This text book is an essential resource representing the medical treatment of psychological disorders for the mental health professional. The book provides information concerning neuron and glia cell functions. Neuroinflammatory activation by stress is described and importance of two glia cells in the brain’s immune response to stress via the interaction with of cytokines which coordinates the immune response and activates neuroinflammation. This activation causes the expression of vulnerable phenotypes which produces the particular psychological disorder. Pharmacokinetics of psychotropic drugs are described in-terms of half-life, steady state, enzyme metabolism of the medication in the liver, and the production of active metabolites which dictates the psychological actions of the drug. The particular drug actions are discussed via down-stream transduction cascades in the neuron which actives or de-actives neuronal genes which leads to the psychotropic drug’s psychological actions. The book delineates the three main transporter genes of the Solute Carrier-6 (SLC6) gene family, which produces neurotransmitters and the therapeutic actions of psychotropic drugs. These neurotransmitters are: serotonin (5-HT), dopamine (DA), norepinephrine (NE), acetylcholine (Ach), glutamate (Glu), and gamma-amino butyric acid (GABA). The drugs’ side-effects include, restless leg syndrome, hyponatremia, serotonin side-effects, malignant serotonin syndrome, anti-cholinergic side-effects, extrapyramidal symptoms (EPS), tardive dyskinesia (TD), neuroleptic malignant syndrome, and suicide risk. This section of the book concludes with a discussion of negative drug effects on dental health, diet, and physical complications. The remainder of the text discusses psychological disorders, diagnostic criteria, epidemiology, theoretical models, genetics, neuroanatomy, psychological treatment, and the particular medication used to treat the disorder. For each psychotropic drug the following are provided: dosage, titration, taper, time to work, neurotransmitter profile, specific side effects, enzymes, and metabolites. Switching from one drug to other schedules are listed, along with diagnosis treatment resistant medication strategies. A sample of psychotropic drugs include: Schizophrenia (clozapine, risperidone, paliperidone, and others), anxiety disorders (diazepam, clonazepam, lorazepam, etc.), anti-depressants (fluoxetine, venlafaxine, desvenlafaxine, duloxetine, etc), bipolar disorders (mood stabilizers: lithium, valproic acid, carbamazepine, lamotrigine, etc., and anti-psychotics: aripiprazole, lurasidone, rexulti, and cariprazine), Alzheimer Disease (rivastigmine, donepezil, memantine, aducanumab-avwa, et al.), Attention Deficit Disorder (amphetamine D, methylphenidate, etc.), sleep dysfunctions (suvorexant, exzopiclone, zolpidem, benzodiazepines, etc), and addiction (Eating: naltrexone + bupropion, tirzepatide, etc; Smoking: bupropion; Alcohol: disulfiram, naltrexone, etc; and Opioid: methadone, buprenex + naloxone, etc). The text book concludes with a discussion of psychotropic treatment of children and the elderly, including drug dosing adjustments.
Helps both engineers and students improve their writing skills by learning to analyze target audience, tone, and purpose in order to effectively write technical documents This book introduces students and practicing engineers to all the components of writing in the workplace. It teaches readers how considerations of audience and purpose govern the structure of their documents within particular work settings. The IEEE Guide to Writing in the Engineering and Technical Fields is broken up into two sections: “Writing in Engineering Organizations” and “What Can You Do With Writing?” The first section helps readers approach their writing in a logical and persuasive way as well as analyze their purpose for writing. The second section demonstrates how to distinguish rhetorical situations and the generic forms to inform, train, persuade, and collaborate. The emergence of the global workplace has brought with it an increasingly important role for effective technical communication. Engineers more often need to work in cross-functional teams with people in different disciplines, in different countries, and in different parts of the world. Engineers must know how to communicate in a rapidly evolving global environment, as both practitioners of global English and developers of technical documents. Effective communication is critical in these settings. The IEEE Guide to Writing in the Engineering and Technical Fields Addresses the increasing demand for technical writing courses geared toward engineers Allows readers to perfect their writing skills in order to present knowledge and ideas to clients, government, and general public Covers topics most important to the working engineer, and includes sample documents Includes a companion website that offers engineering documents based on real projects The IEEE Guide to Engineering Communication is a handbook developed specifically for engineers and engineering students. Using an argumentation framework, the handbook presents information about forms of engineering communication in a clear and accessible format. This book introduces both forms that are characteristic of the engineering workplace and principles of logic and rhetoric that underlie these forms. As a result, students and practicing engineers can improve their writing in any situation they encounter, because they can use these principles to analyze audience, purpose, tone, and form.
As the definitive reference for clinical chemistry, Tietz Textbook of Clinical Chemistry and Molecular Diagnostics, 5th Edition offers the most current and authoritative guidance on selecting, performing, and evaluating results of new and established laboratory tests. Up-to-date encyclopedic coverage details everything you need to know, including: analytical criteria for the medical usefulness of laboratory procedures; new approaches for establishing reference ranges; variables that affect tests and results; the impact of modern analytical tools on lab management and costs; and applications of statistical methods. In addition to updated content throughout, this two-color edition also features a new chapter on hemostasis and the latest advances in molecular diagnostics. Section on Molecular Diagnostics and Genetics contains nine expanded chapters that focus on emerging issues and techniques, written by experts in field, including Y.M. Dennis Lo, Rossa W.K. Chiu, Carl Wittwer, Noriko Kusukawa, Cindy Vnencak-Jones, Thomas Williams, Victor Weedn, Malek Kamoun, Howard Baum, Angela Caliendo, Aaron Bossler, Gwendolyn McMillin, and Kojo S.J. Elenitoba-Johnson. Highly-respected author team includes three editors who are well known in the clinical chemistry world. Reference values in the appendix give you one location for comparing and evaluating test results. NEW! Two-color design throughout highlights important features, illustrations, and content for a quick reference. NEW! Chapter on hemostasis provides you with all the information you need to accurately conduct this type of clinical testing. NEW! Six associate editors lend even more expertise and insight to the reference. NEW! Reorganized chapters ensure that only the most current information is included.
The cucurbits (Cucurbitaceae, or gourd family), which include squash, pumpkin, melon, cucumber, and watermelon, have long been of economic significance. As sources of vegetables, fruit, and seeds rich in oils and protein, they have the potential of making an even larger contribution toward meeting the needs of humankind. This book, consisting of 37 papers by 50 cucurbit specialists, emphasizes the practical importance of cucurbit investigation, and also provides a broad overview of the family.
A condensed, easier-to-understand student version of the acclaimed Tietz Textbook of Clinical Chemistry and Molecular Diagnostics, Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics, 7th Edition uses a laboratory perspective in providing the clinical chemistry fundamentals you need to work in a real-world, clinical lab. Coverage ranges from laboratory principles to analytical techniques and instrumentation, analytes, pathophysiology, and more. New content keeps you current with the latest developments in molecular diagnostics. From highly respected clinical chemistry experts Carl Burtis and David Bruns, this textbook shows how to select and perform diagnostic lab tests, and accurately evaluate results. Authoritative, respected author team consists of two well-known experts in the clinical chemistry world. Coverage of analytical techniques and instrumentation includes optical techniques, electrochemistry, electrophoresis, chromatography, mass spectrometry, enzymology, immunochemical techniques, microchips, automation, and point of care testing. Learning objectives begin each chapter, providing measurable outcomes to achieve after completing the material. Key words are listed and defined at the beginning of each chapter, and bolded in the text. A glossary at the end of the book makes it quick and easy to look up definitions of key terms. More than 500 illustrations plus easy-to-read tables help you understand and remember key concepts. New chapters on molecular diagnostics include the principles of molecular biology, nucleic acid techniques and applications, and genomes and nucleic acid alterations, reflecting the changes in this rapidly evolving field. New content on clinical evaluation of methods, kidney function tests, and diabetes is added to this edition. NEW multiple-choice review questions at the end of each chapter allow you to measure your comprehension of the material. NEW case studies on the Evolve companion website use real-life scenarios to reinforce concepts.
(...) Cada vez mais os consumidores se preocupam em adquirir produtos e serviços éticos, ou seja, que foram produzidos, anunciados e comercializados a partir dos princípios expostos no Pacto Global. Os produtos e serviços, na nova percepção dos consumidores, levam junto o contexto da sua linha de produção e comercialização. O livro, agora apresentado, enfrenta estes diversos problemas complexos, com análises fundamentadas e, muitas vezes, com sugestões para aprimoramento do próprio sistema. É a ciência cumprindo seu papel de trazer reflexões no intuito de melhorar as relações humanas. São 17 artigos que dão um destaque ao ESG no contexto do Direito das Relações de Consumo. Por óbvio, pela própria formação dos diversos autores – componentes do Comitê de Relações de Consumo do IBRAC (Instituto Brasileiro de Estudos de Concorrência, Consumo e Comércio Internacional) – os artigos enfrentam o universo das responsabilidades empresariais no contexto de uma sociedade de consumo. (...)" Marcelo Gomes Sodré
This book reviews the geochemical and petrological characteristics of potassic igneous rock complexes, and investigates the different tectonic settings in which these rocks occur. The authors provide an overview and classification of these rocks and elucidate the geochemical differences between barren and mineralized potassic igneous complexes. High-K rocks host a number of epithermal gold and porphyry copper-gold deposits. In recent years, there has also been growing recognition of an association of such rocks with iron-oxide copper-gold (IOCG) deposits, intrusion-related gold deposits (IRGDs) and possibly even Carlin-type gold deposits. This book is not only relevant to academic petrologists working on alkaline rocks, but also to exploration geologists prospecting for epithermal gold and/or porphyry copper-gold deposits in modern and ancient terrains. This fourth, updated and expanded edition incorporates new data and references from Africa, Australia, Brazil, China, Greece, Iran, Mongolia, North America, Russia and Turkey, including new maps and sections and new color plates of high-grade gold-copper ore from major deposits hosted by potassic igneous rocks.
Significant progress has been made on nonlinear control systems in the past two decades. However, many of the existing nonlinear control methods cannot be readily used to cope with communication and networking issues without nontrivial modifications. For example, small quantization errors may cause the performance of a "well-designed" nonlinear control system to deteriorate. Motivated by the need for new tools to solve complex problems resulting from smart power grids, biological processes, distributed computing networks, transportation networks, robotic systems, and other cutting-edge control applications, Nonlinear Control of Dynamic Networks tackles newly arising theoretical and real-world challenges for stability analysis and control design, including nonlinearity, dimensionality, uncertainty, and information constraints as well as behaviors stemming from quantization, data-sampling, and impulses. Delivering a systematic review of the nonlinear small-gain theorems, the text: Supplies novel cyclic-small-gain theorems for large-scale nonlinear dynamic networks Offers a cyclic-small-gain framework for nonlinear control with static or dynamic quantization Contains a combination of cyclic-small-gain and set-valued map designs for robust control of nonlinear uncertain systems subject to sensor noise Presents a cyclic-small-gain result in directed graphs and distributed control of nonlinear multi-agent systems with fixed or dynamically changing topology Based on the authors’ recent research, Nonlinear Control of Dynamic Networks provides a unified framework for robust, quantized, and distributed control under information constraints. Suggesting avenues for further exploration, the book encourages readers to take into consideration more communication and networking issues in control designs to better handle the arising challenges.
Undeniable Solidarity tells the story of our long partnership with dogs from the first friendly wolves who guarded our sleep during the Stone Age to their roles today as our best friends, trusted and joyful pets, and their service as therapy, detection, and rescue dogs. Dogs and humans have lived together for thirty thousand years, and they have changed us as much as we have changed them. Based on author David Hagner’s work as a rehabilitation counselor with therapy and service dogs, drawing on information from archaeology, world mythology, sleep science, dog behavior, and philosophy and enlivened with stories of the role dogs have played in the lives of famous historical figures, Undeniable Solidarity revolutionizes our understanding of the bond between dogs and humans and gives us a deeper appreciation of our partner species.
A compelling examination of how a religious brotherhood administered charity in its local community and acted as mediator between provincial elites and the early modern state. Civic Christianity in Renaissance Italy explores the often subtle and sometimes harsh realities of life on the Venetian mainland. Focusing on the confraternity of Santa Maria dei Battuti and its Ospedale, the book addressesa number of well-established and newly articulated historiographical questions: the governance of territorial states, the civic and religious role of confraternities, the status of women and marginalized groups, and popular religious devotion. Adapting the objectives and methods of microhistory, D'Andrea has written neither a traditional history of political subjugation nor a straightforward survey of poor relief. Instead, thematic chapters survey the activities of a powerful religious brotherhood [Santa Maria dei Battuti] and document the interconnected local, regional, and international factors that fashioned the social world of Venetian subjects. Grounded in previously unexplored archival material, the book is an innovative study of the nexus between local religion and Venetian territorial power, providing scholars with this first scholarly monograph of the city that served as the keystone of Venice's mainland empire. This original approach to the critical relationship between provincial powers and the central government also contributes to other important areas of historical inquiry, including the history of popular religion, poor relief, medicine, and education. David D'Andrea is Associate Professor of History at Oklahoma State University.
Human language is not the same as human speech. We use gestures and signs to communicate alongside, or instead of, speaking. Yet gestures and speech are processed in the same areas of the human brain, and the study of how both have evolved is central to research on the origins of human communication. Written by one of the pioneers of the field, this is the first book to explain how speech and gesture evolved together into a system that all humans possess. Nearly all theorizing about the origins of language either ignores gesture, views it as an add-on or supposes that language began in gesture and was later replaced by speech. David McNeill challenges the popular 'gesture-first' theory that language first emerged in a gesture-only form and proposes a groundbreaking theory of the evolution of language which explains how speech and gesture became unified.
V.1. The catalogue of music, All's well that ends well-Love's labour's lost -- v.2. The catalogue of music, Macbeth-The taming of the shrew -- v.3. The catalo gue of music, The tempest-The two nobel kinsmen, the sonnets ... -- v.4. Indices --v.5. Bibliography.
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