This volume provides background knowledge useful to those setting out to do genetic studies of aging in mammals, and raises vital questions: How many genes are important in mammalian aging? What are the optimal methods for their study? To what degree are patterns of aging, and patterns of growth and development part of the same process? Do patterns of development predict subsequent patterns of growth and aging? Are there a few fundamental aging processes, or does every biological system age? The rapid rate of progress in this field required a new volume with a new approach, based on the combination of classical genetics and the powerful new tools of molecular genetics. Although mammalian systems are emphasized, representatives of the advanced genetic studies in Drosophila and other model systems are included. The purpose is to enrich and stimulate genetic studies of mammalian aging by suggesting and evaluating future possibilities.
The success of movies like The Artist and Hugo recreated the wonder and magic of silent film for modern audiences, many of whom might never have experienced a movie without sound. But while the American silent movie was one of the most significant popular art forms of the modern age, it is also one that is largely lost to us, as more than eighty percent of silent films have disappeared, the victims of age, disaster, and neglect. We now know about many of these cinematic masterpieces only from the collections of still portraits and production photographs that were originally created for publicity and reference. Capturing the beauty, horror, and moodiness of silent motion pictures, these images are remarkable pieces of art in their own right. In the first history of still camera work generated by the American silent motion picture industry, David S. Shields chronicles the evolution of silent film aesthetics, glamour, and publicity, and provides unparalleled insight into this influential body of popular imagery. Exploring the work of over sixty camera artists, Still recovers the stories of the photographers who descended on early Hollywood and the stars and starlets who sat for them between 1908 and 1928. Focusing on the most culturally influential types of photographs—the performer portrait and the scene still—Shields follows photographers such as Albert Witzel and W. F. Seely as they devised the poses that newspapers and magazines would bring to Americans, who mimicked the sultry stares and dangerous glances of silent stars. He uncovers scene shots of unprecedented splendor—visions that would ignite the popular imagination. And he details how still photographs changed the film industry, whose growing preoccupation with artistry in imagery caused directors and stars to hire celebrated stage photographers and transformed cameramen into bankable names. Reproducing over one hundred and fifty of these gorgeous black-and-white photographs, Still brings to life an entire long-lost visual culture that a century later still has the power to enchant.
This is a guide book for the field of studies on talent development and human excellence. It reviews the existing literature on the topic and helps map out a taxonomy of research with detailed description of purposes and methods of specific kinds of research on the topic and how each of them contributes to the larger scheme of understanding, identifying, and promoting talent development and human excellence for the vitality of society as well as the fulfillment of individuals. It fits with the new trend of developmental science that promotes use-inspired research and seeks a deep understanding of developmental diversity and aims to promote positive development, including human excellence. It is intended to guide researchers and graduate students in this emerging field of studies from a broad developmental science perspective.
Praise for the Third Edition “Future mathematicians, scientists, and engineers should find the book to be an excellent introductory text for coursework or self-study as well as worth its shelf space for reference.” —MAA Reviews Applied Mathematics, Fourth Edition is a thoroughly updated and revised edition on the applications of modeling and analyzing natural, social, and technological processes. The book covers a wide range of key topics in mathematical methods and modeling and highlights the connections between mathematics and the applied and natural sciences. The Fourth Edition covers both standard and modern topics, including scaling and dimensional analysis; regular and singular perturbation; calculus of variations; Green’s functions and integral equations; nonlinear wave propagation; and stability and bifurcation. The book provides extended coverage of mathematical biology, including biochemical kinetics, epidemiology, viral dynamics, and parasitic disease. In addition, the new edition features: Expanded coverage on orthogonality, boundary value problems, and distributions, all of which are motivated by solvability and eigenvalue problems in elementary linear algebra Additional MATLAB® applications for computer algebra system calculations Over 300 exercises and 100 illustrations that demonstrate important concepts New examples of dimensional analysis and scaling along with new tables of dimensions and units for easy reference Review material, theory, and examples of ordinary differential equations New material on applications to quantum mechanics, chemical kinetics, and modeling diseases and viruses Written at an accessible level for readers in a wide range of scientific fields, Applied Mathematics, Fourth Edition is an ideal text for introducing modern and advanced techniques of applied mathematics to upper-undergraduate and graduate-level students in mathematics, science, and engineering. The book is also a valuable reference for engineers and scientists in government and industry.
David Weiss Halivni's The Formation of the Babylonian Talmud, originally published in Hebrew and here translated by Jeffrey L. Rubenstein, is widely regarded as the most comprehensive scholarly examination of the processes of composition and editing of the Babylonian Talmud. Halivni presents the summation of a lifetime of scholarship and the conclusions of his multivolume Talmudic commentary, Sources and Traditions (Meqorot umesorot). Arguing against the traditional view that the Talmud was composed c. 450 CE by the last of the named sages in the Talmud, the Amoraim, Halivni proposes that its formation took place over a much longer period of time, not reaching its final form until about 750 CE. The Talmud consists of many literary strata or layers, with later layers commenting upon and reinterpreting earlier layers. The later layers differ qualitatively from the earlier layers, and were composed by anonymous sages whom Halivni calls Stammaim. These sages were the true author-editors of the Talmud. They reconstructed the reasons underpinning earlier rulings, created the dialectical argumentation characteristic of the Talmud, and formulated the literary units that make up the Talmudic text. Halivni also discusses the history and development of rabbinic tradition from the Mishnah through the post-Talmudic legal codes, the types of dialectical analysis found in the different rabbinic works, and the roles of reciters, transmitters, compilers, and editors in the composition of the Talmud. This volume contains an introduction and annotations by Jeffrey L. Rubenstein.
This book develops the theory of ordinary differential equations (ODEs), starting from an introductory level (with no prior experience in ODEs assumed) through to a graduate-level treatment of the qualitative theory, including bifurcation theory (but not chaos). While proofs are rigorous, the exposition is reader-friendly, aiming for the informality of face-to-face interactions. A unique feature of this book is the integration of rigorous theory with numerous applications of scientific interest. Besides providing motivation, this synthesis clarifies the theory and enhances scientific literacy. Other features include: (i) a wealth of exercises at various levels, along with commentary that explains why they matter; (ii) figures with consistent color conventions to identify nullclines, periodic orbits, stable and unstable manifolds; and (iii) a dedicated website with software templates, problem solutions, and other resources supporting the text (www.math.duke.edu/ode-book). Given its many applications, the book may be used comfortably in science and engineering courses as well as in mathematics courses. Its level is accessible to upper-level undergraduates but still appropriate for graduate students. The thoughtful presentation, which anticipates many confusions of beginning students, makes the book suitable for a teaching environment that emphasizes self-directed, active learning (including the so-called inverted classroom).
Bone Marrow Pathology has been extensively revised to reflect the significant advances which have occurred in the application of cytogenetics and in particular, molecular genetics in the diagnosis, classification and understanding of haematological disorders. This comprehensive book not only provides information on all common disease entities, but also covers rare disorders in which bone marrow examination is useful. It is designed as practical resource with ‘Problems and Pitfalls’ sections throughout to aid laboratory diagnosis. This fourth edition: Incorporates the recommendations of the 2008 WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues Covers key diagnostic techniques such as flow cytometric immunophenotyping, immunohistochemistry and cytogenetic and molecular genetic analysis Includes new diagnostic algorithms and summary boxes Contains 550 colour illustrations including high-quality digital photomicrographs Haematologists and histopathologists will find this book an invaluable desktop reference when performing daily blood and bone marrow investigations.
Despite its crucial importance, scientists interested in the limitations of human physical performance have only just started to give the field of oxygen uptake kinetics the attention it deserves. Understanding the principal determinant of the oxygen uptake kinetics is fundamental to improving human performance or the quality of life. This book provides a detailed overview of the current state of knowledge of this emerging field of study, and features: * an introduction to oxygen uptake kinetics and historical development of the discipline * measurement and analysis of oxygen uptake kinetics * control of and limitations to oxygen uptake kinetics * applications of oxygen uptake kinetics in a range of human populations. Oxygen Uptake Kinetics in Sport, Health and Medicine is richly illustrated and structured to enable easy access of information and represents an invaluable resource for students and researchers in exercise physiology, as well as for respiratory physiologists and pulmonary clinicians.
This unique textbook focuses exclusively on wound healing of the face and neck; integrating scientific principle with state-of-the-art clinical precept. Detailed, step-by-step surgical techniques demonstrate the best methods of repair of tissue. The book benefits from the diverse backgrounds and expertise of each of its authors bringing the reader new insights to the question of why some facial and neck wounds heal satisfactorily and others do not. The authors and editors created the textbook to suggest a holistic approach to surgery of the face and neck that includes the healing process. Future directions for wound healing of the face and neck are also illuminated. The text features three sections: (1) Basic Science-salient healing features of specific tissues, (2) common clinical problems and (3) specific therapies used to optimize healing. This text is an excellent state of the art comprehensive reference for anyone who has an interest in the face and neck.
Exploring the themes of the human relationship with the marine environment and the ways in which the peoples of Northern Europe have experienced and exploited their seas, this book reveals how human perception of the northern seas has changed over time. Drawing on a wide variety of sources, from Denmark and Britain to Norway, Finland and Germany, The Baltic and the North Seas is an insightful and colourful history of the politics, economy and culture of this intriguing region.
The series of volumes to which this book belongs honors contributors who have made a major impact in computational fluid dynamics. This fourth volume in the series is dedicated to David Caughey on the occasion of his 60th birthday. The first volume was published in 1994 and was dedicated to Prof Antony Jameson. The second, dedicated to Earl Murman, was published in 1998. The third volume was dedicated to Robert MacCormack in 2002. Written by leading researchers from academia, government laboratories, and industry, the contributions in this volume present descriptions of the latest developments in techniques for numerical analysis of fluid flow problems, as well as applications to important problems in industry.
A practical guide to understanding the way, the mind, and the heart of a boy. A boy’s endless imagination, hunger for adventure, and passionate spirit are matched only by his deep desire to be affirmed, esteemed, and loved. Yet over the past few decades, our culture has adopted a model of parenting and educating children that doesn’t affirm, celebrate, nurture, or embrace a boy’s wildness but rather seeks to tame it. As a result, many moms and dads find themselves frustrated, confused, and wearied by their sons’ behavior. The truth is, boys don’t need to be tamed—they need to be understood, loved, challenged, and encouraged. Based on clinical research and filled with practical tips and suggestions, therapists Stephen James and David Thomas Stephen James and David Thomas give fresh insight and much-needed encouragement on the road to raising boys by talking about: Parenting the different stages in a boy’s life Healthy discipline and correction Sitting still and paying attention Hot topics like screen time and dating Wild Things helps Christian parents, teachers, mentors, and coaches understand and explore the hearts, minds, and ways of boys and the vital role parents and caregivers play on the journey to authentic manhood.
Among the theoretical methods for solving many problems of applied mathematics, physics, and technology, asymptotic methods often provide results that lead to obtaining more effective algorithms of numerical evaluation. Presenting the mathematical methods of perturbation theory, Introduction to Asymptotic Methods reviews the most important m
This book presents an overview of Shiga toxin-producing E. coli (STEC), with in-depth coverage of key areas such as recent Shiga toxin-related poisonings in Europe and the US, the structure, production, and mechanism of action of Shiga toxin, and current methods of detection. The globalization of food production has introduced new risk factors and intensified existing hazards, complicating the assurance of food safety. Foodborne illness outbreaks, such as those related to STEC, are becoming more common and more dangerous. The threat that these bacterial toxins pose to the food supply is magnified by the frequent occurrence and severity of Shiga toxin-caused disease. As a result, STEC and their toxins remain a primary concern in food safety. This review serves as a key resource for scientists in the field and public health and regulatory officials charged with maintaining food safety. This book also looks to the future of treatment of Shiga toxin-associated disease, specifically the translation of lab bench science into clinical therapeutic strategies.
The Stockholm Conference of 1972 drew the world’s attention to the global environmental crisis, but for people in Sweden the threat was nothing new. Anyone who read the papers or watched the television news was already familiar with the issues. Five years early, in the summer of 1967, the situation was very different. So what happened in between? This book explores the ‘environmental turn’ that took place in Sweden in the late-1960s. This radical change, the realisation that human beings were in the process of destroying their own environment, had major and far-reaching consequences. What was it that opened people’s eyes to the crisis? When did it happen? Who set the ball rolling? These are some of the questions the book addresses, shedding new light on the history of environmentalism.
The updated fourth edition of this comprehensive, highly respected reference covers all you need to know about obstetric anesthesia-from basic science to various anesthesia techniques to complications. The editorial team of leading authorities in the field now features Drs. Linda S. Polley, Lawrence C. Tsen, and Cynthia A. Wong and presents the latest on anesthesia techniques for labor and delivery and medical disorders that occur during pregnancy. This edition features two new chapters and rewritten versions of key chapters such as Epidural and Spinal Analgesia and Anesthesia. Emphasizes the treatment of the fetus and the mother as separate patients with distinct needs to ensure the application of modern principles of care. Delivers contributions from many leaders in the fields of obstetric anesthesia and maternal-fetal medicine from all over the world. Offers abundant figures, tables, and boxes that illustrate the step-by-step management of a full range of clinical scenarios. Presents key point summaries in each chapter for quick, convenient reference. Features new chapters on Patient Safety and Maternal Mortality to address the latest developments in the field and keep you current. Presents completely rewritten chapters on Epidural and Spinal Analgesia and Anesthesia, Anesthesia for Cesarean Section, and Hypertension Disorders, updated by new members of the editorial team-Drs. Linda S. Polley, Lawrence C. Tsen, and Cynthia A. Wong, for state-of-the-art coverage of key topics and new insights. Covers all the latest guidelines and protocols for safe and effective practice so you can offer your patients the very best.
This small but information-packed book is the first to focus exclusively on iatrogenic vascular injuries. It is a timely first, for the scope and magnitude of this subject have reached almost epidemic proportions recently, as a result of exponential increases in the use of invasive diagnostic and therapeutic procedures by almost every medical and surgical speciality. The data on vascular trauma from "civilian" experiences are becoming dominated by injuries of iatrogenic cause. Even were it not for medical-legal liability, the importance of prompt recognition and correct treatment of injuries that we ourselves cause is obvious, as is the need for preventive measures to be clearly identified and adopted. This book serves these needs well through a nicely balanced focus on prevention, on the one hand, with its comprehensive review of epidemiology and etiology, and on management, on the other, with its practical comments on diagnosis, treatment and outcome. The organization of this book makes it very usable. After chapters on both arterial and venous catheterization injuries, there follows a thorough analysis of injuries associated with percutaneous transluminal angioplasty and other endovascular procedures. Then, after a chapter on noninvasive vascular injuries, there follows a series of chapters dealing with vascular injuries associated with the practice of specific specialties: radiation therapy, orthopedics, neurosurgery (especially lumbar disc surgery), gynecology, head and neck surgery, urology, adult general surgery, and pediatric surgery.
As adaptive capacities decline, and disease increases, the elderly become major consumers of drugs. Because of the special needs of older patients, physicians, geriatricians, health providers, and researchers must know how the aging process changes the pharmacokinetic and pharmacodynamic properties of drugs prescribed to the elderly. The Second Edition of this essential handbook is an up-to-date source that analyses the major drug groups, the disorders they treat, and the age-associated changes in cellular processes that affect drug action. Disorders prevalent in older people, such as Alzheimer's disease and Parkinson's disease, are examined in great detail. The book also discusses a wide range of drugs, including bronchodilators for asthma, nonsteroid anti-inflammatory drugs for arthritis, antibiotics, and treatments for cardiovascular disease, cancer, and mental disorders. The handbook also provides insight into future research problems dealing with the expanding aging population, their drug usage, and increasing adverse drug reactions.
There are numerous monographs devoted to rheumatoid arthritis. What sets this issue apart is that it keeps an eye to the future. Topics explored include measurement of RA disease activity today and in the future; epidemiology of RA – implications for prevention and risk assessment; genes that predispose to RA – relevance to current and future therapeutic strategies; multiple kinases – assessment of the best targets in treating RA; assessment, prevention and treatment of cardiovascular morbidity in RA; mechanistic insights and approaches to prevention of bone damage in RA; cell-cell interactions in RA synovium as potential new targets for treatment; alternative strategies for modulating the function of B lymphocytes in RA; innate immunity in RA; ascertainment and management of preclinical RA.
At the end of the time of the dinosaurs, Transylvania was an island in what was to become southeastern Europe. The island's limited resources affected the size and life histories of its animals, resulting in a local dwarfism. For example, sauropods found on the island measured only six meters long, while their cousins elsewhere grew up to five times larger. Here, David B. Weishampel and Coralia-Maria Jianu present unique evolutionary interpretations of this phenomenon. The authors bring together the latest information on the fauna, flora, geology, and paleogeography of the region, casting these ancient reptiles in their phylogenetic, paleoecological, and evolutionary contexts. What the authors find is that Transylvanian dinosaurs experienced a range of unpredictable successes as they evolved. Woven throughout the detailed history and science of these diminutive dinosaurs is the fascinating story of the man who first discovered them, the mysterious twentieth-century paleontologist Franz Baron Nopcsa, whose name is synonymous with Transylvanian dinosaurs. Hailed by some as the father of paleobiology, it was Nopcsa alone who understood the importance of the dinosaur discoveries in Transylvania; their story cannot be told without recounting his. Transylvanian Dinosaurs strikes an engaging balance between biography and scientific treatise and is sure to capture the imagination of professional paleontologists and amateur dinophiles alike.
For the instructor or student confronting an introductory course in ordinary differential equations there is a need for a brief guide to the key concepts in the subject. Important topics like stability, resonance, existence of periodic solutions, and the essential role of continuation of solutions are often engulfed in a sea of exercises in integration, linear algebra theory, computer programming and an overdose of series expansions. This book is intended as that guide. It is more conceptual than definitive and more light-hearted than pedagogic. It covers key topics and theoretical underpinnings that are necessary for the study of rich topics like nonlinear equations or stability theory. The [Author]; has included a great many illuminating examples and discussions that uncover the conceptual heart of the matter.
The text begins with an in-depth discussion of pharmaco-epidemiology, including information on the value of nationwide databases in forensic toxicology. The use and abuse of drugs in driving, sport and the workplace are then discussed by industry experts who are conducting case work in their fields. Not only are new drug groups discussed (NPS), but also their constantly changing impact on drug legislation. Synthetic cannabinoids, khat and mephodrone are discussed in detail. Following a section devoted to legislation and defence, readers will find comprehensive chapters covering sample choice reflecting the increasing use of hair and oral fluid, also the less commonly used sweat and nail analysis. New and old case examples are compared and contrasted in the final part of the book, which will enable readers to understand how drugs impact on each other and how the interpretative outcome of a case are dependent on many aspects. -- Provided by publisher.
This issue of Clinics in Geriatric Medicine features expert clinical reviews on Geriatric Dermatology which includes current information on topics such as diagnosis and management of bullous disease, common skin cancers in older adults, psoriasis, management of pressure ulcers, management of venous stasis disease, approach to diabetic and vascular ulcers, diagnosis and management of soft tissue infections, cutaneous fungal infections in older adults, management of scabies and generalized pruritus, herpes zoster and other herpes infections, and adverse drug effects in aging skin.
This book is a survey of asymptotic methods set in the current applied research context of wave propagation. It stresses rigorous analysis in addition to formal manipulations. Asymptotic expansions developed in the text are justified rigorously, and students are shown how to obtain solid error estimates for asymptotic formulae. The book relates examples and exercises to subjects of current research interest, such as the problem of locating the zeros of Taylor polynomials of entirenonvanishing functions and the problem of counting integer lattice points in subsets of the plane with various geometrical properties of the boundary. The book is intended for a beginning graduate course on asymptotic analysis in applied mathematics and is aimed at students of pure and appliedmathematics as well as science and engineering. The basic prerequisite is a background in differential equations, linear algebra, advanced calculus, and complex variables at the level of introductory undergraduate courses on these subjects. The book is ideally suited to the needs of a graduate student who, on the one hand, wants to learn basic applied mathematics, and on the other, wants to understand what is needed to make the various arguments rigorous. Down here in the Village, this is knownas the Courant point of view!! --Percy Deift, Courant Institute, New York Peter D. Miller is an associate professor of mathematics at the University of Michigan at Ann Arbor. He earned a Ph.D. in Applied Mathematics from the University of Arizona and has held positions at the Australian NationalUniversity (Canberra) and Monash University (Melbourne). His current research interests lie in singular limits for integrable systems.
The circular economy offer opportunities to reduce resource use and waste whilst providing business opportunities. This is also true in the mobile phone industry that has been characterised by high rates of product obsolescence. The emergence of the smart phone has changed the landscape, making repair, refurbishment and resell attractive to businesses and consumers. Moreover, emerging modular phone design should allow functional upgrades with low resource wastage. This report investigates the adoption of circular business models within Nordic markets. Producers, retailers, refurbishers, recyclers and resellers tell of their motivation, experiences and the challenges that they face. A special look is taken at consumer and waste law and the challenges and opportunities they represent. The report ends with 17 policy proposals that can accelerate the adoption of circularity in the sector.
Explores the history and significance of interplanetary space missions. Features detailed explanations and mathematical methods for trajectory optimization. Includes detailed explanations and mathematical methods for mission analysis for interplanetary missions. Covers the introduction, mathematical methods, and applications of the N-body problem (N>2). Discusses navigation and targeting for interplanetary mission.
What guy doesn't need some pointers on how to be the man he wants to be? And we know that being a man is so much more than building a successful career and mastering the mechanics of daily life (like oil changes), those functional things are really important too. By addressing the basic, primal, and archetypal moments that all men experience, this book helps men become more invested in their passions, their families, their lives, and God.
Providing an elementary introduction to analytic continuation and monodromy, the first part of this volume applies these notions to the local and global study of complex linear differential equations, their formal solutions at singular points, their monodromy and their differential Galois groups. The Riemann-Hilbert problem is discussed from Bolibrukh’s point of view. The second part expounds 1-summability and Ecalle’s theory of resurgence under fairly general conditions. It contains numerous examples and presents an analysis of the singularities in the Borel plane via “alien calculus”, which provides a full description of the Stokes phenomenon for linear or non-linear differential or difference equations. The first of a series of three, entitled Divergent Series, Summability and Resurgence, this volume is aimed at graduate students, mathematicians and theoretical physicists interested in geometric, algebraic or local analytic properties of dynamical systems. It includes useful exercises with solutions. The prerequisites are a working knowledge of elementary complex analysis and differential algebra.
This volume reviews recent developments in our understanding of che~ ical signaling in vertebrates. After sections dealing with general princi ples and chemical aspects of vertebrate pheromones, it follows a taxonomic approach, progressing from fish to. mammals. The editors asked a diverse, international group of leading investigators, working on a wide array of vertebrate taxa and specific issues, to consider their efforts from compar ative, evolutionary, and ecological viewpoints. The relative number of manuscripts in each part does not necessarily reflect current intensity of research, since the editors invited speakers who together would provide a balanced and comprehensive overview, while avoiding duplication. Still, the part on mammals is the longest. Fourth in a series dating from 1977, this volume illuminates current trends and likely future developments in the field of chemical signaling in vertebrates. Going back even farther, the first chapter, a personal account of the past quarter century by Dr. Mykytowycz recalls the most important milestones, such as symposia, or the founding of societies and journals. He also credits those investigators who stand out by their seminal studies.
This book advances the growing area of language policy and planning (LPP) by examining the epistemological and theoretical foundations that engendered and sustain the field, drawing on insights and approaches from anthropology, linguistics, economics, political science, and education to create an accessible and inter-disciplinary overview of LPP as a coherent discipline. Throughout the book, the authors address LPP from different perspectives, exploring the interface between planning in theory and its practical problems in implementation. This volume will be of interest to students and scholars with an interest in LPP in particular, and educational, social, and public policy more broadly.
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