. Booderee packs an extraordinary level of biodiversity into a small area (roughly 6500 hectares), with more than 260 species of terrestrial vertebrates and over 625 species of plants. It is home to species of significant conservation concern, such as the globally endangered Eastern Bristlebird for which the park is one of its last and most important strongholds. The diversity of vegetation is also astounding: in some parts of the park, it is possible to walk from ankle-high sedgelands, through woodlands and forest and into subtropical rainforest in less than 150 metres. Chapters are arranged around key ecological processes – predators and predation, herbivores and herbivory, invasive plants and fire – emphasising the interactions between species, between vegetation and animals, and between disturbances and animal and plant responses. The book highlights how Booderee National Park is a functional natural ecosystem and, in turn, how management practices aim to improve environmental conditions and promote biodiversity conservation. Richly illustrated with colour images from award-winning photographer Esther Beaton, this book will delight visitors to Booderee National Park as well as anyone with an interest in natural history.
This highly effective guide is designed to help attorneys differentiate expert testimony that is scientifically well-established from authoritative pronouncements that are mainly speculative. Building on the foundation of Jay Ziskin's classic work, this updated text blends the best of previous editions with discussion of positive scientific advances in the field to provide practical guidance for experts and lawyers alike. Major contributors in the field summarize the state of the literature in numerous key areas of the behavioral sciences and law. Working from these foundations, the text provides extensive guidance, tips, and strategies for improving the quality of legal evaluations and testimony, appraising the trustworthiness of experts' opinions, and as follows, bolstering or challenging conclusions in a compelling manner. Distinctive features of this text include detailed coverage of admissibility and Daubert challenges, with unique chapters written by an eminently qualified judge and attorney; hundreds of helpful suggestions covering such topics as forensic evaluations, discovery, and the conduct of depositions and cross-examinations; and two chapters on the use of visuals to enhance communication and persuasiveness, including a unique chapter with over 125 model visuals for cases in psychology and law. More than ever, the sixth edition is an invaluable teaching tool and resource, making it a 'must have' for mental health professionals and attorneys"--
As in the Great War, Reading in the Second World War was a town permanently in a state of flux. So close to London, so easily pinpointed by its proximity to the Thames, with railway lines converging near the town centre and with much of the town’s industry geared up to essential war work, it was an obvious target for the German Luftwaffe when the war broke out. Knowing this, the council had set up an efficient Civil Defence system aided by government finance. Fortunately for the citizens, although they were bombed on many occasions, only one raid had any significant impact. The book covers the daily life of a town ready for the worst, but one that continued with its daily life and just got on with its efforts to aid the war effort. The book is profusely illustrated with photographs, illustrations and human interest stories. Much of the material used has not been seen since the war so it provides a valuable and unique insight into daily life of the town.
Focusing on cancer in dogs and cats, this extensively updated 4th edition provides comprehensive coverage of the latest advances in clinical oncology, including chemotherapy, surgical oncology, and diagnostic techniques. Ideal for students, practitioners, and those involved in academic research, this book's full-color images and user-friendly format provide quick and easy access to today's most important information on cancer in the small animal patient. Full-color format throughout and full-color illustrations make information more accessible and provide accurate representations of clinical appearance. Chapters are clustered into four major sections: The Biology and Pathogenesis of Cancer, Diagnostic Procedures for the Cancer Patient, Therapeutic Modalities for the Cancer Patient, and Specific Malignancies in the Small Animal Patient. The consistent format includes incidence and risk factors, pathology, natural behavior of tumors, history and clinical signs, diagnostic techniques and workup, treatment options, and prognosis for specific malignancies in the small animal cancer patient. Features cutting edge information on the complications of cancer, pain management, and the latest treatment modalities. The latest information on the etiology of cancer, including genetic, chemical, physical, and hormonal factors, as well as cancer-causing viruses. Coverage of molecular-targeted therapy of cancer, plus new and emerging therapeutic techniques. New information on molecular diagnostic procedures for the cancer patient. The latest diagnostic imaging techniques in clinical oncology. Discussions of compassion and supportive care, from chronic pain management and nutrition to end-of-life issues and grief support.
With a unique focus on the most effective interventional techniques, Withrow & MacEwen's Small Animal Clinical Oncology, 5th Edition tells the full story of cancer in dogs and cats - what it is, how to diagnose it, and how to treat many of the most common cancers encountered in clinical practice. Nearly 500 color photographs, diagrams, x-rays, and gross views depict the clinical manifestations of various cancers. This edition covers the latest advances in clinical oncology, including chemotherapy, surgical oncology, and diagnostic techniques. With contributions from 65 veterinary oncology experts, this authoritative reference is a must-have for current, evidence-based therapeutic strategies on canine and feline oncology. "I really love this book. If you are interested in veterinary oncology, have a flick through this book online or at a conference when you get the chance. I hope that you agree with me that this is the definitive oncology reference source for the early 21st century and that you feel compelled to buy it. Your patients will thank you for it." Reviewed by: Gerry Polton MA VetMB MSc(Clin Onc) DipECVIM-CA(Onc) MRCVS, UK Date: July 2014 Cutting-edge information on the complications of cancer, pain management, and the latest treatment modalities prepares you to diagnose and treat pets with cancer rather than refer cases to a specialist. A consistent format for chapters on body system tumors includes coverage of incidence and risk factors, pathology, natural behavior of tumors, history and clinical signs, diagnostic techniques and workup, treatment options, and prognosis for specific malignancies. A systems approach to the diagnosis and management of cancer facilitates access to information about the many malignancies affecting small animal patients. Nearly 500 color images provide accurate depictions of specific diseases and procedures. Helpful drug formularies provide quick access to information on indications, toxicities, and recommended dosages for chemotherapeutic and analgesic drugs used in cancer treatment. Expert contributors provide in-depth coverage of the most current information in his or her respective specialty in veterinary oncology. Chemotherapy protocols are included when case studies prove clinical efficacy. Discussion of compassion and supportive care for the management of pain, nutritional needs, and grief includes methods for handling the pet's pain and nutritional complications as well as the pet owner's grief when treatment is not successful. Thoroughly UPDATED chapters cover the most recent changes in the clinical management of melanoma, mast cell tumors, tumors of the skeletal system, tumors of the endocrine system, tumors of the mammary gland, urinary cancers, nervous system cancers, lymphoma, and histiocytic diseases. NEW Clinical Trials and Developmental Therapeutics chapter discusses the various phases of clinical trials as well as current challenges and opportunities in oncology drug development. NEW! A focus on the best recommended treatment options highlights therapeutic strategies that have been vetted by veterinary oncology experts. NEW co-author Dr. Rodney L. Page adds his valuable perspective, expertise, and research experience.
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