Indianapolis has long been steeped in important moments in African American history, from businesswoman Madame C. J. Walker's success to the rise of the Ku Klux Klan to the founding of Crispus Attucks High School, which remained segregated through the 1960s. In African Americans in Indianapolis, author and historian David Leander Williams explores this history by examining the daunting and horrendous historical events African Americans living in Indianapolis encountered between 1820 and 1970, as well as the community's determination to overcome these challenges. Revealing many events that have yet to be recorded in history books, textbooks, or literature, Williams chronicles the lives and careers of many influential individuals and the organizations that worked tirelessly to open doors of opportunity to the entire African American community. African Americans in Indianapolis serves as a reminder of the advancements that Black midwestern ancestors made toward freedom and equality, as well as the continual struggle against inequalities that must be overcome.
Volume Four of this series contains the alphabetical rosters of each of the 144 cemeteries in the study area of Jackson and Sandy Ridge Townships, Union Co., NC. It includes over 27,524 graves.
This quick reference handbook covers the diagnosis and treatment of eye disease in a range of exotic companion animal species, including rabbits, rodents, reptiles, birds, amphibians and fish. It clarifies when extrapolation from cat or dog eyes is appropriate, or when new information is needed to ensure that diagnoses and treatments are appropriate for the particular species. Writing in an accessible and down to earth style, the author brings a wealth of personal experience to this specialised subject area. The book contains many ophthalmic photographs of both anatomy in normal eyes and pathology in abnormal cases. It also includes a separate chapter on the common ophthalmic features of exotic pets, discussing what can be learnt from cross-species comparison and another chapter giving a brief history of comparative ophthalmology. Ophthalmology of Exotic Pets is an invaluable aid for veterinary practitioners and students with an interest in exotic pet species, as well as for veterinary ophthalmologists. KEY FEATURES Covers lagomorphs, rodents, reptiles, birds, amphibians and fish Offers clear guidance for species-specific treatment Facilitates extrapolations from the cat or dog to the exotic eye Written in a concise quick reference format Highly illustrated with colour photographs
While the near 1,500 victims of Titanic accounted for a huge loss of life, each of the ships here had a greater number of casualties, in some cases more than five times as many. In total, these 27 merchant ship sinkings resulted in a staggering loss of life at sea – more than 96,000 in total, 3,840 per ship. While the circumstances were different to Titanic, the outcome in each case was no less tragic. Yet, despite the fact that Titanic ranks behind so many other losses, so powerful has her name become that it was the inevitable choice to describe some of these other events, ‘Germany’s Titanic’ and ‘The Titanic of Japan’ being two examples. Ships include the Lancastria, Britain’s worst maritime disaster with 3,000 lost; the Ryusei Maru, a Japanese ‘Hellship’ loaded with 6,000 Allied POWs, torpedoed by a US submarine; and the Wilhelm Gustloff, a German liner packed with 7,800 civilians, sunk by a Russian submarine. There were no survivors and this tragedy was the worst maritime disaster of all time.
This title is the second volume in a four volume series on the cemeteries of Jackson and Sandy Ridge Townships in Union County, North Carolina. It contains information on 144 cemeteries and 27,524 graves.
An expert guide to targeting protein kinases in cancer therapy Research has shown that protein kinases can instigate the formation and spread of cancer when they transmit faulty signals inside cells. Because of this fact, pharmaceutical scientists have targeted kinases for intensive study, and have been working to develop medicinal roadblocks to sever their malignant means of communication. Complete with full-color presentations, Targeting Protein Kinases for Cancer Therapy defines the structural features of protein kinases and examines their cellular functions. Combining kinase biology with chemistry and pharmacology applications, this book enlists emerging data to drive the discovery of new cancer-fighting drugs. Valuable information includes: Comprehensive overviews of the major kinase families involved in oncology, integrating protein structure and function, and providing important tools to assist pharmaceutical researchers to understand and work in this dynamic area of cancer drug research Focus on small molecule inhibitors as well as other therapeutic modalities Discussion of kinase inhibitors that have entered clinical trials for the treatment of cancer, with an emphasis on molecules that have progressed to late stage clinical trials and, in a few cases, to market Providing a platform for further study, this important work reviews both the successes and challenges of kinase inhibitor therapy, and provides insight into future directions in the war against cancer.
This new edition combines lucid exposition and clarity of expression with careful scholarship and originality, making it highly attractive both to students and to experts in the field.
This enhanced edition contains match footage highlights from every tour from 1955 to 2009, additional photographs and text, as well as a statistical section and an abridged history of the Lions. This is the history of the British & Irish Lions... in their own words. For 125 years the British & Irish Lions have stood out as a symbol of the ethics, values and romance at the heart of rugby union. To represent the Lions is the pinnacle for every international player in Britain and Ireland, and the dream of tens of thousands of avid fans who follow them. A Lions tour, undertaken every four years to the southern hemisphere, is more than a series of rugby matches played out on foreign fields; it is an epic crusade where the chosen few face a succession of mental and physical challenges on their way to the Test arena, where they do battle with the superpowers of the world game. Behind the Lions sees four esteemed rugby writers from each of the Home Nations delve to the very heart of what it means to be a Lion, using diaries and letters from those who pioneered the concept, to interviews with a vast array of players who have followed in their footsteps. In so doing they have uncovered the passion, pride and honour experienced when taking up the unique challenge of a Lions tour. This is a tale of heart-break and ecstasy, humour and poignancy that is at once inspirational, moving and utterly compelling. And it is the only story worth hearing: the players' own.
The desire for greater fuel efficiency and reduced emissions have accelerated a shift from traditional materials to design solutions that more closely match materials and their properties with key applications. The Multi-Material Lightweight Vehicle (MMLV) Project presents cutting edge engineering that meets future challenges in a concept vehicle with weight and life-cycle assessment savings. These results significantly contribute to achieving fuel reduction and to meeting future Corporate Average Fuel Economy (CAFÉ) regulations without compromising vehicle performance or occupant safety. The MMLV Project presents: • Lightweight materials applications. • Body in white design and computer aided engineering • Engine and transmission design and lightweighting. • Full vehicle test results that are specific to the MMLV subsystems including crash, corrosion, durability and Noise Vibration and Harshness (NVH). • The Life Cycle Analysis (LCA) for the MMLV The aluminum-intensive structure, combined with carbon fiber, magnesium, and titanium results in full vehicle mass reduction of a C/D class family sedan to that of a subcompact B-car (two vehicle segments lighter). The MMLV Project presents engineering solutions that frame materials selection and applications for the future.
Foundations of Epidemiology has been widely used as an introductory text in a broad range of epidemiology courses. Minimal familiarity with statistics is assumed in the book. The text gives lucid, well-organized explanations of basic epidemiologic concepts such as rates and... FROM LONG DESCRIPTION.
William Hannibal Thomas (1843-1935) served with distinction in the U.S. Colored Troops in the Civil War (in which he lost an arm) and was a preacher, teacher, lawyer, state legislator, and journalist following Appomattox. In many publications up through the 1890s, Thomas espoused a critical though optimistic black nationalist ideology. After his mid-twenties, however, Thomas began exhibiting a self-destructive personality, one that kept him in constant trouble with authorities and always on the run. His book The American Negro (1901) was his final self-destructive act. Attacking African Americans in gross and insulting language in this utterly pessimistic book, Thomas blamed them for the contemporary "Negro problem" and argued that the race required radical redemption based on improved "character," not changed "color." Vague in his recommendations, Thomas implied that blacks should model themselves after certain mulattoes, most notably William Hannibal Thomas. Black Judas is a biography of Thomas, a publishing history of The American Negro, and an analysis of that book's significance to American racial thought. The book is based on fifteen years of research, including research in postamputation trauma and psychoanalytic theory on selfhatred, to assess Thomas's metamorphosis from a constructive race critic to a black Negrophobe. John David Smith argues that his radical shift resulted from key emotional and physical traumas that mirrored Thomas's life history of exposure to white racism and intense physical pain.
Den engelske ubåd HMS TROOPER., hejste kommando den 29. august 1942 og forsvandt den 17. oktober 1943 i det Ægæiske hav. Det har været forfatterens mening at sætte denne ubåd og dens besætning et glorværdigt minde, og han har haft personlige grunde hertil.
Managing the Drug Discovery Process, Second Edition thoroughly examines the current state of pharmaceutical research and development by providing experienced perspectives on biomedical research, drug hunting and innovation, including the requisite educational paths that enable students to chart a career path in this field. The book also considers the interplay of stakeholders, consumers, and drug firms with respect to a myriad of factors. Since drug research can be a high-risk, high-payoff industry, it is important to students and researchers to understand how to effectively and strategically manage both their careers and the drug discovery process. This new edition takes a closer look at the challenges and opportunities for new medicines and examines not only the current research milieu that will deliver novel therapies, but also how the latest discoveries can be deployed to ensure a robust healthcare and pharmacoeconomic future. All chapters have been revised and expanded with new discussions on remarkable advances including CRISPR and the latest gene therapies, RNA-based technologies being deployed as vaccines as well as therapeutics, checkpoint inhibitors and CAR-T approaches that cure cancer, diagnostics and medical devices, entrepreneurship, and AI. Written in an engaging manner and including memorable insights, this book is aimed at anyone interested in helping to save countless more lives through science. A valuable and compelling resource, this is a must-read for all students, educators, practitioners, and researchers at large—indeed, anyone who touches this critical sphere of global impact—in and around academia and the biotechnology/pharmaceutical industry. - Considers drug discovery in multiple R&D venues - big pharma, large biotech, start-up ventures, academia, and nonprofit research institutes - with a clear description of the degrees and training that will prepare students well for a career in this arena - Analyzes the organization of pharmaceutical R&D, taking into account human resources considerations like recruitment and configuration, management of discovery and development processes, and the coordination of internal research within, and beyond, the organization, including outsourced work - Presents a consistent, well-connected, and logical dialogue that readers will find both comprehensive and approachable - Addresses new areas such as CRISPR gene editing technologies and RNA-based drugs and vaccines, personalized medicine and ethical and moral issues, AI/machine learning and other in silico approaches, as well as completely updating all chapters
Understanding Wine Chemistry Understand the reactions behind the world’s most alluring beverages The immense variety of wines on the market is the product of multiple chemical processes – whether acting on components arising in the vineyard, during fermentation, or throughout storage. Winemaking decisions alter the chemistry of finished wines, affecting the flavor, color, stability, and other aspects of the final product. Knowledge of these chemical and biochemical processes is integral to the art and science of winemaking. Understanding Wine Chemistry has served as the definitive introduction to the chemical components of wine, their properties, and their reaction mechanisms. It equips the knowledgeable reader to interpret and predict the outcomes of physicochemical reactions involved with winemaking processes. Now updated to reflect recent research findings, most notably in relation to wine redox chemistry, along with new Special Topics chapters on emerging areas, it continues to set the standard in the subject. Readers of the second edition of Understanding Wine Chemistry will also find: Case studies throughout showing chemistry at work in creating different wine styles and avoiding common adverse chemical and sensory outcomes Detailed treatment of novel subjects like non-alcoholic wines, non-glass alternatives to wine packaging, synthetic wines, and more An authorial team with decades of combined experience in wine chemistry research and education Understanding Wine Chemistry is ideal for college and university students, winemakers at any stage in their practice, professionals in related fields such as suppliers or sommeliers, and chemists with an interest in wine.
Discovery Practice, Eighth Edition gives you hard-nosed, trial-tested guidance through all the intricacies of what to do, whether to do it, and how to do it -- at every stage of the discovery process. Turn to this trusted guide for thorough, up-to-date clarification of: Insurance discoverability Discovery abuse -- its penalties and sanctions Confidentiality and discovery of trade secrets Use of experts Use of investigation files Use of witness statements Protective orders Invoking Rule 29 powers Tapes and telephones depositions Using the Manual for Complex Litigation Foreign discovery Discovery in administrative hearings Discovery in arbitration. Plus detailed coverage of such cutting edge areas as e-mail depositions and FOIA proceedings. Appendices include ready to adapt sample forms. Now, with all the practice tips and valuable strategies packed into Discovery Practice, you can Facilitate early and thorough disclosure of information Quickly determine a core of undisputed facts Intensively promote and pursue a negotiated settlement.
Any healthcare professional with, or developing an interest in, clinical nutrition will be able to use this textbook, first published in 2001, as a source of information for the formation of a clinical nutrition support service of excellence. The first three parts of the book will enable a clear perspective of the metabolism and physiology of clinical nutrition to be related to the practical application of support techniques. The fourth part of the book highlights the role of nutrition support in specific disease groups. A number of additional chapters have been added for this second edition, and modifications made to the content of chapters from the first edition to cover newer areas or areas of omission.
The science of toxicology has progressed considerably since Molecular Toxicology was first published in 1997. New advances in biochemical and molecular biological experimental techniques have helped researchers understand the precise effects of toxins and foreign compounds on living things atthe molecular, cellular, and organismal levels. Breakthrough research has recently been completed illuminating the human genome and the role of enzymes in toxic biochemical reaction mechanisms. Toxicology now covers drug metabolism and design, carcinogenesis, programmed cell death, and DNA repair,among other subjects. The second edition captures these and other advances, and broadens its scope to address the experimental science of toxicology. The first edition of Molecular Toxicology has become an indispensable resource for graduate students in molecular and biochemical toxicology courses,as well as academic researchers and industrial researchers in toxicology. Rigorously updated and revised, the new edition commands an unrivaled authority in the field of molecular toxicology.
In On the Edge of Freedom, David G. Smith breaks new ground by illuminating the unique development of antislavery sentiment in south central Pennsylvania—a border region of a border state with a complicated history of slavery, antislavery activism, and unequal freedom. During the antebellum decades every single fugitive slave escaping by land east of the Appalachian Mountains had to pass through the region, where they faced both significant opportunities and substantial risks. While the hundreds of fugitives traveling through south central Pennsylvania (defined as Adams, Franklin, and Cumberland counties) during this period were aided by an effective Underground Railroad, they also faced slave catchers and informers. “Underground” work such as helping fugitive slaves appealed to border antislavery activists who shied away from agitating for immediate abolition in a region with social, economic, and kinship ties to the South. And, as early antislavery protests met fierce resistance, area activists adopted a less confrontational approach, employing the more traditional political tools of the petition and legal action. Smith traces the victories of antislavery activists in south central Pennsylvania, including the achievement of a strong personal liberty law and the aggressive prosecution of kidnappers who seized innocent African Americans as fugitives. He also documents how their success provoked Southern retaliation and the passage of a strengthened Fugitive Slave Law in 1850. The Civil War then intensified the debate over fugitive slaves, as hundreds of escaping slaves, called “contrabands,” sought safety in the area, and scores were recaptured by the Confederate army during the Gettysburg campaign. On the Edge of Freedom explores in captivating detail the fugitive slave issue through fifty years of sectional conflict, war, and reconstruction in south central Pennsylvania and provocatively questions what was gained by the activists’ pragmatic approach of emphasizing fugitive slaves over immediate abolition and full equality. Smith argues that after the war, social and demographic changes in southern Pennsylvania worked against African Americans’ achieving equal opportunity, and although local literature portrayed this area as a vanguard of the Underground Railroad, African Americans still lived “on the edge of freedom.” By the 1920s, the Ku Klux Klan was rallying near the Gettysburg battlefield, and south central Pennsylvania became, in some ways, as segregated as the Jim Crow South. The fugitive slave issue, by reinforcing images of dependency, may have actually worked against the achievement of lasting social change.
The long-awaited Pistachio Production Manual from the University of California is here! The combined knowledge of 42 UC and industry experts and years of research and field trials are brought to fruition in this long awaited, 321-page manual. From an overview of the state of the industry to physiological disorders, the 8-part manual covers everything you need to know. Chapters cover topics including orchard design; rootstocks and cultivars; planting and training young trees; weed, insect, mite, and vertebrate management; irrigation and salinity management; disease management; and physiological disorders including alternate bearing, nut blanking and shell splitting. Over 200 color photographs and 60 diagrams, charts, and tables illustrate key points. The back cover includes a photographic guide to the developmental stages of the pistachio.
Poets extol the burst of aroma when the bottle is opened, the wine poured, the flavor on the palate as it combines with the olfactory expression detected and the resulting glow realized. But what is the chemistry behind it? What are the compounds involved and how do they work their wonder? What do we know? Distinct and measurable differences in terroir, coupled with the plasticity of the grape berry genome and the metabolic products, as well as the work of the vintner, are critical to the production of the symphony of flavors found in the final bottled product. Analytical chemistry can inform us about the chemical differences and similarities in the grape berry constituents with which we start and what is happening to those and other constituents as the grape matures. The details of the grape and its treatment produce substantive detectable differences in each wine. While there are clear generalities - all wine is mostly water, ethanol is usually between 10% - 20% of the volume, etc - it is the details, shown to us by Analytical Chemistry and structural analysis accompanying it, that clearly allow one wine to be distinguished from another.
Samantha Hannum is the kind of experienced, calm-under-fire paramedic you'd want if you were badly injured, but the crises and threats she faces each day have begun to erode her compassion and will. She's lost all sense of purpose, a dilemma that is affecting the relationships with her family, friends and the people she serves. Samantha and her rookie partner stumble onto a plot to distribute contaminated medicine. Their discovery puts the medics in grave danger and tests the limits of their cunning and loyalty. Set against the backdrop of a gang war and a violent protest against a local abortion clinic, it's difficult at times for the partners to know if there is an actual plot against them or if they're simply in the wrong place at the wrong time. Samantha's world is brutal and unpredictable, but it is also a place where strangers care for others in the most extraordinary conditions. To triumph--and survive--Samantha must find a way to rekindle the humanity she believes she has lost.
There is enormous and growing worldwide interest in reptiles and amphibians in their natural habitats and in captivity. As the number of herpetologists, and the range of their interests, increases fast, veterinary practitioners are faced by an even wider array of animals kept as pets, in collections or for research, and knowledge of reptile and amphibian medicine is thus routinely expected of them. This Self-Assessment Colour Review presents the reader with some 250 short cases in the form of colour photos and questions at different levels of expertise, plus detailed explanatory answers. The cases appear in random order, just as they would in real life, and enable the reader - by solving the clinical puzzle - to make differential diagnoses, treatment plans and prognoses. Both authors lecture internationally and Dr Frye is among the world’s foremost authorities on reptile and amphibian medicine. Experienced and less experienced veterinary practitioners and students, plus professional and amateur herpetologists, find in this Colour Review a wealth of problem-oriented information of value - and enjoyment - in their formal and informal training and continuing education.
Synopsis: John and Michelle, a lovely young New York couple, are faced with a problem: The TV news just told them Armageddon is here. Talk about ruining a Friday night! But John and Michelle turn lemons into lemonade by throwing an end of the world party. With dancing!! When the friends and friends of friends packed into the apartment learn the end is nigh, the party takes a turn. Guests list everything they won't miss about the world, fights ensue, people ask to be killed, others grants their requests, lovers couple and uncouple for Armageddon sex, and talk of Revelation and great music fill the air. Like any good party. Cast Size: 4 Males, 5 Females "Insightful" - NYTheatre.com "inspired, hilarious take on our precarious times" - The Gothamist
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