While drug therapies developed in the last 80 years have markedly improved treatment outcomes and the management of some types of cancers, the lack of effectiveness and side effects associated with the most common treatment types remain unacceptable. However, recent technological advances are leading to improved therapies based on targeting distinct biological pathways in cancer cells. Chemistry and Pharmacology of Anticancer Drugs is a comprehensive survey of all families of anticancer agents and therapeutic approaches currently in use or in advanced stages of clinical trials, including biological-based therapies. The book is unique in providing molecular structures for all anticancer agents, discussing them in terms of history of development, chemistry, mechanism of action, structure–function relationships, and pharmacology. It also provides relevant information on side effects, dosing, and formulation. The authors, renowned scientists in cancer research and drug discovery, also provide up-to-date information on the drug discovery process, including discussions of new research tools, tumor-targeting strategies, and fundamental concepts in the relatively new areas of precision medicine and chemoprevention. Chemistry and Pharmacology of Anticancer Drugs is an indispensable resource for cancer researchers, medicinal chemists and other biomedical scientists involved in the development of new anticancer therapies. Its breadth of coverage, clear explanations, and illustrations also make it suitable for undergraduate and postgraduate courses in medicine, pharmacy, nursing, dentistry, nutrition, the biomedical sciences, and related disciplines. Key Features: Summarizes the fundamental causes of cancer, modes of treatment, and strategies for cancer drug discovery Brings together a broad spectrum of information relating to the chemistry and pharmacology of all families of anticancer agents and therapies Includes up-to-date information on cutting-edge aspects of cancer treatments such as biomarkers, pharmacogenetics, and pharmacogenomics Features new chapters on the "Evolution of Anticancer Therapies", "Antibody-Based Therapies", and "Cancer Chemoprevention
This Atlas presents records of climatic variability and change in Europe starting before 1901 and focuses especially on trends of extreme temperatures and precipitation. The authors have used software developed within EMULATE (European and North Atlantic daily to MULtidecadal climATE variability) to obtain the extremes indices and temporal trends. The trend atlas provides an easy way to identify spatial patterns for a given time period, region, season, and index. The Atlas clearly shows that climate in Europe has changed over the last 100 to 150 years, such that the occurrence and intensity of warm temperature extremes have increased. Precipitation extremes have also changed, but with a less clear pattern compared to the temperature extremes.
At the core of the many debates throughout cognitive science concerning how decisions are made are the processes governing the time course of preference formation and decision. From perceptual choices, such as whether the signal on a radar screen indicates an enemy missile or a spot on a CT scan indicates a tumor, to cognitive value-based decisions, such as selecting an agreeable flatmate or deciding the guilt of a defendant, significant and everyday decisions are dynamic over time. Phenomena such as decoy effects, preference reversals and order effects are still puzzling researchers. For example, in a legal context, jurors receive discrete pieces of evidence in sequence, and must integrate these pieces together to reach a singular verdict. From a standard Bayesian viewpoint the order in which people receive the evidence should not influence their final decision, and yet order effects seem a robust empirical phenomena in many decision contexts. Current research on how decisions unfold, especially in a dynamic environment, is advancing our theoretical understanding of decision making. This Research Topic aims to review and further explore the time course of a decision - from how prior beliefs are formed to how those beliefs are used and updated over time, towards the formation of preferences and choices and post-decision processes and effects. Research literatures encompassing varied approaches to the time-scale of decisions will be brought into scope: a) Speeded decisions (and post-decision processes) that require the accumulation of noisy and possibly non-stationary perceptual evidence (e.g., randomly moving dots stimuli), within a few seconds, with or without temporal uncertainty. b) Temporally-extended, value-based decisions that integrate feedback values (e.g., gambling machines) and internally-generated decision criteria (e.g., when one switches attention, selectively, between the various aspects of several choice alternatives). c) Temporally extended, belief-based decisions that build on the integration of evidence, which interacts with the decision maker's belief system, towards the updating of the beliefs and the formation of judgments and preferences (as in the legal context). Research that emphasizes theoretical concerns (including optimality analysis) and mechanisms underlying the decision process, both neural and cognitive, is presented, as well as research that combines experimental and computational levels of analysis.
Developing Resilience in FE Teaching explores the essence of resilience and provides practical approaches for working in the Further Education sector. Emphasising the importance of reflection and self-growth, it outlines strategies to help teachers identify and deal with stress, using real-life case studies to exemplify key concerns. This book is divided into three main sections: Part One identifies the sector’s needs and recognizes resilience as a key attribute for FE teachers to survive and thrive in the modern world, explores the importance of strength and positivity in both physical and mental health, and examines the many ways in which these contribute to the development of individual resilience; Part Two outlines a variety of practical strategies and approaches for teachers to utilise their experiences to construct resilience over time; and Part Three presents real-life scenarios of resilience-building from various professionals working in the sector. Developing Resilience in FE Teaching synthesizes a wide range of current ideas and research to provide a practical and useful guide for FE teachers, and for those working in the FE sector. It serves as an important resource for teachers and equips them with the necessary skills to become resilient professionals in the modern workplace.
Our understanding of psychophysiological states are now more broadly defined by the inclusion of the lateralized ultradian rhythms of the autonomic and central nervous systems (ANS and CNS) that play a key regulatory role in mind-body states. These neural rhythms are a unique step in the evolution of the nervous system that have mostly been ignored or missed in our understanding of physiology, mental activities, brain rhythms, and in the treatment of psychiatric disorders. The multivariate physiological experiments reviewed in this book provide a new "big picture for how the body's major systems (ANS, CNS, neuroendocrine, cardiovascular, fuel-regulatory, gastrointestinal, immune) are regulated, integrated, and coordinated by the ANS via the hypothalamus during both waking and sleep. This discovery has implications for psychiatrists, psychologists, stress physiologists, cardiologists, sleep researchers, neuroscientists, neuroendocrinologists, cognitive scientists, and those interested in performance, anxiety, depression, schizophrenia, autism, and addictive and impulse control disorders. This book includes the translational neuroscience aspect of this discovery, including implications for vagal nerve stimulation studies. - This book is a study in Lateralized rhythms and Ultradian rhythms and their context in the ANS-CNS, a very new field - Implications of these rhythms in Anxiety, Depression and Schizophrenia will be explored - The book will present theories of possible causes for the assignment of causal mechanisms of these lateralizations - The reader will understand the Nasal Cycle, the rhythmic; alternating side-to-side fluctuation in nasal airflow which is regulated by the ANS - Unilateral Forced Breathing techniques will be discussed - Vagal nerve stimulation and its effects will be discussed - Yoga breathing techniques are analyzed and theorized scientifically
Foundations of Biochemical Psychiatry provides information pertinent to the development of biochemical psychiatry, including biochemical studies of psychiatric patients before and after pharmacological intervention and genetic studies. This book discusses the development of biochemical psychiatry as a significant experimental and conceptual approach to understanding mental illness. Organized into 24 chapters, this book begins with an overview of the neurochemical processes involved in the elaboration of a behavior and the extent to which alterations in those processes are responsible for behavioral differences. This text then discusses the clinical characteristics of schizophrenia, including common symptoms, natural history, and subtypes. Other chapters consider the contribution of genetic factors to the etiology of schizophrenia. This book discusses as well the similarities among hallucinations, dreams, and primary process thinking. The final chapter deals with the factors that may influence the neuroendocrine system. This book is a valuable resource for psychiatrists, neuropharmacologists, neurobiologists, behavioral biologists, and psychoanalysts.
Brings to light critiques of modern tyranny written by German socialist intellectuals before and during World War II about the definition, origins, nature, and means of overcoming totalitarianism.
Scholars have often been puzzled by the fact that the basic word-order rule of Welsh seems to have changed twice in the last 1000 years. David Willis explores how and why these changes have taken place. He examines the relationship between the literary and spoken language throughout the history of Welsh, points out similarities between the rules of earlier Welsh and other European languages, and looks at the forces that cause languages to change over time.
This book deals with the history of surgery in Papua New Guinea from the early 1800s until the beginning of the 21st Century. It spans the period from the first European contact to the emergence of highly educated sub-specialist national surgeons. It tells the story from the first impressions of ships surgeons to the introduction and development of surgery. Between 1870 and 1950 the country and the lives of its peoples changed greatly as a result of exploration, evangelisation, colonisation and war. The history traces the surgical challenges encountered as well as the colourful characters who provided the health services run by missions, companies, governments and armies. After World War II PNG progressed politically from an Australian Administered Territory to become an Independent Nation. Within a generation it had trained its own doctors and surgeons. The history is set within the context of tropical pathologies, introduced diseases, surgical progress and the lives of the medics who have contributed to the Stori bilong kamapim long dokta bilong katim man (The history of surgery).
Praise for The Cancer Treatment Revolution "A wonderful journey through modern medical science, told with warmth and insight, brought to life through the stories of people confronting cancer. This book will inspire and educate both laymen and caregivers." —Jerome Groopman, M.D., author of The Measure of Our Days and The Anatomy of Hope and Recanati, Professor, Harvard Medical School "This is probably the best book on cancer that exists--beautifully written and unfailingly interesting, conveying a clear sense of hope for cancer patients and survivors. Cancer treatment has come a long way but not without intense struggles and passions, which David Nathan narrates from the inside as one of the leading players. He explains cancer more clearly than anyone else, and his portraits of great cancer doctors are sharp and unforgettable, a contribution to history." —Richard Preston, author of The Hot Zone and The Demon in the Freezer "No one is better positioned to tell the tale of the cancer treatment revolution of the last half century than David Nathan. A brilliant physician-scientist, he has been present at the cusps of history in this life-and-death field. The story he tells here is fascinating, and his book is captivating." —Atul Gawande, M.D., author of Complications: A Surgeon's Notes on an Imperfect Science and Better: A Surgeon's Notes on Performance and Assistant Professor of Surgery, Harvard Medical School "David Nathan is a true storyteller. In The Cancer Treatment Revolution, he tells stories that bridge cancer patients and cancer research as few others could. These gripping tales will be appreciated by those who live with cancer and those who strive to create new therapies." —Thomas Cech, Ph.D., recipient of the 1989 Nobel Prize in Chemistry and President of the Howard Hughes Medical Institute "David Nathan, one of the nation's preeminent clinician-scientists, tells the stories of three cancer patients, revealing compelling human facets--the dedication of the remarkable teams that care for these patients and, even more, the bravery and fortitude of the patients and their families." —Harold Varmus, M.D., recipient of the 1989 Nobel Prize in Medicine, President of the Memorial Sloan-Kettering Cancer Center, and former director of the National Institutes of Health "Engaged by the compelling triumphs and tragedies of patients whose normal lives are inevitably altered by a life-threatening cancer, the reader of The Cancer Treatment Revolution will easily appreciate the impact of the new cancer diagnostics and therapies compared to even relatively recent cancer treatments." —Karen Antman, M.D., Dean, Boston University School of Medicine "This personal, highly readable account by one of the leaders of the cancer treatment revolution explains how the revolution has come about and how it will change the future." —Sir Paul Nurse, Ph.D., President of Rockefeller University and recipient of the 2001 Nobel Prize in Medicine
The first global history of 1917 -- a turning point in the development of WWI and of the modern world. Blends political and military history to highlight the key decisions and debates which escalated the war, and would influence world politics into the twenty first century.
This electronic version has been made available under a Creative Commons (BY-NC-ND) open access license. Comparing and contrasting propaganda in Serbia and Croatia from 1986 to 1999, this book analyses each group's contemporary interpretations of history and current events. It offers a detailed discussion of Holocaust imagery and the history of victim-centred writing in nationalist theory, including the links between the comparative genocide debate, the so-called Holocaust industry, and Serbian and Croatian nationalism. There is a detailed analysis of Serbian and Croatian propaganda over the Internet, detailing how and why the Internet war was as important as the ground wars in Kosovo, Croatia and Bosnia-Hercegovina, and a theme-by-theme analysis of Serbian and Croatian propaganda, using contemporary media sources, novels, academic works and journals.
I am unaware of any textbook which provides such comprehensive coverage of the field and doubt that this work will be surpassed in the foreseeable future, if ever!' From the foreword by Robert C. Moellering, Jr., M.D, Shields Warren-Mallinckrodt Professor of Medical Research, Harvard Medical School, USA Kucers' The Use of Antibiotics is the leading major reference work in this vast and rapidly developing field. More than doubled in length compared to the fifth edition, the sixth edition comprises 3000 pages over 2-volumes in order to cover all new and existing therapies, and emerging drugs not yet fully licensed. Concentrating on the treatment of infectious diseases, the content is divided into 4 sections: antibiotics, anti-fungal drugs, anti-parasitic drugs and anti-viral drugs, and is highly structured for ease of reference.Within each section, each chapter is structured to cover susceptibility, formulations and dosing (adult and paediatric), pharmacokinetics and pharmacodynamics, toxicity and drug distribution, detailed discussion regarding clinical uses, a feature unique to this title. Compiled by an expanded team of internationally renowned and respected editors, with a vast number of contributors spanning Europe, Africa, Asia, Australia, South America, the US and Canada, the sixth edition adopts a truly global approach. It will remain invaluable for anyone using antimicrobial agents in their clinical practice and provides in a systematic and concise manner all the information required when treating infections requiring antimicrobial therapy. Kucers' The Use of Antibiotics is available free to purchasers of the books as an electronic version on line or on your desktop: It provides access to the entire 2-volume print material It is fully searchable, so you can find the relevant information you need quickly Live references are linked to PubMed referring you to the latest journal material Customise the contents - you can highlight sections and make notes Comments can be shared with colleagues/tutors for discussion, teaching and learning The text can also be reflowed for ease of reading Text and illustrations copied will be automatically referenced to Kucers' The Use of Antibiotics
This book covers a wide range of novel biochemical targets that appear to be the best leads in terms of designing novel targets for anticancer drug design. New Molecular Targets for Cancer Chemotherapy is a unique, multi-disciplinary effort, with internationally respected authors from the fields of growth factor-receptor interaction, phosphoinositide and phospholipase signal transduction, and DNA-drug binding interactions. The science is placed in clinical context and illustrations explain how clinicians can incorporate a mechanistic, pharmacodynamic approach into early clinical trial design.
It is generally assumed that whatever else has changed about the human condition since the dawn of civilization, basic human emotions - love, fear, anger, envy, shame - have remained constant. David Konstan, however, argues that the emotions of the ancient Greeks were in some significant respects different from our own, and that recognizing these differences is important to understanding ancient Greek literature and culture. With The Emotions of the Ancient Greeks, Konstan reexamines the traditional assumption that the Greek terms designating the emotions correspond more or less to those of today. Beneath the similarities, there are striking discrepancies. References to Greek 'anger' or 'love' or 'envy,' for example, commonly neglect the fact that the Greeks themselves did not use these terms, but rather words in their own language, such as org? and philia and phthonos, which do not translate neatly into our modern emotional vocabulary. Konstan argues that classical representations and analyses of the emotions correspond to a world of intense competition for status, and focused on the attitudes, motives, and actions of others rather than on chance or natural events as the elicitors of emotion. Konstan makes use of Greek emotional concepts to interpret various works of classical literature, including epic, drama, history, and oratory. Moreover, he illustrates how the Greeks' conception of emotions has something to tell us about our own views, whether about the nature of particular emotions or of the category of emotion itself.
This book attempts to trace the key experimental developments that led to the discovery of weak neutral currents in 1973 and the W, Z bosons in 1983, all of the results of which culminated in the identification of the unified-electroweak force.
Written with useful practicality in mind, Breast Pathology, 3rd Edition, provides surgical pathologists with authoritative guidance on the selection and best use of proper diagnostic techniques when reporting on breast specimens. Dr. David J. Dabbs and a team of internationally acclaimed pathologists incorporate genomic and molecular information, gross and microscopic findings, radiologic and laboratory diagnosis, theranostics, and immunohistochemistry to cover every aspect of benign and malignant lesions of the breast, helping you minimize diagnostic variation and error in the sign-out room. - Brings you fully up to date with recent advances, including new molecular information for breast entities, new surgical techniques, more widely used multigene prognostic tests, and assays used to determine treatment, such as PD-L1 as a new immunotherapy biomarker for triple-negative breast cancer. - Incorporates the latest classifications of breast pathology and molecular diagnosis. - Organizes each topical chapter around relevant genomic and molecular information, clinical presentation, gross and microscopic pathologic findings and diagnostic and molecular immunohistochemistry. - Maps immunohistochemistry for each entity according to diagnostic, theranostic, and genomic applications, with specific regard to disease entities in each chapter. - Discusses breast specimen handling in detail to assure proper sampling and processing for optimal molecular and immunohistochemistry resulting. - Supplies a convenient quick reference at the beginning of each chapter that includes all relevant diagnostic, theranostic, and genomic data for fast retrieval. - Features approximately 2,000 full-color pathological images that clearly depict clinical, radiological, molecular, immunohistochemical, and theranostic aspects of disease. - Includes biomarker guideline updates throughout. - Reflects updates to new tumor staging data in the American Joint Committee on Cancer (AJCC) 8th Edition and updated ASCO/CAP guidelines for interpreting HER2 assays.
Covering the full spectrum of rehabilitation after traumatic brain injury, this practical reference by Drs. Blessen C. Eapen and David X. Cifu presents best practices and considerations for numerous patient populations and their unique needs. In an easy-to-read, concise format, it covers the key information you need to guide your treatment plans and help patients relearn critical life skills and regain their independence. - Covers neuroimaging, neurosurgical and critical care management, management of associated complications after TBI, pharmacotherapy, pain management, sports concussion, assistive technologies, and preparing patients for community reintegration. - Discusses special populations, including pediatric, geriatric, and military and veteran patients. - Consolidates today's available information and guidance in this challenging and diverse area into one convenient resource.
In recent years there has been an explosive growth in the field of calixarene chemistry. Calixarenes Revisited, a sequel to the 1989 publication Calixarenes, brings researchers right up to date with current developments in this increasingly competitive area. Covering in depth the synthesis, characterization and properties, as well as conformation, reactions and complex formations of these 'baskets', Calixarenes Revisited is the most complete treatment of the subject available for researchers employing calixarenes in their work. It builds on the framework of the first volume, and can be used by readers already familiar with the field. For those with a less detailed background, it can be used in tandem with Calixarenes to provide a complete picture. Spanning the period 1989 to 1996, items are fully referenced and an extensive bibliography is included.
In the 25 years since the first edition of Comprehensive Gynecology, many scientific advances have occurred in medical practice. The first four editions were largely the work of the original four editors: Drs. William Droegemueller, Arthur L. Herbst, Daniel R. Mishell, Jr., and Morton A. Stenchever...With the staggering volume of medical literature published and the complexities of the gynecologic subspecialties, we have collaborated with additional experts for the sixth edition. We've "examined disease" and added a new chapter on the interaction of medical diseases and female physiology. We've "investigated discord" with new authors to completely rewrite the emotional and psychological issues in gynecology and the legal issues for obstetrician-gynecologists. Other chapters have delved into the controversies in breast cancer screening, vitamin D use, the ongoing debates in hormone therapy, and vaginal mesh use for pelvic organ prolapse surgery. (from Preface -- MD Consult, viewed April 9, 2012)
Calixarenes: An introduction 2nd Edition provides a concise overview of the field with particular attention to the historical development of calixarenes. Topics covered include: how to synthesize and functionalize calixarenes, examination of calixarenes properties, and applied uses of calixarenes." "This book contains extensive references to recent literature, offering the reader a valid presentation of information, and will be of immediate value to researchers, as well as graduates and professionals, who require a comprehensive introduction to the subject."--P. 4 of cover.
Comprehensive Gynecology provides you with complete, timely, and easy access to vital information on all the medical and surgical issues affecting your practice. Whether you’re a resident or practioner, you’ll get all the practical, in-depth coverage you need to stay at the forefront of your field. Now in its sixth edition, this core reference, formerly edited by Drs. Droegemueller, Stenchever, Mishell and Herbst, continues to be your primary resource for in-depth and up-to-date information. Stay up to date with the latest gynecologic advances through clear writing, a clinical focus, and a focus on evidence-based practices. Prepare for the challenges you’ll face in practice with a completely overhauled legal chapter containing factual scenarios. Stay current in your field with the most recent advances in breast care; endoscopy and hysteroscopy; menopausal bone health; legal issues affecting our practice; and much more. Access state-of-the-art guidance on the latest applications in diagnostic and interventional ultrasound - and many other essential aspects of today's practice - through detailed sections on the molecular biology of specific gynecologic malignancies and a new chapter on Fallopian Tube and Primary Peritoneal Cancer. Recognize the interactions and influences of female physiology on major disease processes with a new chapter on The Interaction of Medical Diseases and Female Physiology. Address every patient’s needs with the Emotional Issues in Gynecology chapter, now modified in partnership with a psychiatrist, and updated information on depression/anxiety treatment.
This in-depth resource combines international perspectives and expertise on genomic and molecular information, clinical presentation, gross and microscopic pathologic findings, radiologic and laboratory diagnosis, immunohistochemistry, and theranostics so you can accurately diagnose the full spectrum of breast diseases. Stay current on hot topics in breast pathology, including theranostic aspects of diagnosis, genomic applications and molecular diagnosis, proper handling of breast specimens to ensure proper sampling and processing, and up-to-date immunohistochemical information. Get a clear picture of how diseases present from over 1750 high-quality images in full color. Tap into the expertise of leading authorities from around the world who offer an integrated approach, incorporating genomic and molecular information, clinical presentation, gross and microscopic pathologic findings, radiologic and laboratory diagnosis, and immunohistochemistry. Find information quickly and easily with the consistent format that features quick reference points at the beginning of each chapter.
Thoroughly updated to reflect the latest advances and technologies, Braddom's Physical Medicine and Rehabilitation, 6th Edition, remains the market leader in the field of PM&R. For more than 20 years, this bestselling reference has been the go-to resource for the entire rehabilitation team, providing in-depth coverage of essential core principles along with the latest research, technologies, and procedures that enhance patient care and facilitate optimal return to function. In this edition, lead editor Dr. David X. Cifu and his team of expert associate editors and contributing authors employ a more succinct format that emphasizes need-to-know material, incorporating new key summary features, including high-yield information and study sheets for problem-based learning. - Focuses more heavily on rehabilitation, with case studies throughout and more comprehensive coverage of stroke evaluation, rehabilitation, and therapies. - Provides expanded information on key topics such as interventional pain management options, gait and prosthetics, USG, fluoroscopy, electrodiagnosis and more. - Features a new chapter on Occupational Medicine and Vocational Rehabilitation, plus enhanced coverage of the neurogenic bladder, rehabilitation and prosthetic restoration in upper limb amputation, and acute medical conditions including cardiac disease, medical frailty, and renal failure. - Discusses quality and outcome measures for medical rehabilitation, practical aspects of impairment rating and disability determination, integrative medicine in rehabilitation, and assistive technology. - Offers highly illustrated, templated chapters that are easy to navigate without sacrificing coverage of key topics. - Includes access to dozens of even more practical videos and hundreds of integrated self-assessment questions for more effective learning and retention. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
Feedback from users suggest this resource book is more comprehensive and more practical than many others in the market. One of its strengths is that it was written by trainees in internal medicine who understand the need for rapid access to accurate and concise clinical information, with a practical approach to clinical problem solving.
Peripheral neuropathies represent a challenging subject for most physicians. This is an up-to-date, comprehensive, and readable book on peripheral neuropathies that includes concise information on the clinical, electrophysiological, pathological, pathogenic, and treatment aspects of the most important disorders. New molecular and serologic diagnostic tests are discussed. Sections are devoted to nerve and skin biopsy techniques and findings, quantitative sensory and autonomic reflex tests. Case examples are used liberally throughout the text. The editors: Mendell, Kissel, and Cornblath are experienced clinicians that bring complementary knowledge to each of the subjects. Additional authors have been handpicked for specific topics which add to the value of the edition.
Extensively illustrated and liberally laced with clinically helpful tools, Clinical Adult Neurology is an affordable reference for all clinicians and residents. With emphasis on diagnostic tools and strategies as well as management pearls and perils, Clinical Adult Neurology will meet the needs of all health care practitioners caring for patients with neurologic disorders. The book is organized into three sections, with Section 1 covering all aspects of neurologic evaluation, Section 2 describing common clinical problems in neurology, and Section 3 discussing all aspects of neurologic diseases. All sections and chapters emphasize the clinical approach to the patient with consistently useful pedagogical tools, including Features tables for diagnostic help with all neurologic diseases, Pearls and Perils boxes that represent pithy distillations of clinical wisdom from leading experts, Key Clinical Questions boxes that help clinicians frame patient diagnosis and management; and annotated bibliographies that highlight the most important references for further study. The book's organization, format, and features all stress the efficient and well-rationed use of medical care for patients with neurologic disease. Succinct content presentations make all information easy to locate and digest. The format will also be a helpful tool for those preparing for examinations. Highlights include: An emphasis on diagnosis, management, and all pertinent clinical issues Heavily illustrated Contributions by the foremost experts on all aspects of neurologic diseases Extensive use of clinically helpful tables, charts, and boxes with practical advice on all aspects of diagnosis and management
This volume brings together a selection of the most stimulating and influential writing on Haydn and his music in the English language. Written by a range of established and younger scholars it probes a variety of aesthetic, biographical, compositional, performance and reception issues. A specially written introduction summarizes the significance of each essay, directs the reader to appropriate complementary material and seeks the common ground between the essays; to assist with consistent referencing the individual essays retain their original pagination. This representative compendium of Haydn research provides the opportunity to explore the intellectual diversity of recent scholarship and is an indispensable publication for students of Haydn, whether new or old, amateur or professional.
As the definitive reference for clinical chemistry, Tietz Textbook of Clinical Chemistry and Molecular Diagnostics, 5th Edition offers the most current and authoritative guidance on selecting, performing, and evaluating results of new and established laboratory tests. Up-to-date encyclopedic coverage details everything you need to know, including: analytical criteria for the medical usefulness of laboratory procedures; new approaches for establishing reference ranges; variables that affect tests and results; the impact of modern analytical tools on lab management and costs; and applications of statistical methods. In addition to updated content throughout, this two-color edition also features a new chapter on hemostasis and the latest advances in molecular diagnostics. Section on Molecular Diagnostics and Genetics contains nine expanded chapters that focus on emerging issues and techniques, written by experts in field, including Y.M. Dennis Lo, Rossa W.K. Chiu, Carl Wittwer, Noriko Kusukawa, Cindy Vnencak-Jones, Thomas Williams, Victor Weedn, Malek Kamoun, Howard Baum, Angela Caliendo, Aaron Bossler, Gwendolyn McMillin, and Kojo S.J. Elenitoba-Johnson. Highly-respected author team includes three editors who are well known in the clinical chemistry world. Reference values in the appendix give you one location for comparing and evaluating test results. NEW! Two-color design throughout highlights important features, illustrations, and content for a quick reference. NEW! Chapter on hemostasis provides you with all the information you need to accurately conduct this type of clinical testing. NEW! Six associate editors lend even more expertise and insight to the reference. NEW! Reorganized chapters ensure that only the most current information is included.
Written through a collaboration of expert faculty and medical students from Harvard Medical School, this innovative text delivers a straightforward and clear overview of the major principles, agents, and processes governing human physiology. Emphasis is on understanding the higher-order processes in each organ system. Concepts in Medical Physiology avoids long lists of unprioritized information and undefined jargon by presenting fresh concept diagrams and figures alongside clear explanations of quantitative concepts. It can function equally well as a primary resource or as a review. Eight major sections, comprising a total of 36 chapters, cover general principles, muscle and bone, blood and the immune system, cardiovascular physiology, pulmonary physiology, renal physiology, gastrointestinal physiology, and endocrine physiology. Many useful features simplify mastery of difficult concepts: Case studies for each major section present detailed cases with signs and symptoms, history, and laboratory data. Questions at the conclusion of each case reinforce important clinical concepts. Reviews of cell biology, basic science, and biochemistry refresh students on the foundations of physiological knowledge. Clinical Application boxes draw the connection between physiology to practical issues students face and help with preparation for the USMLE. Pathophysiology sections are featured in every chapter. Review questions with answers in each chapter aid in preparation for the examination. Integrative Physiology inserts highlight how specific systems, organs, and tissues work together. More than 350 illustrations aid with visual learning, including original schematic diagrams, photos, and tables. Concept-focused summaries conclude each chapter for more effective learning and review. Suggested readings in every chapter provide a valuable resource for further investigation in physiological and clinical ideas.
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