David Mast's Books

Withrow and MacEwen's Small Animal Clinical Oncology - E-Book

By: Stephen J. Withrow,David M. Vail

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Withrow and MacEwen's Small Animal Clinical Oncology - E-Book

By: Stephen J. Withrow,David M. Vail

Focusing on cancer in dogs and cats, this extensively updated 4th edition provides comprehensive coverage of the latest advances in clinical oncology, including chemotherapy, surgical oncology, and diagnostic techniques. Ideal for students, practitioners, and those involved in academic research, this book's full-color images and user-friendly format provide quick and easy access to today's most important information on cancer in the small animal patient. Full-color format throughout and full-color illustrations make information more accessible and provide accurate representations of clinical appearance. Chapters are clustered into four major sections: The Biology and Pathogenesis of Cancer, Diagnostic Procedures for the Cancer Patient, Therapeutic Modalities for the Cancer Patient, and Specific Malignancies in the Small Animal Patient. The consistent format includes incidence and risk factors, pathology, natural behavior of tumors, history and clinical signs, diagnostic techniques and workup, treatment options, and prognosis for specific malignancies in the small animal cancer patient. Features cutting edge information on the complications of cancer, pain management, and the latest treatment modalities. The latest information on the etiology of cancer, including genetic, chemical, physical, and hormonal factors, as well as cancer-causing viruses. Coverage of molecular-targeted therapy of cancer, plus new and emerging therapeutic techniques. New information on molecular diagnostic procedures for the cancer patient. The latest diagnostic imaging techniques in clinical oncology. Discussions of compassion and supportive care, from chronic pain management and nutrition to end-of-life issues and grief support.

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865

Publisher

Elsevier Health Sciences

Published Date

ISBN 10

1437702015

ISBN 13

9781437702019

British Warship Losses in the Age of Sail

1649-1859

By: David Hepper

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British Warship Losses in the Age of Sail

1649-1859

By: David Hepper

This significant new reference book provides a complete list of the ships of the Royal Navy which were lost at sea in the age of sail. Arranged in chronological order, it includes outline details of each vessel lost and the circumstances of her loss. 1649 is the start date, which coincides with the execution of Charles I and that time when the Royal Navy entered a new phase as an instrument of state: the launch of the steam-powered and iron-hulled Warrior in 1860 effectively marks the end of the great era of the wooden-hulled sailing warship. Life at sea in the age of sail was a hazardous pursuit, and there were many reasons for a ship being lost. A correspondent to the Nautical Magazine in 1841 detailed some fifty reasons and causes, from being short of crew, abandonment without sufficient cause, the poor condition of a ship, incorrectness of charts, poor dead-reckoning as well as less obvious reasons such as the presence of captains wives and other women. Navigational error, particularly before the chronometer allowed for the accurate calculation of longitude, was a common reason, while poor weather in the form of fog or gales was an obvious peril. So many ships suffered the melancholy fate of lonely disappearance overwhelmed by storm and sea, and witnessed by none. Collisions and fire feature regularly as does, of course, loss to the enemy. Each entry includes details of the ship, its name and type, tonnage and dimensions, origin and place of build, the circumstances of the loss, the date and a list of the main references used. All this material is presented here in a single and highly accessible volume, and represents a major milestone both in naval research and publishing; it offers too a fund of fascinating and compelling stories of maritime misadventure. Praise for the author's previous work: This volume is an amazing encyclopaedic, catalogue of British warships lost between 1920 and 1982 It is strongly recommended to historians, authors, researchers and all those with an interest in the history of the Royal Navy and the Second World War. -Scuttlebut Magazine

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401

Publisher

Seaforth Publishing

Published Date

ISBN 10

1399031058

ISBN 13

9781399031059

Innervation of the Gut

By: Yvette Tache,David L. Wingate,Thomas F. Burks

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Innervation of the Gut

By: Yvette Tache,David L. Wingate,Thomas F. Burks

Innervation of the Gut provides a stimulating discussion of gut innervations based on exciting developments generated by advanced neuroanatomical and electrophysiological approaches. All components of the nervous system are covered, including central, spinal, autonomic, and enteric systems. This information is relative to secretory, motor, and immune regulatory functions of the gut, as well as visceral sensation. Brain transmitters involved in mediating stress-induced alterations of gastrointestinal motor function and the central regulation of vagal outflow to the gut are discussed in detail. The book will stimulate basic scientists and gastroenterologists to expand research efforts that may enable them to unravel the mechanisms of brain-gut interactions under physiological and pathological conditions. Students, psychologists, and psychiatrists will find Innervation of the Gut an essential reference for their studies.

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380

Publisher

CRC Press

Published Date

ISBN 10

0849347181

ISBN 13

9780849347184

Lever's Histopathology of the Skin

By: David E. Elder

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Lever's Histopathology of the Skin

By: David E. Elder

Rely on Lever’s for more accurate, more efficient diagnoses! Continuously in publication for more than 65 years, Lever's Histopathology of the Skin remains your authoritative source for comprehensive coverage of those skin diseases in which histopathology plays an important role in diagnosis. This edition maintains the proven, clinicopathologic classification of cutaneous disease while incorporating a “primer” on pattern-algorithm diagnosis. More than 1800 full-color illustrations, including photomicrographs and clinical photographs, help you visualize and make the most of the clinical diagnostic process.

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4275

Publisher

Lippincott Williams & Wilkins

Published Date

ISBN 10

1496301013

ISBN 13

9781496301017

Atlas and Synopsis of Lever's Histopathology of the Skin

By: David E. Elder,Rosalie Elenitsas,Adam I. Rubin,Michael Ioffreda,Jeffrey Miller,O. Fred Miller

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Atlas and Synopsis of Lever's Histopathology of the Skin

By: David E. Elder,Rosalie Elenitsas,Adam I. Rubin,Michael Ioffreda,Jeffrey Miller,O. Fred Miller

Atlas and Synopsis of Lever's Histopathology of the Skin provides a systematic approach to diagnosing skin diseases. Written for trainees as well as experienced dermatopathologists, this text classifies skin diseases by location, reaction patterns, and cell type, if applicable. Revised and updated based on the 10th edition of Lever's Histopathology of the Skin, it greatly expands the concept of pattern recognition in differential diagnosis.

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561

Publisher

Lippincott Williams & Wilkins

Published Date

ISBN 10

1451171633

ISBN 13

9781451171631

The Elements and Practice of Rigging, Seamanship, and Naval Tactics

By: David Steel

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The Elements and Practice of Rigging, Seamanship, and Naval Tactics

By: David Steel

The first English manual of best naval practice for aspiring young officers, first published in 1794.

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208

Publisher

Cambridge University Press

Published Date

ISBN 10

1108026524

ISBN 13

9781108026529

Bone Marrow Pathology

By: Barbara J. Bain,David M. Clark,Bridget S. Wilkins,Vishakha Sovani

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Bone Marrow Pathology

By: Barbara J. Bain,David M. Clark,Bridget S. Wilkins,Vishakha Sovani

Discover a comprehensive and up-to-date reference resource for bone marrow pathology, complete with an extensive list of references The diagnosis and treatment of bone marrow pathologies is one of the most critical areas of medical research and care. For years, Bone Marrow Pathology has served as the essential reference and teaching tool in the field of haematology, with an authoritative treatment of the subject written by acknowledged leaders in the field. Now fully updated to reflect urgent new changes to the theory and practice of haematology, it promises to serve a new generation of practitioners. In the book, the characteristics and function of normal bone marrow are extensively discussed. Bone marrow pathology, including both aspirate films and trephine biopsy sections, is examined in a clinical context. The content is augmented by discussion of the peripheral blood findings and supplementary bone marrow tests. Readers of the sixth edition of Bone Marrow Pathology will also find: Lavish illustrations with high-quality images of bone marrow and other associated images Incorporation of new classifications including the WHO and International Consensus classifications, as well as new and expanded research areas Emphasis on practical tools including differential diagnosis and common problems and pitfalls A practical, integrated approach to diagnosis Perfect for trainee and consultant haematologists and haematopathologists, Bone Marrow Pathology will also prove itself invaluable for cytogeneticists, molecular geneticists and anyone working in immunophenotyping.

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1639

Publisher

John Wiley & Sons

Published Date

ISBN 10

1394244827

ISBN 13

9781394244829

Essential Histology

By: David H. Cormack

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Essential Histology

By: David H. Cormack

The Second Edition presents a compact and concise alternative to the larger histology texts on the market today. Great for students with a limited amount of time to devote to the subject. Improvements to the art program--adding more color and new illustrations--have been made to this edition.

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546

Publisher

Lippincott Williams & Wilkins

Published Date

ISBN 10

0781716683

ISBN 13

9780781716680

Molecular Basis of Lymphokine Action

By: David R. Webb,Carl W. Pierce,Stanley Cohen

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Molecular Basis of Lymphokine Action

By: David R. Webb,Carl W. Pierce,Stanley Cohen

The Fifth International Lymphokine Workshop was convened in Clearwater Beach, Florida, January 11-15, 1987. The theme chosen for the meeting was 'The Molecular Basis of Lymphokine Action," which reflected the opinion of the organizers as to how far the field had moved since the first Lymphokine Workshop only eleven years ago. As was evident at the last Lymphokine Workshop held in 1985, the contribution of molecular biology, particularly in the cloning of lymphokine genes, continues to play an important role in clarifying the structure of lymphokines, providing recombinant (read "pure") proteins for biological studies, and suggesting directions for studies of the molecular basis of lymphokine activity. The most recent lymphokines to yield to molecular cloning meth odology were the B-cell growth and differentiation factors, in partic ular BSF-1 or, as it is sometimes termed, interleukin 4. One of the surprises from this research is the broad spectrum of activities that can be attributed to this molecule, aside from its effects on B-cells, thus perhaps justifying its being called an interleukin. The interleukin 2 symposium demonstrated that even in a well-established research area, controversy and excitement can continue, when evidence was presented by several investigators indicating the presence of a second "converter" protein that changes the affinity of the now classical Tac antigen from a low to a high affinity IL-2 receptor.

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495

Publisher

Springer Science & Business Media

Published Date

ISBN 10

1461245982

ISBN 13

9781461245988

Nathan and Oski's Hematology and Oncology of Infancy and Childhood E-Book

By: Stuart H. Orkin,David G. Nathan,David Ginsburg,A. Thomas Look,David E. Fisher,Samuel Lux

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Nathan and Oski's Hematology and Oncology of Infancy and Childhood E-Book

By: Stuart H. Orkin,David G. Nathan,David Ginsburg,A. Thomas Look,David E. Fisher,Samuel Lux

Written by the leading names in pediatric oncology and hematology, Nathan and Oski's Hematology and Oncology of Infancy and Childhood offers you the essential tools you need to overcome the unique challenges and complexities of childhood cancers and hematologic disorders. Meticulously updated, this exciting full-color set brings together the pathophysiology of disease with detailed clinical guidance to provide you with the most comprehensive, authoritative, up-to-date information for diagnosing and treating children. - Form a definitive diagnosis and create the best treatment plans possible with comprehensive coverage of all pediatric cancers, including less-common tumors, as well as all hematologic disorders, including newly recognized ones. - Develop a thorough, understanding of the underlying science of diseases through summaries of relevant pathophysiology balanced with clear, practical clinical guidance. Nathan and Oski's is the only comprehensive product on the market that relates pathophysiology in such depth to hematologic and oncologic diseases affecting children. - Quickly and effortlessly access the key information you need with the help of a consistent organization from chapter to chapter and from volume to volume. - Stay at the forefront of your field thanks to new and revised chapters covering topics such as paroxysmal nocturnal hemoglobinuria, lysosomal storage diseases, childhood genetic predisposition to cancer, and oncology informatics. - Learn about the latest breakthroughs in diagnosis and management, making this the most complete guide in pediatric hematology and oncology. - Discover the latest in focused molecularly targeted therapies derived from the exponential growth of knowledge about basic biology and genetics underlying the field. - Rely on it anytime, anywhere! Access the full text, images, and more at Expert Consult.

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3517

Publisher

Elsevier Health Sciences

Published Date

ISBN 10

0323291775

ISBN 13

9780323291774

Flow Cytometry, An Issue of Clinics in Laboratory Medicine

By: David M. Dorfman

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Flow Cytometry, An Issue of Clinics in Laboratory Medicine

By: David M. Dorfman

This issue of Clinics in Laboratory Medicine, edited by David M. Dorfman, will cover Flow Cytometry. Topics covered in this issue include: Flow cytometric evaluation of primary immunodeficiencies; Flow cytometry of B cell neoplasms; Flow cytometry of T cell neoplasms; Flow cytometry of acute myeloid leukemias; AML minimal residual disease (MRD) assessment by flow cytometric analysis; Acute lymphoblastic leukemia minimal residual disease (MRD) assessment by flow cytometric analysis; Flow cytometric assessment of myelodysplasia and myeloproliferative neoplasms; Flow cytometry of plasma cell neoplasms, including MRD testing; Paroxysmal nocturnal hemoglobinuria (PNH) assessment by flow cytometric analysis; Mast cell disease assessment by flow cytometric analysis; Flow cytometry in pediatric hematopathology; Clinical applications of mass cytometry; Automated analysis of clinical flow cytometry data; and Cost-effective flow cytometric testing strategies.

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289

Publisher

Elsevier Health Sciences

Published Date

ISBN 10

0323552838

ISBN 13

9780323552837

Bone Marrow Diagnosis

An Illustrated Guide

By: Kevin Gatter,David Brown

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Bone Marrow Diagnosis

An Illustrated Guide

By: Kevin Gatter,David Brown

Bone Marrow Diagnosis, Third Edition, is an essential resource for pathologists and haematologists who need to report bone marrow trephine biopsies. Practical and highly illustrated this edition has been comprehensively updated whilst remaining succinct and concentrating on the core information necessary to make an accurate diagnosis. The text provides comparisons of the common methods of sample collection, fixation and staining, and a clear description of how to examine a trephine section. Applying a consistent approach, the chapters cover the range of disorders of bone marrow, discussing the clinical features, histopathology of bone marrow and diagnostic problems of each condition. Each chapter closes with a summary of key points and each diagnostic entity is accompanied by high quality images, over 900 in all, showing typical and more unusual examples of histological features. This compact text, oriented at diagnosis and comprehensively accompanied by usable illustrations, is an invaluable reference tool for the trainee and practicing histopathologists, pathologists and haematologists. A practical guide aimed at allowing a busy pathologist to easily find the essential description and illustration of the most common bone marrow diseases seen in trephines Covers new treatment for chronic myeloid leukaemia, B-cell lymphoma and antibody treatments High quality colour images accompany each diagnostic entity Coverage of cytology in sections relating to myeloid dysplasias and acute leukaemias Addresses lymphoma categorization and individual lymphoma entities Incorporates new WHO classifications of lymphomas and leukaemias

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232

Publisher

John Wiley & Sons

Published Date

ISBN 10

1118253655

ISBN 13

9781118253656

Eaches or Pieces Order Fulfillment, Design, and Operations Handbook

By: David E. Mulcahy

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Eaches or Pieces Order Fulfillment, Design, and Operations Handbook

By: David E. Mulcahy

If your business uses warehouses to deal with the sales of goods, then you know that facility operations, shipping, and customer service are important to your company's health. Eaches or Pieces Order Fulfillment, Design, and Operations Handbook offers insights for warehouse, distribution, or logistics professionals to make their "eaches or pieces

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952

Publisher

CRC Press

Published Date

ISBN 10

1420013092

ISBN 13

9781420013092

Microbiology

By: Dave Wessner,David R. Wessner,Christine Dupont,Trevor Charles,Josh D. Neufeld

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Microbiology

By: Dave Wessner,David R. Wessner,Christine Dupont,Trevor Charles,Josh D. Neufeld

Microbiology is a comprehensive textbook that facilitates a thorough understanding of the scope, nature, and complexity of the science of microscopic organisms. It gives a balanced presentation of foundational concepts, real-world applications, and current research and experimentation. The text approaches the subject within the context of exploration and experimentation, integrating a wealth of classroom-tested pedagogical features. The material is organized around the three pillars of physiology, ecology, and genetics -- helping students appreciate the interconnected and dynamic nature of microbiology and explore the relationship between different types of microbes, other organisms, and the environment. This international adaptation contains up-to-date coverage of topics including DNA replication and gene expression, viral pathogenesis, microbial biotechnology, adaptive immunity, the control of infectious diseases, and the microbiology of food and water. It also offers integrated coverage of SARS-CoV-2 and the impacts of COVID-19, relating it to the importance of an interdisciplinary response to a global pandemic. It also focuses on strengthening the organization of the content and updating the end of chapter problems

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1027

Publisher

John Wiley & Sons

Published Date

ISBN 10

1119701767

ISBN 13

9781119701767

Essential Tissue Healing of the Face and Neck

By: David B. Hom

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Essential Tissue Healing of the Face and Neck

By: David B. Hom

This unique textbook focuses exclusively on wound healing of the face and neck, integrating scientific principle with state-of-the-art clinical precept. Detailed, step-by-step surgical techniques demonstrate the best methods of repair of tissue. Contemporary healing concepts encompass the structures of the skin, cartilage, bone, nerve, oral mucosa, middle ear mucosa and airway mucosa. The book benefits from the diverse backgrounds and expertise of each of its authors bringing the reader new insights to the question of why some facial and neck wounds heal satisfactorily and others do not. Dr. Hom suggests a holistic approach to surgery of the face and neck that includes the healing process. Future directions for wound healing of the face and neck are also illuminated. The first section describes the healing aspects of the structures of the face and neck the second section addresses common clinical tissue healing problems encountered and methods to treat them. The third section discusses specific therapies used to optimize healing.

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484

Publisher

PMPH-USA

Published Date

ISBN 10

1607950073

ISBN 13

9781607950073

Arabella of Mars

By: David D. Levine

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Arabella of Mars

By: David D. Levine

“A fanciful romp through a cosmic 1812, Hugo Award–winning Levine’s first novel is a treat for steampunk fantasy fans.” —Library Journal (starred review) Born on Mars, sixteen-year-old Arabella Ashby enjoys many more freedoms than most girls her age, tramping around the desert with her older brother. But that liberty is not to last. Finding Mars much too unladylike for her daughters, Arabella’s mother takes the girls back to London, where they’re sure to find suitable husbands among the ton. Weighed down by Earth’s gravity—and her own unhappiness—Arabella dearly misses her father and their shared passion for automata. When she learns of his death, she also uncovers her cousin’s devious plot to travel to Mars, murder her brother, and claim the family inheritance for himself. To foil his dastardly plans, Arabella disguises herself as a boy to gain employment on an airship to Mars. Though she is valued by the captain for her talent with the automaton navigator he invented, she must survive French privateers, mutiny, and her own unmasking, only to reach a Mars embroiled in rebellion . . . “If Edgar Rice Burroughs, Jules Verne, and Patrick O’Brien had sat down together to compose a tale to amuse Jane Austen, the result might be Arabella of Mars. So. Much. Fun!” —Madeleine Robins, author of the Sarah Tolerance Regency mystery series “A very clever and entertaining start to a memorable saga.” —Kim Stanley Robinson, New York Times–bestselling author “Arabella, a human teenager born on Mars, is catapulted into adventure in a tale that cleverly combines some of the most intriguing elements of steampunk and classic science fiction.” —Publishers Weekly (starred review)

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Page Count

401

Publisher

Open Road Media

Published Date

ISBN 10

1504091701

ISBN 13

9781504091701

Lever's Dermatopathology

Histopathology of the Skin

By: David E. Elder,Rosalie Elenitsas,George F. Murphy,Misha Rosenbach,Adam I. Rubin,John T. Seykora,Xiaowei Xu

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Lever's Dermatopathology

Histopathology of the Skin

By: David E. Elder,Rosalie Elenitsas,George F. Murphy,Misha Rosenbach,Adam I. Rubin,John T. Seykora,Xiaowei Xu

Used by generations of physicians who encounter patients with dermatological diseases, Lever’s Dermatopathology: Histopathology of the Skin comprehensively covers skin disease in which histopathology plays an important role in diagnosis. The updated 12th Edition, edited by Drs. David E. Elder, Rosalie Elenitsas, George F. Murphy, Misha Rosenbach, Adam I. Rubin, John T. Seykora, and Xiaowei Xu, maintains the proven, clinicopathologic classification of cutaneous disease while incorporating a “primer” on pattern-algorithm diagnosis. It features larger images throughout, as well as thoroughly revised content with new diseases and new information on pathophysiology and molecular pathogenesis—all in an easy-to-navigate, highly readable format.

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3866

Publisher

Lippincott Williams & Wilkins

Published Date

ISBN 10

197517450X

ISBN 13

9781975174507

Old Ironsides

Eagle of the Sea: The Story of the USS Constitution

By: David Fitz-Enz

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Old Ironsides

Eagle of the Sea: The Story of the USS Constitution

By: David Fitz-Enz

This is the story of the oldest warship afloat in the world, the venerable frigate USS Constitution, the cornerstone of the nascent American navy created by act of Congress in 1794. Colonel David Fitz-Enz re-creates the world of sail, when seven knots an hour was considered blinding speed for a warship. In Old Ironsides, Fitz-Enz tells the story of the ship, from its construction to the ongoing restoration efforts that keep it active today.

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304

Publisher

Taylor Trade Publications

Published Date

ISBN 10

1589794281

ISBN 13

9781589794283

Order-Fulfillment and Across-the-Dock Concepts, Design, and Operations Handbook

By: David E. Mulcahy

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Order-Fulfillment and Across-the-Dock Concepts, Design, and Operations Handbook

By: David E. Mulcahy

Order-Fulfillment and Across-the-Dock Concepts, Design, and Operations Handbook provides insights and tips that warehouse and distribution professionals can use to make their order fulfillment or across-the-dock operations more efficient and cost-effective. Each chapter focuses on key aspects of planning and managing, making it easy to find informa

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742

Publisher

CRC Press

Published Date

ISBN 10

0203998146

ISBN 13

9780203998144

Respiratory Genetics

By: Edwin Silverman,Scott Weiss,Steven Shapiro,David Lomas

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Respiratory Genetics

By: Edwin Silverman,Scott Weiss,Steven Shapiro,David Lomas

There has been a recent explosion of knowledge in the field of respiratory genetics. This authoritative text brings together current knowledge in respiratory genetics in a single volume. The book includes a comprehensive introductory section to provide guidance and aid understanding of key basic concepts in respiratory genetics, including statistical methods, sample collection, bioinformatics, and functional genomics. This is followed by a series of disease-specific chapters that review epidemiology, natural history, monogenic determinants, complex disease components, disease management, and likely future developments. Respiratory Genetics is an essential reference for pulmonologists, translational researchers, and clinical geneticists, and the text will also be a useful library reference.

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555

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CRC Press

Published Date

ISBN 10

0340814322

ISBN 13

9780340814321

Marine Physiology Down East: The Story of the Mt. Desert Island Biological Laboratory

By: David H. Evans

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Marine Physiology Down East: The Story of the Mt. Desert Island Biological Laboratory

By: David H. Evans

This volume offers a comprehensive history of the Mount Desert Island Biological Laboratory (MDIBL), one of the major marine laboratories in the United States and a leader in using marine organisms to study fundamental physiological concepts. Beginning with its founding as the Harpswell Laboratory of Tufts University in 1898, David H. Evans follows its evolution from a teaching facility to a research center for distinguished renal and epithelial physiologists. He also describes how it became the site of major advances in cytokinesis, regeneration, cardiac and vascular physiology, hepatic physiology, endocrinology and toxicology, as well as studies of the comparative physiology of marine organisms. Fundamental physiological concepts in the context of the discoveries made at the MDIBL are explained and the social and administrative history of this renowned facility is described.

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1108

Publisher

Springer

Published Date

ISBN 10

1493929607

ISBN 13

9781493929603

The Radiation Biology of the Vascular Endothelium

By: David B. Rubin

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The Radiation Biology of the Vascular Endothelium

By: David B. Rubin

Endothelial cells are early targets of radiation injury. Because these cells are tissues easily damaged by radiation, if we can understand the causes of radiation injury, then normal cells can be well protected and tumors can be destroyed. The Radiation Biology of the Vascular Endothelium brings together expert reviews on the biology and radiobiology of the vasculature, with emphasis on the endothelial cell component of blood vessels. The book covers both the basic aspects of endothelial cell biology and the practical consequences of this for the oncologist, with special reference to the radiation oncologist. After reading The Radiation Biology of the Vascular Endothelium, no clinical or experimental oncologist should be able to ignore the intimate relationship between tumor and normal tissue cells and endothelial cells that form the barrier to, and are the bearers of, essential nutrient supplies.

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274

Publisher

CRC Press

Published Date

ISBN 10

0849348404

ISBN 13

9780849348402

Targeting Protein Kinases for Cancer Therapy

By: David J. Matthews,Mary E. Gerritsen

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Targeting Protein Kinases for Cancer Therapy

By: David J. Matthews,Mary E. Gerritsen

An expert guide to targeting protein kinases in cancer therapy Research has shown that protein kinases can instigate the formation and spread of cancer when they transmit faulty signals inside cells. Because of this fact, pharmaceutical scientists have targeted kinases for intensive study, and have been working to develop medicinal roadblocks to sever their malignant means of communication. Complete with full-color presentations, Targeting Protein Kinases for Cancer Therapy defines the structural features of protein kinases and examines their cellular functions. Combining kinase biology with chemistry and pharmacology applications, this book enlists emerging data to drive the discovery of new cancer-fighting drugs. Valuable information includes: Comprehensive overviews of the major kinase families involved in oncology, integrating protein structure and function, and providing important tools to assist pharmaceutical researchers to understand and work in this dynamic area of cancer drug research Focus on small molecule inhibitors as well as other therapeutic modalities Discussion of kinase inhibitors that have entered clinical trials for the treatment of cancer, with an emphasis on molecules that have progressed to late stage clinical trials and, in a few cases, to market Providing a platform for further study, this important work reviews both the successes and challenges of kinase inhibitor therapy, and provides insight into future directions in the war against cancer.

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719

Publisher

John Wiley & Sons

Published Date

ISBN 10

1118210778

ISBN 13

9781118210772

How to Build a Wooden Boat

By: David C. McIntosh

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How to Build a Wooden Boat

By: David C. McIntosh

David C. "Bud" McIntosh was a designer, builder, and sailor of large and small wooden cruising boats for more than 50 years, and wrote about it for over 10 of those years. He made his home on New Hampshire's Piscataqua River, where he was teacher and friend to both amateur and professional boatbuilders.

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276

Publisher

WoodenBoat Books

Published Date

ISBN 10

0937822108

ISBN 13

9780937822104

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