Gene regulation is an essential process in the development and maintenance of a healthy body, and as such, is a central focus in both basic science and medical research. Gene Regulation, Fifth Edition provides the student and researcher with a clear, up-to-date description of gene regulation in eukaryotes, distilling the vast and complex primary literature into a concise overview.
The new edition of Gene Control has been updated to include significant advances in the roles of the epigenome and regulatory RNAs in gene regulation. The chapter structure remains the same: the first part consists of pairs of chapters that explain the mechanisms involved and how they regulate gene expression, and the second part deals with specific biological processes (including diseases) and how they are controlled by genes. Coverage of methodology has been strengthened by the inclusion more explanation and diagrams.The significant revision and updating will allow Gene Control to continue to be of value to students, scientists and clinicians interested in the topic of gene control.
Presents the principles of human gene evolution in a concise and easy to understand fashion. Uses examples of how evolutionary processes have molded present day genes, drawn from the evolution of humans and other primates, as well as from more primitive organisms. With increasing attention in this expanding area, this review forms a timely publication of our current knowledge of this important field. Structure and function in the human genome The evolution of gene structure Mutational mechanisms in evolution
Gene Control offers a current description of how gene expression is controlled in eukaryotes, reviewing and summarizing the extensive primary literature into an easily accessible format. Gene Control is a comprehensively restructured and expanded edition of Latchman’s Gene Regulation: A Eukaryotic Perspective, Fifth Edition. The first part of the book deals with the fundamental processes of gene control at the levels of chromatin structure, transcription, and post-transcriptional processes. Three pairs of chapters deal with each of these aspects, first describing the basic process itself, followed by the manner in which it is involved in controlling gene expression. The second part of the book deals with the role of gene control in specific biological processes. Certain chapters deal with the importance of gene control in cellular signaling processes and for normal development of the embryo. Another chapter discusses the key roles played by gene-regulatory processes in the specification of differentiated cell types such as muscle cells and neurons. The final chapters discuss the consequences of errors in gene control; the relationship between gene misregulation and human diseases, especially cancer; and potential therapies designed specifically to target particular levels of gene control. Gene Control will be of value to students in biological sciences, as well as to scientists and clinicians interested in how genes are regulated in health and disease.
Now in two-colour throughout, the fourth edition of Eukaryotic Transcription Factors has been completely rewritten and restructured to take into account the tremendous advances in our understanding of transcription factors and the mechanisms by which they act. Considerable emphasis has been given to the interaction between transcription factors and chromatin structure. Also included is an entirely new section on the mediator complex and expansion of the space devoted to co-activators and co-repressors.This book is essential reading for all those who wish to understand the impact of molecular biology on medicine, whatever their speciality. - Major families of eukaryotic transcription factors described - Mechanisms of gene activation and repression analysed - Structure-function relationships indicated - Interaction between transcription factors and chromatin structure described - Roles in inducible and cell type-specific gene expression - Roles in development, differentiation and human diseases including cancer - Methods of study in vitro and in vivo
This lucid, well structured and jargon-free book provides an up-to-date and comprehensive account of the processes involved in gene expression and the mechanisms by which such expression is regulated. New information on how viruses modify host gene regulation has been included in this new edition. Methods used to analyze gene expression have also been given more attention, with a new section added on methods for examining DNA binding by transcriptional factors.
This book provides an outstanding single-volume resource on the topic of solar energy for young adults and general audiences. While how much longer the world's supply of fossil fuels will last is debatable, it is a fact that the fossil fuels that we depend on so heavily today are non-renewable resources that will inevitably be exhausted—making the need to shift to alternative sources of energy such as solar extremely important. Solar Energy: A Reference Handbook presents encyclopedic coverage of the social, political, economic, and environmental issues associated with the development and use of solar energy in the United States and around the world. This book provides an in-depth description of the ways solar power has been used for at least 2,000 years. It outlines how humankind has utilized various forms of energy from the sun by way of photovoltaic cells, concentrating or focusing solar power, active and passive solar heating, and other mechanisms; and provides perspectives on today's solar energy issues from a variety of subject experts. Readers will better understand not only the advantages and disadvantages of solar power but also the critical nature of energy production to sustaining life on earth, thereby underscoring the importance of developing solar power and other alternative sources of energy to meet the world's energy needs in coming decades. The book also includes profiles of key individuals and organizations related to the field of solar energy, a chronology of important events in the history of solar energy, and a glossary that defines the key terms used in discussing the topic of solar energy.
Bundled with the eBook, which will be updated regularly as new information about each virus is available, this text serves as the authoritative, up-to-date reference book for virologists, infectious disease specialists, microbiologists, and physicians, as well as medical students pursuing a career in infectious diseases.
For those of us who came from the Seventies, it should be obligatory reading. But younger folk should take a look too, for it beautifully captures a bygone era - Brian Viner, The IndependentThere is a rough edge to his diary that reinforces its immediacy and credibility... a funny and fascinating document - Michael Parkinson, The Daily Telegraph
This Fiji handbook provides a thought-provoking introduction to Fiji's turbulent history, diverse population, and cultural riches. Travelers gain from seasoned traveler Stanley's extensive descriptions and evaluations of Fiji's lodgings, from luxury resorts to simple hotels on the beach. His comprehensive reporting of outdoor recreation makes it simple to locate the perfect activities, such as scuba diving, snorkeling, surfing, sailing, kayaking, hiking, camping, and golf.
No one feels the heat of an Ashes battle more than the captains of England and Australia. The weight of national expectation, and more than 120 years of history, is on their shoulders from the moment they walk out to toss a coin and start a Test match that is like no other. The Captains' Tales offers a unique insight into the minds of a generation of captains from two great nations, who share with the reader what it feels like to call the shots in Test cricket's greatest cauldron. From Mike Brearley's cajoling of Ian Botham during the famous summer of 1981 to Ricky Ponting's revenge mission of 2006-07, each Ashes captain from the last quarter-century reveals what made him tick, his vision of where he wanted to take his team and how he handled key characters within the dressing-room. The author, former Kent captain David Fulton, delves behind the scenes for clues about how these sporting generals constructed their battle plans and uses his own experience to determine their strengths and weaknesses as leaders of men. The Captains' Tales will strike a chord not just with cricket lovers but with sporting captains of all abilities and readers who seek a greater insight into the broader issues of management and leadership.
The International Thermal Conductivity Conference was started in 1961 with the initiative of Mr. Charles F. Lucks, who passed away on 8 July 1982 and to the memory of whom this volume is dedicated. These Conferences on thermal conductivity grew out of the needs of researchers in the field. The Conferences were held annu ally from 1961 to 1973 and have been held biennially since 1975 when our Center for Information and Numerical Data Analysis and Synthesis (CINDAS) of Purdue University became the Permanent Sponsor of the Conferences. These Conferences provide a broadly based forum for researchers actively working on the thermal conduc tivity and closely related properties to convene on a regular basis to exchange their ideas and experiences and report their findings and results. The Conferences have been self-perpetuating and are an example of how a technical community with a common purpose can transcend the invisible, artificial barriers between disciplines and gather together in increasing numbers without the need of national pub licity and continuing funding support, when they see something worthwhile going on. It is believed that this series of Conferences not only will grow stronger, but will set an example for research ers in other fields on how to jointly attack their own problem areas.
For many years, the authors have investigated the adaptive role of heat shock proteins (HSPs) in different animals, including the representatives of homothermic and poikilothermic organisms that inhabit regions with contrasting thermal conditions. This book will summarize the data accumulated in the course of these studies and describe the general molecular mechanisms underlying the adaptation of various organisms to aggressive environments. We also concentrate on different evolutionary trends characteristic for HSP systems in the course of adaptation to fluctuating environmental conditions. In addition, we describe the peculiarities in the regulatory regions of heat shock genes necessary for fine tuning of these systems providing the adaptation to adverse conditions. Special emphasis is given to the role of mobile elements in the evolution and functioning of various groups of HSP genes. The book combines the results of field studies and laboratory analysis of stress genes systems.
Referred to in his time as “the Pretender” and “the sphinx of the Tuileries,” Louis Napoléon Bonaparte—the nephew of Emperor Napoleon I of France and himself ruler of the Second Empire (1852–1870)—so managed the manufacture of his public image and the masking of his private self that he is, ultimately, unknowable to this day. From the mysterious circumstances of his conception in 1807 to the strange events of his downfall in 1870 and death in 1873, he lived, loved, and reigned in an extraordinary aura of myth and fantasy under the shadow of his more famous uncle. Taking a highly innovative approach to this intriguing historical figure, David Baguley entertains sources in a mélange of media and forms—pictures, performances, spectacles, rituals, music, fiction, poems, plays, architecture, fashion, as well as Louis Napoléon’s own writings—to explore how the ruler was represented, invented, and interpreted by detractors and defenders alike. The dynamic process by which the legend of Napoleon III was elaborately fabricated and then vigorously dismantled unfolds under Baguley’s hand not chronologically but by generic categories, reflecting the author’s underlying conviction that history and literary depictments are not as incompatible as is often assumed. Baguley examines works by, among many others, Victor Hugo, Karl Marx, Émile Zola, Honoré Daumier, Jacques Offenbach, Gustave Flaubert, and Elizabeth Barrett Browning that range from history and biography to romanticized versions of the Emperor’s feats to parody, caricature, and satire. With its conspiratorial origins, its rising and dramatically falling action, its schemes, scandals, and tragic denouement, the Second Empire appears designed to inspire writers and artists. Napoleon III, Baguley observes, could well have been the central character, or temperament, in a naturalist novel. While most historians consider Louis Napoléon’s coup d’état of December 1851 to be his boldest endeavor, Baguley shows in this expansive and eloquent work that his most extravagant venture was to found a second Napoleonic empire, and he illustrates not only the power of the name and the image but also the precariousness of the Emperor’s reliance upon them. For Napoleon III, dissimulation was his natural state; opportunist or utopian reformer, or something in between, he must remain one of history’s most elusive and controversial figures, ever resisting final assessment.
Going beyond the usual focus on unemployment, this 2004 book explores the health effects of other kinds of underemployment including forms of inadequate employment as involuntary part-time and poverty wage work. Using the National Longitudinal Survey of Youth, this compares falling into unemployment versus inadequate employment relative to remaining adequately employed. Outcomes include self-esteem, alcohol abuse, depression, and low birth weight. The panel data permit study of the plausible reverse causation hypothesis of selection. Because the sample is national and followed over two decades, the study explores cross-level effects (individual change and community economic climate) and developmental transitions. Special attention is given to school leavers and welfare mothers, and, in cross-generational analysis, the effect of mothers' employment on babies' birth weights. There emerges a way of conceptualizing employment status as a continuum ranging from good jobs to bad jobs to employment with implications for policy on work and health.
Now thoroughly updated to include new advances in the field,and with regular content updates to the eBook, Principles and Practice of Pediatric Oncology, 7th Edition remains the gold standard text for the care and research of children with cancer. This authoritative reference is the single most comprehensive resource on the biology and genetics of childhood cancer and the diagnosis, multimodal treatment, and long-term management of young patients with cancer. Also addressed are a broad array of topics on the supportive and psychosocial aspects of care of children and families. Covering virtually every aspect of the breadth and depth of childhood cancer, this 7th Edition provides expert guidance on state-of-the-art, multidisciplinary care for children and families. Stay up to date with the most recent advances in the field with the contributions by new and returning contributors, including the perspective from patients and parents in the chapter titled “The Other Side of the Bed.” Reference your eBook version for key updates in the field during the life of the edition! Chapters included on palliative care and education. Supportive care is covered broadly and specifically – in contexts such as emergencies, infectious disease, and nutrition. The most updated and authoritative information is provided by the leading experts in the field. Gain a thorough understanding of every aspect of pediatric oncology, with comprehensive information regarding basic science, diagnostic tools, principles of treatment, and clinical trials, as well as highly detailed, definitive coverage of each pediatric malignancy. Collaborate more effectively with others on the cancer care team to enhance quality-of-life issues for patients and families. Understand the cooperative nature of pediatric oncology as a model for cancer research with information from cooperative clinical trial groups and consortia.
Our understanding of psychophysiological states are now more broadly defined by the inclusion of the lateralized ultradian rhythms of the autonomic and central nervous systems (ANS and CNS) that play a key regulatory role in mind-body states. These neural rhythms are a unique step in the evolution of the nervous system that have mostly been ignored or missed in our understanding of physiology, mental activities, brain rhythms, and in the treatment of psychiatric disorders. The multivariate physiological experiments reviewed in this book provide a new "big picture for how the body's major systems (ANS, CNS, neuroendocrine, cardiovascular, fuel-regulatory, gastrointestinal, immune) are regulated, integrated, and coordinated by the ANS via the hypothalamus during both waking and sleep. This discovery has implications for psychiatrists, psychologists, stress physiologists, cardiologists, sleep researchers, neuroscientists, neuroendocrinologists, cognitive scientists, and those interested in performance, anxiety, depression, schizophrenia, autism, and addictive and impulse control disorders. This book includes the translational neuroscience aspect of this discovery, including implications for vagal nerve stimulation studies. - This book is a study in Lateralized rhythms and Ultradian rhythms and their context in the ANS-CNS, a very new field - Implications of these rhythms in Anxiety, Depression and Schizophrenia will be explored - The book will present theories of possible causes for the assignment of causal mechanisms of these lateralizations - The reader will understand the Nasal Cycle, the rhythmic; alternating side-to-side fluctuation in nasal airflow which is regulated by the ANS - Unilateral Forced Breathing techniques will be discussed - Vagal nerve stimulation and its effects will be discussed - Yoga breathing techniques are analyzed and theorized scientifically
This text focuses on the contemporary economic, social, geographical, environmental and political realities of the Caribbean region. Historical aspects of the Caribbean, such as slavery, the plantation system and plantocracy are explored in order to explain the contemporary nature of, and challenges faced by, the Caribbean. The book is divided into three parts, dealing respectively with: the foundations of the Caribbean, rural and urban bases of the contemporary Caribbean, and global restructuring and the Caribbean: industry, tourism and politics.
The most readable, most comprehensive book in its field, Clinical Gynecologic Oncology, 9th Edition is the leading reference for diagnosis and treatment of gynecologic cancers – a must-have reference for improving outcomes and providing effective care. A "who’s who" list of contributing authors, under the editorial direction of Drs. Philip DiSaia and William Creasman, provides expert guidance on clinical presentations and management, now fully up to date with a brand-new design for faster, easier reference. Contains useful appendices covering staging, screening, nutritional therapy, toxicity criteria, blood component therapy, and radiation therapy. Covers hot topics such as multi-panel genetic testing, target therapies, sentinel node concept in endometrial cancer and vulvar cancer, and robotic surgery. Updates include new quick-reference features such as key point boxes with bulleted lists, highlighted key text, enhanced chapter outlines, and a brand-new design throughout. Includes up-to-date references and algorithms, making this text a comprehensive resource for clinical practice, personal study, and exam review. Helps you take advantage of the latest advances in early detection and improved treatment options for gynecologic cancers, especially uterine and cervical cancers.
Biochemistry: The Chemical Reactions of Living Cells is a well-integrated, up-to-date reference for basic chemistry and underlying biological phenomena. Biochemistry is a comprehensive account of the chemical basis of life, describing the amazingly complex structures of the compounds that make up cells, the forces that hold them together, and the chemical reactions that allow for recognition, signaling, and movement. This book contains information on the human body, its genome, and the action of muscles, eyes, and the brain.* Thousands of literature references provide introduction to current research as well as historical background* Contains twice the number of chapters of the first edition* Each chapter contains boxes of information on topics of general interest
Biochemistry: The Chemical Reactions of Living Cells is a well-integrated, up-to-date reference for basic biochemistry, associated chemistry, and underlying biological phenomena. Biochemistry is a comprehensive account of the chemical basis of life, describing the amazingly complex structures of the compounds that make up cells, the forces that hold them together, and the chemical reactions that allow for recognition, signaling, and movement. This book contains information on the human body, its genome, and the action of muscles, eyes, and the brain. * Thousands of literature references provide introduction to current research as well as historical background * Contains twice the number of chapters of the first edition * Each chapter contains boxes of information on topics of general interest
Commonwealth Caribbean Administrative Law comprehensively explores the nature and function of administrative law in contemporary Caribbean society. The text considers the administrative machinery of Caribbean States, Parliament, the Executive and the Judiciary, and examines the basis for judicial review of executive and administrative action in the Caribbean. The book will also examine how the courts on the Commonwealth Cariibeen have sought to define principles of administrative law.
To address the exponential growth in the fields of pediatric hematology and oncology, this classic reference has been separated into two distinct volumes. With this volume, devoted strictly to pediatric hematology, and another to pediatric oncology, you'll keep you on the cutting-edge of these two specialties. The completely revised 7th edition of Nathan and Oski's Hematology of Infancy and Childhood is now in full color, and provides you with the most comprehensive, authoritative, up-to-date information for diagnosing and treating children with hematologic disorders. It brings together the pathophysiology of disease with detailed clinical guidance on diagnosis and management for the full range of blood diseases that you encounter in everyday practice. Written by the leading names in pediatric hematology, this resource is an essential tool for anyone involved in caring for children with hematologic disorders. And, as an Expert Consult title, this thoroughly updated 7th edition comes with access to the complete contents online, fully searchable. Balances summaries of relevant pathophysiology with clear, practical clinical guidance to help you thoroughly understand the underlying science of diseases. Offers comprehensive coverage of all hematologic disorders, including newly recognized ones, along with the latest breakthroughs in diagnosis and management. Uses many boxes, graphs, and tables to highlight complex clinical diagnostic and management guidelines at a glance. Presents an all-new full-color design that includes clear illustrative examples of relevant science and clinical problems for quick access to the answers you need. Provides access to the complete contents online, fully searchable, enabling you to consult it rapidly from any computer with an Internet connection. Your purchase entitles you to access the web site until the next edition is published, or until the current edition is no longer offered for sale by Elsevier, whichever occurs first. If the next edition is published less than one year after your purchase, you will be entitled to online access for one year from your date of purchase. Elsevier reserves the right to offer a suitable replacement product (such as a downloadable or CD-ROM-based electronic version) should access to the web site be discontinued.
To address the exponential growth in the fields of pediatric hematology and oncology, this classic reference has been separated into two distinct volumes. With this volume, devoted strictly to pediatric hematology, and another to pediatric oncology, you’ll keep you on the cutting-edge of these two specialties. The completely revised 7th edition of Nathan and Oski’s Hematology of Infancy and Childhood is now in full color, and provides you with the most comprehensive, authoritative, up-to-date information for diagnosing and treating children with hematologic disorders. It brings together the pathophysiology of disease with detailed clinical guidance on diagnosis and management for the full range of blood diseases that you encounter in everyday practice. Written by the leading names in pediatric hematology, this resource is an essential tool for anyone involved in caring for children with hematologic disorders. Balances summaries of relevant pathophysiology with clear, practical clinical guidance to help you thoroughly understand the underlying science of diseases. Offers comprehensive coverage of all hematologic disorders, including newly recognized ones, along with the latest breakthroughs in diagnosis and management. Uses many boxes, graphs, and tables to highlight complex clinical diagnostic and management guidelines at a glance. Presents an all-new full-color design that includes clear illustrative examples of relevant science and clinical problems for quick access to the answers you need.
The purpose of the book is to bring together in one place the different facets of regenerative biology and medicine while providing the reader with an overview of the basic and clinically-oriented research that is being done. Not only does the content cover a plethora tissues and systems, it also includes information about the developmental plasticity of adult stem cells and the regeneration of appendages.As part of its balanced presentation, Regenerative Biology and Medicine does address the biological/bioethical issues and challanges involved in the new and exciting field of regenerative biology and medicine. *Tissues covered include skin, hair, teeth, cornea, and central neural types*Systems presented are digestive, respiratory, urogenital, musculoskeletal, and cardiovascular*Includes amphibians as powerful research models*Discusses appendage regeneration in amphibians and mammals
This companion to Brenner and Rector's The Kidney offers a state-of-the-art summary of the most recent advances in renal genetics. Molecular and Genetic Basis for Renal Disease provides the nephrologist with a comprehensive look at modern investigative tools in nephrology research today, and reviews the molecular pathophysiology of the nephron as well as the most common genetic and acquired renal diseases. A comprehensive clinical review of Medelian renal disease is also be included. Detailed review of the molecular anatomy and pathophysiology of the nephron that provides relevant basic science to consider when diagnosing and managing patients with these disorders.
Written by the leading names in pediatric oncology and hematology, Nathan and Oski's Hematology and Oncology of Infancy and Childhood offers you the essential tools you need to overcome the unique challenges and complexities of childhood cancers and hematologic disorders. Meticulously updated, this exciting full-color set brings together the pathophysiology of disease with detailed clinical guidance to provide you with the most comprehensive, authoritative, up-to-date information for diagnosing and treating children. - Form a definitive diagnosis and create the best treatment plans possible with comprehensive coverage of all pediatric cancers, including less-common tumors, as well as all hematologic disorders, including newly recognized ones. - Develop a thorough, understanding of the underlying science of diseases through summaries of relevant pathophysiology balanced with clear, practical clinical guidance. Nathan and Oski's is the only comprehensive product on the market that relates pathophysiology in such depth to hematologic and oncologic diseases affecting children. - Quickly and effortlessly access the key information you need with the help of a consistent organization from chapter to chapter and from volume to volume. - Stay at the forefront of your field thanks to new and revised chapters covering topics such as paroxysmal nocturnal hemoglobinuria, lysosomal storage diseases, childhood genetic predisposition to cancer, and oncology informatics. - Learn about the latest breakthroughs in diagnosis and management, making this the most complete guide in pediatric hematology and oncology. - Discover the latest in focused molecularly targeted therapies derived from the exponential growth of knowledge about basic biology and genetics underlying the field. - Rely on it anytime, anywhere! Access the full text, images, and more at Expert Consult.
Provides historical and travel information for visitors to Polynesia and Melanesia, including Cook Islands, Samoa, Fiji Islands, New Caledonia, and Solomon Islands
FOLLOW THE STORM, a personal account of mass suicides in Guyana at "Jonestown" in 1978, the 1978-1979 civil war in Nicaragua, the 1982 civil wars in El Salvador & Beirut, the volcanic eruption of El Chichonal in Mexico in 1982, & the invasion of the Falkland Islands that same year, is based upon daily journals kept by the author when he was a radio & television correspondent for CBS News. David Dick's close encounters with death on numerous occasions during his 19-year career with CBS News are described in graphic detail. The author won an Emmy for his coverage of the shooting of Governor George C. Wallace in 1972. FOLLOW THE STORM includes coverage of earthquakes, hurricanes & tornadoes. David Dick writes only about the events he has actually witnessed, & he gives a moving, nonfictional account of his relationship with the victims of disaster, the global impact of the folly & frailty of man & the bravery of the messengers willing to place their lives on the line in order to bring the "big story" home to the reader & the viewer. FOLLOW THE STORM chronicles the successes & the failures of network television news against the background of tragic consequences.
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