Molecular Biology, Second Edition, examines the basic concepts of molecular biology while incorporating primary literature from today's leading researchers. This updated edition includes Focuses on Relevant Research sections that integrate primary literature from Cell Press and focus on helping the student learn how to read and understand research to prepare them for the scientific world.The new Academic Cell Study Guide features all the articles from the text with concurrent case studies to help students build foundations in the content while allowing them to make the appropriate connections to the text. Animations provided deal with topics such as protein purification, transcription, splicing reactions, cell division and DNA replication and SDS-PAGE. The text also includes updated chapters on Genomics and Systems Biology, Proteomics, Bacterial Genetics and Molecular Evolution and RNA. An updated ancillary package includes flashcards, online self quizzing, references with links to outside content and PowerPoint slides with images.This text is designed for undergraduate students taking a course in Molecular Biology and upper-level students studying Cell Biology, Microbiology, Genetics, Biology, Pharmacology, Biotechnology, Biochemistry, and Agriculture. - NEW: "Focus On Relevant Research" sections integrate primary literature from Cell Press and focus on helping the student learn how to read and understand research to prepare them for the scientific world - NEW: Academic Cell Study Guide features all articles from the text with concurrent case studies to help students build foundations in the content while allowing them to make the appropriate connections to the text - NEW: Animations provided include topics in protein purification, transcription, splicing reactions, cell division and DNA replication and SDS-PAGE - Updated chapters on Genomics and Systems Biology, Proteomics, Bacterial Genetics and Molecular Evolution and RNA - Updated ancillary package includes flashcards, online self quizzing, references with links to outside content and PowerPoint slides with images - Fully revised art program
Biotechnology, Second Edition approaches modern biotechnology from a molecular basis, which has grown out of increasing biochemical understanding of genetics and physiology. Using straightforward, less-technical jargon, Clark and Pazdernik introduce each chapter with basic concepts that develop into more specific and detailed applications. This up-to-date text covers a wide realm of topics including forensics, bioethics, and nanobiotechnology using colorful illustrations and concise applications. In addition, the book integrates recent, relevant primary research articles for each chapter, which are presented on an accompanying website. The articles demonstrate key concepts or applications of the concepts presented in the chapter, which allows the reader to see how the foundational knowledge in this textbook bridges into primary research. This book helps readers understand what molecular biotechnology actually is as a scientific discipline, how research in this area is conducted, and how this technology may impact the future. - Up-to-date text focuses on modern biotechnology with a molecular foundation - Includes clear, color illustrations of key topics and concept - Features clearly written without overly technical jargon or complicated examples - Provides a comprehensive supplements package with an easy-to-use study guide, full primary research articles that demonstrate how research is conducted, and instructor-only resources
Unlike most biotechnology textbooks, Dr. David P. Clark's Biotechnology approaches modern biotechnology from a molecular basis, which grew out of the increasing biochemical understanding of physiology. Using straightforward, less-technical jargon, Clark manages to introduce each chapter with a basic concept that ultimately evolves into a more specific detailed principle. This up-to-date text covers a wide realm of topics, including forensics and bioethics, using colorful illustrations and concise applications.This book will help readers understand molecular biotechnology as a scientific discipline, how the research in this area is conducted, and how this technology may impact the future.· Up-to-date text focuses on modern biotechnology with a molecular foundation· Basic concepts followed by more detailed, specific applications · Clear, color illustrations of key topics and concepts · Clearly written without overly technical jargon or complicated examples
Explore a world of amazing trivia and exciting spiritual truths! Every daily devotion in 365 Trivia Twist Devotions is based on a historical happening, intriguing invention, or offbeat holiday associated with that calendar day. From George Washington's birthday to National Waffle Day, each reveals the truths of God's Word in a fun new way. Bible verses and additional fun facts help to give every day of the year its own unique trivia twist.
An expert guide to targeting protein kinases in cancer therapy Research has shown that protein kinases can instigate the formation and spread of cancer when they transmit faulty signals inside cells. Because of this fact, pharmaceutical scientists have targeted kinases for intensive study, and have been working to develop medicinal roadblocks to sever their malignant means of communication. Complete with full-color presentations, Targeting Protein Kinases for Cancer Therapy defines the structural features of protein kinases and examines their cellular functions. Combining kinase biology with chemistry and pharmacology applications, this book enlists emerging data to drive the discovery of new cancer-fighting drugs. Valuable information includes: Comprehensive overviews of the major kinase families involved in oncology, integrating protein structure and function, and providing important tools to assist pharmaceutical researchers to understand and work in this dynamic area of cancer drug research Focus on small molecule inhibitors as well as other therapeutic modalities Discussion of kinase inhibitors that have entered clinical trials for the treatment of cancer, with an emphasis on molecules that have progressed to late stage clinical trials and, in a few cases, to market Providing a platform for further study, this important work reviews both the successes and challenges of kinase inhibitor therapy, and provides insight into future directions in the war against cancer.
Molecular Biology, Second Edition, examines the basic concepts of molecular biology while incorporating primary literature from today's leading researchers. This updated edition includes Focuses on Relevant Research sections that integrate primary literature from Cell Press and focus on helping the student learn how to read and understand research to prepare them for the scientific world.The new Academic Cell Study Guide features all the articles from the text with concurrent case studies to help students build foundations in the content while allowing them to make the appropriate connections to the text. Animations provided deal with topics such as protein purification, transcription, splicing reactions, cell division and DNA replication and SDS-PAGE. The text also includes updated chapters on Genomics and Systems Biology, Proteomics, Bacterial Genetics and Molecular Evolution and RNA. An updated ancillary package includes flashcards, online self quizzing, references with links to outside content and PowerPoint slides with images.This text is designed for undergraduate students taking a course in Molecular Biology and upper-level students studying Cell Biology, Microbiology, Genetics, Biology, Pharmacology, Biotechnology, Biochemistry, and Agriculture. - NEW: "Focus On Relevant Research" sections integrate primary literature from Cell Press and focus on helping the student learn how to read and understand research to prepare them for the scientific world - NEW: Academic Cell Study Guide features all articles from the text with concurrent case studies to help students build foundations in the content while allowing them to make the appropriate connections to the text - NEW: Animations provided include topics in protein purification, transcription, splicing reactions, cell division and DNA replication and SDS-PAGE - Updated chapters on Genomics and Systems Biology, Proteomics, Bacterial Genetics and Molecular Evolution and RNA - Updated ancillary package includes flashcards, online self quizzing, references with links to outside content and PowerPoint slides with images - Fully revised art program
The Londoner John Blackwell (1624-1701), shaped by his parents’ Puritanism and merchant interests of his iconoclast father, became one of Oliver Cromwell’s New Model Army captains. Working with his father in Parliament’s financial administration both supported the regicide and benefitted financially from the subsequent sales of land from those defeated in the civil wars. Surviving the Restoration, Blackwell pursued interests in Ireland and banking schemes in London and Massachusetts, before being governor of Pennsylvania. Blackwell worked with his son, Lambert Blackwell, who established himself as a merchant, financier and representative of the state in Italy during the wars of William III before being embroiled in the South Sea Bubble. The linked histories of the three Blackwells reinforce the importance of kinship and the development of the early modern state centred in an increasingly global London and illustrate the ownership of the memory of the civil wars, facilitated by their kin links to Cromwell and John Lambert, architect of Cromwell’s Protectorate, by those who fought against Charles I. Suitable for specialists in the area and students taking courses on early modern English, European and American history as well as those with a more general interest in the period.
This collection discusses both the history and theory of anarchism and in particular examines italian anarchism, the relationship between Marxism and anarchism, the influence of Kropotkin, new social movements and the anarchist theory of history.
Professor Palliser focuses here on towns in England in the centuries between the Norman Conquest and the Tudor period, on which he is an acknowledged authority. Urban topography, archaeology, economy, society and politics are all brought under review, and particular attention is given to relationships between towns and the Crown, to the evidence for migration into towns, and to the vexed question of urban fortunes in the 15th and 16th centuries. Two essays set urban history in a broader framework by considering recent work on town and village formation and on the development of parishes. The collection includes two hitherto unpublished studies and is introduced and put in context by a new survey of English towns from the 7th to the 16th centuries.
This is the first of three volumes concerning the history of the oldest press in the world,a history that extends from the sixteenth century to the present day.
“The best and the most accessible one-volume history of communism now available . . . A far-reaching, vividly written account.” —Foreign Affairs In The Red Flag, Oxford professor David Priestland tells the epic story of a movement that has taken root in dozens of countries across two hundred years, from its birth after the French Revolution to its ideological maturity in nineteenth-century Germany to its rise to dominance (and subsequent fall) in the twentieth century. Beginning with the first modern Communists in the age of Robespierre, Priestland examines the motives of thinkers and leaders including Marx, Engels, Lenin, Stalin, Castro, Che Guevara, Mao, Ho Chi Minh, Gorbachev, and many others. Priestland also shows how Communism, in all its varieties, appealed to different societies for different reasons, in some as a response to inequalities and in others more out of a desire to catch up with the West. But paradoxically, while destroying one web of inequality, Communist leaders were simultaneously weaving another. It was this dynamic, together with widespread economic failure and an escalating loss of faith in the system, that ultimately destroyed Soviet Communism itself. At a time when global capitalism is in crisis and powerful new political forces have arisen to confront Western democracy, The Red Flag is essential reading if we are to apply the lessons of the past to navigating the future. “Detailed and scholarly but written in lively prose, this is a rich, satisfying account of the most successful utopian political movement in history.” —Publishers Weekly, starred review
During the expedition, twenty-three-year-old Bodmer sketched and painted a wealth of landscapes and Native American portraits that would be immortalized as engravings in Maximilian's published journals and accompanying atlas. Now considered the most vivid and instructive depiction of the nineteenth-century American West and its people prior to the decimation of many Plains tribes by disease, Bodmer's artwork continues to intrigue historians, scholars, and collectors.".
The authoritative compendium of facts, statistics, photographs, and analysis that defines baseball in its formative first decades This comprehensive reference work covers the early years of major league baseball from the first game—May 4, 1871, a 2-0 victory for the Fort Wayne Kekiongas over the visiting Cleveland Forest City team—through the 1900 season. Baseball historian David Nemec presents complete team rosters and detailed player, manager, and umpire information, with a wealth of statistics to warm a fan’s heart. Sidebars cover a variety of topics, from oddities—the team that had the best record but finished second—to analyses of why Cleveland didn’t win any pennants in the 1890s. Additional benefits include dozens of rare illustrations and narrative accounts of each year’s pennant race. Nemec also carefully charts the rule changes from year to year as the game developed by fits and starts to formulate the modern rules. The result is an essential work of reference and at the same time a treasury of baseball history. This new edition adds much material unearthed since the first edition, fills gaps, and corrects errors, while presenting a number of new stories and fascinating details. David Nemec began the lifetime labor that helped produced this work in 1954 and admits it may never end, as there always will be some obscure player whose birth date has not yet been found. Until perfection is achieved, this work offers state-of-the-art accuracy and detail beyond that supplied by even modern baseball encyclopedias. As Casey Stengel, who was born during this era, was wont to say, “you could look it up.” Now you can.
The damming of the Saguenay brought industrialisation on a grand scale to rural Quebec in the form of newsprint and aluminum manufacture. Tapping into rich and diverse sources in Canada, the United States, and Europe, Massell provides an interdisciplinary, cross-border study of American capital and Canadian resources. He shows us how ever-larger amounts of capital yielded increasingly massive and sophisticated applications of hydroelectric technology. Grand industrial plans, in turn, encroached upon provincial water rights and farmers' lands, which drew the attention of the state. He examines the protracted power struggle between public and private interests - between American capitalists and the nascent bureaucracy of the province of Quebec - and describes the origins and evolution of the events that led to state control over hydraulic resources in the province. In doing so he provides vivid portraits of Duke and of Quebec politicians of the period and gives a dramatic account of the protracted battle of wits between Duke's chief engineer, William States Lee, and Quebec's chief of Hydraulic Service, Arthur Amos. Amassing Power speaks to the integration of North American economies, vividly illustrating the process by which American capital drew Canada's resource-rich North into the economic orbit of the United States.
Glaciers and Glaciation is the classic textbook for all students of glaciation. Stimulating and accessible, it has established a reputation as a comprehensive and essential resource. In this new edition, the text, references and illustrations have been thoroughly updated to give today's reader an up-to-the minute overview of the nature, origin and behaviour of glaciers and the geological and geomorphological evidence for their past history on earth. The first part of the book investigates the processes involved in forming glacier ice, the nature of glacier-climate relationships, the mechanisms of glacier flow and the interactions of glaciers with other natural systems such as rivers, lakes and oceans. In the second part, the emphasis moves to landforms and sediment, the interpretation of the earth's glacial legacy and the reconstruction of glacial depositional environments and palaeoglaciology.
Originally published in 1989 this book gives an overview of the empirical work on new technology objectives, together with an analysis of management strategies for adoption at the corporate, technological and people levels. It also reviews previous work on the extent to which staff at different levels, and from different specialism, are involved in decision-making, as well as the adoption process more generally. The book looks at different approaches to analysing organizational contexts and provides a framework for studying the stages of the adoption process. The book includes case studies - two in financial services and two in engineering contexts.
How to use CBT within a typical 10 minute consultation Using CBT in General Practice, second edition provides GPs with an overview of the basic principles of CBT and shows how these principles can be applied within a typical 10 minute consultation. The book is written in a user-friendly, interactive and practical style and focuses on realistic ways to make CBT work by helping patients to make positive changes to their lives. Key features of this second edition include: case examples to highlight how the techniques can be applied in practice for patients with particular problems or clinical conditions, such as coping with negative thoughts problem-solving sections describe how to manage time constraints a new consultation model that can be used to implement CBT in general practice detailed overviews of the major clinical psychological conditions that can be treated using CBT, such as panic, low self-esteem, and insomnia. Using CBT in General Practice uniquely provides the practical advice needed to implement CBT within the time constraints of a busy practice – it is therefore essential reading for all GPs, who must now offer CBT as a treatment option. As this is a practical manual and not just a book of theory, it will also appeal to other professionals involved in the management of patients with psychological problems such as practice nurses, health visitors, community psychiatric nurses, practice counsellors and palliative care doctors.
The regal courts of the English Stuart Kings, from James I (1603-1625) to the ill-fated James II (1685-1689), were magnificent affairs. In a country otherwise given to increasingly austere Puritan ways of living, the royal court shone with a brilliance usually associated with the courts of the Catholic kings of mainland Europe. They were centres of great culture, patronage, ceremony and politics. The real importance of the courts, though down-played for many years, is now beginning to be fully recognised and this first major study of the Stuart courts in England, Scotland and Ireland examines them in their full cultural and historical context. Scholars of international reputation and up and coming, younger scholars have been brought together to give us an insight into many aspects of the Stuart courts. This book includes essays on culture and patronage of the arts and social history. What was it really like at the court? What rules applied? How did the courtiers behave? Finally, the crucial interplay between court life and political life, and politics, is examined in detail. This book is a major contribution to a flourishing area of scholarship and will be required reading for anyone interested in seventeenth-century history, court studies or the arts in the early modern period.
Breakthrough bioscience and its implications: 3 extraordinary boks take you to the cutting edge of biology, genetics, evolution, and human health Three remarkable books take you to the cutting edge of biology, genetics, evolution, and human health — explaining the newest science, and revealing its incredible implications! Germs, Genes, & Civilization: How Epidemics Shaped Who We Are Today reveals how microbes have shaped our health, genetics, history, culture, politics, religion and ethics… and how they’re shaping our future right now. Allies and Enemies: How the World Depends on Bacteria offers an even closer look at humans’ intimate partnership with bacteria… how they keep you alive, how they can kill you, and how we can all live together happily in peace. Finally, in It Takes a Genome: How a Clash Between Our Genes and Modern Life Is Making Us Sick, Greg Gibson explains today’s explosion in chronic disease through a revolutionary new hypothesis: our genome is out of equilibrium with itself, its environment, and modern culture. From world-renowned leaders in science and science journalism, including David Clark, Anne Maczulak, and Greg Gibson
Winner of the Pulitzer Prize: The definitive biography of Martin Luther King Jr. In this monumental account of the life of Martin Luther King Jr., professor and historian David Garrow traces King’s evolution from young pastor who spearheaded the 1955–56 bus boycott of Montgomery, Alabama, to inspirational leader of America’s civil rights movement. Based on extensive research and more than seven hundred interviews, with subjects including Andrew Young, Jesse Jackson, and Coretta Scott King, Garrow paints a multidimensional portrait of a charismatic figure driven by his strong moral obligation to lead—and of the toll this calling took on his life. Bearing the Cross provides a penetrating account of King’s spiritual development and his crucial role at the Southern Christian Leadership Conference, whose protest campaigns in Birmingham and Selma, Alabama, led to enactment of the landmark Civil Rights Act of 1964 and Voting Rights Act of 1965. This comprehensive yet intimate study reveals the deep sense of mission King felt to serve as an unrelenting crusader against prejudice, inequality, and violence, and his willingness to sacrifice his own life on behalf of his beliefs. Written more than twenty-five years ago, Bearing the Cross remains an unparalleled examination of the life of Martin Luther King Jr. and the legacy of the civil rights movement.
Three meticulously researched works—including Pulitzer Prize winner Bearing the Cross—spanning the life of civil rights icon Martin Luther King Jr. This collection from professor and historian David J. Garrow provides a multidimensional and fascinating portrait of Martin Luther King Jr., and his mission to upend deeply entrenched prejudices in society, and enact legal change that would achieve equality for African Americans one hundred years after their emancipation from slavery. Bearing the Cross traces King’s evolution from the young pastor who spearheaded the 1955–56 bus boycott in Montgomery to the inspirational leader of America’s civil rights movement, focusing on King’s crucial role at the Southern Christian Leadership Conference. Garrow captures King’s charisma, his moral obligation to lead a nonviolent crusade against racism and inequality—and the toll this calling took on his life. Garrow delves deeper into one of the civil rights movement’s most decisive moments in Protest at Selma. These demonstrations led to the landmark Voting Rights Act of 1965 that, along with the Civil Rights Act of 1964, remains a key aspect of King’s legacy. Garrow analyzes King’s political strategy and understanding of how media coverage—especially reports of white violence against peaceful African American protestors—elicited sympathy for the cause. King’s fierce determination to overturn the status quo of racial relations antagonized FBI director J. Edgar Hoover. The FBI and Martin Luther King, Jr. follows Hoover’s personal obsession to destroy the civil rights leader. In an unprecedented abuse of governmental power, Hoover led one of the most invasive surveillance operations in American history, desperately trying to mar King’s image. As a collection, these utterly engrossing books are a key to understanding King’s inner life, his public persona, and his legacy, and are a testament to his impact in forcing America to confront intolerance and bigotry at a critical time in the nation’s history.
Now available with the most current and relevant journal articles from Cell Press, Biotechnology Academic Cell Update Edition approaches modern biotechnology from a molecular basis, which grew out of the increasing biochemical understanding of physiology. Using straightforward, less-technical jargon, Clark and Pazdernik manage to introduce each chapter with a basic concept that ultimately evolves into a more specific detailed principle. This up-to-date text covers a wide realm of topics, including the forensics used in crime scene investigations, the burgeoning field of nanobiotechnology, bioethics and other cutting edge topics in today's world of biotechnology. - Basic concepts followed by more detailed, specific applications with clear, color illustrations of key topics and concepts
In the late 1920s an exciting discovery was made at the New Mexico site of Folsom - spear points, found embedded between the ribs of an Iron Age bison - that was to resolve decades of bitter conflict amongst archaeologists.
Edited and written by true leaders in the field, Psychopathology provides comprehensive coverage of adult psychopathology, including an overview of the topic in the context of the DSM. Individual chapters cover the history, theory, and assessment of Axis I and Axis II adult disorders such as panic disorder, social anxiety, bipolar disorders, schizophrenia, and borderline personality disorder.
This is a compelling book for lovers of sea and air stories from the Great War era. In the thirteen stories told by the participants, many of whom were decorated for bravery, they describe their experiences of events: stories of luck, tenacity, courage, extreme danger, excitement and bravery. Also included are photographs to help set the scene for the vignettes and details of the authors' lives where possible. Seven stories detail the war at sea, while the other six reflect the war in the air from a civilian and combatant point of view. The exciting thing about the stories, apart from their freshness, is that they have remained unpublished for nearly eighty years and they are written by participants who describe exactly what they experienced and felt. Mrs Peel describes what an air raid was like from a civilians point of view, and pilots describe both the humdrumness of some of their work and how it could suddenly change in to a fight for their life, in which luck often played a part in their survival. At sea, the authors describe the struggle to overcome the U-boat menace using Q ships and reveal the boredom, suspense and danger involved in laying a trap. The Battle of Jutland is described from an officers active view of events, and the sinking of the Audacious is described by someone who was aboard and sworn to silence about the events. There is also the exciting story of the chase and fight between the Carmania and the Cap Trafalgar.
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