Natural Autoantibodies provides an in-depth analysis of all aspects of natural antibodies. The book examines the advantages and pitfalls of every type of technique that is widely used for detecting autoantibodies. It also covers the sequencing of human autoantibody genes, discussing how sequencing is undertaken and the genetic clues available to elucidate the genetic origins of autoimmunity. Animal models of autoimmunity are also covered, and the up-to-date account provided in this book explains how natural autoantibodies have important regulatory functions and also occasionally serve as templates for autoimmunity. Other topics examined in Natural Autoantibodies: Their Physiological Role and Regulatory Significance include idiotypes of natural autoantibodies; the pathogenic role of natural autoantibodies; and methods to measure the effects of genetic and sex hormones, as well as aging, on natural autoantibodies. The book will be an excellent research tool and reference for immunologists, rheumatologists, and others interested in the topic.
Get a thorough review of vital research issues! Fundamentals of Business Marketing Research examines recent industrial/business research, evaluates its current effectiveness, and offers suggestions for future use. This unique book includes and is based on Business Marketing: A Twenty Year Review, a thorough study of industrial/business research from 1978-1997 with critical commentary from a distinguished panel of business academics and the response of the study's authors. The combination of critiques, insights, and viewpoints will challenge you to think beyond the traditional role of B2B marketing into a future that's anything but business as usual. Through an unusual format that gives you access to critical academic analysis, Fundamentals of Business Marketing Research presents a comprehensive review of vital research areas, including marketing to businesses/institutions/governments; buyer-seller relationships; computer use for business marketing; industrial segmentation; channel management and development; physical distribution; advertising; and public relations. The book’s give-and-take is equally focused on areas that have traditionally received a larger share of the research effort (organizational buyer behavior, business marketing strategy and planning, industrial selling and sales management) and those that have taken a back seat in terms of research attention (computers and ethical business marketing). The original study, its criticisms, and the authors’ subsequent assessment spotlight major themes, individual contributions, and future trends in major topic areas, including: business marketing strategy organizational buying behavior and purchasing management business marketing research methodology products/services pricing management issues distribution/logistics and supply chain management promotion Fundamentals of Business Marketing Research is equally effective as a practical guide for professionals and researchers, and as an academic text for doctoral studies.
With contributions from experts in orthopaedic surgery, the latest edition of this comprehensive resource presents up-to-date technical procedures for treating a wide range of fractures in children and adolescents. Content and chapters are easier to read than ever before. How? All clinical sections follow a templatized format—as in previous editions—and now you’ll find even more treatment algorithms, checklists, charts, and tables, helping you quickly identify and apply critical information in a care situation.
Abundant evidence indicates that TENS can be used effectively to alleviate certain pain syndromes. For patients suffering from chronic musculo-skeletal pain in particular, TENS offers an alternative means of pain management. This book addresses the need among physiotherapists for a practical manual on the application of this relatively new technique. Numerous illustrations provide guidelines for the choice of stimulation parameters, the selection of electrode positions, as well as other aspects related to technique. A brief introduction to the neurophysiological mechanisms of pain and the pain-relieving effects of TENS is also given. These special features make this comprehensive presentation of particular interest to physiotherapists and clinicians actively engaged in the management of patients suffering from pain.
High-Resolution Electrophoresis and Immunofixation: Techniques and Interpretation acquaints the reader with the available methodologies and instrumentation for performing high-resolution electrophoresis and immunofixation. This text presents the use of procedures of high-resolution electrophoresis and immunofixation to facilitate the diagnosis of a variety of serum protein abnormalities. It also provides case examples to illustrate the uses of these procedures and their possible caveats. The book contains chapters devoted to the methods and rationale for high-resolution electrophoresis; interpretation of high-resolution electrophoresis patterns in serum, urine, and cerebrospinal fluid; the immunofixation technique; and strategies for diagnosing monoclonal gammopathies. Medical technologists, physicians, and pathologists will find the book invaluable.
In his new book, The Ketogenic Metabolic Breakthrough, Dr. David Jockers delivers a revolutionary new approach to transforming your health by using the principles of the ketogenic diet to reset your metabolism. Chronic illness, degenerative disease and obesity often appears as a direct result of metabolic dysfunction. Using the principles of the low-carb, high-fat ketogenic diet, Jockers will show you how remedy these health problems on finite level by changing your metabolic state. Throughout his book, Dr. Jockers brings you a wealth of expertise, and walks you through step-by-step how to begin and sustain a ketogenic diet. He also highlights and debunks the most common myths circulating about the keto diet and offers the real science behind this nutritional plan that - with the right approach - can forever change your life! This book is also designed to help people trouble shoot common challenges they may experience as they go through the process of keto adaptation so they know what to expect and what to do if they are struggling through this phase. Jockers also incorporates best practices for how to transition from the standard American diet and into the keto diet and lifestyle in a way that is gentle on the body and provides exceptional resources for how to shop, set up refrigerator and pantry and meal plan to ensure success!
Consumer Behavior: Building Marketing Strategy International Edition builds on theory to provide students with a usable, strategic understanding of consumer behaviour that acknowledges recent changes in internet, mobile and social media marketing, ethnic subcultures, internal and external influences, global marketing environments, and other emerging trends. Updated with strategy-based examples from an author team with a deep understanding of each principle's business applications, the international edition contains current and classic examples of both text and visual advertisements throughout to engage students and bring the material to life and four chapters written specifically to focus on the European context. Topics such as ethics and social issues in marketing as well as consumer insights are integrated throughout the text and cases.
For the gold-standard resource on pediatric fractures, reach for Rockwood and Wilkins’ Fractures in Children. Written by leading orthopaedic surgeons from around the world, the revised and expanded 8th edition of this classic bestselling text presents complete, up-to-date coverage of all types of children’s fractures. A must-read for pediatric orthopedic surgeons and orthopedic residents.
With over 45.7 million uninsured in the United States and health reform a national priority, the need for population health management has never been more eminent. Sixty percent of American deaths are attributable to behavioral factors, social circumstances and environmental exposures. Employment of population health management techniques advocating use of preventative services and quality clinical care are imperative. Important Notice: The digital edition of this book is missing some of the images or content found in the physical edition.
At once a major resource for historians of science and an excellent introduction to natural history for the general reader, David Allen's The Naturalist in Britain established a precedent for investigating natural history as a social phenomenon. Here the author traces the evolution of natural history from the seventeenth to the early twentieth centuries, from the "herbalizings" of apprentice apothecaries to the establishment of national reserves and international societies to the emergence of natural history as an organized discipline. Along the way he describes the role of scientific ideas, popular fashion, religious motivations, literary influences, the increase of leisure time and disposable income, and the tendency of like-minded persons to form clubs. His comprehensive and entertaining discussion creates a vibrant portrait of a scientific movement inextricably woven into a particular culture.
As the definitive reference for clinical chemistry, Tietz Textbook of Clinical Chemistry and Molecular Diagnostics, 5th Edition offers the most current and authoritative guidance on selecting, performing, and evaluating results of new and established laboratory tests. Up-to-date encyclopedic coverage details everything you need to know, including: analytical criteria for the medical usefulness of laboratory procedures; new approaches for establishing reference ranges; variables that affect tests and results; the impact of modern analytical tools on lab management and costs; and applications of statistical methods. In addition to updated content throughout, this two-color edition also features a new chapter on hemostasis and the latest advances in molecular diagnostics. Section on Molecular Diagnostics and Genetics contains nine expanded chapters that focus on emerging issues and techniques, written by experts in field, including Y.M. Dennis Lo, Rossa W.K. Chiu, Carl Wittwer, Noriko Kusukawa, Cindy Vnencak-Jones, Thomas Williams, Victor Weedn, Malek Kamoun, Howard Baum, Angela Caliendo, Aaron Bossler, Gwendolyn McMillin, and Kojo S.J. Elenitoba-Johnson. Highly-respected author team includes three editors who are well known in the clinical chemistry world. Reference values in the appendix give you one location for comparing and evaluating test results. NEW! Two-color design throughout highlights important features, illustrations, and content for a quick reference. NEW! Chapter on hemostasis provides you with all the information you need to accurately conduct this type of clinical testing. NEW! Six associate editors lend even more expertise and insight to the reference. NEW! Reorganized chapters ensure that only the most current information is included.
In 1920, David O. McKay embarked on a journey that forever changed the Church of Jesus Christ of Latter-day Saints. His visits to the Latter-day Saint missions, schools, and branches in the Pacific solidified the Church leadership's commitment to global outreach. As importantly, the trip inspired McKay's own initiatives when he later became Church president. McKay's account of his odyssey brings to life the story of the Church of Jesus Christ’s transformation into a global faith. Throughout his diary, McKay expressed his humanity, curiosity, and fascination with cultures and places--the Maori hongi, East Asian customs, Australian wildlife, and more. At the same time, he and his travel companion, Hugh J. Cannon, detailed the Latter-day Saint missionary life of the era, closely observing logistical challenges and cultural differences, guiding various church efforts, and listening to followers' impressions and concerns. Reid L. Neilson and Carson V. Teuscher's meticulous notes provide historical, religious, and general context for the reader.Blending travelogue with history, Pacific Apostle illuminates the thought and work of an essential figure in the twentieth-century Church of Jesus Christ.
This book constitutes the refereed proceedings of the Second International Conference on Case-Based Reasoning, ICCBR-97, held in Providence, RI, USA, in July 1997. The volume presents 39 revised full scientific papers selected from a total of 102 submissions; also included are 20 revised application papers. Among the topics covered are representation and formalization, indexing and retrieval, adaptation, learning, integrated approaches, creative reasoning, CBR and uncertainty. This collection of papers is a comprehensive documentation of the state of the art in CBR research and development.
This book focusses on ground stone tools, stone vessels, and devices carved into rock across the Near East and Egypt from prehistory to the later periods. The aim is to explore all aspects of these tools and stimulate a debate about new methodologies to approach this material.
Classical Sobolev spaces, based on Lebesgue spaces on an underlying domain with smooth boundary, are not only of considerable intrinsic interest but have for many years proved to be indispensible in the study of partial differential equations and variational problems. Many developments of the basic theory since its inception arise in response to concrete problems, for example, with the (ubiquitous) sets with fractal boundaries. The theory will probably enjoy substantial further growth, but even now a connected account of the mature parts of it makes a useful addition to the literature. Accordingly, the main themes of this book are Banach spaces and spaces of Sobolev type based on them; integral operators of Hardy type on intervals and on trees; and the distribution of the approximation numbers (singular numbers in the Hilbert space case) of embeddings of Sobolev spaces based on generalised ridged domains. This timely book will be of interest to all those concerned with the partial differential equations and their ramifications. A prerequisite for reading it is a good graduate course in real analysis.
The continued debate regarding the stage at which the human embryo conceived in the laboratory should be placed in the mother, combined with recent developments in culture media formulations, have brought the role of the human blastocyst in ART back into the spotlight. ART and the Human Blastocyst presents the proceedings of the International Symposium on ART and the Human Blastocyst held from March 30- April 2, 2000 in Dana Point, California. This book brings to the forefront the main issues raised with the transfer of embryos at the blastocyst stage, including the reduction of high order multiple gestations and the role of the blastocyst culture and transfer in facilitating successful single embryo transfer. Sections include gamete quality and pregnancy outcome, physiology of the embryo, blastocyst development in culture, blastocyst transfer and fate, and implantation. More than 40 illustrations and 25 tables complement the text.
A comprehensive clinical reference on managing the entire spectrum of movement disorders NEW DVD with video clips Featuring contributions from more than one hundred leading experts, this full-color text covers pathophysiology, diagnosis, and management of all movement disorders - from ataxia to Parkinson's Disease. Movement Disorders examines the neurobehavioral changes and comorbidities that frequently occur and incorporates the latest genetic information and the most current references. Chapters cover Clinical Presentation and Course, Pathophysiology, Differential Diagnosis, Etiologies, and Treatment. The third edition is highlighted by a new full-color presentation, more than 240 color illustrations and photos, and a DVD with video clips of patients with movement disorders.
Gliese 581 is a red dwarf star some 20.3 light years from Earth. Red dwarfs are among the most numerous stars in the galaxy, and they sport diverse planetary systems. At magnitude 10, Gliese 581 is visible to amateur observers but does not stand out. So what makes this star so important? It is that professional observers have confirmed that it has at least four planets orbiting it, and in 2009, Planet d was described in the letters of The Astrophysical Journal as “the first confirmed exoplanet that could support Earth-like life.” Under a Crimson Sun looks at the nature of red dwarf systems such as Gliese as potential homes for life. Realistically, what are prospects for life on these distant worlds? Could life evolve and survive there? How do these planetary surfaces and geology evolve? How would life on a red dwarf planet differ from life on Earth? And what are the implications for finding further habitable worlds in our galaxy? Stevenson provides readers with insight into the habitability of planets and how this changes as time progresses and the central star evolves. Explore with him in this engaging, fascinating book the possibilities for finding life, from bacteria to more complex and even intelligent organisms, on red dwarf system planets.
This thought-provoking book looks at the nature of red dwarf systems as potential homes for life. Realistically, what are the prospects for life on these distant worlds? Could life evolve and survive there? How do these planetary surfaces and geologies evolve? How would life on a planet orbiting a red dwarf differ from life on Earth? And what are the implications for finding further habitable worlds in our galaxy? The author provides readers with insight into the habitability of planets and how this changes as time progresses and the central star evolves. Since the previous 2013 edition Under a Crimson Sun, there has been a rise in newly discovered planets orbiting red dwarfs, accompanied by controversial areas of research that test what we think we know about these systems. This revised edition delves into the wealth of new material uncovered since that date. It explains the often conflicting results and analyses put forward and clarifies our understanding of these exciting new worlds. The chapters explore the full width of relevant scientific discovery and speculation on the potential for red dwarf planets to host life. New content includes improved atmospheric models, new understandings of the impact of stellar radiation on the atmosphere of red dwarf worlds, tidal-locking, and comparisons with terrestrial geology and climate.
A condensed, easier-to-understand student version of the acclaimed Tietz Textbook of Clinical Chemistry and Molecular Diagnostics, Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics, 7th Edition uses a laboratory perspective in providing the clinical chemistry fundamentals you need to work in a real-world, clinical lab. Coverage ranges from laboratory principles to analytical techniques and instrumentation, analytes, pathophysiology, and more. New content keeps you current with the latest developments in molecular diagnostics. From highly respected clinical chemistry experts Carl Burtis and David Bruns, this textbook shows how to select and perform diagnostic lab tests, and accurately evaluate results. Authoritative, respected author team consists of two well-known experts in the clinical chemistry world. Coverage of analytical techniques and instrumentation includes optical techniques, electrochemistry, electrophoresis, chromatography, mass spectrometry, enzymology, immunochemical techniques, microchips, automation, and point of care testing. Learning objectives begin each chapter, providing measurable outcomes to achieve after completing the material. Key words are listed and defined at the beginning of each chapter, and bolded in the text. A glossary at the end of the book makes it quick and easy to look up definitions of key terms. More than 500 illustrations plus easy-to-read tables help you understand and remember key concepts. New chapters on molecular diagnostics include the principles of molecular biology, nucleic acid techniques and applications, and genomes and nucleic acid alterations, reflecting the changes in this rapidly evolving field. New content on clinical evaluation of methods, kidney function tests, and diabetes is added to this edition. NEW multiple-choice review questions at the end of each chapter allow you to measure your comprehension of the material. NEW case studies on the Evolve companion website use real-life scenarios to reinforce concepts.
This book if a tribute to one of the leading scientists in meteorology, Dr. David Atlas. It was written by a group of specialists and presented at a symposium to honor Dr. Atlas' life and career as meteorologist. It serves as a comprehensive resource for scientists and educators, and also as an inspiring historical record of scientific research and important discoveries in the field of meteorology.
It is increasingly important for physicians who treat older persons, and for researchers on aging, to understand how molecular biology informs clinical expressions of aging and age-related conditions such as osteoporosis, diabetes, osteoarthritis, frailty, cancer, and dementia. Dr. David Hamerman translates basic scientific concepts into precepts of clinical practice and sheds light on the links among biology, natural aging, longevity, and disease. Exploring the connections between disease and the science behind it, Geriatric Bioscience addresses how mechanisms of inflammation, cytokine expression, and stress responses influence disease and how preventive gerontology in the practice of medicine could compress morbidity. Hamerman also discusses cutting-edge therapies such as cyclo-oxygenases, bisphosphonates, statins, cytokine inhibitors, and hormone therapies. Examining the science of geriatrics and converting its concepts into clinical applications, this groundbreaking work provides clinicians and researchers with a solid foundation for a greater understanding of the diagnosis, treatment, and prevention of age-related diseases as well as recommendations for promoting healthy aging.
Now in four convenient volumes, Field’s Virology remains the most authoritative reference in this fast-changing field, providing definitive coverage of virology, including virus biology as well as replication and medical aspects of specific virus families.
Now in four convenient volumes, Field’s Virology remains the most authoritative reference in this fast-changing field, providing definitive coverage of virology, including virus biology as well as replication and medical aspects of specific virus families. This volume of Field’s Virology: Emerging Viruses, 7th Edition covers recent changes in emerging viruses, providing new or extensively revised chapters that reflect these advances in this dynamic field.
In this student-friendly introduction, the authors consider the psychological effects of sport on both the individual and the group. Topics covered include motivation, performance, mental health and leadership, offering a balanced and in-depth resource for students interested in learning more about sport psychology.
Sport Psychology is an essential introduction to the field's key issues, suitable for psychology, sport science and sport studies students at all levels. Encompassing the history of sport psychology to more recent distinctions between sport and exercise psychology, it is ideal reading for students looking to learn about issues such as motivation, concentration and anxiety and the connection between physical activity and psychological well-being. This new edition provides updated case studies, guidance on further reading, study questions and brand new content on self-harm in sport and metaimagery. Real-life examples put the theory into practice, and the authors' focus on the freshest theories shows how the discipline has evolved in recent years.
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