An illustrated history of American innovators -- some well known, some unknown, and all fascinating -- by the author of the bestselling The American Century.
Power, Speed, and Form is the first accessible account of the engineering behind eight breakthrough innovations that transformed American life from 1876 to 1939—the telephone, electric power, oil refining, the automobile, the airplane, radio, the long-span steel bridge, and building with reinforced concrete. Beginning with Thomas Edison's system to generate and distribute electric power, the authors explain the Bell telephone, the oil refining processes of William Burton and Eugene Houdry, Henry Ford's Model T car and the response by General Motors, the Wright brothers' airplane, radio innovations from Marconi to Armstrong, Othmar Ammann's George Washington Bridge, the reinforced concrete structures of John Eastwood and Anton Tedesko, and in the 1930s, the Chrysler Airflow car and the Douglas DC-3 airplane. These innovations used simple numerical ideas, which the Billingtons integrate with short narrative accounts of each breakthrough—a unique and effective way to introduce engineering and how engineers think. The book shows how the best engineering exemplifies efficiency, economy and, where possible, elegance. With Power, Speed, and Form, educators, first-year engineering students, liberal arts students, and general readers now have, for the first time in one volume, an accessible and readable history of engineering achievements that were vital to America's development and that are still the foundations of modern life.
Democracy may be one of the most admired ideas ever concocted, but what if it’s also one of the most harebrained? After many years of writing about democracy for a living, David Harsanyi has concluded that it’s the most overrated, overused, and misunderstood idea in political life. The less we have of it the better. “Democracy” is not synonymous with “freedom.” It is not the opposite of tyranny. In fact, the Founding Fathers knew that democracy can lead to tyranny. That’s why they built so many safeguards against it into the Constitution. Democracy, Harsanyi argues, has made our government irrational, irresponsible, and invasive. It has left the American people with only two options—domination by the majority or a government that can’t possibly work. The modern age has imbued democracy with the mystique of infallibility. But Harsanyi reminds us that the vast majority of political philosophers, including the founders, have thought that responsible, limited government based on direct majority rule over a large, let alone continental scale was a practical impossibility. In The People Have Spoken, you’ll learn: Why the Framers of our Constitution were intent on establishing a republic, not a “democracy” How democracy undermines self-government How shockingly out of touch with reality most voters really are Why democracy is an economic wrecking ball—and an invitation to a politics of envy and corruption How the great political philosophers from Plato and Aristotle to Burke and Tocqueville predicted with uncanny accuracy that democracy could lead to tyranny Harsanyi warns that if we don’t recover the Founders’ republican vision, “democracy” might very well spell the end of American liberty and prosperity.
The pieces of a satisfying novel or story seem to fit together so effortlessly, so seamlessly, that it's easy to find yourself wondering, "How on earth did the author do this?" The answer is simple: He sat alone at his desk, considered an array of options, and made smart, careful choices. In On Writing Fiction, award-winning author and respected creative writing professor David Jauss offers practical information and advice that will help you make smart creative and technical decisions about such topics as: • Writing prose with syntax and rhythm to create a "soundtrack" for the narrative • Choosing the right point of view to create the appropriate degree of "distance" between your characters and the reader • Harnessing the power of contradiction in the creative process In one thought-provoking essay after another, Jauss sorts through unique fiction-writing conundrums, including how to create those exquisite intersections between truth and fabrication that make all great works of fiction so much more resonant than fiction that follows the "write what you know" approach that's so often used.
This bestselling coursebook introduces current understanding about culture and provides a model for teaching culture to translators, interpreters and other mediators. The approach is interdisciplinary, with theory from Translation Studies and beyond, while authentic texts and translations illustrate intercultural issues and strategies adopted to overcome them. This new (third) edition has been thoroughly revised to update scholarship and examples and now includes new languages such as Arabic, Chinese, German, Japanese, Russian and Spanish, and examples from interpreting settings. This edition revisits the chapters based on recent developments in scholarship in intercultural communication, cultural mediation, translation and interpreting. It aims to achieve a more balanced representation of written and spoken communication by giving more attention to interpreting than the previous editions, especially in interactional settings. Enriched with discussion of key recent scholarly contributions, each practical example has been revisited and/ or updated. Complemented with online resources, which may be used by both teachers and students, this is the ideal resource for all students of translation and interpreting, as well as any reader interested in communication across cultural divides. Additional resources are available on the Routledge Translation Studies Portal: http://routledgetranslationstudiesportal.com/
The art of the Netherlands (Dutch and Flemish) is unique in Early Modern Europe in its concern for military cruelty against civilians, principally the peasantry. Decimated by time and changes in taste, this popular iconography proves varied and extensive, stretching from Bruegel to and past Rubens. 'Massacres of the Innocents' continue to be a favourite subject through the Eighty Years War, in contrast to ruling-class glorifications of war. Dutch patriotic siege prints lay claim to 'scientific' precision in landscapes free of military terror, while the idea of military conquest is presented as generous rather than cruel in the ever-popular figure of Scipio Africanus. Most of the pictorial material is unfamiliar, some of it even to specialists and never before published; new light is shed on the more familiar phenomena of the civic guard groups and Ter Borch courtier-officers, 'good soldiers' overcoming a bad image.
Cham, real name Count Amédée de Noé and a serious rival to Daumier, may have been the epitome of a célèbre inconnu, a famous unknown. He is one much deserving, at last, of this first account of his huge oeuvre as a caricaturist. This book concentrates on his mastery of the important newcomer to the field of caricature, which we call comic strip, picture story, and graphic novel. The volume features facsimiles of nearly twenty of these from 1839 to 1863 and ranging from one page to forty (this last a parody of Victor Hugo’s Les Misérables). In addition, summaries and sample illustrations of twenty-seven “minor works” demonstrate that Cham is by far the most important specialist of what was then a new genre in Europe. Born to an ancient aristocratic family, Cham was from early on wholly dedicated to an art considered far beneath his class. Starting as a disciple of the father of the modern comic strip, Swiss Rodolphe Töpffer, Cham soon launched out on his own, evolving an original form of comedy, his own comédie humaine, farcical, absurd, and parodic. His productivity was legendary and comprised all the known genres of caricature, the full-page cartoon lithograph, the thematic seasonal group, weekly and monthly humorous comment (much like the daily newspaper cartoonist today), and a feature called the Revue Comique, which made him the supreme graphic journalist of his day. Hitherto unknown correspondence reveals an attractive personality who was fond of animals and who honored a low-class woman he eventually made his countess. Vaunted comics scholar David Kunzle has created a fitting tribute to Cham’s impact and genius.
Serpins constitute a superfamily of proteins that possess a unique tertiary structure and mechanism of proteinase inhibition. In humans, serpins constitute 10% of the plasma proteins and are best known as critical regulators of both the thrombotic and fibrinolytic systems. Serpins also participate in the regulation of the complement cascade, angiogenesis, tumor metastasis, apoptosis and innate immunity. Considering the importance of these molecules in regulating proteolytic cascades, it is not surprising to find that loss- and gain-of-function mutations result in significant human diseases. Massive thrombosis or bleeding, hereditary angioedema, Alzheimer''s disease, diabetic angiopathy and tumor invasion are some of the human diseases associated with serpins. In addition, mutations that alter serpin conformations (the serpinopathies) lead to lung disease, cirrhosis and a form of familial dementia. The goal of this text is to present the current knowledge on the molecular and cellular basis of serpins and their diseases.
This book is a completely revised new edition of the definitive reference on disorders of hemoglobin. Authored by world-renowned experts, the book focuses on basic science aspects and clinical features of hemoglobinopathies, covering diagnosis, treatment, and future applications of current research. While the second edition continues to address the important molecular, cellular, and genetic components, coverage of clinical issues has been significantly expanded, and there is more practical emphasis on diagnosis and management throughout. The book opens with a review of the scientific underpinnings. Pathophysiology of common hemoglobin disorders is discussed next in an entirely new section devoted to vascular biology, the erythrocyte membrane, nitric oxide biology, and hemolysis. Four sections deal with α and β thalassemia, sickle cell disease, and related conditions, followed by special topics. The second edition concludes with current and developing approaches to treatment, incorporating new agents for iron chelation, methods to induce fetal hemoglobin production, novel treatment approaches, stem cell transplantation, and progress in gene therapy.
The undisputed gold standard text in the field, Ryan's Retina is your award-winning choice for the most current, authoritative information on new technologies, surgical approaches, scientific advances and diagnostic and therapeutic options for retinal diseases and disorders. Packed with timely updates throughout, new illustrations, and a dedicated team of editors who extend Dr. Ryan’s legacy in retina, this outstanding 6th Edition is a must-have reference for retinal specialists, ophthalmologists, and fellows in training. Offers the most comprehensive content available on retina, balancing the latest scientific research and clinical correlations, covering everything you need to know on retinal diagnosis, treatment, development, structure, function, and pathophysiology. Provides a truly global perspective from five highly esteemed section editors and more than 350 other world authorities from across Europe, Asia, Australasia, and the Americas. Bullets Includes new chapters on widefield imaging, intraoperative OCT imaging, medical management of diabetes mellitus and age-related macular degeneration, and senile retinoschisis. Includes more than 1,150 brand-new illustrations, scans, and photographs throughout. Covers the explosion of new imaging options across optical coherence tomography (OCT), fundus imaging, and autofluorescence imaging, including a greatly expanded OCT imaging chapter that features crucial information on OCT-Angiography (OCT-A). Presents new pharmacotherapy data and the latest approaches in anti-VEGF therapy for age-related macular degeneration, diabetic retinopathy, and venous occlusive disease. Contains thorough content updates in every area of retina, including advanced imaging technologies, gene therapy, inflammation and immune responses, white dot syndromes, epigenetic mechanisms, transplantation frontiers to improve retinal function, macular hole, myopic eye disease, ocular trauma, drug delivery to the posterior segment, advances in macular surgery, vitrectomy and complex retinal detachment, tumors, and retinal genetics and biology.
This best-selling book provides you with a comprehensive guide to the diagnostic applications of exfoliative and aspiration cytology. The book takes a systemic approach and covers the recognized normal and abnormal cytological findings encountered in a particular organ. Appropriate histopathological correlations and a consideration of the possible differential diagnosis accompany the cytological findings. The book is lavishly illustrated, making it the perfect practical resource for daily reference in the laboratory. Provides an accessible guide to diagnostic investigation and screening. Includes a summary of major diagnostic criteria and discusses the pitfalls and limitations of cytology. Utilizes a consistent chapter structure to make finding the answers you need quick and easy. Provides updates to crucial chapters to keep you on top of the latest diagnosis and techniques. Incorporates differential diagnosis tables for easy comparison/contrast of diagnoses. Offers more than 1800 full-color images depicting a full range of normal and abnormal findings. Discusses new concepts on molecular basis of neoplasia. Explores the role of cytogenetics in cancer development.
David Walsh examines the historically insular unions in the airline industry, where the need for cooperation has been heightened in the era since deregulation. Guided by organizational theory, he analyzes extensive data on pairs of unions, coalitions, and the airline union network as a whole, finding a complex web of connections. Drawing on quantitative data from his network analysis, on the historical background, and on descriptive case studies, including the Eastern Airlines strike, Walsh identifies the possibilities and the limitations of labor solidarity.
“It is not only the cause, but our manner of conducting it, that will establish character.” —John Dickinson, 1773 A nation at war and widespread mistrust of the military. A financial crash and an endless economic crisis. A Congress so divided it barely functioned. Bitter partisan disputes over everything from taxation and the distribution of wealth to the role of banks and corporations in society. Welcome to the world of the Founding Fathers. According to most narratives of the American Revolution, the founders were united in their quest for independence and steadfast in their efforts to create a stable, effective government. But the birth of our republic was far more complicated than many realize. The Revolution was nearly derailed by extremists who wanted to do too much, too quickly and who refused to rest until they had remade American society. If not for a small circle of conservatives who kept radicalism in check and promoted capitalism, a strong military, and the preservation of tradition, our country would be vastly different today. In the first book to chronicle the critical role these men played in securing our freedom, David Lefer provides an insightful and gripping account of the birth of modern American conservatism and its impact on the earliest days of our nation. Among these founding conservatives were men like John Dickinson, who joined George Washington’s troops in a battle against the British on July 4, 1776, and that same week drafted the Articles of Confederation; James Wilson, a staunch free-market capitalist who defended his home against a mob of radicals demanding price controls and in the process averted a bloody American equivalent to Bastille Day; Silas Deane, who mixed patriotism with profit seeking while petitioning France to aid America; and Robert Morris, who financed the American Revolution and founded the first bank and the first modern multinational corporation in the United States. Drawing on years of archival research, Lefer shows how these and other determined founders championed American freedom while staying faithful to their ideals. In the process, they not only helped defeat the British but also laid the groundwork for American capitalism to thrive. The Founding Conservatives is an intellectual adventure story, full of gunfights and big ideas. It is also an extraordinary reminder of the punishing battles our predecessors fought to create and maintain the free and prosperous nation we know today.
Captures the extraordinary companionships of 30 otherwise ordinary couples, together with intimate interviews and both vintage and contemporary photos.
The most comprehensive textbook/reference ever to cover the chemical basis of life, the "Green Bible of Biochemistry" has been a well-respected contribution to the field for more than twenty years. The complex structures that make up cells are described in detail, along with the forces that hold them together, and the chemical reactions that allow for recognition, signaling and movement. There is ample information on the human body, its genome, and the action of muscles, eyes, and the brain. The complete set deals with the natural world, treating the metabolism of bacteria, toxins, antibiotics, specialized compounds made by plants, photosynthesis, luminescence of fireflies, among many other topics.* The most comprehensive biochemistry text reference available on the market* Organized into two volumes, comprising 32 chapters and containing the latest research in the field* Biological content is emphasized: for example, macromolecular structures and enzyme action are discussed
This book contains the necessary knowledge and tools to incorporate nutrition into primary care practice. As a practical matter, this effort is led by a dedicated primary care physician with the help of motivated registered dietitians, nurses, psychologists, physical therapists, and office staff whether within a known practice or by referral to the community. It is essential that the nutrition prescription provided by the physician be as efficient as possible. While many team members have superior knowledge in the areas of nutrition, exercise, and psychology, the health practitioner remains the focus of patient confidence in a therapy plan. Therefore, the endorsement of the plan rather than the implementation of the plan is the most important task of the physician. This book proposes a significant change in attitude of primary health care providers in terms of the power of nutrition in prevention and treatment of common disease. It features detailed and referenced information on the role of nutrition in the most common conditions encountered in primary care practice. In the past, treatment focused primarily on drugs and surgery for the treatment of disease with nutrition as an afterthought. Advanced technologies and drugs are effective for the treatment of acute disease, but many of the most common diseases such as heart disease, diabetes, and cancer are not preventable with drugs and surgery. While there is mention of prevention of heart disease, this largely relates to the use of statins with some modest discussion of a healthy diet. Similarly, prevention of type 2 diabetes is the early introduction of metformin or intensive insulin therapy.
Get the tools and knowledge you need for effective diagnosis, evaluation, and management of patients with acute myocardial infarction. Myocardial Infarction: A Companion to Braunwald's Heart Disease, by David A. Morrow, MD, is a comprehensive, hands-on resource that provides practical guidance from a name you trust. Concise and easy to use, this text explores the most recent tools for diagnosis and therapeutic decision-making, as well as the full range of available management strategies, providing outcomes data for each strategy. Myocardial Infarction also includes regular updates with late-breaking clinical trials, reviews of important new articles, and the latest guidance on clinical practice, all selected and masterfully edited by Dr. Eugene Braunwald. - Provides thorough discussions of ECG, established and emerging biochemical markers, angiography, nuclear cardiology, echocardiography, and cardiac MRI and CT. - Features an extensive treatment section that covers the latest drugs and most recent clinical trials of antiplatelet therapy, coronary revascularization, gene therapy, and approaches to reperfusion injury and ventricular remodeling. - Discusses special considerations for the evaluation of acute coronary syndromes in the emergency department, and use of advanced technologies in cardiac critical care. - Covers key topics such as in-hospital complications, cardiogenic shock, transitions to post-discharge care, and cardiac rehabilitation. - Includes Clinical Practice/Controversy chapters that highlight management-focused, practical topics covering expert approaches for areas of uncertainty. - Offers guidance on the management of special populations. - Consult this title on your favorite e-reader for access to regularly added update content, to conduct rapid searches, and adjust font sizes for optimal readability.
Unequalled in scope, depth, and clinical precision, Retina, 5th Edition keeps you at the forefront of today's new technologies, surgical approaches, and diagnostic and therapeutic options for retinal diseases and disorders. Comprehensively updated to reflect everything you need to know regarding retinal diagnosis, treatment, development, structure, function, and pathophysiology, this monumental ophthalmology reference work equips you with expert answers to virtually any question you may face in practice. Benefit from the extensive knowledge and experience of esteemed editor Dr. Stephen Ryan, five expert co-editors, and a truly global perspective from 358 other world authorities across Europe, Asia, Australasia the Americas.Examine and evaluate the newest diagnostic technologies and approaches that are changing the management of retinal disease, including future technologies which will soon become the standard.Put the very latest scientific and genetic discoveries, diagnostic imaging methods, drug therapies, treatment recommendations, and surgical techniques to work in your practice.
Unequalled in scope, depth, and clinical precision, Retina, 5th Edition keeps you at the forefront of today’s new technologies, surgical approaches, and diagnostic and therapeutic options for retinal diseases and disorders. Comprehensively updated to reflect everything you need to know regarding retinal diagnosis, treatment, development, structure, function, and pathophysiology, this monumental ophthalmology reference work equips you with expert answers to virtually any question you may face in practice. Consult this title on your favorite e-reader with intuitive search tools and adjustable font sizes. Elsevier eBooks provide instant portable access to your entire library, no matter what device you're using or where you're located. Examine and evaluate the newest diagnostic technologies and approaches that are changing the management of retinal disease, including future technologies which will soon become the standard. Put the very latest scientific and genetic discoveries, diagnostic imaging methods, drug therapies, treatment recommendations, and surgical techniques to work in your practice. Benefit from the extensive knowledge and experience of esteemed editor Dr. Stephen Ryan, five expert co-editors, and a truly global perspective from 358 other world authorities across Europe, Asia, Australasia, and the Americas. Make the best use of new technologies with expanded and updated coverage of optical coherence tomography (OCT), fundus imaging, and autofluorescence imaging. Apply the latest knowledge on anti-VEGF therapy for age related macular degeneration, diabetic retinopathy and vein disease. Learn about artificial vision, drug delivery to the posterior segment, advances in macular surgery, vitrectomy, and complex retinal detachment, with updates on tumors, retinal genetics, cell biology, important basic science topics, and much more. Get the most out of new pharmacologic approaches in the management of age-related macular degeneration and diabetic retinopathy. In your practice, diagnostic evaluations, and now even treatments, will be influenced by recent scientific discoveries such as in the areas of nanotechnology, neuro protection, stem cells and gene therapy, among other scientific contributions. View videos of surgical procedures and access the complete contents of Retina, 5th Edition online at www.expertconsult.com, fully searchable, with regular updates and a downloadable image gallery.
“It is not only the cause, but our manner of conducting it, that will establish character.” —John Dickinson, 1773 A nation at war and widespread mistrust of the military. A financial crash and an endless economic crisis. A Congress so divided it barely functioned. Bitter partisan disputes over everything from taxation and the distribution of wealth to the role of banks and corporations in society. Welcome to the world of the Founding Fathers. According to most narratives of the American Revolution, the founders were united in their quest for independence and steadfast in their efforts to create a stable, effective government. But the birth of our republic was far more complicated than many realize. The Revolution was nearly derailed by extremists who wanted to do too much, too quickly and who refused to rest until they had remade American society. If not for a small circle of conservatives who kept radicalism in check and promoted capitalism, a strong military, and the preservation of tradition, our country would be vastly different today. In the first book to chronicle the critical role these men played in securing our freedom, David Lefer provides an insightful and gripping account of the birth of modern American conservatism and its impact on the earliest days of our nation. Among these founding conservatives were men like John Dickinson, who joined George Washington’s troops in a battle against the British on July 4, 1776, and that same week drafted the Articles of Confederation; James Wilson, a staunch free-market capitalist who defended his home against a mob of radicals demanding price controls and in the process averted a bloody American equivalent to Bastille Day; Silas Deane, who mixed patriotism with profit seeking while petitioning France to aid America; and Robert Morris, who financed the American Revolution and founded the first bank and the first modern multinational corporation in the United States. Drawing on years of archival research, Lefer shows how these and other determined founders championed American freedom while staying faithful to their ideals. In the process, they not only helped defeat the British but also laid the groundwork for American capitalism to thrive. The Founding Conservatives is an intellectual adventure story, full of gunfights and big ideas. It is also an extraordinary reminder of the punishing battles our predecessors fought to create and maintain the free and prosperous nation we know today.
Using an integrated, "team" approach, leading authority David N. Herndon, MD, FACS explains how to meet the clinical, physical, psychological, and social needs of every burn patient - and thus achieve optimal recovery and rehabilitation. The 3rd Edition of this definitive reference covers all of the latest advances in the treatment of burns...features new a full-color layout with new color illustrations and clinical photographs. Compiled and edited by one of the world's leading authorities on the management of patients with burns. Discusses the management of burn patients from their initial presentation through long-term rehabilitation. Addresses the clinical, physical, and social needs of the burn patient and emphasizes a multi-faceted, "team approach" to treatment. Covers how to devise integrated treatment programs for different groups of patients, such as elderly and pediatric patients. Uses color illustrations and clinical photographs throughout for the first time-incorporating the illustrative strengths of Barret & Herndon's Color Atlas of Burn Care to provide you with a single source of definitive guidance on diagnosis and management. Presents new chapters on barotrauma and inhalation injury - the tissue bank - the role of exercise - and the use of dermal templates and burn scar resurfacing. Offers fresh perspectives from more than 50% new authors. With more than 100 additional contributing experts
Now in vibrant full color throughout, Rogers’ Textbook of Pediatric Intensive Care, 5th Edition, continues its tradition of excellence as the gold standard in the field. For more than 25 years, readers have turned to this comprehensive resource for clear explanations of both the principles underlying pediatric critical care disease and trauma as well as how these principles are applied in clinical practice. In the 5th Edition, more than 250 global contributors bring you completely up to date on today’s understanding, treatments, technologies, and outcomes regarding critical illness in children.
The book deals with the role of both oxygen- and nitrogen-centred free radicals in inflammatory diseases such as rheumatoid arthritis. The well-known involvement of the superoxide anion radical in the bactericidal action of inflammatory cells suggests that radicals and the inflammatory response are inextricably linked. The widespread involvement of radicals in human disease seems inevitable, because inflammation is such a conspicuous component of human disease. For the first time, the present text integrates contributions from leading research groups who have been investigating the role of radicals within the context of all stages of inflammtion, such as the recruitment of inflammatory cells, their bactericidal action, inflammatory tissue destruction and inflammatory cell death by apoptosis. The chapters are broadly organised so that they trace the clinical course of the acute and chronic inflammtory response, emphasising the therapeutic implications of recent data on the contribution of nitric oxide and related nitrogen-centred species. The book will be of interest to academic and industrial researchers and clinicians with interests in the fields of inflammation or free radical biology.
The Devil's Topographer explores the wider implications of Bierce's contribution to war short fiction and the significance of the war story as a subgenre in American literature. This volume is a significant contribution to the body of literary commentary on Ambrose Bierce and to the study of the development of the American short story."--Jacket.
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