An introduction to dependent types, demonstrating the most beautiful aspects, one step at a time. A program's type describes its behavior. Dependent types are a first-class part of a language, and are much more powerful than other kinds of types; using just one language for types and programs allows program descriptions to be as powerful as the programs they describe. The Little Typer explains dependent types, beginning with a very small language that looks very much like Scheme and extending it to cover both programming with dependent types and using dependent types for mathematical reasoning. Readers should be familiar with the basics of a Lisp-like programming language, as presented in the first four chapters of The Little Schemer. The first five chapters of The Little Typer provide the needed tools to understand dependent types; the remaining chapters use these tools to build a bridge between mathematics and programming. Readers will learn that tools they know from programming—pairs, lists, functions, and recursion—can also capture patterns of reasoning. The Little Typer does not attempt to teach either practical programming skills or a fully rigorous approach to types. Instead, it demonstrates the most beautiful aspects as simply as possible, one step at a time.
A dense, challenging and important book.' Philip French Observer 'At the very least, this blockbuster is probably the best single volume history of Hollywood we're likely to get for a very long time.' Paul Kerr City Limits 'Persuasively argued, the book is also packed with facts, figures and photographs.' Nigel Andrews Financial Times Acclaimed for their breakthrough approach, Bordwell, Staiger and Thompson analyze the basic conditions of American film-making as a historical institution and consider to what extent Hollywood film production constitutes a systematic enterprise, in both its style and its business operations. Despite differences of director, genre or studio, most Hollywood films operate within a set of shared assumptions about how a film should look and sound. Such assumptions are neither natural nor inevitable; but because classical-style films have been the type most widely seen, they have come to be accepted as the 'norm' of film-making and viewing. The authors show how these classical conventions were formulated and standardized, and how they responded to the arrival of sound, colour, widescreen ratios and stereophonic sound. They argue that each new technological development has served a function within an existing narrational system. The authors also examine how the Hollywood cinema standardized the film-making process itself. They describe how, over the course of its history, Hollywood developed distinct modes of production in a constant search for maximum efficiency, predictability and novelty. Set apart by its combination of theoretical analysis and empirical evidence, this book is the standard work on the classical Hollywood cinema style of film-making from the silent era to the 1960s. Now available in paperback, it is a 'must' for film students, lecturers and all those seriously interested in the development of the film industry.
Travel Medicine, 3rd Edition, by Dr. Jay S. Keystone, Dr. Phyllis E. Kozarsky, Dr. David O. Freedman, Dr. Hans D. Nothdruft, and Dr. Bradley A. Connor, prepares you and your patients for any travel-related illness they may encounter. Consult this one-stop resource for best practices on everything from immunizations and pre-travel advice to essential post-travel screening. From domestic cruises to far-flung destinations, this highly regarded guide offers a wealth of practical guidance on all aspects of travel medicine. "This is an excellent reference source that contains words of wisdom which covers an area of medicine which can sometimes get lost on the radar screen". Reviewed by: Dr Harry Brown on behalf of Glycosmedia, Apr 2014 Benefit from the advice of international experts on the full range of travel-related illnesses, including cruise travel, bird flu, SARS, traveler's diarrhea, malaria, environmental problems, and much more. Prepare for the travel medicine examination with convenient cross references for the ISTM "body of knowledge" to specific chapters and/or passages in the book. Search the complete text and download images at expertconsult.com. Effectively protect your patients before they travel with new information on immunizations and emerging and re-emerging disease strains, including traveler's thrombosis. Update your knowledge of remote destinations and the unique perils they present. Stay abreast of best practices for key patient populations, with new chapters on the migrant patient, humanitarian aid workers, medical tourism, and mass gatherings, as well as updated information on pediatric and adolescent patients.
This timesaving resource features: Treatment plan components for 39 behaviorally based presenting problems Over 1,000 prewritten treatment goals, objectives, and interventions plus space to record your own treatment plan options A step-by-step guide to writing treatment plans that meet the requirements of most insurance companies and third-party payors Includes Evidence-Based Practice Interventions as required by many public funding sources and private insurers PracticePlanners® THE BESTSELLING TREATMENT PLANNING SYSTEM FOR MENTAL HEALTH PROFESSIONALS The Veterans and Active Duty Military Psychotherapy Treatment Planner provides all the elements necessary to quickly and easily develop formal treatment plans that satisfy the demands of HMOs, managed care companies, third-party payors, and state and federal agencies. Features empirically supported, evidence-based treatment interventions Organized around 39 main presenting problems in treating veterans and active duty military personnel, including substance abuse, adjustment to killing, anger management and domestic violence, pre-deployment stress, survivors' guilt, and combat and operational stress reaction Over 1,000 prewritten treatment goals, objectives, and interventions plus space to record your own treatment plan options Easy-to-use reference format helps locate treatment plan components by behavioral problem Designed to correspond with The Veterans and Active Duty Military Psychotherapy Progress Notes Planner Includes a sample treatment plan that conforms to the requirements of most third-party payors and accrediting agencies including CARF, The Joint Commission (TJC), COA, and the NCQA Additional resources in the PracticePlanners® series: Progress Notes Planners contain complete, prewritten progress notes for each presenting problem in the companion Treatment Planners. Homework Planners feature behaviorally based, ready-to-use assignments to speed treatment and keep clients engaged between sessions. For more information on our PracticePlanners®, including our full line of Treatment Planners, visit us on the Web at: www.wiley.com/practiceplanners
Provide optimal anesthetic care to your young patients with A Practice of Anesthesia in Infants and Children, 5th Edition, by Drs. Charles J. Cote, Jerrold Lerman, and Brian J. Anderson. 110 experts representing 10 different countries on 6 continents bring you complete coverage of the safe, effective administration of general and regional anesthesia to infants and children - covering standard techniques as well as the very latest advances. Consult this title on your favorite e-reader with intuitive search tools and adjustable font sizes. Elsevier eBooks provide instant portable access to your entire library, no matter what device you're using or where you're located. Find authoritative answers on everything from preoperative evaluation through neonatal emergencies to the PACU. Get a free laminated pocket reference guide inside the book! Quickly review underlying scientific concepts and benefit from expert information on preoperative assessment and anesthesia management, postoperative care, emergencies, and special procedures. Stay on the cutting edge of management of emergence agitation, sleep-disordered breathing and postoperative vomiting; the use of new devices such as cuffed endotracheal tubes and new airway devices; and much more. Familiarize yourself with the full range of available new drugs, including those used for premedication and emergence from anesthesia. Benefit from numerous new figures and tables that facilitate easier retention of the material; new insights from neonatologists and neonatal pharmacologists; quick summaries of each chapter; and more than 1,000 illustrations that clarify key concepts. Access the entire text online, fully searchable, at www.expertconsult.com, plus an extensive video library covering simulation, pediatric airway management, burn injuries, ultra-sound guided regional anesthesia, and much more; and new online-only sections, tables and figures.
An expert guide to targeting protein kinases in cancer therapy Research has shown that protein kinases can instigate the formation and spread of cancer when they transmit faulty signals inside cells. Because of this fact, pharmaceutical scientists have targeted kinases for intensive study, and have been working to develop medicinal roadblocks to sever their malignant means of communication. Complete with full-color presentations, Targeting Protein Kinases for Cancer Therapy defines the structural features of protein kinases and examines their cellular functions. Combining kinase biology with chemistry and pharmacology applications, this book enlists emerging data to drive the discovery of new cancer-fighting drugs. Valuable information includes: Comprehensive overviews of the major kinase families involved in oncology, integrating protein structure and function, and providing important tools to assist pharmaceutical researchers to understand and work in this dynamic area of cancer drug research Focus on small molecule inhibitors as well as other therapeutic modalities Discussion of kinase inhibitors that have entered clinical trials for the treatment of cancer, with an emphasis on molecules that have progressed to late stage clinical trials and, in a few cases, to market Providing a platform for further study, this important work reviews both the successes and challenges of kinase inhibitor therapy, and provides insight into future directions in the war against cancer.
Introduction to Bioorganic Chemistry and Chemical Biology is the first textbook to blend modern tools of organic chemistry with concepts of biology, physiology, and medicine. With a focus on human cell biology and a problems-driven approach, the text explains the combinatorial architecture of biooligomers (genes, DNA, RNA, proteins, glycans, lipids, and terpenes) as the molecular engine for life. Accentuated by rich illustrations and mechanistic arrow pushing, organic chemistry is used to illuminate the central dogma of molecular biology. Introduction to Bioorganic Chemistry and Chemical Biology is appropriate for advanced undergraduate and graduate students in chemistry and molecular biology, as well as those going into medicine and pharmaceutical science.
Learn effective PTSD group treatment The awareness of psychological trauma has grown exponentially in the past decade, and clinicians in many areas have increasingly found themselves confronted with the need to provide trauma-related services to clients. Still, there remains a serious lack of manuals that guide clinicians using group therapy to treat posttraumatic stress disorder (PTSD). Trauma-Centered Group Psychotherapy for Women: A Clinician’s Manual is the important, “how-to” resource that fills this void with a successful theory-based, field-tested model of group therapy for traumatized women. Concise and full of clinical examples, this helpful text includes a session-by-session guide for clinicians and a workbook for clients. Comprehensive and practical, Trauma-Centered Group Psychotherapy for Women: A Clinician’s Manual not only describes the theory, method, and rationale for this effective treatment, but also offers a complete, step-by-step clinician’s manual and client workbook to help implement the model and establish effective practice. Explained in-depth are unique methods such as the use of testimonial and ceremonial structures to heighten the therapeutic impact and case examples of individual client histories and progress through treatment. In addition, appendices detailing a treatment contract and a script for a trauma program “Graduation Ceremony” are also included. Chapters in Trauma-Centered Group Psychotherapy for Women cover: concepts of group therapy with traumatized populations developmental theory of trauma and posttraumatic stress disorder usefulness and challenges of various formats of group therapy session-by-session instructions for clinicians session-by-session workbook for clients guidance in handling difficult treatment and clinical situations group therapy procedures and rules managing traumatic re-enactments empirical support for TCGP and much more! With a detailed bibliography and numerous diagrams, charts, and tables for visualizing information, Trauma-Centered Group Psychotherapy for Womenis an ideal resource for mental health clinicians of all types, graduate students and educators, state mental health commissions and agencies, libraries, hospitals, and clinics.
This book provides a scientific explanation of drug abuse and addiction for the general public. It clarifies the meaning of concepts such as intoxication, physical dependence, and addiction, and describes the changes in the brain that underlie these states. Indeed, this volume is unique because it presents a comprehensive picture of what actually happens to people and their brains when they chronically self-administer opiates, stimulants or alcohol. Complex mechanisms of drug action in the brain are made simple and comprehensible to the layman through use of informative analogies and salient graphics. Accounts of the effects of drug use and abuse on normal people create meaningful, easy-to-relate-to examples from everyday life.
This book represents the final work of the late Professor C. David Marsden, who was the most influential figure in the field of movement disorders, in terms of his contributions to both research and clinical practice, in the modern era. It was conceived and written by David Marsden and his colleague at the Institute of Neurology, Prof. Ivan Donaldson. It was their intention that this would be the most comprehensive book on movement disorders and also that it would serve as the 'clinical Bible' for the management of these conditions. It provides a masterly survey of the entire topic, which has been made possible only by vast laboratory and bedside experience. Marsden's Book of Movement Disorders covers the full breadth of movement disorders, from the underlying anatomy and understanding of basal ganglia function to the diagnosis and management of specific movement disorders, including the more common conditions such as Parkinson's Disease through to rare, and very rare conditions such as Niemann-Pick disease. Chapters follow a structured format with historical overviews, definitions, clinical features, differential diagnosis, investigations and treatment covered in a structured way. It is extensively illustrated with many original photographs and diagrams of historical significance. Among these illustrations are still images of some original film clips of some of Dr. Marsden's patients published here for the first time. Comprehensively referenced and updated by experts from the Institute of Neurology at Queen Square, this book is a valuable reference for, not just movement disorder specialists and researchers, but also for clinicians who care for patients with movement disorders.
This issue of Hematology/Oncology Clinics, guest edited by David P. Steensma, will cover key topics in Myelodysplastic Syndromes. This issue is one of six selected each year by our series consulting editors, George P. Canellos and Edward J. Benz. Topics discussed in this issue will include: Novel prognostic models for MDS, Evaluating MDS patients with genetic mutations that might be germline, Implications of splicing mutations in MDS for pathophysiology and therapy, Assessing quality of life in MDS/MPN overlap patients, Creation of a clinic for patients with clonal hematopoiesis, Luspatercept in MDS, Prospects for venetoclax in MDS, Treatment of acquired sideroblastic anemias, Treatment of patients with AML arising from MDS, Targeting TP53 mutations in MDS, among others.
This textbook provides a concise overview of malignant haematology, including reviews of cell and molecular biology, and implications for new trends in treatment.
Fifty Years of Peeling Away the Lead Paint Problem: Saving Our Children's Future with Healthy Housing documents the history of childhood lead poisoning from paint between 1970 and 2022. Tracing the failure of the medical model (treatment after exposure) that marked the 1970s and 1980s and its replacement with a prevention housing-focused effort, the book documents the changes in health, housing and environmental science and policy. It is the first book to examine how the lead poisoning law in the U.S. was passed in 1992 and later implemented, with implications for the future, in particular, the emergence of a healthy housing movement. The book describes the roles played by Congress, various administrations, agencies, local governments, the private sector, researchers, and a popular citizen's movement, especially parents. The role of the courts is discussed, including a controversial lead paint case on research ethics in Baltimore through an environmental justice lens. This book is the first to examine another recent case in California, where ten local jurisdictions established a precedent by successfully suing the lead paint industry to help pay for abatement. Elucidates sources and pathways of lead paint exposure Details how the environment, housing and public health sectors can best collaborate with researchers and citizens to develop and implement change in housing and health Contains new stories and archived scientific data not available elsewhere
This practical resource provides up-to-date coverage of how to structure and negotiate profitable corporate alliances, covering both the strategic benefits and potential risks involved in these complex arrangements. In clear and straightforward language, this handbook explains the proprietary rights issues involved and then walks the reader through the chronology of a deal, from the definition of objectives to the decision to seek an alliance, identification of potential partners, negotiations, and closing. Corporate Partnering: Structuring and Negotiating Domestic and International Strategic Alliances, Fifth Edition is full of practical forms covering all aspects of strategic alliances annotated with crisp, clear commentary that explains the real-world issues addressed by each provision and how alternative solutions may be used to accomplish different aims. These carefully crafted agreements cover the broad range of areas from supply and distribution agreements, product and technology licenses, and research and development agreements to investment and investment-related arrangements. Thoroughly revised and updated to reflect the latest developments, the Fourth Edition includes new sections on Spin-Out Transactions, virtual companies, and off-shoring arrangements plus updated transaction forms, intellectual property summary, and partnering transactions checklists.
Language is one of our most precious and uniquely human capacities, so it is not surprising that research on its neural substrates has been advancing quite rapidly in recent years. Until now, however, there has not been a single introductory textbook that focuses specifically on this topic. Cognitive Neuroscience of Language fills that gap by providing an up-to-date, wide-ranging, and pedagogically practical survey of the most important developments in the field. It guides students through all of the major areas of investigation, beginning with fundamental aspects of brain structure and function, and then proceeding to cover aphasia syndromes, the perception and production of speech, the processing of language in written and signed modalities, the meanings of words, and the formulation and comprehension of complex expressions, including grammatically inflected words, complete sentences, and entire stories. Drawing heavily on prominent theoretical models, the core chapters illustrate how such frameworks are supported, and sometimes challenged, by experiments employing diverse brain mapping techniques. Although much of the content is inherently challenging and intended primarily for graduate or upper-level undergraduate students, it requires no previous knowledge of either neuroscience or linguistics, defining technical terms and explaining important principles from both disciplines along the way.
Prepare yourself for a revealing tour through the most incredible scientific mysteries of the world with your guide David Wilcock, the New York Times bestselling author of Awakening in the Dream. More than two million people have seen David Wilcock’s incredible tour of the 2012 prophecies in his Internet documentary, The 2012 Enigma. Now, he expands his vision with a cutting-edge investigation into alternative sciences with deep insights into what is coming in our immediate future. A stunning synthesis of hidden science and lost prophecies, The Source Field Investigations exposes DNA transformation, wormholes, ancient conspiracies, the Maya calendar, and a new model of galactic energy fields triggering mental, biological, and spiritual evolution. Unlike the apocalyptic viewpoints depicted in big-budget disaster films, Wilcock believes that 2012 will be a watermark for widespread acceptance of a greater reality—and here, he lays out the blueprints for such a Golden Age.
As adaptive capacities decline, and disease increases, the elderly become major consumers of drugs. Because of the special needs of older patients, physicians, geriatricians, health providers, and researchers must know how the aging process changes the pharmacokinetic and pharmacodynamic properties of drugs prescribed to the elderly. The Second Edition of this essential handbook is an up-to-date source that analyses the major drug groups, the disorders they treat, and the age-associated changes in cellular processes that affect drug action. Disorders prevalent in older people, such as Alzheimer's disease and Parkinson's disease, are examined in great detail. The book also discusses a wide range of drugs, including bronchodilators for asthma, nonsteroid anti-inflammatory drugs for arthritis, antibiotics, and treatments for cardiovascular disease, cancer, and mental disorders. The handbook also provides insight into future research problems dealing with the expanding aging population, their drug usage, and increasing adverse drug reactions.
To address the exponential growth in the fields of pediatric hematology and oncology, this classic reference has been separated into two distinct volumes. With this volume, devoted strictly to pediatric hematology, and another to pediatric oncology, you’ll keep you on the cutting-edge of these two specialties. The completely revised 7th edition of Nathan and Oski’s Hematology of Infancy and Childhood is now in full color, and provides you with the most comprehensive, authoritative, up-to-date information for diagnosing and treating children with hematologic disorders. It brings together the pathophysiology of disease with detailed clinical guidance on diagnosis and management for the full range of blood diseases that you encounter in everyday practice. Written by the leading names in pediatric hematology, this resource is an essential tool for anyone involved in caring for children with hematologic disorders. Balances summaries of relevant pathophysiology with clear, practical clinical guidance to help you thoroughly understand the underlying science of diseases. Offers comprehensive coverage of all hematologic disorders, including newly recognized ones, along with the latest breakthroughs in diagnosis and management. Uses many boxes, graphs, and tables to highlight complex clinical diagnostic and management guidelines at a glance. Presents an all-new full-color design that includes clear illustrative examples of relevant science and clinical problems for quick access to the answers you need.
To address the exponential growth in the fields of pediatric hematology and oncology, this classic reference has been separated into two distinct volumes. With this volume, devoted strictly to pediatric hematology, and another to pediatric oncology, you'll keep you on the cutting-edge of these two specialties. The completely revised 7th edition of Nathan and Oski's Hematology of Infancy and Childhood is now in full color, and provides you with the most comprehensive, authoritative, up-to-date information for diagnosing and treating children with hematologic disorders. It brings together the pathophysiology of disease with detailed clinical guidance on diagnosis and management for the full range of blood diseases that you encounter in everyday practice. Written by the leading names in pediatric hematology, this resource is an essential tool for anyone involved in caring for children with hematologic disorders. And, as an Expert Consult title, this thoroughly updated 7th edition comes with access to the complete contents online, fully searchable. Balances summaries of relevant pathophysiology with clear, practical clinical guidance to help you thoroughly understand the underlying science of diseases. Offers comprehensive coverage of all hematologic disorders, including newly recognized ones, along with the latest breakthroughs in diagnosis and management. Uses many boxes, graphs, and tables to highlight complex clinical diagnostic and management guidelines at a glance. Presents an all-new full-color design that includes clear illustrative examples of relevant science and clinical problems for quick access to the answers you need. Provides access to the complete contents online, fully searchable, enabling you to consult it rapidly from any computer with an Internet connection. Your purchase entitles you to access the web site until the next edition is published, or until the current edition is no longer offered for sale by Elsevier, whichever occurs first. If the next edition is published less than one year after your purchase, you will be entitled to online access for one year from your date of purchase. Elsevier reserves the right to offer a suitable replacement product (such as a downloadable or CD-ROM-based electronic version) should access to the web site be discontinued.
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