The science of toxicology has progressed considerably since Molecular Toxicology was first published in 1997. New advances in biochemical and molecular biological experimental techniques have helped researchers understand the precise effects of toxins and foreign compounds on living things atthe molecular, cellular, and organismal levels. Breakthrough research has recently been completed illuminating the human genome and the role of enzymes in toxic biochemical reaction mechanisms. Toxicology now covers drug metabolism and design, carcinogenesis, programmed cell death, and DNA repair,among other subjects. The second edition captures these and other advances, and broadens its scope to address the experimental science of toxicology. The first edition of Molecular Toxicology has become an indispensable resource for graduate students in molecular and biochemical toxicology courses,as well as academic researchers and industrial researchers in toxicology. Rigorously updated and revised, the new edition commands an unrivaled authority in the field of molecular toxicology.
SUNDAY TIMES TOP TEN BESTSELLER DAILY MAIL BOOK OF THE WEEK THE FIRST OFFICIAL HISTORY OF THE RED ARROWS 'Heart-pounding, exhilarating . . . A fascinating testimony of jeopardy, cool heads and the sheer exultant addiction of flying.' SINCLAIR MCKAY 'Fantastic . . . It was wonderful to read about so many old chums and truly legendary aviators. Highly recommended.' JOHN NICHOL (Twitter) 'An exhilarating read! The next-best thing to taking the controls of a Hawk fast-jet. And you're much less likely to throw up.' BEN MILLER 'Inspirational . . . Precision, style and dedication. The Red Arrows are the ultimate in teamwork.' TIM PEAKE 'Perfectly enjoyable . . . As the Red Arrows head towards their 60th anniversary, it's clear the team's place in our hearts is secure.' DAILY MAIL 'A wild ride . . . The ultimate insider guide, relating with great enthusiasm and insight what it means to be inside the cockpit as you scream through the skies at 350 to 450 miles per hour, within what feels like touching distance of your wingman, making continual nanosecond decisions that will result in certain death if you get them wrong.' TELEGRAPH, Patrick Bishop _________________________________________ "Occasionally, you and the team come within read of perfection, up there in the rarefied air of the skies. You never know when those moments will come, but it's what you yearn for as a pilot." The Red Arrows represent the very best speed, agility and precision aerobatic flying in the Royal Air Force, and the people who wear those iconic red flight suits are rigorously selected not just for their flying skills, lightning-fast reflexes and nerves of steel, but for their mental resilience, courage and humility. Written by the Officer Commanding and former Red 1 Team Leader, Wing Commander David Montenegro, and full of never-before-shared tales from pilots past and present, this thrilling history is both a faithful record and a fascinating account of not only what it takes, but what it means, to be a Red Arrow. _________________________________________ Praise for the Red Arrows: 'A lifetime's ambition . . . I still can't believe I've been in a fighter jet. It was fantastic - just to feel the G-force was spectacular.' LEWIS HAMILTON 'So tight, crisp and professional' CHRIS HADFIELD 'I can never quite believe that anyone can fly and aircraft with such precision' PROF. BRIAN COX 'The skill level they have is just off the scale. The Red Arrows is an amazing display of quality' DAVID COULTHARD
Presents the principles of human gene evolution in a concise and easy to understand fashion. Uses examples of how evolutionary processes have molded present day genes, drawn from the evolution of humans and other primates, as well as from more primitive organisms. With increasing attention in this expanding area, this review forms a timely publication of our current knowledge of this important field. Structure and function in the human genome The evolution of gene structure Mutational mechanisms in evolution
**Selected for Doody's Core Titles® 2024 with "Essential Purchase" designation in Pediatric Surgery** Now in brilliant full color and reflecting recent significant changes in the field, Critical Heart Disease in Infants and Children, 3rd Edition, keeps you abreast of the skills and knowledge required to safely care for children with congenital and acquired heart disease in the ICU. Pediatric intensivists, cardiologists, cardiac surgeons, and anesthesiologists from leading centers around the world provide a well-rounded perspective on basic scientific principles, medical and pharmacologic treatments, surgical techniques, and equipment. - Features comprehensive updates throughout the text, including indications, techniques, potential complications in perioperative management of patients, and surgical techniques for congenital heart disease. - Covers recent advances in the treatment of pulmonary hypertension, developments in mechanical assist devices, heart and lung transplantation, and interventional cardiac catheterization. - Features an all-new, full-color format that speeds navigation and helps clarify complex concepts. - Contains 27 new chapters with an emphasis on the team approach to patient care in the ICU including creating multidisciplinary teams, quality and performance improvement, training , and challenges and solutions to developing a cohesive team environment. - Includes a detailed chapter on bedside ultrasound, walking you through the techniques you're most likely to encounter in the ICU. - Employs well-documented tables, text boxes, and algorithms to make clinical information easy to access, and more than two dozen video clips provide a more complete understanding of echocardiography, imaging modalities, pulmonary hypertension, and more. - Describes the basic pharmacology and clinical applications of new pharmacologic agents. - Examines issues affecting adults with congenital heart disease. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices. - Offers four completely new chapters: Cardiac Trauma, Congenital Heart Disease in the Adult, Congenitally Corrected Transposition of the Great Arteries, and Outcome Evaluation. - Describes the basic pharmacology and clinical applications of all of the new pharmacologic agents. - Details important refinements and developments in surgical techniques, including the Ross pulmonary autograft replacement of the aortic valve, video-assisted fluoroscopy, and the extracardiac Fontan connection, and discusses their indications and potential complications. - Explores the latest advances in the treatment of pulmonary hypertension, new developments in mechanical assist devices, heart and lung transplantation, and interventional cardiac catheterization. - Examines issues affecting adults with congenital heart disease.
Genetic epidemiology plays a key role in discovering genetic factors influencing health and disease, and in understanding how genes and environmental risk factors interact. There is growing interest in this field within public health, with the goal of translating the results into promoting health and preventing disease in both families and populations. This textbook provides graduate students with a working knowledge of genetic epidemiology research methods. Following an overview of the field, the book reviews key genetic concepts, provides an update on relevant genomic technology, including genome-wide chips and DNA sequencing, and describes methods for assessing the magnitude of genetic influences on diseases and risk factors. The book focuses on research study designs for discovering disease susceptibility genes, including family-based linkage analysis, candidate gene and genome-side association studies, assessing gene-environment interactions and epistasis, studies of Non-Mendelian inheritance, and statistical analyses of data from these studies. Specific applications of each research method are illustrated using a variety of diseases and risk factors relevant to public health, and useful web-based genetic analysis software, human reference panels, and repositories, that can greatly facilitate this work, are described.
A valuable resource for researchers and workers in the fields of both pharmaceuticals and biotechnology as well as undergraduates in biochemistry, applied biology, biomedical sciences and pharmacy, this book compares established techniques of antibody production with the new. Antibody structure and the implications of antibody engineering are fully
An interdisciplinary history of the campaign to secure international protection of indications of geographic origin, including 'Made in ...' slogans. It will appeal to students of business and economic history, geography, legal history and marketing.
This book argues that Ann Leckie’s novel Ancillary Justice offers a devastating rebuke to the political, social, cultural, and economic injustices of American imperialism in the post 9/11 era. Following an introductory overview, the study offers four chapters that examine key themes central to the novel: gender, imperial economics, race, and revolutionary agency. Ancillary Justice’s exploration of these four themes, and the way it reveals how these issues are all fundamentally entangled with the problem of contemporary imperial power, warrants its status as a canonical work of science fiction for the twenty-first century. The book concludes with a brief interview with Leckie herself touching on each of the topics examined during the preceding chapters.
Reverse colonization narratives are stories like H. G. Wells's War of the Worlds (where technologically superior Martians invade and colonize England) that ask Western audiences to imagine what it's like to be the colonized rather than the colonizers. In this book, David M. Higgins argues that although some reverse colonization stories are thoughtful and provocative (because they ask us to think critically about what empire feels like from the receiving end), reverse colonization fantasy has also led to the prevalence of a very dangerous kind of science fictional thinking in our current political culture. Everyone, now (including anti-feminists, white supremacists, and far-right reactionaries) likes to imagine themselves as the Rebel Alliance fighting against the Empire (or Neo trying to escape the Matrix, or Katniss Everdeen waging war against the Capitol). Reverse colonization fantasy, in other words, has a dangerous tendency to enable white men (and other subjects of privilege) to appropriate a sense of victimhood for their own social and political advantage"--
This book presents an overview of Shiga toxin-producing E. coli (STEC), with in-depth coverage of key areas such as recent Shiga toxin-related poisonings in Europe and the US, the structure, production, and mechanism of action of Shiga toxin, and current methods of detection. The globalization of food production has introduced new risk factors and intensified existing hazards, complicating the assurance of food safety. Foodborne illness outbreaks, such as those related to STEC, are becoming more common and more dangerous. The threat that these bacterial toxins pose to the food supply is magnified by the frequent occurrence and severity of Shiga toxin-caused disease. As a result, STEC and their toxins remain a primary concern in food safety. This review serves as a key resource for scientists in the field and public health and regulatory officials charged with maintaining food safety. This book also looks to the future of treatment of Shiga toxin-associated disease, specifically the translation of lab bench science into clinical therapeutic strategies.
Textbook of Assisted Reproductive Technologies is a truly comprehensive manual for the whole team at the IVF clinic. Information is presented in a highly visual manner, allowing both methods and protocols to be consulted easily. The text provides clinical and scientific teams with the A to Zs of setting up an embryology laboratory, gives research fellows insight into technical developments, and supplies seasoned professionals with a review of the latest techniques and advances. New to the Third Edition: fully revised and expanded chapters, with new information on: single embryo transfer artificial gametes pharmacogenetics
Dysfunctional organizations result from individual behavior and the cultures they develop. Many individuals have directly experienced some form of dysfunctional behavior, including trauma from nonfatal workplace violence, bullying, harassment, violence, and unsafe work practices. These and other unacceptable workplace behaviors pose significant problems in organizations. Psychological safety deals with these behaviors and prevents organizations from becoming dysfunctional. It may not be “the” way to prevent dysfunctions, but it certainly is “a” way. This book uses simple and direct words to describe forms of behavior that are obstacles to developing psychological safety. It then provides practical guidance for what can and should be done to remove those obstacles. A unique framework (V-REEL) enables a better understanding of how and why behaviors are associated with dysfunctional organizations. It indicates the value of having psychologically, psychosocially, and physically safe workplaces. Its use helps the reader to carefully identify factors that erode or chip away safe workplaces as well as factors that enable or help to create them.
This guide covers all aspects pertaining to the use of zebrafish including their basic biology, humane care and management, husbandry, life support systems, regulatory compliance, technical procedures, veterinary care, and water quality management. The zebrafish is now a mainstream model animal employed by scientists to study everything from stem cells to the basis of behavioral changes induced by drug addiction. However, there are few accepted and established standards for husbandry, management, and care for the fish in laboratory settings and even fewer comprehensive and constantly reliable resources. To this end, the goal of this handbook is to provide managers, veterinarians, investigators, technicians, and regulatory personnel with a concise yet thorough reference on zebrafish biology, care, husbandry, and management. The new edition includes more figures, tables and bullet points, a wealth of new full-color images, major updates on health and welfare (including colony health surveillance and viruses), and a complete overhaul of the compliance section to address more international concerns.
Examines the history of All-Star baseball, providing play-by-plays, rosters, and box scores of each game; and discusses how All-Star games have been influenced by racial integration, expansion teams, and the designated hitter.
Farm dams, creeklines, vegetation and rocky outcrops are natural assets that are essential for healthy, sustainable farms. Protecting and enhancing these elements of natural capital on farms not only supports biodiversity, but also contributes to farm productivity and to the well-being of farmers and farming communities. Natural Asset Farming: Creating Productive and Biodiverse Farms reveals seven key natural assets and why they are so valuable for biodiversity and productivity on farms. Drawing on two decades of long-term ecological monitoring and knowledge exchange with farmers, Landcare groups and natural resource management experts, this book is a tool for building and enhancing natural assets in agricultural landscapes. In bringing together ecological science and the experience of farmers in the wheat–sheep belt of south-eastern Australia, Natural Asset Farming will help foster ideas, boost resilience and improve the sustainability of agricultural production.
An important milestone in medicine has been the recent completion of the Human Genome Project. The identification of 30,000 genes and their regulatory proteins provides the framework for understanding the metabolic basis of disease. This advance has also laid the foundation for a broad range of genomic tools that have opened the way for targeted genetic testing in a number of medical disorders. This book is designed to be the first major text to discuss genomics-based advances in disease susceptibility, diagnosis, prognostication,and prediction of treatment outcomes in various areas of medicine. After building a strong underpinning in the basic concepts of genomics, the authors of this book, all leaders in the field, proceed to discuss a wide range of clinical areas and the applications now afforded by genomic analysis.
Textbook of Emergency Medicine (Vol. 1 and 2) is a comprehensive and contemporary exposition of the vast array of disorders and emergencies that might present to the emergency or casualty department of a hospital.
In this Very Short Introduction, Peter Hainsworth and David Robey take a different approach to Dante, by examining the main themes and issues that run through all of his work, ranging from autobiography, to understanding God and the order of the universe. In doing so, they highlight what has made Dante a vital point of reference for modern writers and readers, both inside and outside Italy. They emphasize the distinctive and dynamic interplay in Dante's writing between argument, ideas, and analysis on the one hand, and poetic imagination on the other. Dante was highly concerned with the political and intellectual issues of his time, demonstrated most powerfully in his notorious work,The Divine Comedy. Tracing the tension between the medieval and modern aspects, Hainsworth and Robey provide a clear insight into the meaning of this masterpiece of world literature. They highlight key figures and episodes in the poem, bringing out the originality and power of Dante's writing to help readers understand the problems that Dante wanted his audience to confront but often left up to the reader to resolve. ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable.
How do you transform a classroom of individuals into a community of compassionate peers? The process of teaching empathy involves recognizing and naming the skill, practicing it, modeling it through action, and encouraging it. This resource focuses on teaching empathy and building a culture of caring in the classroom. A CD of the author’s original music enhances the learning experience.
Civil engineering produces the structures of all human settlements worldwide and is a vital discipline for many aspects modern life, underlying housing, transport, and our major areas and buildings related to work, study, and leisure. In this Very Short Introduction, David Muir Wood demonstrates the nature and importance of civil engineering not only in the history of civilization and urbanization, but its range of facets today, and its challenges for the future. Beginning with the challenge of creating a settlement on a deserted island, which sets out the problems that civil engineers need to solve, he looks at the social and environmental considerations as well as the science, technology, and craft of building bridges, tunnels, houses, and areas of recreation. He highlights the lives of some major civil engineers, including Brunel and Bazalgette, considers the challenges of managing water and energy, and looks at our increasing sensitivity to building and the environment. ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable.
Using light, electrons, or X-rays, microscopes today form a vital tool not only in biology but in many other disciplines, including materials science and nanotechnology. In this Very Short Introduction Terence Allen describes the scientific principles behind the main forms of microscopy, and the exciting new developments in the field. Beginning with a brief history of microscopy, Allen surveys the diverse and powerful forms of microscopes available today, illustrating how microscopy impinges on almost every aspect of our daily lives."--Inside front cover.
Maintaining the high standards that made the previous editions such well-respected and widely used references, Food Lipids: Chemistry, Nutrition, and Biotechnology, Third Edition tightens its focus to emphasize lipids from the point of entry into the food supply and highlights recent findings regarding antioxidants and lipid oxidation. Always representative of the current state of lipid science, this edition provides four new chapters reflecting the latest advances in antioxidant research. New chapters include: Polyunsaturated Lipid Oxidation in Aqueous Systems, Tocopherol Stability and the Prooxidant Mechanisms of Oxidized Tocopherols in Lipids, Effects and Mechanisms of Minor Compounds in Oil on Lipid Oxidation, and Total Antioxidant Evaluation and Synergism. The most comprehensive and relevant treatment of food lipids available, this book highlights the role of dietary fats in foods, human health, and disease. Divided into five parts, it begins with the chemistry and properties of food lipids covering nomenclature and classification, extraction and analysis, and chemistry and function. Part II addresses processing techniques including recovery, refining, converting, and stabilizing, as well as chemical interesterification. The third Part has been renamed and expanded to honor the growing data on oxidation and antioxidants. Part IV explores the myriad interactions of lipids in nutrition and health with information on heart disease, obesity, and cancer, and Part V continues with contributions on biotechnology and biochemistry including a chapter on the genetic engineering of crops that produce vegetable oil. Revised and updated with new information and references throughout the text, this third edition of a bestselling industry standard once again draws on the contributions of leading international experts to establish the latest benchmark in the field and provide the platform from which to further advance lipid science.
Stream Ecology: Structure and Function of Running Waters is designed to serve as a textbook for advanced undergraduate and graduate students, and as a reference source for specialists in stream ecology and related fields. This Third Edition is thoroughly updated and expanded to incorporate significant advances in our understanding of environmental factors, biological interactions, and ecosystem processes, and how these vary with hydrological, geomorphological, and landscape setting. The broad diversity of running waters – from torrential mountain brooks, to large, lowland rivers, to great river systems whose basins occupy sub-continents – makes river ecosystems appear overwhelming complex. A central theme of this book is that although the settings are often unique, the processes at work in running waters are general and increasingly well understood. Even as our scientific understanding of stream ecosystems rapidly advances, the pressures arising from diverse human activities continue to threaten the health of rivers worldwide. This book presents vital new findings concerning human impacts, and the advances in pollution control, flow management, restoration, and conservation planning that point to practical solutions. Reviews of the first edition: ".. an unusually lucid and judicious reassessment of the state of stream ecology" Science Magazine "..provides an excellent introduction to the area for advanced undergraduates and graduate students..." Limnology & Oceanography "... a valuable reference for all those interested in the ecology of running waters." Transactions of the American Fisheries Society Reviews of the second edition: "Overall, a must for the field centre and a good starter text in stream ecology." (TEN News, October, 2007) "Highly recommended. Upper-division undergraduates through faculty." (P. R. Pinet, CHOICE, Vol. 45 (7), 2008) "... a very good, fluidly readable book which contains the latest key scientific knowledge of the ecology of running waters." (Daniel Graeber, International Review of Hydrobiology, Vol. 94 (2), 2009)
This new bedside manual guides you through all the practical aspects of managing patients following cardiothoracic surgery and critically ill cardiology patients. Primarily designed to use in cardiothoracic intensive care units and coronary care units, it covers the perioperative management for the full range of cardiothoracic surgical procedures, the management of complications, and related issues. Core topics in cardiothoracic critical care, such as hemodynamic instability, arrhythmias, bleeding, and mechanical cardiac support, are afforded broad coverage. Also included are sections on advanced ventilatory techniques and veno-venous ECMO for treating severe respiratory failure, as well as nutritional support, treating and preventing infection, renal failure, and care of the dying patient. Concisely written and featuring liberal use of illustrations as well as an integrated, tightly edited style, and a limited number of key references, this volume will become your reference of choice for the care of of cardiothoracic surgery patients and critically ill cardiology patients. Also included is a companion CD-ROM featuring over 700 still and 200 video clips of radiographs, CT scans, MRI scans, and echocardiograms, both transthoracic and transesophageal. Find information quickly with concisely written text. Get a more complete picture with extensive illustrations. Focus on just the information you need using a a limited number of key references. Navigate the complexities of critical care for a fulll range of cardiothoracic surgery patients with in-depth coverage of perioperative care, management of complications, and more. Enhance your knowledge through a companion CD-ROM featuring the latest in cardiothoracic imaging techniques.
For fifty years, the American Richard Stern has been praised as a "writer's writer." His collected stories in Noble Rot 1949-1989 earned him a Book of the Year Award from the Chicago Sun-Times, adding to his recognition as one of America's most acclaimed writers of fiction in novels and short stories. This study of Stern's life and writings discusses major themes Stern has dealt with, explores the issue of fictional autobiography as it relates to Stern's work, and analyzes each of his published novels and short stories from Golk(1960) to Pacific Tremors and What Is What Was (both 2001). An interview with Richard Stern is included.
Textbook of Assisted Reproductive Technologies is a truly comprehensive manual for the whole team at the IVF clinic. Information is presented in a highly visual manner, allowing both methods and protocols to be consulted easily. The text provides clinical and scientific teams with the A to Zs of setting up an embryology laboratory, gives research fellows insight into technical developments, and supplies seasoned professionals with a review of the latest techniques and advances. New to the Third Edition: fully revised and expanded chapters, with new information on: single embryo transfer artificial gametes pharmacogenetics
Molecular biology is one of the most rapidly growing developing and at the same time most exciting disciplines. The key to molecular biology lies in the understanding of nucleic acids - their structure, function, and interaction with proteins. Nucleic Acids in Molecular Biology keeps scientists informed of the explosively growing information and complies with the great interest in this field by offering a continued high standard of review.
The authors address claims that vertical ownership ties reduce programming diversity, restrict entry of competitors to cable, or have other socially undesirable effects
This book traces the history of what it terms the “lie of innocence” as represented in literary texts from the late 18th century to contemporary times. The writers selected here – William Blake, Herman Melville, William Faulkner, Graham Greene, and Cormac McCarthy – write at various points in which the western world was undergoing a process of secularization. This work commences with a study of the bible demonstrating the extent to which “innocence” is realized there as a lie. It identifies in the bible how “innocence” is used for political, social and ethical expediency, and suggests that the explications of each reference can be demonstrated to testify to an absence of innocence, to indeed the lie of its supposed meaning. In analyzing the selected texts, emphasis is given to the continuation of biblical relevance even when the described world of social behavior works outside religious and biblical notions of good and evil. Instead, this book embraces an interconnection between Nietzsche’s “innocence of becoming” and the biblical tree of life that had been rejected in western mythology. It is, this work argues, the choice to sanctify the biblical tree of knowledge that presumed to know what was good and what was evil that brought about the lie of innocence. The book focuses on the relationship between fathers and sons, arguing that it is the orphan son, cut away from paternal ties, who embodies the possibility for the world to embrace an “innocence of becoming”. It further shows, with some optimism, that in a post-apocalyptical world, as envisaged by McCarthy, the son can be freed to choose the tree of life over the tree of knowledge.
Doing Meta-Analysis with R: A Hands-On Guide serves as an accessible introduction on how meta-analyses can be conducted in R. Essential steps for meta-analysis are covered, including calculation and pooling of outcome measures, forest plots, heterogeneity diagnostics, subgroup analyses, meta-regression, methods to control for publication bias, risk of bias assessments and plotting tools. Advanced but highly relevant topics such as network meta-analysis, multi-three-level meta-analyses, Bayesian meta-analysis approaches and SEM meta-analysis are also covered. A companion R package, dmetar, is introduced at the beginning of the guide. It contains data sets and several helper functions for the meta and metafor package used in the guide. The programming and statistical background covered in the book are kept at a non-expert level, making the book widely accessible. Features • Contains two introductory chapters on how to set up an R environment and do basic imports/manipulations of meta-analysis data, including exercises • Describes statistical concepts clearly and concisely before applying them in R • Includes step-by-step guidance through the coding required to perform meta-analyses, and a companion R package for the book
This will help us customize your experience to showcase the most relevant content to your age group
Please select from below
Login
Not registered?
Sign up
Already registered?
Success – Your message will goes here
We'd love to hear from you!
Thank you for visiting our website. Would you like to provide feedback on how we could improve your experience?
This site does not use any third party cookies with one exception — it uses cookies from Google to deliver its services and to analyze traffic.Learn More.