Here is a phenomenological inquiry into the fruitful ministry of Calvary Chapel Costa Mesa’s Sunday Morning Worship Service. The purpose was to uncover and explicate the quintessential elements of worship leading from the life experiences of those worship leaders who shared the platform with Pastor Chuck Smith, known as the father of the Jesus Movement. The book examines Calvary Chapel’s inauspicious beginnings in a senior citizen trailer park recreation center as it explores key elements of Kay and Chuck Smith’s ministry. The church and the couple combined in 1965. By 1968, the church and the Smiths became a spiritual home replete with a spiritual mama and papa, ministering to hippies seeking everlasting love and eternal peace. The fruitfulness of Calvary Chapel’s ministry is its ability to reproduce maturing Christians that reproduce maturing Christians. This replication occurred thousands of times as the movement blossomed and spread to new churches and new ministries across the United States and globally. The phenomenon spawned a megachurch movement and birthed the modern Christian worship music industry. The hippies were alternately loathed and loved in their era. Perhaps the hippies’ most enduring and endearing contributions to twenty-first-century culture are traced to the Jesus movement.
When Computers Went to Sea explores the history of the United States Navy's secret development of code-breaking computers and their adaptation to solve a critical fleet radar data handling problem in the Navy's first seaborne digital computer system - that went to sea in 1962. This is the only book written on the United States Navy's initial application of shipboard digital computers to naval warfare. Considered one of the most successful projects ever undertaken by the US Navy, the Naval Tactical Data System (NTDS) was the subject of numerous studies attempting to pinpoint the reason for the systems inordinate success in the face of seemingly impossible technical challenges and stiff resistance from some in the military. The system's success precipitated a digital revolution in naval warfare systems. Dave Boslaugh details the innovations developed by the NTDS project managers including: project management techniques, modular digital hardware for ship systems, top-down modular computer programming techniques, innovative computer program documentation, and other novel real-time computer system concepts. Automated military systems users and developers, real-time process control systems designers, automated system project managers, and digital technology history students will find this account of a United States military organization's initial foray into computerization interesting and thought provoking.
An important milestone in medicine has been the recent completion of the Human Genome Project. The identification of 30,000 genes and their regulatory proteins provides the framework for understanding the metabolic basis of disease. This advance has also laid the foundation for a broad range of genomic tools that have opened the way for targeted genetic testing in a number of medical disorders. This book is designed to be the first major text to discuss genomics-based advances in disease susceptibility, diagnosis, prognostication,and prediction of treatment outcomes in various areas of medicine. After building a strong underpinning in the basic concepts of genomics, the authors of this book, all leaders in the field, proceed to discuss a wide range of clinical areas and the applications now afforded by genomic analysis.
Serpins constitute a superfamily of proteins that possess a unique tertiary structure and mechanism of proteinase inhibition. In humans, serpins constitute 10% of the plasma proteins and are best known as critical regulators of both the thrombotic and fibrinolytic systems. Serpins also participate in the regulation of the complement cascade, angiogenesis, tumor metastasis, apoptosis and innate immunity. Considering the importance of these molecules in regulating proteolytic cascades, it is not surprising to find that loss- and gain-of-function mutations result in significant human diseases. Massive thrombosis or bleeding, hereditary angioedema, Alzheimer''s disease, diabetic angiopathy and tumor invasion are some of the human diseases associated with serpins. In addition, mutations that alter serpin conformations (the serpinopathies) lead to lung disease, cirrhosis and a form of familial dementia. The goal of this text is to present the current knowledge on the molecular and cellular basis of serpins and their diseases.
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