The author of the The Children’s Blizzard delivers an epic work of twentieth century history through the riveting story of one extraordinary Jewish family In tracing the roots of this family—his own family—Laskin captures the epic sweep of the twentieth century. A modern-day scribe, Laskin honors the traditions, the lives, and the choices of his ancestors: revolutionaries and entrepreneurs, scholars and farmers, tycoons and truck drivers. The Family is a deeply personal, dramatic, and emotional account of people caught in a cataclysmic time in world history. A century and a half ago, a Torah scribe and his wife raised six children in a yeshivatown at the western fringe of the Russian empire. Bound by their customs and ancient faith, the pious couple expected their sons and daughter to carry family traditions into future generations. But the social and political crises of our time decreed otherwise. The torrent of history took the scribe’s family down three very different roads. One branch immigrated to America and founded the fabulously successful Maidenform Bra Company; another went to Palestine as pioneers and participated in the contentious birth of the state of Israel; the third branch remained in Europe and suffered the onslaught of the Nazi occupation. With cinematic power and beauty, bestselling author David Laskin brings to life the upheavals of the twentieth century through the story of one family, three continents, two world wars, and the rise and fall of nations.
Written to convey an intuitive feel for both theory and practice, its main objective is to illustrate what a powerful tool density estimation can be when used not only with univariate and bivariate data but also in the higher dimensions of trivariate and quadrivariate information. Major concepts are presented in the context of a histogram in order to simplify the treatment of advanced estimators. Features 12 four-color plates, numerous graphic illustrations as well as a multitude of problems and solutions.
This book explains the relationships between physical activity, health and disease, and examines the benefits of exercise in the prevention and treatment of various important conditions. This book offers an examination of the evidence linking levels of physical activity with disease and mortality.
The quality of life of millions of people living in cities could be improved if the form of the city were to evolve in a manner appropriate to its climatic context. Climatically responsive urban design is vital to any notion of sustainability: it enables individual buildings to make use of renewable energy sources for passive heating and cooling, it enhances pedestrian comfort and activity in outdoor spaces, and it may even encourage city dwellers to moderate their dependence on private vehicles. Urban Microclimate bridges the gap between climatology research and applied urban design. It provides architects and urban design professionals with an understanding of how the structure of the built environment at all scales affects microclimatic conditions in the space between buildings, and analyzes the interaction between microclimate and each of the elements of the urban landscape. In the first two sections of the book, the extensive body of work on this subject by climatologists and geographers is presented in the language of architecture and planning professionals. The third section follows each step in the design process, and in part four a critical analysis of selected case study projects provides a demonstration of the complexity of applied urban design. Practitioners will find in this book a useful guide to consult, as they address these key environmental issues in their own work.
When pundits refer to the death of community, they are speaking of a number of social ills, which include, but are not limited to, the general increase in isolation and cynicism of our citizens, widespread concerns about declining political participation and membership in civic organizations, and periodic outbursts of small town violence. Making a Place for Community argues that this death of community is being caused by contemporary policies that, if not changed, will continue to foster the decline of community. Increased capital flow between nations is not at the root of the problem, however, increased capital flow within our nation is. Small towns shouldn't have to hope for a prison to open nearby and downtown centers shouldn't sit empty as suburban sparwl encroaches, but they do and it's a result of widely agreed upon public policies.
Diagnostic Immunohistochemistry presents the latest information and most reliable guidance on immunohistological diagnoses in surgical pathology. David J. Dabbs, MD and other leading experts bring you state-of-the-art coverage on genomic and theranostic applications, molecular anatomic pathology, immunocytology, Non-Hodgkin’s lymphoma, and more. Additional features such as tables discussing antibody specifications, differential diagnosis boxes, ancillary anatomic molecular diagnostics, and full-color histological images ensure user-friendly coverage that makes key information easy to find and apply. This concise and complete resource is today’s indispensable guide to the effective use of immunohistochemical diagnosis. Discusses diagnostic pitfalls through immunohistologic differential diagnosis wherever appropriate so you can provide the most accurate diagnoses. Presents chapters arranged by organ system for comprehensive coverage of all relevant information in a convenient and intuitive organization. Provides quick reference graphs for antibodies throughout the text that illustrate the frequency of immunostaining for a variety of antibodies in tumors. Includes Key Diagnostic Points boxes in every chapter for a quick summary of text areas that are of particular importance. Features an expert author for each chapter to ensure coverage of the current state of the art. Provides guidance on the role of genomics in identifying genetic and molecular aspects of disease that may affect patient care and therapeutic approaches. Covers theranostic applications to enable you to evaluate therapeutic choices based on immunohistochemical results. Reflects the latest developments in the field through new chapters on molecular anatomic pathology and immunocytology, as well as updated chapters on immunohistology of the prostate, bladder, testis, and kidney and Non-Hodgkin’s lymphoma. Discusses antibody specifications with tables that convey information on uses, clones, vendors, sources, antibody titers, and types of antigen retrieval. Presents key differential diagnoses boxes that provide tabular summaries of DDx and algorithms. Features discussions of ancillary anatomic molecular diagnostics as an adjunct to immunohistochemistry for a more well-rounded diagnostic approach.
Comprehensive, practical and extensively illustrated, this book accumulates years of practical knowledge when dealing with injured birds of prey. Written by a practicing veterinarian it is a concise, helpful, day-to-day guide which outlines everything from handling and the intake examination, through to practical procedures and the treatment of a comprehensive range of conditions and injuries. Also covering advice on housing, rehabilitation and eventual release, and fully updated throughout, this new edition incorporates new images as well as new and expanded information on electrocution, pesticides, feeding puppets and species habitats.
The aftermath of Hurricane Katrina laid bare the tragedy of American cities. What the storm revealed about the social conditions in New Orleans shocked many Americans. Even more shocking is how widespread these conditions are throughout much of urban America. Plagued by ineffectual and inegalitarian governance, acute social problems such as extreme poverty, and social and economic injustice, many American cities suffer a fate similar to that of New Orleans before and after the hurricane. Gentrification and corporate redevelopment schemes merely distract from this disturbing reality. Compounding this tragedy is a failure in urban analysis and scholarship. Little has been offered in the way of solving urban America's problems, and much of what has been proposed or practiced remains profoundly misguided, in David Imbroscio's view. In Urban America Reconsidered, he offers a timely response. He urges a reconsideration of the two reigning orthodoxies in urban studies: regime theory, which provides an understanding of governance in cities, and liberal expansionism, which advocates regional policies linking cities to surrounding suburbs. Declaring both approaches to be insufficient—and sometimes harmful—Imbroscio illuminates another path for urban America: remaking city economies via an array of local economic alternative development strategies (or LEADS). Notable LEADS include efforts to build community-based development institutions, worker-owned firms, publicly controlled businesses, and webs of interdependent entrepreneurial enterprises. Equally notable is the innovative use of urban development tools to generate indigenous, stable, and balanced growth in local economies. Urban America Reconsidered makes a strong case for the LEADS approach for constructing progressive urban regimes and addressing America's deepest urban problems.
Covering CUSUMs from an application-oriented viewpoint, while also providing the essential theoretical underpinning, this is an accessible guide for anyone with a basic statistical training. The text is aimed at quality practitioners, teachers and students of quality methodologies, and people interested in analysis of time-ordered data. Further support is available from a Web site containing CUSUM software and data sets.
A work of uncanny originality, David Huddle's nineteenth book is the account of an extraordinary death trip taken by a charismatic and beloved woman, her husband, and an astonishing number of offspring, from infants to young adults. The Faulkes Chronicle explores how children grieve, and shows how the wit and courage of even the littlest brothers and sisters can be a source of resilience. Familial conversation composes an intimate requiem, transforming loss into comprehension. Only one of our finest writers could manage this delicate material. The Faulkes Chronicle is a brief, autumnal novel— made of momentary details yet with an encompassing grandeur.
Bone Marrow Diagnosis is an essential resource for all those who need to report bone marrow trephine biopsies. The text is succinct and concentrates on the core information necessary to make an accurate diagnosis. Each diagnostic entity is accompanied by high quality images which show typical and more unusual examples of histological features. This new edition has been completely revised and updated throughout and includes many new images including conditions not illustrated in the first edition. A simply written and well-illustrated text for the busy diagnostician Every section comprehensively revised by international team of authors Over 900 high quality colour images to accompany each diagnostic entity Coverage of cytology in sections relating to myeloid dysplasias and acute leukemias Incorporates new WHO classification of lymphomas and leukemias Author team expanded to include experts from Stanford University, California
Someone is assassinating the leaders of both the Star Kingdom of Manticore and the recently liberated former slave planet of Torch. Though most believe the Republic of Haven is behind the murders, Anton Zilwicki and Havenite secret agent Victor Cachat believe there is another sinister player behind the scenes. Queen Berry of Torch narrowly escaped one assassination attempt, and a security officer from Beowulf has been assigned to protect her, a task complicated by the young monarch's resentment of bodyguards, and the officer's growing attachment to her. Meanwhile, powerful forces in the Solarian League are maneuvering against each other to gain the upper hand, not realizing or, perhaps, not caring that their power struggle is threatening the League's very existence and could plunge the galaxy into war. Once again New York Times best-selling authors David Weber and Eric Flint join forces in an exciting new novel in the Honorverse. At the publisher's request, this title is sold without DRM (Digital Rights Management).
Most Americans would be surprised to learn that their government has declined to join most other nations in UN treaties addressing inadequate housing, poverty, children's rights, health care, racial discrimination, and migrant workers. Yet this book documents how the U.S. has, for decades, declined to ratify widely accepted treaties on these and many other basic human rights. Providing the first comprehensive topical survey, the contributors build a case and specific agendas for the nation to change course and join the world community as a protector of human rights.
In the midst of an addiction epidemic, this newly updated edition of The American Society of Addiction Medicine Principles of Addiction Medicine, 5th edition is the sought-after text every addiction researcher and care provider needs. This comprehensive reference text dedicates itself to both the science and treatment of addiction. You’ll receive a thorough grounding in both the scientific principles behind the causes of addiction and the practical aspects of clinical care. Chapters are written by recognized experts, covering areas such as the basic science of addiction medicine; diagnosis, assessment and early intervention; pharmacologic and behavioral interventions; mutual help and twelve-step; and co-occurring addiction, medical and psychiatric disorders—backed by the latest research data and successful treatment methods. Features: Numerous figures, tables and diagrams elucidate the text Chapters include case examples List of data research reports provided at end of each chapter NEW material on Prescription Drug Abuse, Club Drugs, Nursing Roles in Addressing Addiction, Conceptual and Treatment Issues in Behavioral Addictions, Rehabilitation Approaches to Pain Management, Comorbid Pain and Addiction, Pharmacotherapy for Adolescents with Substance Use Disorders, Preventing and Treating Substance Use Disorders in Military Personnel, and more.
It is perhaps not too much of an exaggeration to claim that experimental hematology as it flourishes today originated largely from the pioneering attempts to protect lethally radiated animals (1) by shielding of hemopoietic tissues by L.O. Jacobson (9), and (2) by treatment with bone marrow suspensions by E. Lorenz and his col laborators (12). The site chosen for this annual meeting of the International Society for Experi mental Hematology is given a special historic sig nificance by the fact that it was 25 years ago that the first publication on this subject by Lorenz ap peared from his laboratory at the National Insti tutes of Health. Lorenz's discovery marked the beginning of a period which lasted until 1956, during which the protection afforded by hemopoietic cell suspensions was confirmed by many. This soon led to an intensive scientific de bate on the mechanism of this protective effect: was it due to a humoral factor produced and pro vided by the bone marrow-as Lorenz The Appearance of postulated-or to transplantation and subsequent proliferation of hemop- etic cells? This question was defini- 1 the Multipotential tively answered in 1956 by evidence from three different laboratories (7, 15, 26), which demonstrated the origin of the cells Hemopoietic in the repopulated tissues using a variety of cellu lar and immunologic markers. By the same token, these contributions marked the birth of radiation Stem Cell chimeras.
Exploring the chromosomal imbalance (aneuploidy) theory of cancer, this volume describes how cancer is initiated and why progression takes years to decades. It clarifies why cancer cells often become drug resistant, provides objective, quantitative measures for detecting cancer and monitoring its progression, and suggests non-toxic strategies of ca
An expert guide to targeting protein kinases in cancer therapy Research has shown that protein kinases can instigate the formation and spread of cancer when they transmit faulty signals inside cells. Because of this fact, pharmaceutical scientists have targeted kinases for intensive study, and have been working to develop medicinal roadblocks to sever their malignant means of communication. Complete with full-color presentations, Targeting Protein Kinases for Cancer Therapy defines the structural features of protein kinases and examines their cellular functions. Combining kinase biology with chemistry and pharmacology applications, this book enlists emerging data to drive the discovery of new cancer-fighting drugs. Valuable information includes: Comprehensive overviews of the major kinase families involved in oncology, integrating protein structure and function, and providing important tools to assist pharmaceutical researchers to understand and work in this dynamic area of cancer drug research Focus on small molecule inhibitors as well as other therapeutic modalities Discussion of kinase inhibitors that have entered clinical trials for the treatment of cancer, with an emphasis on molecules that have progressed to late stage clinical trials and, in a few cases, to market Providing a platform for further study, this important work reviews both the successes and challenges of kinase inhibitor therapy, and provides insight into future directions in the war against cancer.
This quick reference handbook covers the diagnosis and treatment of eye disease in a range of exotic companion animal species, including rabbits, rodents, reptiles, birds, amphibians and fish. It clarifies when extrapolation from cat or dog eyes is appropriate, or when new information is needed to ensure that diagnoses and treatments are appropriate for the particular species. Writing in an accessible and down to earth style, the author brings a wealth of personal experience to this specialised subject area. The book contains many ophthalmic photographs of both anatomy in normal eyes and pathology in abnormal cases. It also includes a separate chapter on the common ophthalmic features of exotic pets, discussing what can be learnt from cross-species comparison and another chapter giving a brief history of comparative ophthalmology. Ophthalmology of Exotic Pets is an invaluable aid for veterinary practitioners and students with an interest in exotic pet species, as well as for veterinary ophthalmologists. KEY FEATURES Covers lagomorphs, rodents, reptiles, birds, amphibians and fish Offers clear guidance for species-specific treatment Facilitates extrapolations from the cat or dog to the exotic eye Written in a concise quick reference format Highly illustrated with colour photographs
As Americans and citizens of other industrializing countries began to enjoy lives of increasing affluence and ease during the first half of the 20th century, a rising tide of heart attacks and strokes displaced infectious diseases as the leading cause of death, killing millions in the United States and throughout the world. Although cardiovascular disease remains serious and widespread, the significant decline of per capita deaths is one of the greatest accomplishments of modern public health and medicine. Death rates from heart attack and stroke have fallen dramatically by 80% in the past 50 years -- the progress has been hard won by a combination of basic and applied laboratory research, broad and far-reaching epidemiological studies by physicians, scientists, and public health experts. Cardiovascular disease is no longer viewed as an as an inevitable feature of the natural course of aging, and complacency has given way to hope. This book focuses on developments that influenced the rise and decline of cardiovascular mortality since 1900, but also includes insider insights from the author, a 42-year NIH employee.
This preeminent book in the field of Neurology has been extensively updated and expanded by 70 leading authorities, providing a single, encyclopedic summary the scientific advances and new clinical practices that can be immediately considered for your patients. It brings together nearly the entire spectrum of motor disorders and Neurology into one convenient resource to aid in a comprehensive evaluation, diagnosis, distinction, and treatment of various disorders. Additionally, by using the perspectives of different subspecialties, the book also provides a comprehensive yet concise account of any disorder with motor manifestations. This new edition now includes the following content and features: Edited by David S. Younger, MD, a highly respected practitioner and researcher, with scholarly chapters by leaders in the field and more international authors than other texts. Up-to-date articles on highly changing subjects related to Neurogenetics. Chapters on Neurorehabilitation – coverage not usually found in other neurological textbooks. Advances in Alzheimer Disease, Parkinson Disease, Amyotophic Lateral Sclerosis. Both adult and pediatric topics in one book. High quality figures of neuroimaging and neuropathology.
Handbook of Behavioral Medicine presents a comprehensive overview of the current use of behavioral science techniques in the prevention, diagnosis, and treatment of various health related disorders. Features contributions from a variety of internationally recognized experts in behavioral medicine and related fields Includes authors from education, social work, and physical therapy Addresses foundational issues in behavioral medicine in Volume 1, including concepts, theories, treatments, doctor/patient relationships, common medical problems, behavioral technologies, assessment, and methodologies Focuses on medical interface in Volume 2, including issues relating to health disorders and specialties; social work, medical sociology, and psychosocial aspects; and topics relating to education and health 2 Volumes
Public speaking can be terrifying. For David Nihill, the idea of standing in front of an audience was scarier than cliff jumping into a thorny pit of spiders and mothers-in-law. Without a parachute or advanced weaponry. Something had to change. In what doesn't sound like the best plan ever, David decided to overcome his fears by pretending to be an accomplished comedian called "Irish Dave" for one full year, crashing as many comedy clubs, festivals, and shows as possible. One part of the plan was at least logical: he was already Irish and already called Dave. In one year, David went from being deathly afraid of public speaking to hosting a business conference, regularly performing stand-up comedy and winning storytelling competitions in front of packed houses. And he did it by learning from some of the best public speakers in the world: stand-up comedians. Do You Talk Funny?: 7 Comedy Habits to Become a Better (and Funnier) Public Speaker shows how the key principles of stand-up comedy can be applied to your speaking engagements and presentations to make you funnier, more interesting, and better looking. (Or at least two of the three.) Whether you are preparing for a business presentation, giving a wedding toast, defending your thesis, raising money from investors, or simply want to take on something you're afraid of, this book will take you from sweaty to stage-ready. You'll learn how to: - Craft a story and content that your audience will want to listen to - Find the funniest parts of your material and how to get to them faster - Deal with stage fright - Master the two most important parts of your performance: timing and delivery Ten percent of the author's proceeds from this book will go to Arash Bayatmakou via Help Hope Live until he is fully back on his feet and thereafter to one of the many facing the same challenges after suffering a severe spinal cord injury.
Legal Murder is the true story of the courtroom shoot-out that occurred in Hillsville, Virginia, in 1911. The events leading to the shooting and its tragic aftermath involve a large, well-positioned family and corrupt government officials who coveted their land. The true story is as strange, complicated, and exciting as any novel could be.
Praise for the fifth edition: I applaud Dr. Haber for addressing key concepts and issues in health promotion and aging, and making them accessible, respectful, mindful, and empowering. -Marilyn R. Gugliucci, PhD Director, Geriatrics Education and Research, University of New England Past President, AGHE David Haber has done it again! ...A must-have for students and faculty alike. -Barbara Resnick, PhD, CRNP, FAAN Substantially revised and updated, the sixth edition of this classic text continues to define healthy aging by illustrating how to prevent disease and make large-scale improvements toward health and wellness. New to this edition is current information regarding the future of Medicare, Social Security, and the Affordable Care Act, information about the Healthy People 2020 initiative supported with examples, up-to-date and comprehensive medical screening recommendations, and an extensive review of new developments in complementary and alternative medicine, geriatric mental health, community health, and public health policy. A new section on technology and aging is also included, as well as an instructor's manual. The text synthesizes current research findings with practical applications, and includes detailed and updated descriptions of the author's own programs that have been recognized by the National Council on the Aging's Best Practices in Health Promotion and Aging. New to this Edition: Up-to-date coverage of the future of Medicare, Social Security, the Affordable Care Act, and the Healthy People 2020 initiative New section on technology and aging Current developments in complementary and alternative medicine New findings regarding geriatric physical and mental health and community health Current information about exercise, nutrition and weight management Updated information on public health policy Current trends in long-term care and end-of-life-care Updated sociodemographic trends Instructor's manual
b>The Judges of the Secret Court, first published in 1961, is a historical novel about John Wilkes Booth and the aftermath of the assassination of President Abraham Lincoln in 1865. The book vividly portrays the setting and sentiments of the time, as well as Wilkes’ befuddled thinking and his short-lived escape from justice, followed by the trial of those involved in the assassination. David Stacton’s The Judges of The Secret Court is a long-lost triumph of American fiction as well as one of the finest books ever written about the Civil War. Stacton’s gripping and atmospheric story revolves around the brothers Edwin and John Wilkes Booth, members of a famous theatrical family. Edwin is a great actor, himself a Hamlet-like character whose performance as Hamlet will make him an international sensation. Wilkes is a blustering mediocrity on stage who is determined, however, to be an actor in history, and whose assassination of Abraham Lincoln will change America. Stacton’s novel about how the roles we play become, for better or for worse, the lives we lead, takes us back to the day of the assassination, immersing us in the farrago of bombast that fills Wilkes’s head while following his footsteps up to the fatal encounter at Ford’s Theatre. The political maneuvering around Lincoln’s deathbed and Wilkes’s desperate flight and ignominious capture then set the stage for a political show trial that will condemn not only the guilty but the—at least relatively—innocent. For as Edwin Booth broods helplessly many years later, and as Lincoln, whose tragic death and wisdom overshadow this tale, also knew, “We are all accessories before or after some fact....We are all guilty of being ourselves.”
This issue, guest edited by Dr. David Sanchez-Migallon Guzman, focuses on Exotic Animal Oncology. Topics include: Invertebrate Oncology; Fish Oncology,Reptile Oncology; Amphibian Oncology; Ferret Oncology; Rabbit Oncology; Rodent Oncology; Principles and Applications of Surgical Oncology in Exotic Animals; Principles and Applications of Medical Oncology in Exotic Animals; Principles and Applications or Radiation Therapy in Exotic Animals; and Avian Oncology
This textbook provides a concise overview of malignant haematology, including reviews of cell and molecular biology, and implications for new trends in treatment.
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