Written by the leading names in pediatric oncology and hematology, Nathan and Oski's Hematology and Oncology of Infancy and Childhood offers you the essential tools you need to overcome the unique challenges and complexities of childhood cancers and hematologic disorders. Meticulously updated, this exciting full-color set brings together the pathophysiology of disease with detailed clinical guidance to provide you with the most comprehensive, authoritative, up-to-date information for diagnosing and treating children. - Form a definitive diagnosis and create the best treatment plans possible with comprehensive coverage of all pediatric cancers, including less-common tumors, as well as all hematologic disorders, including newly recognized ones. - Develop a thorough, understanding of the underlying science of diseases through summaries of relevant pathophysiology balanced with clear, practical clinical guidance. Nathan and Oski's is the only comprehensive product on the market that relates pathophysiology in such depth to hematologic and oncologic diseases affecting children. - Quickly and effortlessly access the key information you need with the help of a consistent organization from chapter to chapter and from volume to volume. - Stay at the forefront of your field thanks to new and revised chapters covering topics such as paroxysmal nocturnal hemoglobinuria, lysosomal storage diseases, childhood genetic predisposition to cancer, and oncology informatics. - Learn about the latest breakthroughs in diagnosis and management, making this the most complete guide in pediatric hematology and oncology. - Discover the latest in focused molecularly targeted therapies derived from the exponential growth of knowledge about basic biology and genetics underlying the field. - Rely on it anytime, anywhere! Access the full text, images, and more at Expert Consult.
Cancer Therapy with Radiolabeled Antibodies explores the most current experimental and clinical advances in the newly emerging field of cancer radioimmunotherapy (RAIT). Providing a multidisciplinary and international context, some of the world's leading experts examine the problems and prospects of RAIT from radiation, immunological, chemical, physical, physiological, and clinical perspectives with both overviews and original research. Discussions cover the up-to-date clinical results in the RAIT of ovarian, breast, colorectal, and brain cancers, as well as the current status of RAIT in the management of B cell lymphomas. Radiobiology, dosimetry, radiochemistry, targeting biology in experimental models, clinical experiences in hematopoietic and solid tumors, and new approaches to improve cancer radioimmunotherapy are also discussed. In addition, new dosimetry concepts, new labeling methods, new concepts of antibody pharmacokinetics, and new methods to enhance selective cancer radioimmunotherapy are included.
Studies of the Curse of Ham, the belief that the Bible consigned blacks to everlasting servitude, confuse and conflate two separate origins stories (etiologies), one of black skin and the other of black slavery. This work unravels the etiologies and shows how the Curse, an etiology of black slavery, evolved from an earlier etiology explaining the existence of dark-skinned people. We see when, where, why, and how an original mythic tale of black origins morphed into a story of the origins of black slavery, and how, in turn, the second then supplanted the first as an explanation for black skin. In the process we see how formulations of the Curse changed over time, depending on the historical and social contexts, reflecting and refashioning the way blackness and blacks were perceived. In particular, two significant developments are uncovered. First, a curse of slavery, originally said to affect various dark-skinned peoples, was eventually applied most commonly to black Africans. Second, blackness, originally incidental to the curse, in time became part of the curse itself. Dark skin now became an intentional marker of servitude, the visible sign of the blacks’ degradation, and in the process deprecating black skin itself.
IN THIS STIMULATING debut novel, protagonist Dr. Milt Davidson, a pathologist and cancer researcher working at a NYC medical school, is recruited by the CIA to spy on Russia’s bioweapons research involving odors that target the brain through smell receptors in the nose. Davidson studied human olfaction during his graduate education. Under the cover of starting up a Moscow-based biopharmaceutical company focused on developing odor therapies for neurological diseases, the young scientist/novice spy, who is on sabbatical from NY, quickly becomes entangled in romances with female spies that pose risks to the mission and their lives. Because the sense of smell is the least studied and understood of our five senses, this novel introduces a potentially new drug therapy involving smelling defined odors. Can Milt escape the scrutiny of the Russian military GRU? Can he gain the loyalty of the Jewish chemist who directs the Russian research on odor bioweaponry? The answers to these questions unfold over the page-turning course of this exciting first novel breaking through the conventional genre, leaving us yearning for the sequel. The science described is authentic, but the author speculates on new medical pursuits for both the lay reader and scientist.
How old is prejudice against black people? Were the racist attitudes that fueled the Atlantic slave trade firmly in place 700 years before the European discovery of sub-Saharan Africa? In this groundbreaking book, David Goldenberg seeks to discover how dark-skinned peoples, especially black Africans, were portrayed in the Bible and by those who interpreted the Bible--Jews, Christians, and Muslims. Unprecedented in rigor and breadth, his investigation covers a 1,500-year period, from ancient Israel (around 800 B.C.E.) to the eighth century C.E., after the birth of Islam. By tracing the development of anti-Black sentiment during this time, Goldenberg uncovers views about race, color, and slavery that took shape over the centuries--most centrally, the belief that the biblical Ham and his descendants, the black Africans, had been cursed by God with eternal slavery. Goldenberg begins by examining a host of references to black Africans in biblical and postbiblical Jewish literature. From there he moves the inquiry from Black as an ethnic group to black as color, and early Jewish attitudes toward dark skin color. He goes on to ask when the black African first became identified as slave in the Near East, and, in a powerful culmination, discusses the resounding influence of this identification on Jewish, Christian, and Islamic thinking, noting each tradition's exegetical treatment of pertinent biblical passages. Authoritative, fluidly written, and situated at a richly illuminating nexus of images, attitudes, and history, The Curse of Ham is sure to have a profound and lasting impact on the perennial debate over the roots of racism and slavery, and on the study of early Judaism, Christianity, and Islam.
IN THIS SECOND book of The Scenturion Spy series, Dr. Milt Davidson has been recruited from the Empire State University (ESU) in New York, where he is an academic pathologist, to spy for the CIA. Since the Russians are developing bioweaponry based on odors that activate receptors in the nose and affect the brain, Milt – who completed graduate studies for a Ph.D.-degree on the sense of smell (olfaction) while in medical school – developed a biotechnology company (Pharmascent Sciences, Inc.) for new neurological therapies administered via smell. This became his cover to spy on Russia’s military’s research on olfaction after taking a sabbatical leave from ESU to work for the CIA. Milt - 43-year-old, handsome, smart, single, and unexpectedly suave for a scientist - gets involved with a French/Israeli spy, Marie Chalfont, as well as Dr. Natasha Petrushkin, a deputy science minister in the Russian parliament. Both help him settle in Moscow, seduce him, and are suspected of being double-agents. The book begins with Milt secretly escaping to St. Martin, where Marie is hiding from the Hezbollah, having assassinated one of their leaders. In Moscow, Milt spies on the Russian olfactory bioweaponry research program through both scientific pretexts and some seduction tactics of his own. Will Milt uncover major secrets of the Russian bioweaponry program? Or will his cover be blown, and American security threatened? Readers will find out soon enough in this thrilling page-turner.
For hundreds of years, the biblical story of the Curse of Ham was marshalled as a justification of serfdom, slavery and human bondage. According to the myth, having seen his father Noah naked, Ham's is cursed to have his descendants be forever slaves. In this new book the Curse of Ham is explored in its Reformation context, revealing how it became the cornerstone of the Christian defence of slavery and the slave trade for the next four hundred years. It shows how broader medieval interpretations of the story became marginalized in the early modern period as writers such as Annius of Viterbo and George Best began to weave the legend of Ham into their own books, expanding and adding to the legend in ways that established a firm connection between Ham, Africa, slavery and race. For although in the original biblical text Ham himself is not cursed and race is never mentioned, these writers helped develop the story of Ham into an ideological and theological defence for African slavery, at the precise time that the Transatlantic Slave Trade began to establish itself as a major part of the European economy during the sixteenth and seventeenth centuries. Skilfully weaving together elements of theology, literature and history, this book provides a fascinating insight into the ways that issues of religion, economics and race could collide in the Reformation world. It will prove essential reading, not only for those with an interest in early modern history, but for anyone wishing to try to comprehend the origins of arguments used to justify slavery and segregation right up to the 1960s.
The third volume of the first series devoted to coenzymes and cofactors, Glutathione, Parts A and B presents a comprehensive review of the sulphur-containing coenzymes. It covers glutathione metabolism and functions, and gives a history of their study. Also examined are optical properties, NMR, and MS of glutathione and its derivatives; thiols; glutathione metal complexes; chemical and industrial applications of glutathione, and much more.
For the very first time in America, a clear health and safety primer explains to educators and parents how to handle life-threatening situations for the kids, from A to Z. Emergency situations such as, advances by strangers, bullying, school shootings, sexual abuse, and even terrorist attacks are all covered in this extremely valuable handbook for all parents and caregivers! Once you have it, youll never leave it!
IN THIS STIMULATING debut novel, protagonist Dr. Milt Davidson, a pathologist and cancer researcher working at a NYC medical school, is recruited by the CIA to spy on Russia’s bioweapons research involving odors that target the brain through smell receptors in the nose. Davidson studied human olfaction during his graduate education. Under the cover of starting up a Moscow-based biopharmaceutical company focused on developing odor therapies for neurological diseases, the young scientist/novice spy, who is on sabbatical from NY, quickly becomes entangled in romances with female spies that pose risks to the mission and their lives. Because the sense of smell is the least studied and understood of our five senses, this novel introduces a potentially new drug therapy involving smelling defined odors. Can Milt escape the scrutiny of the Russian military GRU? Can he gain the loyalty of the Jewish chemist who directs the Russian research on odor bioweaponry? The answers to these questions unfold over the page-turning course of this exciting first novel breaking through the conventional genre, leaving us yearning for the sequel. The science described is authentic, but the author speculates on new medical pursuits for both the lay reader and scientist.
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