Now entirely in four-color for the first time, Handbook of Nephrology, Second Edition is a concise introduction to Nephrology and features vividly-described patient cases that illuminate core concepts and topics, such as patient history, physical assessment, diagnosis, lab findings and more. This edition has been expanded with numerous additional cases, which now reflect the day-to-day activities of a practicing nephrologist.
How should changes in plasma creatinine be interpreted? What is a fractional excretion, and how does measuring it help in clinical practice? Is it helpful to diagnose a triple acid-base disturbance, or is it just a mental exercise? Focusing on the areas that are particularly challenging for trainees, Dr. David Leehey presents 20 of the most perplexing and clinically relevant nephrology questions faced by medical students, residents, and nephrology fellows and attendings. His three decades of teaching experience provide real-world perspective on topics such as complex acid base disturbances, sodium concentration disorders, and the utility of urine anion and osmolal gaps. This concise title is an excellent teaching and learning tool for anyone who needs expert insight on this often-difficult subspecialty of medicine. Provides accurate, concise answers to 20 of today’s most difficult questions in nephrology. Pays particular attention to the principal concepts involved with each challenging nephrology question. Includes questions that involve controversy in treatment, such as the use of bicarbonate to treat metabolic acidosis and phosphorus binders to treat hyperphosphatemia.
This book represents the final work of the late Professor C. David Marsden, who was the most influential figure in the field of movement disorders, in terms of his contributions to both research and clinical practice, in the modern era. It was conceived and written by David Marsden and his colleague at the Institute of Neurology, Prof. Ivan Donaldson. It was their intention that this would be the most comprehensive book on movement disorders and also that it would serve as the 'clinical Bible' for the management of these conditions. It provides a masterly survey of the entire topic, which has been made possible only by vast laboratory and bedside experience. Marsden's Book of Movement Disorders covers the full breadth of movement disorders, from the underlying anatomy and understanding of basal ganglia function to the diagnosis and management of specific movement disorders, including the more common conditions such as Parkinson's Disease through to rare, and very rare conditions such as Niemann-Pick disease. Chapters follow a structured format with historical overviews, definitions, clinical features, differential diagnosis, investigations and treatment covered in a structured way. It is extensively illustrated with many original photographs and diagrams of historical significance. Among these illustrations are still images of some original film clips of some of Dr. Marsden's patients published here for the first time. Comprehensively referenced and updated by experts from the Institute of Neurology at Queen Square, this book is a valuable reference for, not just movement disorder specialists and researchers, but also for clinicians who care for patients with movement disorders.
Textbook of Emergency Medicine (Vol. 1 and 2) is a comprehensive and contemporary exposition of the vast array of disorders and emergencies that might present to the emergency or casualty department of a hospital.
The Handbook of Nephrology offers an analytical yet understandable overview of nephrology — with an emphasis on principles and pathophysiology. Written in a clear, outline format, this handbook provides learning strategies and content not found in other books. This pocket-sized book offers medical students, interns, and residents a concise introduction to the field. Primary care physicians, internists, surgeons, nurse practitioners, pharmacists, and physician assistants will also find this book useful.
A comprehensive clinical reference on managing the entire spectrum of movement disorders NEW DVD with video clips Featuring contributions from more than one hundred leading experts, this full-color text covers pathophysiology, diagnosis, and management of all movement disorders - from ataxia to Parkinson's Disease. Movement Disorders examines the neurobehavioral changes and comorbidities that frequently occur and incorporates the latest genetic information and the most current references. Chapters cover Clinical Presentation and Course, Pathophysiology, Differential Diagnosis, Etiologies, and Treatment. The third edition is highlighted by a new full-color presentation, more than 240 color illustrations and photos, and a DVD with video clips of patients with movement disorders.
Electrochemical Detection in HPLC: Analysis of Drugs and Poisons is the first monograph devoted to the application of this mode of analysis to the assay of exogenous compounds such as drugs in biological fluids and associated areas. The introductory chapters provide information on basic electrochemistry and HPLC-ED, and on trouble-shooting. The specialized area of thiol analysis is also discussed in detail. Salient practical details of published applications of the technique in analytical toxicology and related areas are provided in a standard format. Alternative techniques are suggested throughout. The emphasis is on the analysis of exogenous compounds, although catecholamines and other endogenous species are discussed in so far as they may be used as drugs. The practical nature of this book will make it useful to professionals working in the field. It will also be of benefit to analysts wishing to use HPLC-ED in the analysis of biological samples for analytes not specifically covered in the volume.
Fragile X syndrome is one of the main causes of child developmental delay and autism spectrum disorders. This book breaks down the complex science of this genetic disorder and provides the facts and advice that every bewildered parent or professional needs to support individuals with Fragile X syndrome.
A revealing book about how government, law enforcement, and bureaucratic interests are seizing our property, our children, our savings, and our fundamental American rights—and how to fight back. Liberty and justice for all is the bedrock of American democracy, but has America betrayed our founders’ vision for the nation? In When They Come For You, New York Times bestselling author David Kirby exposes federal, state, and local violations of basic constitutional rights that should trouble every American, whether liberal, conservative, or libertarian. Free speech, privacy, protection from unreasonable search and seizure, due process, and equal protection under the law are rights that belong to every American citizen, but are being shredded at an alarming rate all across the country. Police and prosecutorial misconduct, overzealous bureaucrats with virtually unchecked power, unwarranted searches, SWAT-style raids on the homes of innocent Americans, crackdowns on a free press and the right to protest, removing children from their parents without cause, “debtors prisons," restricting freedom of health choice, seizing private assets for government profit, and much more demonstrate how deeply our rights and our national values are eroding. When They Come For You uses true stories of everyday citizens to reveal how our federal, state, and municipal governments, police, lawmakers, judges, revenue agents, unelected power brokers, and even government social workers are eviscerating our most fundamental liberties. And, it shows how people are fighting back—and winning.
This new and completely revised third edition is a concise, systematic and highly practical guide to the care of patients with Type 1 and Type 2 diabetes. Clinically and problem-based, it covers emergency, inpatient and ambulatory diabetes care in the hospital and community, focusing particularly on difficult, grey and contentious areas of management, and seeks to guide advanced practitioners through problems that are not always emphasised. Up to date clinical trial results have been incorporated, as well as concise discussions of lifestyle approaches to diabetes management, and it includes a new chapter on psychological problems in diabetes. It is now fully referenced with PubMed PMID numbers and all HbA1c measurements are quoted in DCCT and IFCC units. It will be valuable for foundation year and specialist trainees in general medicine, diabetes and endocrinology; community and hospital diabetes specialist nurses and nurse practitioners; hospital-based ward staff in specialist and non-diabetes-specialist departments, especially cardiology and emergency medicine; and general practice diabetes leads and general practitioners with a specialist diabetes interest. It will be equally valuable for hands-on reference use in the clinical situation, and for clinicians in hospital medicine and general practice studying for postgraduate diplomas and examinations.
This book combines the reference material of a nephrology textbook with the everyday relevance of a clinical handbook. This second edition develops and expands upon the success of the first. All the content has been updated and entirely new chapters on acid-base disorders and stone disease have been added. Understanding Kidney Diseases includes over 60 real-life case studies and is illustrated with over 200 figures. Readers can test their knowledge with a bank of multiple-choice questions and put it into practice by answering questions that patients frequently ask. The book provides all that students, residents and fellows need in order to approach a patient with a kidney problem with confidence.
Textbook of Clinical Neuropsychiatry provides a comprehensive, encyclopedic and up to date coverage of the complete range of neuropsychiatric disorders. The text is clearly written and well organized, utilizing a consistent and easy to read format throughout. Part I describes the diagnostic assessment of patients and details the interview, mental s
Highly Commended, BMA Medical Book Awards 2013Previously published as Textbook of Clinical Neuropsychiatry, this book has been re-titled and thoroughly updated, redesigned, and enhanced to include the fundamentals of neuroscience. This highly acclaimed text provides a definitive, clinically oriented, yet comprehensive book covering neuropsychiatry
This best-selling book provides you with a comprehensive guide to the diagnostic applications of exfoliative and aspiration cytology. The book takes a systemic approach and covers the recognized normal and abnormal cytological findings encountered in a particular organ. Appropriate histopathological correlations and a consideration of the possible differential diagnosis accompany the cytological findings. The book is lavishly illustrated, making it the perfect practical resource for daily reference in the laboratory. Provides an accessible guide to diagnostic investigation and screening. Includes a summary of major diagnostic criteria and discusses the pitfalls and limitations of cytology. Utilizes a consistent chapter structure to make finding the answers you need quick and easy. Provides updates to crucial chapters to keep you on top of the latest diagnosis and techniques. Incorporates differential diagnosis tables for easy comparison/contrast of diagnoses. Offers more than 1800 full-color images depicting a full range of normal and abnormal findings. Discusses new concepts on molecular basis of neoplasia. Explores the role of cytogenetics in cancer development.
Greenfield's Neuropathology, the worlds leading neuropathology reference, provides an authoritative, comprehensive account of the pathological findings in neurological disease, their biological basis and their clinical manifestations. This account is underpinned throughout by a clear description of the molecular and cellular processes and reactions that are relevant to the development, and normal and abnormal functioning of, the nervous system. While this scientific content is of paramount importance, however, care has been taken to ensure that the information is presented in a way that is accessible to readers working within a range of disciplines in the clinical neurosciences, and that also places the neuropathological findings within the context of a broader diagnostic process. The new eighth edition incorporates much new information, new illustrations and many new authors, while retaining the depth, breadth and quality of content so praised in previous editions. Each chapter opens with an introductory section designed to offer an integrated approach to diagnosis, taking account of clinical manifestations, neuroradiological and laboratory findings as well as the neuropathological and molecular genetic features of the diseases being considered. Strong emphasis has been placed on facilitating the retrieval of neuropathological information by non-neuropathologists grapping with differential diagnoses or seeking information on broad categories of neurological disease, and boxes and tables are used to present important symptoms and signs, patterns of disease and other features for ease of reference. High quality line and photographic illustrations, the majority in full colour, are all available on a companion CD, to complete the offering.
Greenfield's Neuropathology, the worlds leading neuropathology reference, provides an authoritative, comprehensive account of the pathological findings in neurological disease, their biological basis and their clinical manifestations. This account is underpinned throughout by a clear description of the molecular and cellular processes and reactions that are relevant to the development, and normal and abnormal functioning of, the nervous system. While this scientific content is of paramount importance, however, care has been taken to ensure that the information is presented in a way that is accessible to readers working within a range of disciplines in the clinical neurosciences, and that also places the neuropathological findings within the context of a broader diagnostic process. The new eighth edition incorporates much new information, new illustrations and many new authors, while retaining the depth, breadth and quality of content so praised in previous editions. Each chapter opens with an introductory section designed to offer an integrated approach to diagnosis, taking account of clinical manifestations, neuroradiological and laboratory findings as well as the neuropathological and molecular genetic features of the diseases being considered. Strong emphasis has been placed on facilitating the retrieval of neuropathological information by non-neuropathologists grapping with differential diagnoses or seeking information on broad categories of neurological disease, and boxes and tables are used to present important symptoms and signs, patterns of disease and other features for ease of reference. High quality line and photographic illustrations, the majority in full colour, are all available on a companion CD, to complete the offering.
Imaging in Parkinson's Disease provides up-to-date information concerning new applications of brain imaging to the study of Parkinson's disease. Written by experts in the field, the book focuses on structural and functional imaging methodologies that have recently been applied to study the natural history of Parkinson's disease, with emphasis on the development of the major motor manifestations of the illness as well as cognitive impairment and dementia.
Offering comprehensive coverage of this fast-changing field for more than 20 years, Urologic Surgical Pathology is an expert guide to all common and rare entities in the genitourinary system. The 4th Edition keeps you fully up to date with discussions of newly recognized tumors and terminologies, the latest classification schemes, current grading approaches, molecular alterations, and commonly used ancillary diagnostic techniques. With its clinical focus on day-to-day urological pathology sign-out and an emphasis on clinicopathologic and radiographic-pathologic correlations, this thoroughly revised uropathology reference is an excellent resource for diagnostic decision making. - Includes expanded coverage of differential diagnosis for all tumor types encountered in urological surgical pathology practice. - Incorporates the latest TNM staging and WHO classification systems, as well as new diagnostic biomarkers and their utility in differential diagnosis, newly described variants and new histologic entities. - Discusses advances in molecular diagnostic testing, its capabilities, and its limitations, including targeted therapy/personalized medicine. - Covers new developments in immunohistochemistry and the latest diagnostic tumor markers. - Features more than 1,600 high-quality images – all in color – including gross pictures, histopathologic and cytopathologic images, special stains, other ancillaries, drawings, and illustrations. - Helps you find information quickly with a consistent chapter format; an abundance of tables, diagrams and flowcharts; boxed lists of types and causes of diseases; differential diagnosis; characteristic features of diseases; complications; classifications; and staging. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
As the definitive reference for clinical chemistry, Tietz Textbook of Clinical Chemistry and Molecular Diagnostics, 5th Edition offers the most current and authoritative guidance on selecting, performing, and evaluating results of new and established laboratory tests. Up-to-date encyclopedic coverage details everything you need to know, including: analytical criteria for the medical usefulness of laboratory procedures; new approaches for establishing reference ranges; variables that affect tests and results; the impact of modern analytical tools on lab management and costs; and applications of statistical methods. In addition to updated content throughout, this two-color edition also features a new chapter on hemostasis and the latest advances in molecular diagnostics. Section on Molecular Diagnostics and Genetics contains nine expanded chapters that focus on emerging issues and techniques, written by experts in field, including Y.M. Dennis Lo, Rossa W.K. Chiu, Carl Wittwer, Noriko Kusukawa, Cindy Vnencak-Jones, Thomas Williams, Victor Weedn, Malek Kamoun, Howard Baum, Angela Caliendo, Aaron Bossler, Gwendolyn McMillin, and Kojo S.J. Elenitoba-Johnson. Highly-respected author team includes three editors who are well known in the clinical chemistry world. Reference values in the appendix give you one location for comparing and evaluating test results. NEW! Two-color design throughout highlights important features, illustrations, and content for a quick reference. NEW! Chapter on hemostasis provides you with all the information you need to accurately conduct this type of clinical testing. NEW! Six associate editors lend even more expertise and insight to the reference. NEW! Reorganized chapters ensure that only the most current information is included.
An important milestone in medicine has been the recent completion of the Human Genome Project. The identification of 30,000 genes and their regulatory proteins provides the framework for understanding the metabolic basis of disease. This advance has also laid the foundation for a broad range of genomic tools that have opened the way for targeted genetic testing in a number of medical disorders. This book is designed to be the first major text to discuss genomics-based advances in disease susceptibility, diagnosis, prognostication,and prediction of treatment outcomes in various areas of medicine. After building a strong underpinning in the basic concepts of genomics, the authors of this book, all leaders in the field, proceed to discuss a wide range of clinical areas and the applications now afforded by genomic analysis.
Biochemistry: The Chemical Reactions of Living Cells is a well-integrated, up-to-date reference for basic biochemistry, associated chemistry, and underlying biological phenomena. Biochemistry is a comprehensive account of the chemical basis of life, describing the amazingly complex structures of the compounds that make up cells, the forces that hold them together, and the chemical reactions that allow for recognition, signaling, and movement. This book contains information on the human body, its genome, and the action of muscles, eyes, and the brain. It also features: thousands of literature references that provide introduction to current research as well as historical background; twice the number of chapters of the first edition; and each chapter contains boxes of information on topics of general interest. -- Publisher description.
This superbly written text gives students, residents, and practitioners the edge in understanding the mechanisms and clinical management of acid-base disorders. Presents the core information to understand renal and electrolyte physiology, and reviews the treatment rationale for all major acid-base and electrolyte disturbances. The entire text is exhaustively revised, and now includes questions and answers in each chapter.
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